Lrpprc (leucine-rich pentatricopeptide repeat containing) - Rat Genome Database

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Gene: Lrpprc (leucine-rich pentatricopeptide repeat containing) Rattus norvegicus
Analyze
Symbol: Lrpprc
Name: leucine-rich pentatricopeptide repeat containing
RGD ID: 1306575
Description: Predicted to enable several functions, including beta-tubulin binding activity; mRNA 3'-UTR binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in regulation of mitochondrial translation. Predicted to act upstream of or within negative regulation of mitochondrial RNA catabolic process. Predicted to be located in several cellular components, including condensed nuclear chromosome; mitochondrial nucleoid; and perinuclear region of cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in French Canadian Leigh disease and Leigh disease. Orthologous to human LRPPRC (leucine rich pentatricopeptide repeat containing); PARTICIPATES IN CRM1 export pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aconitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 130 kDa leucine-rich protein; leucine rich protein 157; leucine-rich PPR motif-containing protein, mitochondrial; leucine-rich PPR-motif containing; leucine-rich protein 157; LOC313867; LRP 130; Lrp157; rLRP157
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8615,612,638 - 15,695,113 (+)NCBIGRCr8
mRatBN7.269,859,816 - 9,942,294 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl69,859,867 - 9,942,293 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx610,148,236 - 10,230,722 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0610,457,631 - 10,540,115 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.069,979,042 - 10,061,742 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.067,984,043 - 8,066,874 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl67,984,019 - 8,066,868 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.067,919,928 - 8,001,949 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,086,606 - 8,168,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.168,086,606 - 8,168,261 (-)NCBI
Celera69,581,533 - 9,663,935 (+)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
LrpprcRatcytochrome-c oxidase deficiency disease  ISOLRPPRC (Homo sapiens)1600676 RGD 
LrpprcRatLeigh disease  ISOLRPPRC (Homo sapiens)1600674Leigh syndrome French Canadian variant RGD 
LrpprcRatLeigh disease  ISOLRPPRC (Homo sapiens)1600676 RGD 
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Original Reference(s)
LrpprcRatepilepsy  ISOLRPPRC (Homo sapiens)8554872ClinVar Annotator: match by term: SeizuresClinVarPMID:25741868 and PMID:28492532
LrpprcRatFrench Canadian Leigh disease  ISOLRPPRC (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12529507 more ...
LrpprcRatFrench Canadian Leigh disease  ISOLRPPRC (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12529507 more ...
LrpprcRatgenetic disease  ISOLRPPRC (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:17576681 more ...
LrpprcRatholoprosencephaly 2  ISOLRPPRC (Homo sapiens)8554872ClinVar Annotator: match by term: Holoprosencephaly 2ClinVarPMID:18791198 more ...
LrpprcRatLeigh disease  ISOLRPPRC (Homo sapiens)8554872ClinVar Annotator: match by term: Leigh syndromeClinVarPMID:25741868 and PMID:28492532
LrpprcRatLynch syndrome  ISOLRPPRC (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal neoplasmsClinVarPMID:28492532
LrpprcRatsitosterolemia  ISOLRPPRC (Homo sapiens)8554872ClinVar Annotator: match by term: SitosterolemiaClinVarPMID:28492532
LrpprcRatSubacute Necrotizing Encephalopathy of Leigh, Infantile  ISOLRPPRC (Homo sapiens)8554872ClinVar Annotator: match by term: Leigh's necrotizing encephalopathyClinVarPMID:28492532
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Original Reference(s)
LrpprcRatFrench Canadian Leigh disease  ISOLRPPRC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12529507
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Original Reference(s)
LrpprcRatFrench Canadian Leigh disease  ISOLRPPRC (Homo sapiens)7240710 OMIM 

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Original Reference(s)
LrpprcRat(1->4)-beta-D-glucan multiple interactionsISOLrpprc (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of LRPPRC mRNACTDPMID:36331819
LrpprcRat1,2-dimethylhydrazine increases expressionISOLrpprc (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of LRPPRC mRNACTDPMID:22206623
LrpprcRat1,2-dimethylhydrazine multiple interactionsISOLrpprc (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of LRPPRC mRNACTDPMID:22206623
LrpprcRat17alpha-ethynylestradiol multiple interactionsISOLrpprc (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LRPPRC mRNACTDPMID:17942748
LrpprcRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOLrpprc (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LRPPRC mRNACTDPMID:17942748
LrpprcRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of LRPPRC mRNACTDPMID:32277265
LrpprcRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOLrpprc (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of LRPPRC mRNACTDPMID:21570461
LrpprcRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOLRPPRC (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of LRPPRC mRNACTDPMID:21632981
LrpprcRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of LRPPRC mRNACTDPMID:21215274 and PMID:33387578
LrpprcRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOLrpprc (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of LRPPRC mRNACTDPMID:19770486
LrpprcRat2,6-dimethoxyphenol multiple interactionsISOLRPPRC (Homo sapiens)6480464[pyrogallol 1 more ...CTDPMID:38598786
LrpprcRat3',5'-cyclic UMP affects bindingISOLRPPRC (Homo sapiens)6480464LRPPRC protein binds to cyclic 3' and 5'-uridine monophosphateCTDPMID:30528433
LrpprcRat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOLRPPRC (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LRPPRC mRNACTDPMID:28628672
LrpprcRat4,4'-sulfonyldiphenol increases expressionISOLRPPRC (Homo sapiens)6480464bisphenol S results in increased expression of LRPPRC proteinCTDPMID:34186270
LrpprcRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of LRPPRC mRNACTDPMID:30047161
LrpprcRataconitine increases expressionEXP 6480464Aconitine results in increased expression of LRPPRC proteinCTDPMID:33236894
LrpprcRatacrolein multiple interactionsISOLRPPRC (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of LRPPRC mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of LRPPRC mRNACTDPMID:32699268
LrpprcRatacrylamide increases expressionISOLrpprc (Mus musculus)6480464Acrylamide results in increased expression of LRPPRC mRNACTDPMID:30807115
LrpprcRatactinomycin D multiple interactionsISOLRPPRC (Homo sapiens)6480464[Dactinomycin co-treated with nutlin 3] results in increased secretion of LRPPRC proteinCTDPMID:38460933
LrpprcRatall-trans-retinoic acid decreases expressionISOLRPPRC (Homo sapiens)6480464Tretinoin results in decreased expression of LRPPRC mRNACTDPMID:33167477

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Biological Process
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Cellular Component
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Original Reference(s)
LrpprcRatcondensed nuclear chromosome located_inISSUniProtKB:P427041600115GO_REF:0000024HGNC-UCLGO_REF:0000024
LrpprcRatcondensed nuclear chromosome located_inIEAUniProtKB:P42704 and ensembl:ENSP000002606651600115GO_REF:0000107EnsemblGO_REF:0000107
LrpprcRatcondensed nuclear chromosome located_inISOLRPPRC (Homo sapiens)1624291 PMID:12762840RGDPMID:12762840
LrpprcRatcytoplasm located_inISOLrpprc (Mus musculus)1624291 PMID:12071956RGDPMID:12071956
LrpprcRatcytoplasm located_inIEAUniProtKB:Q6PB66 and ensembl:ENSMUSP000001079271600115GO_REF:0000107EnsemblGO_REF:0000107
LrpprcRatcytoskeleton located_inISOLRPPRC (Homo sapiens)1624291 PMID:12762840RGDPMID:12762840
LrpprcRatcytoskeleton located_inIEAUniProtKB:P42704 and ensembl:ENSP000002606651600115GO_REF:0000107EnsemblGO_REF:0000107
LrpprcRatcytoskeleton located_inISSUniProtKB:P427041600115GO_REF:0000024HGNC-UCLGO_REF:0000024
LrpprcRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
LrpprcRatmicrotubule located_inISOLRPPRC (Homo sapiens)1624291 PMID:21525035RGDPMID:21525035
LrpprcRatmicrotubule located_inIEAUniProtKB:P42704 and ensembl:ENSP000002606651600115GO_REF:0000107EnsemblGO_REF:0000107
LrpprcRatmitochondrial matrix located_inISOLRPPRC (Homo sapiens)1624291 PMID:23275553RGDPMID:23275553
LrpprcRatmitochondrial matrix located_inIEAUniProtKB:P42704 and ensembl:ENSP000002606651600115GO_REF:0000107EnsemblGO_REF:0000107
LrpprcRatmitochondrial nucleoid located_inISOLRPPRC (Homo sapiens)1624291 PMID:18063578RGDPMID:18063578
LrpprcRatmitochondrial nucleoid located_inIEAUniProtKB:P42704 and ensembl:ENSP000002606651600115GO_REF:0000107EnsemblGO_REF:0000107
LrpprcRatmitochondrion located_inISSUniProtKB:P427041600115GO_REF:0000024HGNC-UCLGO_REF:0000024
LrpprcRatmitochondrion located_inIEAUniProtKB:Q6PB66 and ensembl:ENSMUSP000001079271600115GO_REF:0000107EnsemblGO_REF:0000107
LrpprcRatmitochondrion located_inIEAUniProtKB:E5KNY5 and ensembl:ENSP000002606651600115GO_REF:0000107EnsemblGO_REF:0000107
LrpprcRatmitochondrion located_inIEAUniProtKB:P42704 and ensembl:ENSP000002606651600115GO_REF:0000107EnsemblGO_REF:0000107
LrpprcRatmitochondrion located_inIEAUniProtKB-SubCell:SL-01731600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function
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Original Reference(s)
LrpprcRatactin filament binding NOT|enablesISSUniProtKB:P427041600115GO_REF:0000024HGNC-UCLGO_REF:0000024
LrpprcRatactin filament binding NOT|enablesISOLRPPRC (Homo sapiens)1624291 PMID:12762840RGDPMID:12762840
LrpprcRatbeta-tubulin binding enablesISSUniProtKB:P427041600115GO_REF:0000024HGNC-UCLGO_REF:0000024
LrpprcRatbeta-tubulin binding enablesIEAUniProtKB:P42704 and ensembl:ENSP000002606651600115GO_REF:0000107EnsemblGO_REF:0000107
LrpprcRatbeta-tubulin binding enablesISOLRPPRC (Homo sapiens)1624291 PMID:12762840RGDPMID:12762840
LrpprcRatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
LrpprcRatmRNA 3'-UTR binding enablesIBAFB:FBgn0284256 and PANTHER:PTN0023670511600115GO_REF:0000033GO_CentralGO_REF:0000033
LrpprcRatprotein binding enablesISOLRPPRC (Homo sapiens)1624291UniProtKB:P05067 more ...RGDPMID:15161933 more ...
LrpprcRatprotein binding enablesISOLrpprc (Mus musculus)1624291UniProtKB:O70343 more ...RGDPMID:17050673
LrpprcRatRNA binding enablesIEAUniProtKB:Q6PB66 and ensembl:ENSMUSP000001079271600115GO_REF:0000107EnsemblGO_REF:0000107
LrpprcRatRNA binding enablesIEAUniProtKB-KW:KW-06941600115GO_REF:0000043UniProtGO_REF:0000043
LrpprcRatRNA binding enablesISOLrpprc (Mus musculus)1624291 PMID:21880015RGDPMID:21880015
LrpprcRatsingle-stranded DNA binding enablesIEAUniProtKB:Q6PB66 and ensembl:ENSMUSP000001079271600115GO_REF:0000107EnsemblGO_REF:0000107
LrpprcRatsingle-stranded DNA binding enablesISOLrpprc (Mus musculus)1624291 PMID:12071956RGDPMID:12071956
LrpprcRatubiquitin protein ligase binding enablesISOLRPPRC (Homo sapiens)1624291UniProtKB:O60260 and PMID:19725078RGDPMID:19725078
LrpprcRatubiquitin protein ligase binding enablesIEAUniProtKB:P42704 and ensembl:ENSP000002606651600115GO_REF:0000107EnsemblGO_REF:0000107
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RGD Manual Annotations


  
Object Symbol
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Original Reference(s)
LrpprcRatCRM1 export pathway  ISOLRPPRC (Homo sapiens)9743967 RGD 

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Reference Title
Reference Citation
1. Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. Cooper MP, etal., Genes Dev. 2006 Nov 1;20(21):2996-3009. Epub 2006 Oct 18.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics. Mootha VK, etal., Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):605-10. Epub 2003 Jan 14.
6. Postage for the messenger: designating routes for nuclear mRNA export. Natalizio BJ and Wente SR, Trends Cell Biol. 2013 Aug;23(8):365-73. doi: 10.1016/j.tcb.2013.03.006. Epub 2013 Apr 11.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
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PMID:12071956   PMID:12762840   PMID:12832482   PMID:14651853   PMID:15525270   PMID:17339062   PMID:18063578   PMID:18614015   PMID:19725078   PMID:19946888   PMID:21525035   PMID:21880015  
PMID:22045337   PMID:22658674   PMID:22681889   PMID:26316108  



Lrpprc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8615,612,638 - 15,695,113 (+)NCBIGRCr8
mRatBN7.269,859,816 - 9,942,294 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl69,859,867 - 9,942,293 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx610,148,236 - 10,230,722 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0610,457,631 - 10,540,115 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.069,979,042 - 10,061,742 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.067,984,043 - 8,066,874 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl67,984,019 - 8,066,868 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.067,919,928 - 8,001,949 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,086,606 - 8,168,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.168,086,606 - 8,168,261 (-)NCBI
Celera69,581,533 - 9,663,935 (+)NCBICelera
Cytogenetic Map6q12NCBI
LRPPRC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38243,886,224 - 43,996,265 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl243,886,224 - 43,996,226 (-)EnsemblGRCh38hg38GRCh38
GRCh37244,113,363 - 44,223,128 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36243,968,391 - 44,076,648 (-)NCBINCBI36Build 36hg18NCBI36
Build 34244,026,537 - 44,134,795NCBI
Celera243,952,087 - 44,062,100 (-)NCBICelera
Cytogenetic Map2p21NCBI
HuRef243,849,689 - 43,959,564 (-)NCBIHuRef
CHM1_1244,042,771 - 44,152,581 (-)NCBICHM1_1
T2T-CHM13v2.0243,891,557 - 44,001,630 (-)NCBIT2T-CHM13v2.0
Lrpprc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391785,012,675 - 85,098,214 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1785,012,675 - 85,098,217 (-)EnsemblGRCm39 Ensembl
GRCm381784,705,247 - 84,790,786 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1784,705,247 - 84,790,789 (-)EnsemblGRCm38mm10GRCm38
MGSCv371785,104,587 - 85,190,126 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361784,613,573 - 84,698,841 (-)NCBIMGSCv36mm8
Celera1789,073,226 - 89,158,633 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.02NCBI
Lrpprc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544111,012,910 - 11,116,965 (-)NCBIChiLan1.0ChiLan1.0
LRPPRC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21282,421,380 - 82,530,685 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A82,425,351 - 82,535,405 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A43,975,949 - 44,083,846 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A44,914,578 - 45,021,434 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A44,914,578 - 45,021,434 (-)Ensemblpanpan1.1panPan2
LRPPRC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11046,325,312 - 46,438,376 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1046,327,223 - 46,438,342 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1046,188,975 - 46,300,206 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01047,205,831 - 47,317,113 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1047,203,961 - 47,317,132 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11046,914,258 - 47,025,488 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01047,203,848 - 47,313,376 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01047,387,584 - 47,498,808 (-)NCBIUU_Cfam_GSD_1.0
Lrpprc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629236,532,488 - 36,638,283 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365087,961,079 - 8,068,228 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRPPRC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl396,474,549 - 96,595,143 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1396,474,510 - 96,590,706 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23102,630,054 - 102,744,878 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRPPRC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11463,263,101 - 63,380,607 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604548,506,466 - 48,623,733 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrpprc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473825,338,098 - 25,452,676 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473825,340,588 - 25,452,593 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Lrpprc
420 total Variants

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:18
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000008200
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 26 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
8693699Alc37Alcohol consumption QTL 372.60.224drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)6796416721301982Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat

1 to 10 of 26 rows
D6Got4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.269,892,700 - 9,892,994 (-)MAPPERmRatBN7.2
Rnor_6.068,033,341 - 8,033,634NCBIRnor6.0
Rnor_5.067,969,226 - 7,969,519UniSTSRnor5.0
RGSC_v3.468,135,903 - 8,136,197RGDRGSC3.4
RGSC_v3.468,135,904 - 8,136,197UniSTSRGSC3.4
RGSC_v3.168,135,903 - 8,136,197RGD
Celera69,614,357 - 9,614,650UniSTS
Cytogenetic Map6q12UniSTS
RH132068  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.269,890,527 - 9,890,736 (-)MAPPERmRatBN7.2
Rnor_6.068,035,599 - 8,035,807NCBIRnor6.0
Rnor_5.067,971,484 - 7,971,692UniSTSRnor5.0
RGSC_v3.468,138,162 - 8,138,370UniSTSRGSC3.4
Celera69,612,184 - 9,612,392UniSTS
Cytogenetic Map6q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000008200   ⟹   ENSRNOP00000008200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl69,859,867 - 9,942,293 (+)Ensembl
Rnor_6.0 Ensembl67,984,019 - 8,066,868 (-)Ensembl
RefSeq Acc Id: NM_001008519   ⟹   NP_001008519
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,612,638 - 15,695,113 (+)NCBI
mRatBN7.269,859,816 - 9,942,294 (+)NCBI
Rnor_6.067,984,043 - 8,066,874 (-)NCBI
Rnor_5.067,919,928 - 8,001,949 (-)NCBI
RGSC_v3.468,086,606 - 8,168,261 (-)RGD
Celera69,581,533 - 9,663,935 (+)RGD
Sequence:
Protein RefSeqs NP_001008519 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ74626 (Get FASTA)   NCBI Sequence Viewer  
  EDM02689 (Get FASTA)   NCBI Sequence Viewer  
  EDM02690 (Get FASTA)   NCBI Sequence Viewer  
  EDM02691 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008200
GenBank Protein Q5SGE0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008519   ⟸   NM_001008519
- Peptide Label: precursor
- UniProtKB: Q5SGE0 (UniProtKB/Swiss-Prot),   A6H9I4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008200   ⟸   ENSRNOT00000008200
PROP1-like PPR

Name Modeler Protein Id AA Range Protein Structure
AF-Q5SGE0-F1-model_v2 AlphaFold Q5SGE0 1-1392 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694377
Promoter ID:EPDNEW_R4902
Type:initiation region
Name:Lrpprc_1
Description:leucine-rich pentatricopeptide repeat containing
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.068,066,908 - 8,066,968EPDNEW


1 to 24 of 24 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-38647 BioCyc
Ensembl Genes ENSRNOG00000005877 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000008200 ENTREZGENE
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
InterPro LRP130 UniProtKB/Swiss-Prot
  Pentatricopeptide_repeat UniProtKB/Swiss-Prot
  PPR_long UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:313867 UniProtKB/Swiss-Prot
NCBI Gene 313867 ENTREZGENE
PANTHER LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR46669 UniProtKB/Swiss-Prot
Pfam PPR UniProtKB/Swiss-Prot
  PPR_3 UniProtKB/Swiss-Prot
  PPR_long UniProtKB/Swiss-Prot
PhenoGen Lrpprc PhenoGen
PROSITE PPR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005877 RatGTEx
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot
UniProt A6H9I4 ENTREZGENE, UniProtKB/TrEMBL
  A6H9I5_RAT UniProtKB/TrEMBL
  A6H9I6_RAT UniProtKB/TrEMBL
  F1LM33_RAT UniProtKB/TrEMBL
  LPPRC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-02 Lrpprc  leucine-rich pentatricopeptide repeat containing  Lrpprc  leucine-rich PPR-motif containing  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Lrpprc  leucine-rich PPR-motif containing  Lrpprc_predicted  leucine-rich PPR-motif containing (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Lrpprc_predicted  leucine-rich PPR-motif containing (predicted)      Symbol and Name status set to approved 70820 APPROVED