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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Arhgef7 | Mouse | (-)-demecolcine | increases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Demecolcine results in increased expression of ARHGEF7 mRNA | CTD | PMID:23649840 | Arhgef7 | Mouse | (1->4)-beta-D-glucan | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ARHGEF7 mRNA | CTD | PMID:36331819 | Arhgef7 | Mouse | (S)-nicotine | decreases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Nicotine results in decreased expression of ARHGEF7 mRNA | CTD | PMID:12588870 | Arhgef7 | Mouse | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of ARHGEF7 mRNA | CTD | PMID:17555576 | Arhgef7 | Mouse | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARHGEF7 mRNA | CTD | PMID:17942748 | Arhgef7 | Mouse | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of ARHGEF7 mRNA | CTD | PMID:17942748 | Arhgef7 | Mouse | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | Arhgef7 | Mouse | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:19095052 | Arhgef7 | Mouse | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | Arhgef7 | Mouse | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:31826744 | Arhgef7 | Mouse | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | Arhgef7 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARHGEF7 mRNA | CTD | PMID:17942748 | Arhgef7 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of ARHGEF7 mRNA | CTD | PMID:22298810 and PMID:34747641 | Arhgef7 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ARHGEF7 mRNA | CTD | PMID:17942748 | Arhgef7 | Mouse | 2,4,6-tribromophenol | decreases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | Arhgef7 | Mouse | 2-methylcholine | affects expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of ARHGEF7 mRNA | CTD | PMID:21179406 | Arhgef7 | Mouse | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of ARHGEF7 protein | CTD | PMID:31675489 | Arhgef7 | Mouse | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of ARHGEF7 mRNA | CTD | PMID:20188158 | Arhgef7 | Mouse | 6-propyl-2-thiouracil | increases expression | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of ARHGEF7 mRNA | CTD | PMID:30047161 | Arhgef7 | Mouse | acrylamide | decreases expression | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | Acrylamide results in decreased expression of ARHGEF7 mRNA | CTD | PMID:15749267 and PMID:28959563 | Arhgef7 | Mouse | aflatoxin B1 | increases methylation | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of ARHGEF7 gene | CTD | PMID:27153756 | Arhgef7 | Mouse | all-trans-retinoic acid | increases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of ARHGEF7 mRNA | CTD | PMID:23724009 | Arhgef7 | Mouse | amiodarone | increases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Amiodarone results in increased expression of ARHGEF7 mRNA | CTD | PMID:19774075 | Arhgef7 | Mouse | amitrole | increases expression | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | Amitrole results in increased expression of ARHGEF7 mRNA | CTD | PMID:30047161 | Arhgef7 | Mouse | ammonium chloride | affects expression | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of ARHGEF7 mRNA | CTD | PMID:16483693 | Arhgef7 | Mouse | antirheumatic drug | increases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of ARHGEF7 mRNA | CTD | PMID:24449571 | Arhgef7 | Mouse | aristolochic acid A | decreases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of ARHGEF7 mRNA | CTD | PMID:33212167 | Arhgef7 | Mouse | arsane | affects methylation | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Arsenic affects the methylation of ARHGEF7 gene | CTD | PMID:25304211 | Arhgef7 | Mouse | arsenic atom | affects methylation | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Arsenic affects the methylation of ARHGEF7 gene | CTD | PMID:25304211 | Arhgef7 | Mouse | arsenite(3-) | multiple interactions | ISO | ARHGEF7 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to ARHGEF7 mRNA] | CTD | PMID:32406909 | Arhgef7 | Mouse | benzo[a]pyrene | increases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of ARHGEF7 mRNA | CTD | PMID:17879257 | Arhgef7 | Mouse | benzo[a]pyrene | affects methylation | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of ARHGEF7 3' UTR and Benzo(a)pyrene affects the methylation of ARHGEF7 promoter | CTD | PMID:27901495 | Arhgef7 | Mouse | benzo[a]pyrene | increases methylation | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of ARHGEF7 exon | CTD | PMID:27901495 | Arhgef7 | Mouse | benzo[a]pyrene diol epoxide I | decreases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | Arhgef7 | Mouse | bisphenol A | affects expression | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of ARHGEF7 mRNA | CTD | PMID:25181051 | Arhgef7 | Mouse | bisphenol A | increases methylation | ISO | ARHGEF7 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of ARHGEF7 gene | CTD | PMID:31601247 | Arhgef7 | Mouse | bisphenol A | decreases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of ARHGEF7 protein | CTD | PMID:31675489 | Arhgef7 | Mouse | bisphenol A | multiple interactions | ISO | ARHGEF7 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of ARHGEF7 gene | CTD | PMID:31601247 | Arhgef7 | Mouse | bisphenol A | increases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of ARHGEF7 mRNA | CTD | PMID:33670352 | Arhgef7 | Mouse | bisphenol A | increases methylation | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of ARHGEF7 gene | CTD | PMID:28505145 | Arhgef7 | Mouse | bisphenol AF | increases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | bisphenol AF results in increased expression of ARHGEF7 protein | CTD | PMID:34186270 | Arhgef7 | Mouse | C60 fullerene | increases expression | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | fullerene C60 results in increased expression of ARHGEF7 mRNA | CTD | PMID:19167457 | Arhgef7 | Mouse | cadmium dichloride | decreases expression | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | Cadmium Chloride results in decreased expression of ARHGEF7 mRNA | CTD | PMID:33453195 | Arhgef7 | Mouse | carbamazepine | affects expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of ARHGEF7 mRNA | CTD | PMID:24752500 | Arhgef7 | Mouse | CGP 52608 | multiple interactions | ISO | ARHGEF7 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ARHGEF7 gene] | CTD | PMID:28238834 | Arhgef7 | Mouse | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ARHGEF7 mRNA | CTD | PMID:20938992 | Arhgef7 | Mouse | cobalt dichloride | increases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of ARHGEF7 mRNA | CTD | PMID:19376846 | Arhgef7 | Mouse | cocaine | affects expression | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | Cocaine affects the expression of ARHGEF7 mRNA | CTD | PMID:20187946 | Arhgef7 | Mouse | copper(II) sulfate | increases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of ARHGEF7 mRNA | CTD | PMID:19549813 | Arhgef7 | Mouse | decabromodiphenyl ether | decreases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of ARHGEF7 protein | CTD | PMID:31675489 | Arhgef7 | Mouse | Dibutyl phosphate | affects expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of ARHGEF7 mRNA | CTD | PMID:37042841 | Arhgef7 | Mouse | diclofenac | affects expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Diclofenac affects the expression of ARHGEF7 mRNA | CTD | PMID:24752500 | Arhgef7 | Mouse | doxorubicin | decreases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of ARHGEF7 mRNA | CTD | PMID:29803840 | Arhgef7 | Mouse | enzyme inhibitor | multiple interactions | ISO | ARHGEF7 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ARHGEF7 protein | CTD | PMID:23301498 | Arhgef7 | Mouse | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of ARHGEF7 mRNA | CTD | PMID:30319688 | Arhgef7 | Mouse | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ARHGEF7 mRNA | CTD | PMID:20938992 | Arhgef7 | Mouse | FR900359 | affects phosphorylation | ISO | ARHGEF7 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of ARHGEF7 protein | CTD | PMID:37730182 | Arhgef7 | Mouse | fulvestrant | multiple interactions | ISO | ARHGEF7 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of ARHGEF7 gene | CTD | PMID:31601247 | Arhgef7 | Mouse | gentamycin | decreases expression | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | Gentamicins results in decreased expression of ARHGEF7 mRNA | CTD | PMID:22061828 | Arhgef7 | Mouse | inulin | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of ARHGEF7 mRNA | CTD | PMID:36331819 | Arhgef7 | Mouse | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ARHGEF7 mRNA | CTD | PMID:20938992 | Arhgef7 | Mouse | manganese(II) chloride | decreases expression | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | manganese chloride results in decreased expression of ARHGEF7 mRNA | CTD | PMID:28801915 | Arhgef7 | Mouse | menadione | affects expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of ARHGEF7 mRNA | CTD | PMID:20044591 | Arhgef7 | Mouse | methimazole | increases expression | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | Methimazole results in increased expression of ARHGEF7 mRNA | CTD | PMID:30047161 | Arhgef7 | Mouse | methoxychlor | affects methylation | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | Methoxychlor affects the methylation of ARHGEF7 gene | CTD | PMID:35440735 | Arhgef7 | Mouse | methylmercury chloride | decreases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of ARHGEF7 mRNA | CTD | PMID:28001369 | Arhgef7 | Mouse | N-methyl-4-phenylpyridinium | decreases expression | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of ARHGEF7 mRNA | CTD | PMID:28801915 | Arhgef7 | Mouse | nicotine | decreases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Nicotine results in decreased expression of ARHGEF7 mRNA | CTD | PMID:12588870 | Arhgef7 | Mouse | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of ARHGEF7 mRNA | CTD | PMID:17562736 | Arhgef7 | Mouse | paracetamol | increases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of ARHGEF7 mRNA | CTD | PMID:21420995 | Arhgef7 | Mouse | PCB138 | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | Arhgef7 | Mouse | pentanal | decreases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | pentanal results in decreased expression of ARHGEF7 mRNA | CTD | PMID:26079696 | Arhgef7 | Mouse | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ARHGEF7 mRNA more ... | CTD | PMID:36331819 | Arhgef7 | Mouse | phenobarbital | multiple interactions | EXP | | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ARHGEF7 mRNA] | CTD | PMID:19482888 | Arhgef7 | Mouse | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of ARHGEF7 mRNA | CTD | PMID:23091169 | Arhgef7 | Mouse | phenobarbital | increases expression | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | Phenobarbital results in increased expression of ARHGEF7 mRNA | CTD | PMID:19162173 | Arhgef7 | Mouse | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of ARHGEF7 mRNA | CTD | PMID:19482888 | Arhgef7 | Mouse | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of ARHGEF7 mRNA | CTD | PMID:18445702 | Arhgef7 | Mouse | poly(I:C) | multiple interactions | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | [Poly I-C co-treated with HU 211] results in decreased expression of ARHGEF7 mRNA | CTD | PMID:26923065 | Arhgef7 | Mouse | propiconazole | increases expression | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | propiconazole results in increased expression of ARHGEF7 mRNA | CTD | PMID:30047161 | Arhgef7 | Mouse | sodium arsenite | increases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of ARHGEF7 mRNA | CTD | PMID:38568856 | Arhgef7 | Mouse | sulfadimethoxine | increases expression | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in increased expression of ARHGEF7 mRNA | CTD | PMID:30047161 | Arhgef7 | Mouse | tamoxifen | affects expression | EXP | | 6480464 | Tamoxifen affects the expression of ARHGEF7 mRNA | CTD | PMID:17555576 | Arhgef7 | Mouse | temozolomide | decreases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of ARHGEF7 mRNA | CTD | PMID:31758290 | Arhgef7 | Mouse | tert-butyl hydroperoxide | decreases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of ARHGEF7 mRNA | CTD | PMID:15336504 | Arhgef7 | Mouse | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of ARHGEF7 mRNA | CTD | PMID:29264374 | Arhgef7 | Mouse | titanium dioxide | decreases methylation | EXP | | 6480464 | titanium dioxide results in decreased methylation of ARHGEF7 promoter | CTD | PMID:35295148 | Arhgef7 | Mouse | titanium dioxide | increases methylation | EXP | | 6480464 | titanium dioxide results in increased methylation of ARHGEF7 gene | CTD | PMID:35295148 | Arhgef7 | Mouse | trichloroethene | increases methylation | ISO | Arhgef7 (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased methylation of ARHGEF7 gene | CTD | PMID:27618143 | Arhgef7 | Mouse | trichostatin A | decreases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of ARHGEF7 mRNA | CTD | PMID:24935251 | Arhgef7 | Mouse | triphenyl phosphate | affects expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of ARHGEF7 mRNA | CTD | PMID:37042841 | Arhgef7 | Mouse | tungsten | decreases expression | EXP | | 6480464 | Tungsten results in decreased expression of ARHGEF7 mRNA | CTD | PMID:30912803 | Arhgef7 | Mouse | valproic acid | affects expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of ARHGEF7 mRNA | CTD | PMID:25979313 | Arhgef7 | Mouse | vincristine | increases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | Vincristine results in increased expression of ARHGEF7 mRNA | CTD | PMID:23649840 | Arhgef7 | Mouse | vorinostat | decreases expression | ISO | ARHGEF7 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of ARHGEF7 mRNA | CTD | PMID:27188386 | Arhgef7 | Mouse | zinc atom | multiple interactions | ISO | ARHGEF7 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of ARHGEF7 mRNA | CTD | PMID:18593933 | Arhgef7 | Mouse | zinc(0) | multiple interactions | ISO | ARHGEF7 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of ARHGEF7 mRNA | CTD | PMID:18593933 | |