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Gene: ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6) Homo sapiens
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Symbol: ARHGEF6
Name: Rac/Cdc42 guanine nucleotide exchange factor 6
Description: Predicted to have guanyl-nucleotide exchange factor activity. Predicted to be involved in lamellipodium assembly. Predicted to localize to the lamellipodium. Implicated in intellectual disability and non-syndromic X-linked intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha-PIX; alphaPIX; Cool-2; COOL2; KIAA0006; mental retardation, X-linked 46; MRX46; PAK-interacting exchange factor alpha; PAK-interacting exchange factor, alpha; PIXA; Rac/Cdc42 guanine exchange factor (GEF) 6; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; rho guanine nucleotide exchange factor 6
Orthologs:
Mus musculus (house mouse) : Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6)
Pan paniscus (bonobo/pygmy chimpanzee) : ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)
Canis lupus familiaris (dog) : ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6)
Sus scrofa (pig) : ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)
Chlorocebus sabaeus (African green monkey) : ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)
Heterocephalus glaber (naked mole-rat) : Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX136,665,547 - 136,780,932 (-)Ensembl
GRCh38X136,665,547 - 136,780,945 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X135,747,708 - 135,863,503 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X135,575,375 - 135,691,169 (-)NCBINCBI36hg18NCBI36
Build 34X135,473,232 - 135,589,023NCBI
CeleraX136,111,384 - 136,227,182 (-)NCBI
Cytogenetic MapXq26.3NCBI
HuRefX125,018,703 - 125,134,374 (-)NCBIHuRef
CHM1_1X135,659,375 - 135,775,269 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ARHGEF6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1343816
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.