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Gene: Chrna2 (cholinergic receptor nicotinic alpha 2 subunit) Mus musculus

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Symbol:

Chrna2

Name:

cholinergic receptor nicotinic alpha 2 subunit

RGD ID:

735908

MGI Page

MGI

Description:

Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity and quaternary ammonium group binding activity. Predicted to contribute to acetylcholine receptor activity and heterocyclic compound binding activity. Predicted to be involved in several processes, including cellular response to nicotine; modulation of inhibitory postsynaptic potential; and synaptic signaling. Located in cell periphery. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and spinal cord. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 4 and benign familial infantile seizures 6. Orthologous to human CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Ac; acetylcholine receptor alpha 2 neural; Acr; Acra-2; Acra2; BC011490; cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal); MGC18795; neuronal acetylcholine receptor subunit alpha-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	66,370,685 - 66,390,397 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	66,372,488 - 66,390,397 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	66,133,236 - 66,152,948 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	66,135,039 - 66,152,948 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	66,759,797 - 66,771,785 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	65,095,070 - 65,107,058 (+)	NCBI		MGSCv36	mm8
Celera	14	63,889,359 - 63,901,395 (+)	NCBI		Celera
Cytogenetic Map	14	D1	NCBI
cM Map	14	34.36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Chrna2	Mouse	autosomal dominant nocturnal frontal lobe epilepsy		ISO	CHRNA2 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:16199547 more ...
Chrna2	Mouse	autosomal dominant nocturnal frontal lobe epilepsy 4		ISO	CHRNA2 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:16222669 more ...
Chrna2	Mouse	benign familial infantile seizures 6		ISO	CHRNA2 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:16199547 more ...
Chrna2	Mouse	epilepsy		ISO	CHRNA2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Seizure	ClinVar	PMID:28492532
Chrna2	Mouse	genetic disease		ISO	CHRNA2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:17576681 more ...
Chrna2	Mouse	intellectual disability		ISO	CHRNA2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Intellectual disability	ClinVar	PMID:25741868 and PMID:28492532
Chrna2	Mouse	Myoclonic Epilepsies		ISO	CHRNA2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: myoclonic epilepsy	ClinVar	PMID:28492532

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Chrna2	Mouse	autosomal dominant nocturnal frontal lobe epilepsy 4		ISO	CHRNA2 (Homo sapiens)	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:19383498
Chrna2	Mouse	Lung Neoplasms		ISO	CHRNA2 (Homo sapiens)	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:28604730

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Chrna2	Mouse	autosomal dominant nocturnal frontal lobe epilepsy 4		ISO	CHRNA2 (Homo sapiens)	7240710		OMIM
Chrna2	Mouse	benign familial infantile seizures 6		ISO	CHRNA2 (Homo sapiens)	7240710		OMIM

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Chrna2	Mouse	(1->4)-beta-D-glucan	multiple interactions	EXP		6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CHRNA2 mRNA	CTD	PMID:36331819
Chrna2	Mouse	(S)-nicotine	multiple interactions	ISO	CHRNA2 (Homo sapiens)	6480464	Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]	CTD	PMID:9454827
Chrna2	Mouse	(S)-nicotine	affects response to substance	ISO	CHRNA2 (Homo sapiens)	6480464	CHRNA2 gene mutant form affects the susceptibility to Nicotine	CTD	PMID:19383498
Chrna2	Mouse	1,1-dimethyl-4-phenylpiperazinium iodide	multiple interactions	ISO	CHRNA2 (Homo sapiens)	6480464	Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]	CTD	PMID:9454827
Chrna2	Mouse	1,1-dimethyl-4-phenylpiperazinium iodide	multiple interactions	ISO	Chrna2 (Rattus norvegicus)	2303194	1 and 1-dimethyl-4-phenylpiperazinium iodide affects binding competes with [Epibatidine binds to Chrna2 protein]	RGD
Chrna2	Mouse	1-naphthyl isothiocyanate	decreases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	1-Naphthylisothiocyanate results in decreased expression of CHRNA2 mRNA	CTD	PMID:30723492
Chrna2	Mouse	17beta-estradiol	increases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Estradiol results in increased expression of CHRNA2 mRNA	CTD	PMID:32145629
Chrna2	Mouse	17beta-estradiol	increases expression	EXP		6480464	Estradiol results in increased expression of CHRNA2 mRNA	CTD	PMID:39298647
Chrna2	Mouse	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	CHRNA2 (Homo sapiens)	6480464	Tetrachlorodibenzodioxin results in increased expression of CHRNA2 mRNA	CTD	PMID:21296121
Chrna2	Mouse	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Tetrachlorodibenzodioxin results in decreased expression of CHRNA2 mRNA	CTD	PMID:33387578
Chrna2	Mouse	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of CHRNA2 mRNA	CTD	PMID:28922406
Chrna2	Mouse	3,7-dihydropurine-6-thione	decreases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Mercaptopurine results in decreased expression of CHRNA2 mRNA	CTD	PMID:23358152
Chrna2	Mouse	4,4'-sulfonyldiphenol	increases methylation	ISO	CHRNA2 (Homo sapiens)	6480464	bisphenol S results in increased methylation of CHRNA2 gene	CTD	PMID:31601247
Chrna2	Mouse	4-hydroxyphenyl retinamide	increases expression	EXP		6480464	Fenretinide results in increased expression of CHRNA2 mRNA	CTD	PMID:28973697
Chrna2	Mouse	acetamide	increases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	acetamide results in increased expression of CHRNA2 mRNA	CTD	PMID:31881176
Chrna2	Mouse	acetylcholine	multiple interactions	ISO	CHRNA2 (Homo sapiens)	6480464	1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]] more ...	CTD	PMID:11821649 and PMID:9454827
Chrna2	Mouse	acetylcholine	multiple interactions	ISO	Chrna2 (Rattus norvegicus)	2303194	acetylcholine affects binding competes with [Epibatidine binds to Chrna2 protein]	RGD
Chrna2	Mouse	acetylcholine	multiple interactions	ISO	Chrna2 (Rattus norvegicus)	6480464	Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein] more ...	CTD	PMID:7808438
Chrna2	Mouse	acetylcholine	affects response to substance	ISO	CHRNA2 (Homo sapiens)	6480464	CHRNA2 gene mutant form affects the susceptibility to Acetylcholine	CTD	PMID:19383498
Chrna2	Mouse	aflatoxin B1	increases methylation	ISO	CHRNA2 (Homo sapiens)	6480464	Aflatoxin B1 results in increased methylation of CHRNA2 gene	CTD	PMID:27153756
Chrna2	Mouse	aldehydo-D-glucose	multiple interactions	EXP		6480464	[lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in decreased expression of CHRNA2 mRNA	CTD	PMID:37567420
Chrna2	Mouse	ammonium chloride	affects expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Ammonium Chloride affects the expression of CHRNA2 mRNA	CTD	PMID:16483693
Chrna2	Mouse	Aroclor 1254	increases expression	EXP		6480464	Chlorodiphenyl (54% Chlorine) results in increased expression of CHRNA2 mRNA	CTD	PMID:23650126
Chrna2	Mouse	atrazine	increases expression	ISO	CHRNA2 (Homo sapiens)	6480464	Atrazine results in increased expression of CHRNA2 mRNA	CTD	PMID:22378314
Chrna2	Mouse	Azoxymethane	multiple interactions	EXP		6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CHRNA2 mRNA	CTD	PMID:29950665
Chrna2	Mouse	barium(0)	multiple interactions	ISO	CHRNA2 (Homo sapiens)	6480464	1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]] more ...	CTD	PMID:11821649
Chrna2	Mouse	benzo[a]pyrene	multiple interactions	EXP		6480464	Benzo(a)pyrene promotes the reaction [AHR protein binds to CHRNA2 promoter]	CTD	PMID:19654925
Chrna2	Mouse	benzo[a]pyrene	decreases methylation	ISO	CHRNA2 (Homo sapiens)	6480464	Benzo(a)pyrene results in decreased methylation of CHRNA2 5' UTR	CTD	PMID:27901495
Chrna2	Mouse	benzo[a]pyrene	affects methylation	ISO	CHRNA2 (Homo sapiens)	6480464	Benzo(a)pyrene affects the methylation of CHRNA2 3' UTR and Benzo(a)pyrene affects the methylation of CHRNA2 promoter	CTD	PMID:27901495 and PMID:30157460
Chrna2	Mouse	benzo[a]pyrene	increases methylation	ISO	CHRNA2 (Homo sapiens)	6480464	Benzo(a)pyrene results in increased methylation of CHRNA2 3' UTR	CTD	PMID:27901495
Chrna2	Mouse	benzo[e]pyrene	decreases methylation	ISO	CHRNA2 (Homo sapiens)	6480464	benzo(e)pyrene results in decreased methylation of CHRNA2 3' UTR	CTD	PMID:30157460
Chrna2	Mouse	bexarotene	increases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	bexarotene results in increased expression of CHRNA2 mRNA	CTD	PMID:16648578 and PMID:17630414
Chrna2	Mouse	bifenthrin	decreases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	bifenthrin results in decreased expression of CHRNA2 mRNA	CTD	PMID:30978409
Chrna2	Mouse	bis(2-ethylhexyl) phthalate	increases expression	EXP		6480464	Diethylhexyl Phthalate results in increased expression of CHRNA2 mRNA	CTD	PMID:19850644
Chrna2	Mouse	bis(2-ethylhexyl) phthalate	multiple interactions	EXP		6480464	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of CHRNA2 mRNA]	CTD	PMID:19850644
Chrna2	Mouse	bisphenol A	decreases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	bisphenol A results in decreased expression of CHRNA2 mRNA	CTD	PMID:25181051 and PMID:34947998
Chrna2	Mouse	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of CHRNA2 mRNA	CTD	PMID:32156529 and PMID:33221593
Chrna2	Mouse	bisphenol A	increases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	bisphenol A results in increased expression of CHRNA2 mRNA	CTD	PMID:30816183 and PMID:32528016
Chrna2	Mouse	bisphenol A	increases methylation	ISO	Chrna2 (Rattus norvegicus)	6480464	bisphenol A results in increased methylation of CHRNA2 gene	CTD	PMID:28505145
Chrna2	Mouse	bisphenol F	increases expression	EXP		6480464	bisphenol F results in increased expression of CHRNA2 mRNA	CTD	PMID:38685157
Chrna2	Mouse	butan-1-ol	multiple interactions	ISO	CHRNA2 (Homo sapiens)	6480464	1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	CTD	PMID:11821649
Chrna2	Mouse	butan-2-ol	multiple interactions	ISO	CHRNA2 (Homo sapiens)	6480464	2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	CTD	PMID:11821649
Chrna2	Mouse	cadmium dichloride	increases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Cadmium Chloride results in increased expression of CHRNA2 mRNA	CTD	PMID:33453195
Chrna2	Mouse	calcitriol	increases expression	ISO	CHRNA2 (Homo sapiens)	6480464	Calcitriol results in increased expression of CHRNA2 mRNA	CTD	PMID:21592394
Chrna2	Mouse	calcitriol	multiple interactions	ISO	CHRNA2 (Homo sapiens)	6480464	[Testosterone co-treated with Calcitriol] results in increased expression of CHRNA2 mRNA	CTD	PMID:21592394
Chrna2	Mouse	cannabidiol	multiple interactions	EXP		6480464	[lipopolysaccharide and E coli O55-B5 co-treated with Cannabidiol] results in decreased expression of CHRNA2 mRNA	CTD	PMID:30742662
Chrna2	Mouse	cannabidiol	decreases expression	EXP		6480464	Cannabidiol results in decreased expression of CHRNA2 mRNA	CTD	PMID:30742662
Chrna2	Mouse	carbachol	multiple interactions	ISO	Chrna2 (Rattus norvegicus)	2303194	carbachol affects binding competes with [Epibatidine binds to Chrna2 protein]	RGD
Chrna2	Mouse	carbamazepine	affects response to substance	ISO	CHRNA2 (Homo sapiens)	6480464	CHRNA2 gene mutant form affects the susceptibility to Carbamazepine	CTD	PMID:19383498
Chrna2	Mouse	carbon nanotube	increases expression	EXP		6480464	Nanotubes more ...	CTD	PMID:25620056
Chrna2	Mouse	clofibrate	increases expression	EXP		6480464	Clofibrate results in increased expression of CHRNA2 mRNA	CTD	PMID:30629241
Chrna2	Mouse	clofibrate	increases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Clofibrate results in increased expression of CHRNA2 mRNA	CTD	PMID:32741897
Chrna2	Mouse	clofibric acid	affects expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Clofibric Acid affects the expression of CHRNA2 mRNA	CTD	PMID:17602206
Chrna2	Mouse	crotyl alcohol	multiple interactions	ISO	CHRNA2 (Homo sapiens)	6480464	crotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	CTD	PMID:11821649
Chrna2	Mouse	cytisine	multiple interactions	ISO	CHRNA2 (Homo sapiens)	6480464	cytisine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]	CTD	PMID:9454827
Chrna2	Mouse	cytisine	multiple interactions	ISO	Chrna2 (Rattus norvegicus)	2303195	cytisine affects binding to Chrna2 protein and cytisine inhibits the reaction [epibatidine affects binding to Chrna2 protein] in rat retina	RGD
Chrna2	Mouse	D-glucose	multiple interactions	EXP		6480464	[lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in decreased expression of CHRNA2 mRNA	CTD	PMID:37567420
Chrna2	Mouse	dextran sulfate	multiple interactions	EXP		6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CHRNA2 mRNA	CTD	PMID:29950665
Chrna2	Mouse	diazinon	decreases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Diazinon results in decreased expression of CHRNA2 mRNA	CTD	PMID:18812211
Chrna2	Mouse	diazinon	increases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Diazinon results in increased expression of CHRNA2 mRNA	CTD	PMID:17452286
Chrna2	Mouse	dichloroacetic acid	increases expression	EXP		6480464	Dichloroacetic Acid results in increased expression of CHRNA2 mRNA	CTD	PMID:28962523
Chrna2	Mouse	dieldrin	decreases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Dieldrin results in decreased expression of CHRNA2 mRNA	CTD	PMID:18812211
Chrna2	Mouse	dihydro-beta-erythroidine	multiple interactions	ISO	Chrna2 (Rattus norvegicus)	2303195	dihydro-beta-erythroidine affects binding to Chrna2 protein and dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrna2 protein] in rat retina	RGD
Chrna2	Mouse	diquat	increases expression	EXP		6480464	Diquat results in increased expression of CHRNA2 mRNA	CTD	PMID:36851058
Chrna2	Mouse	epibatidine	affects binding	ISO	Chrna2 (Rattus norvegicus)	2303194	Epibatidine binds to Chrna2 protein	RGD
Chrna2	Mouse	epibatidine	affects binding	ISO	Chrna2 (Rattus norvegicus)	2303195	epibatidine binds to Chrnb4 protein in the retina	RGD
Chrna2	Mouse	epibatidine	affects binding	ISO	CHRNA2 (Homo sapiens)	6480464	[CHRNB4 protein binds to CHRNA2 protein] which binds to epibatidine	CTD	PMID:9454827
Chrna2	Mouse	epibatidine	multiple interactions	ISO	Chrna2 (Rattus norvegicus)	6480464	epibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNB2 protein] and sazetidine-A analog inhibits the reaction [epibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNB2 protein]]	CTD	PMID:21905669
Chrna2	Mouse	epoxiconazole	decreases expression	EXP		6480464	epoxiconazole results in decreased expression of CHRNA2 mRNA	CTD	PMID:35436446
Chrna2	Mouse	ethanol	affects expression	EXP		6480464	Ethanol affects the expression of CHRNA2 mRNA	CTD	PMID:30319688
Chrna2	Mouse	fenofibrate	increases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Fenofibrate results in increased expression of CHRNA2 mRNA	CTD	PMID:32741897
Chrna2	Mouse	flavonoids	increases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Flavonoids results in increased expression of CHRNA2 mRNA	CTD	PMID:18035473
Chrna2	Mouse	folic acid	decreases expression	EXP		6480464	Folic Acid results in decreased expression of CHRNA2 mRNA	CTD	PMID:25629700
Chrna2	Mouse	fructose	multiple interactions	EXP		6480464	[lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in decreased expression of CHRNA2 mRNA	CTD	PMID:37567420
Chrna2	Mouse	glucose	multiple interactions	EXP		6480464	[lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in decreased expression of CHRNA2 mRNA	CTD	PMID:37567420
Chrna2	Mouse	glyphosate	increases methylation	ISO	Chrna2 (Rattus norvegicus)	6480464	Glyphosate results in increased methylation of CHRNA2 gene	CTD	PMID:31011160
Chrna2	Mouse	isobutanol	multiple interactions	ISO	CHRNA2 (Homo sapiens)	6480464	isobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	CTD	PMID:11821649
Chrna2	Mouse	mercaptopurine	decreases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Mercaptopurine results in decreased expression of CHRNA2 mRNA	CTD	PMID:23358152
Chrna2	Mouse	methapyrilene	decreases methylation	ISO	CHRNA2 (Homo sapiens)	6480464	Methapyrilene results in decreased methylation of CHRNA2 3' UTR	CTD	PMID:30157460
Chrna2	Mouse	methyllycaconitine	multiple interactions	ISO	Chrna2 (Rattus norvegicus)	2303194	methyllycaconitine affects binding competes with [Epibatidine binds to Chrna2 protein]	RGD
Chrna2	Mouse	methylmercury chloride	decreases expression	EXP		6480464	methylmercuric chloride results in decreased expression of CHRNA2 mRNA	CTD	PMID:21385734
Chrna2	Mouse	Muraglitazar	increases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	muraglitazar results in increased expression of CHRNA2 mRNA	CTD	PMID:21515302
Chrna2	Mouse	N-nitrosodiethylamine	multiple interactions	ISO	Chrna2 (Rattus norvegicus)	6480464	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CHRNA2 mRNA	CTD	PMID:20360939
Chrna2	Mouse	nickel atom	decreases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Nickel results in decreased expression of CHRNA2 mRNA	CTD	PMID:18812211
Chrna2	Mouse	nicotine	multiple interactions	ISO	CHRNA2 (Homo sapiens)	6480464	Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]	CTD	PMID:9454827
Chrna2	Mouse	nicotine	multiple interactions	ISO	Chrna2 (Rattus norvegicus)	2303194	nicotine affects binding competes with [Epibatidine binds to Chrna2 protein]	RGD
Chrna2	Mouse	nicotine	multiple interactions	ISO	Chrna2 (Rattus norvegicus)	2303195	nicotine affects binding to Chrna2 protein and nicotine inhibits the reaction [epibatidine affects binding to Chrna2 protein] in rat retina	RGD
Chrna2	Mouse	nicotine	affects response to substance	ISO	CHRNA2 (Homo sapiens)	6480464	CHRNA2 gene mutant form affects the susceptibility to Nicotine	CTD	PMID:19383498
Chrna2	Mouse	paracetamol	decreases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Acetaminophen results in decreased expression of CHRNA2 mRNA	CTD	PMID:33387578
Chrna2	Mouse	pentan-1-ol	multiple interactions	ISO	CHRNA2 (Homo sapiens)	6480464	n-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	CTD	PMID:11821649
Chrna2	Mouse	perfluorooctane-1-sulfonic acid	multiple interactions	EXP		6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CHRNA2 mRNA	CTD	PMID:36331819
Chrna2	Mouse	perfluorooctanoic acid	increases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	perfluorooctanoic acid results in increased expression of CHRNA2 mRNA	CTD	PMID:16221955 and PMID:28511854
Chrna2	Mouse	permethrin	increases expression	EXP		6480464	Permethrin results in increased expression of CHRNA2 mRNA	CTD	PMID:30629241
Chrna2	Mouse	phenethyl caffeate	multiple interactions	ISO	Chrna2 (Rattus norvegicus)	6480464	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CHRNA2 mRNA	CTD	PMID:20360939
Chrna2	Mouse	phenobarbital	affects expression	EXP		6480464	Phenobarbital affects the expression of CHRNA2 mRNA	CTD	PMID:23091169
Chrna2	Mouse	pirinixic acid	increases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	pirinixic acid results in increased expression of CHRNA2 mRNA	CTD	PMID:12832660 more ...
Chrna2	Mouse	pirinixic acid	increases expression	EXP		6480464	pirinixic acid results in increased expression of CHRNA2 mRNA	CTD	PMID:17426115 more ...
Chrna2	Mouse	propan-1-ol	multiple interactions	ISO	CHRNA2 (Homo sapiens)	6480464	1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	CTD	PMID:11821649
Chrna2	Mouse	propan-2-ol	multiple interactions	ISO	CHRNA2 (Homo sapiens)	6480464	2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	CTD	PMID:11821649
Chrna2	Mouse	purine-6-thiol	decreases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Mercaptopurine results in decreased expression of CHRNA2 mRNA	CTD	PMID:23358152
Chrna2	Mouse	sodium arsenite	affects methylation	ISO	CHRNA2 (Homo sapiens)	6480464	sodium arsenite affects the methylation of CHRNA2 gene	CTD	PMID:28589171
Chrna2	Mouse	sodium arsenite	increases expression	ISO	CHRNA2 (Homo sapiens)	6480464	sodium arsenite results in increased expression of CHRNA2 mRNA	CTD	PMID:38568856
Chrna2	Mouse	sodium fluoride	decreases expression	EXP		6480464	Sodium Fluoride results in decreased expression of CHRNA2 mRNA	CTD	PMID:27862939
Chrna2	Mouse	tert-butanol	multiple interactions	ISO	CHRNA2 (Homo sapiens)	6480464	tert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]	CTD	PMID:11821649
Chrna2	Mouse	Tesaglitazar	increases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	tesaglitazar results in increased expression of CHRNA2 mRNA	CTD	PMID:21515302
Chrna2	Mouse	testosterone	multiple interactions	ISO	CHRNA2 (Homo sapiens)	6480464	[Testosterone co-treated with Calcitriol] results in increased expression of CHRNA2 mRNA	CTD	PMID:21592394
Chrna2	Mouse	testosterone	increases expression	ISO	CHRNA2 (Homo sapiens)	6480464	Testosterone results in increased expression of CHRNA2 mRNA	CTD	PMID:21592394
Chrna2	Mouse	titanium dioxide	increases expression	EXP		6480464	titanium dioxide results in increased expression of CHRNA2 mRNA	CTD	PMID:29264374
Chrna2	Mouse	titanium dioxide	multiple interactions	EXP		6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CHRNA2 mRNA	CTD	PMID:29950665
Chrna2	Mouse	trichloroethene	increases expression	EXP		6480464	Trichloroethylene results in increased expression of CHRNA2 mRNA	CTD	PMID:25549359
Chrna2	Mouse	trichloroethene	decreases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Trichloroethylene results in decreased expression of CHRNA2 mRNA	CTD	PMID:33387578
Chrna2	Mouse	triphenyl phosphate	affects expression	ISO	CHRNA2 (Homo sapiens)	6480464	triphenyl phosphate affects the expression of CHRNA2 mRNA	CTD	PMID:37042841
Chrna2	Mouse	troglitazone	increases expression	EXP		6480464	troglitazone results in increased expression of CHRNA2 mRNA	CTD	PMID:28973697
Chrna2	Mouse	troglitazone	increases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	troglitazone results in increased expression of CHRNA2 mRNA	CTD	PMID:21515302
Chrna2	Mouse	tubocurarine	multiple interactions	ISO	Chrna2 (Rattus norvegicus)	6480464	Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]] and Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]	CTD	PMID:7808438
Chrna2	Mouse	valproic acid	increases methylation	ISO	CHRNA2 (Homo sapiens)	6480464	Valproic Acid results in increased methylation of CHRNA2 gene	CTD	PMID:29154799
Chrna2	Mouse	valproic acid	decreases expression	ISO	Chrna2 (Rattus norvegicus)	6480464	Valproic Acid results in decreased expression of CHRNA2 mRNA	CTD	PMID:35594946

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Chrna2	Mouse	acetylcholine receptor signaling pathway	involved_in	IBA	PANTHER:PTN000436077 more ...	2290270		GO_Central	GO_REF:0000033
Chrna2	Mouse	cellular response to nicotine	involved_in	ISO	Chrna2 (Rattus norvegicus)	2290270		GO_Central	GO_REF:0000096
Chrna2	Mouse	cellular response to nicotine	involved_in	IEA	UniProtKB:P12389 and ensembl:ENSRNOP00000023475	2290270		Ensembl	GO_REF:0000107
Chrna2	Mouse	cellular response to nicotine		ISO	Chrna2 (Rattus norvegicus)	9068941	MMO:0000293	RGD	PMID:19385992 and REF_RGD_ID:152995360
Chrna2	Mouse	cerebral cortex GABAergic interneuron development	part_of	ISO	Chrna2 (Rattus norvegicus)	9068941		RGD	PMID:17046198 and REF_RGD_ID:152995358
Chrna2	Mouse	excitatory postsynaptic potential	involved_in	IEA	GO:0022848	2290270		GOC	GO_REF:0000108
Chrna2	Mouse	hippocampus development	part_of	ISO	Chrna2 (Rattus norvegicus)	9068941		RGD	PMID:17046198 and REF_RGD_ID:152995358
Chrna2	Mouse	membrane depolarization	involved_in	IBA	PANTHER:PTN000436077 more ...	2290270		GO_Central	GO_REF:0000033
Chrna2	Mouse	modulation of inhibitory postsynaptic potential		ISO	Chrna2 (Rattus norvegicus)	9068941	MMO:0000293	RGD	PMID:19385992 and REF_RGD_ID:152995360
Chrna2	Mouse	modulation of inhibitory postsynaptic potential	involved_in	IEA	UniProtKB:P12389 and ensembl:ENSRNOP00000023475	2290270		Ensembl	GO_REF:0000107
Chrna2	Mouse	modulation of inhibitory postsynaptic potential	involved_in	ISO	Chrna2 (Rattus norvegicus)	2290270		GO_Central	GO_REF:0000096
Chrna2	Mouse	monoatomic ion transmembrane transport	involved_in	IEA	UniProtKB-KW:KW-0407	2290270		UniProt	GO_REF:0000043
Chrna2	Mouse	monoatomic ion transmembrane transport	involved_in	IBA	PANTHER:PTN000434994 more ...	2290270		GO_Central	GO_REF:0000033
Chrna2	Mouse	neuromuscular synaptic transmission	involved_in	IBA	PANTHER:PTN000436077 more ...	2290270		GO_Central	GO_REF:0000033
Chrna2	Mouse	regulation of synaptic plasticity	acts_upstream_of_or_within	IMP		2290270	PMID:32467358	MGI	PMID:32467358
Chrna2	Mouse	response to acetylcholine	involved_in	IEA	UniProtKB:P12389 and ensembl:ENSRNOP00000023475	2290270		Ensembl	GO_REF:0000107
Chrna2	Mouse	response to acetylcholine	involved_in	ISO	Chrna2 (Rattus norvegicus)	2290270		GO_Central	GO_REF:0000096
Chrna2	Mouse	response to acetylcholine		ISO	Chrna2 (Rattus norvegicus)	9068941		RGD	PMID:15016836 and REF_RGD_ID:2303194
Chrna2	Mouse	response to nicotine	involved_in	IBA	PANTHER:PTN000436077 more ...	2290270		GO_Central	GO_REF:0000033
Chrna2	Mouse	signal transduction	involved_in	ISO	UniProtKB:Q15822	2290270		GO_Central	GO_REF:0000119
Chrna2	Mouse	synaptic transmission, cholinergic	involved_in	IBA	PANTHER:PTN000436077 more ...	2290270		GO_Central	GO_REF:0000033
Chrna2	Mouse	synaptic transmission, cholinergic	involved_in	IEA	GO:0015464	2290270		GOC	GO_REF:0000108

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Chrna2	Mouse	acetylcholine-gated channel complex	part_of	ISO	UniProtKB:Q15822	2290270		GO_Central	GO_REF:0000119
Chrna2	Mouse	acetylcholine-gated channel complex	part_of	IBA	PANTHER:PTN000435923 more ...	2290270		GO_Central	GO_REF:0000033
Chrna2	Mouse	acetylcholine-gated channel complex	part_of	IEA	UniProtKB:Q15822 and ensembl:ENSP00000385026	2290270		Ensembl	GO_REF:0000107
Chrna2	Mouse	cation channel complex	part_of	ISO	CHRNA2 (Homo sapiens)	9068941	PMID:24467848	UniProt	PMID:24467848
Chrna2	Mouse	cell periphery	located_in	IDA		2290270	PMID:21884692	MGI	PMID:21884692
Chrna2	Mouse	intercellular bridge	located_in	IEA	UniProtKB:Q15822 and ensembl:ENSP00000385026	2290270		Ensembl	GO_REF:0000107
Chrna2	Mouse	intercellular bridge	located_in	ISO	UniProtKB:Q15822	2290270		GO_Central	GO_REF:0000119
Chrna2	Mouse	neuron projection	is_active_in	IBA	PANTHER:PTN000434994 more ...	2290270		GO_Central	GO_REF:0000033
Chrna2	Mouse	neuron projection cytoplasm	located_in	IEA	UniProtKB:P12389 and ensembl:ENSRNOP00000023475	2290270		Ensembl	GO_REF:0000107
Chrna2	Mouse	neuron projection cytoplasm	located_in	ISO	Chrna2 (Rattus norvegicus)	2290270		GO_Central	GO_REF:0000096
Chrna2	Mouse	neuron projection cytoplasm		ISO	Chrna2 (Rattus norvegicus)	9068941	MMO:0000293 and MMO:0000656	RGD	PMID:19385992 and REF_RGD_ID:152995360
Chrna2	Mouse	neurotransmitter receptor complex	part_of	ISO	CHRNA2 (Homo sapiens)	9068941	PMID:24467848	UniProt	PMID:24467848
Chrna2	Mouse	nucleoplasm	located_in	ISO	UniProtKB:Q15822	2290270		GO_Central	GO_REF:0000119
Chrna2	Mouse	nucleoplasm	located_in	IEA	UniProtKB:Q15822 and ensembl:ENSP00000385026	2290270		Ensembl	GO_REF:0000107
Chrna2	Mouse	plasma membrane	located_in	ISO	UniProtKB:Q15822	2290270		GO_Central	GO_REF:0000119
Chrna2	Mouse	plasma membrane	is_active_in	IBA	PANTHER:PTN000434994 more ...	2290270		GO_Central	GO_REF:0000033
Chrna2	Mouse	postsynaptic membrane	located_in	IEA	UniProtKB-SubCell:SL-0219	2290270		UniProt	GO_REF:0000044
Chrna2	Mouse	protein-containing complex		ISO	Chrna2 (Rattus norvegicus)	9068941		RGD	PMID:16129735 and REF_RGD_ID:2303195
Chrna2	Mouse	protein-containing complex	part_of	ISO	Chrna2 (Rattus norvegicus)	2290270		GO_Central	GO_REF:0000096
Chrna2	Mouse	synapse	is_active_in	IBA	PANTHER:PTN000434994 more ...	2290270		GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Chrna2	Mouse	acetylcholine receptor activity	contributes_to	IBA	PANTHER:PTN000436077 more ...	2290270		GO_Central	GO_REF:0000033
Chrna2	Mouse	acetylcholine receptor activity	enables	IEA	UniProtKB:Q15822 and ensembl:ENSP00000385026	2290270		Ensembl	GO_REF:0000107
Chrna2	Mouse	acetylcholine receptor activity	enables	ISO	UniProtKB:Q15822	2290270		GO_Central	GO_REF:0000119
Chrna2	Mouse	acetylcholine-gated monoatomic cation-selective channel activity	enables	IEA	UniProtKB:P12389 more ...	2290270		Ensembl	GO_REF:0000107
Chrna2	Mouse	acetylcholine-gated monoatomic cation-selective channel activity	enables	IBA	PANTHER:PTN000436077 more ...	2290270		GO_Central	GO_REF:0000033
Chrna2	Mouse	acetylcholine-gated monoatomic cation-selective channel activity		ISO	Chrna2 (Rattus norvegicus)	9068941		RGD	PMID:2832952 and REF_RGD_ID:728252
Chrna2	Mouse	acetylcholine-gated monoatomic cation-selective channel activity	enables	ISO	UniProtKB:Q15822	2290270		GO_Central	GO_REF:0000119
Chrna2	Mouse	acetylcholine-gated monoatomic cation-selective channel activity	enables	ISO	Chrna2 (Rattus norvegicus)	2290270		GO_Central	GO_REF:0000096
Chrna2	Mouse	heterocyclic compound binding	enables	ISO	Chrna2 (Rattus norvegicus)	2290270		GO_Central	GO_REF:0000096
Chrna2	Mouse	heterocyclic compound binding	contributes_to	ISO	Chrna2 (Rattus norvegicus)	2290270		GO_Central	GO_REF:0000096
Chrna2	Mouse	heterocyclic compound binding	enables	IEA	UniProtKB:P12389 and ensembl:ENSRNOP00000023475	2290270		Ensembl	GO_REF:0000107
Chrna2	Mouse	heterocyclic compound binding		ISO	Chrna2 (Rattus norvegicus)	9068941		RGD	PMID:15016836 and REF_RGD_ID:2303194
Chrna2	Mouse	quaternary ammonium group binding		ISO	Chrna2 (Rattus norvegicus)	9068941	nicotine and carbachol	RGD	PMID:15016836 and REF_RGD_ID:2303194
Chrna2	Mouse	quaternary ammonium group binding	enables	IEA	UniProtKB:P12389 and ensembl:ENSRNOP00000023475	2290270		Ensembl	GO_REF:0000107
Chrna2	Mouse	quaternary ammonium group binding	enables	ISO	Chrna2 (Rattus norvegicus)	2290270		GO_Central	GO_REF:0000096

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Chrna2	Mouse	acetylcholine signaling pathway via nicotinic acetylcholine receptor		ISO	CHRNA2 (Homo sapiens)	8549510		RGD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Chrna2	Mouse	abnormal caudal vertebrae morphology		IEA		5509061		MGI
Chrna2	Mouse	abnormal excitatory postsynaptic currents		IAGP		5509061		MGI	PMID:17466021
Chrna2	Mouse	abnormal inhibitory postsynaptic currents		IAGP		5509061		MGI	PMID:17466021
Chrna2	Mouse	abnormal kidney morphology		IEA		5509061		MGI
Chrna2	Mouse	abnormal long-term potentiation		IAGP		5509061		MGI	PMID:17466021
Chrna2	Mouse	abnormal skin morphology		IEA		5509061		MGI
Chrna2	Mouse	decreased physiological sensitivity to xenobiotic		IAGP		5509061		MGI	PMID:17466021
Chrna2	Mouse	enhanced long-term potentiation		IAGP		5509061		MGI	PMID:28507032
Chrna2	Mouse	impaired contextual conditioning behavior		IAGP		5509061		MGI	PMID:28507032
Chrna2	Mouse	increased locomotor activity		IAGP		5509061		MGI	PMID:28507032
Chrna2	Mouse	increased vertical activity		IAGP		5509061		MGI	PMID:28507032
Chrna2	Mouse	no abnormal phenotype detected		IEA		5509061		MGI
Chrna2	Mouse	small kidney		IEA		5509061		MGI
Chrna2	Mouse	thick skin		IEA		5509061		MGI

#	Reference Title	Reference Citation
1.	Mammalian nicotinic acetylcholine receptors: from structure to function.	Albuquerque EX, etal., Physiol Rev. 2009 Jan;89(1):73-120. doi: 10.1152/physrev.00015.2008.
2.	Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes.	Marritt AM, etal., Mol Pharmacol. 2005 Dec;68(6):1656-68. Epub 2005 Aug 29.
3.	Electronic Transfer of Homolog Data	MGD and Homologene mouse data transfer
4.	MGDs mouse GO annotations	MGD data from the GO Consortium
5.	MGD IEA	MGD IEA
6.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells.	Xiao Y and Kellar KJ, J Pharmacol Exp Ther. 2004 Jul;310(1):98-107. Epub 2004 Mar 11.

PMID:1505988	PMID:2338144	PMID:8838678	PMID:9016344	PMID:10095079	PMID:10454512	PMID:12225896	PMID:12477932	PMID:15489334	PMID:17466021	PMID:18023270	PMID:19228980
PMID:19279237	PMID:21267068	PMID:21873635	PMID:21884692	PMID:22647603	PMID:22949675	PMID:23637165	PMID:23811311	PMID:24260568	PMID:24952961	PMID:25131634	PMID:25641263
PMID:26111579	PMID:27991860	PMID:28182735	PMID:28507032	PMID:29785025	PMID:31676717	PMID:32447811	PMID:32467358	PMID:32481512	PMID:32533922	PMID:34518365	PMID:36029955
PMID:37625400	PMID:38355793	PMID:39028754	PMID:39553292

Chrna2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	66,370,685 - 66,390,397 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	66,372,488 - 66,390,397 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	66,133,236 - 66,152,948 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	66,135,039 - 66,152,948 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	66,759,797 - 66,771,785 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	65,095,070 - 65,107,058 (+)	NCBI		MGSCv36	mm8
Celera	14	63,889,359 - 63,901,395 (+)	NCBI		Celera
Cytogenetic Map	14	D1	NCBI
cM Map	14	34.36	NCBI

CHRNA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	27,459,756 - 27,479,261 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	27,459,756 - 27,479,883 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	27,317,273 - 27,336,778 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	27,373,195 - 27,392,730 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	27,374,181 - 27,392,675	NCBI
Celera	8	26,277,396 - 26,296,925 (-)	NCBI		Celera
Cytogenetic Map	8	p21.2	NCBI
HuRef	8	25,862,340 - 25,881,872 (-)	NCBI		HuRef
CHM1_1	8	27,519,147 - 27,538,678 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	27,737,110 - 27,756,814 (-)	NCBI		T2T-CHM13v2.0

Chrna2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	44,517,862 - 44,534,144 (+)	NCBI		GRCr8
mRatBN7.2	15	40,342,317 - 40,358,601 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	40,342,317 - 40,358,601 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	42,209,601 - 42,225,892 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	43,359,798 - 43,376,089 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	41,802,620 - 41,818,906 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	42,808,897 - 42,825,179 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	42,808,897 - 42,825,179 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	48,768,230 - 48,785,192 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	45,570,809 - 45,587,091 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	45,586,588 - 45,602,871 (+)	NCBI
Celera	15	40,015,644 - 40,031,870 (+)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

Chrna2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	49,970,398 - 49,989,137 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	49,970,398 - 49,989,095 (-)	NCBI	ChiLan1.0	ChiLan1.0

CHRNA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	45,990,058 - 46,009,764 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	21,704,317 - 21,723,990 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	26,729,767 - 26,749,277 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	23,932,846 - 23,952,377 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	23,932,846 - 23,952,377 (-)	Ensembl	panpan1.1		panPan2

CHRNA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	30,117,384 - 30,137,223 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	30,117,239 - 30,135,599 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	30,711,637 - 30,723,506 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	30,316,301 - 30,326,148 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	30,307,340 - 30,325,726 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	30,245,712 - 30,257,580 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	30,126,596 - 30,137,323 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	30,292,990 - 30,304,860 (+)	NCBI		UU_Cfam_GSD_1.0

Chrna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	8,251,532 - 8,258,650 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936675	327,501 - 334,581 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936675	327,501 - 334,493 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CHRNA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	11,195,228 - 11,207,650 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	11,193,732 - 11,204,334 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	12,374,481 - 12,388,291 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CHRNA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	25,571,958 - 25,591,982 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	25,571,863 - 25,591,788 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	16,552,356 - 16,572,243 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Chrna2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	22,182,951 - 22,200,063 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	22,182,468 - 22,200,076 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Chrna2
707 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	704
Count of miRNA genes:	431
Interacting mature miRNAs:	518
Transcripts:	ENSMUST00000022620
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357589	Kdnw2_m	kidney weight 2 (mouse)			Not determined		14	20887473	121269804	Mouse
1300625	Cosz2_m	cocaine seizure 2 (mouse)			Not determined		14	35045797	68785736	Mouse
1301777	Bglq15_m	body growth late QTL 15 (mouse)			Not determined		14	42962416	76962593	Mouse
1301489	Lbm10_m	lean body mass 10 (mouse)			Not determined		14	53761296	87761529	Mouse
1357527	Epfpq1_m	epididymal fat percentage QTL 1 (mouse)			Not determined		14	21062450	71885801	Mouse
1301424	Skull21_m	skull morphology 21 (mouse)			Not determined		14	42962416	76962593	Mouse
4142364	Pbwg18_m	postnatal body weight growth 18 (mouse)			Not determined		14	52281984	86282125	Mouse
4141400	Nilac8_m	nicotine induced locomotor activity 8 (mouse)			Not determined		14	43065847	77066045	Mouse
10043889	Cia52_m	collagen induced arthritis QTL 52 (mouse)			Not determined		14	56082381	90082509	Mouse
27226774	Tibl15_m	tibia length 15, 10 week (mouse)					14	30321957	87937436	Mouse
1301562	Hwq1_m	heart weight quantitative locus 1 (mouse)			Not determined		14	56546745	90546941	Mouse
1357565	wrmod1_m	wobbler modifier 1 (mouse)			Not determined		14	58179640	101859473	Mouse
1300666	Fembm2_m	femoral bone morphometry 2 (mouse)			Not determined		14	62397460	96397680	Mouse
10043888	Cia51_m	collagen induced arthritis QTL 51 (mouse)			Not determined		14	66103893	68785736	Mouse
4142419	Tgq26_m	triglyceride QTL 26 (mouse)			Not determined			40337319	74337319	Mouse
1300605	El5_m	epilepsy 5 (mouse)			Not determined		14	49455425	83455556	Mouse
11039527	Ccc2_m	colitis susceptibility in the Collaborative Cross 2 (mouse)					14	59918612	94138217	Mouse
1301091	Bbaa21_m	B.burgdorferi-associated arthritis 21 (mouse)			Not determined		14	43065847	77066045	Mouse
12880432	Fgf23lq3_m	FGF23 serum level QTL 3 (mouse)					14	53937440	87937440	Mouse
10043887	Cia50_m	collagen induced arthritis QTL 50 (mouse)			Not determined		14	37430185	71430320	Mouse
1300805	Mors3_m	modifier of obesity related sterility 3 (mouse)			Not determined		14	43037270	77037418	Mouse

Chrna2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
MGSCv37	14	66,767,695 - 66,767,792	UniSTS	GRCm37
Celera	14	63,897,305 - 63,897,402	UniSTS
Cytogenetic Map	14	D1	UniSTS
cM Map	14	20.0	UniSTS

Chrna2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	14	66,148,858 - 66,148,955	UniSTS	GRCm38
MGSCv37	14	66,767,695 - 66,767,792	UniSTS	GRCm37
Celera	14	63,897,305 - 63,897,402	UniSTS
Cytogenetic Map	14	D1	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	NM_001425568	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_144803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006518435	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006518436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC126272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF325345	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY574261	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC011490	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000022620 ⟹ ENSMUSP00000022620

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	14	66,378,382 - 66,390,397 (+)	Ensembl
GRCm38.p6 Ensembl	14	66,140,933 - 66,152,948 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000206455 ⟹ ENSMUSP00000145896

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	14	66,372,488 - 66,388,616 (+)	Ensembl
GRCm38.p6 Ensembl	14	66,135,039 - 66,151,167 (+)	Ensembl

RefSeq Acc Id:

NM_001425568 ⟹ NP_001412497

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	14	66,372,387 - 66,390,397 (+)	NCBI

RefSeq Acc Id:

NM_144803 ⟹ NP_659052

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	14	66,378,399 - 66,390,397 (+)	NCBI
GRCm38	14	66,140,960 - 66,152,948 (+)	NCBI
MGSCv37	14	66,759,797 - 66,771,785 (+)	RGD
Celera	14	63,889,359 - 63,901,395 (+)	RGD
cM Map	14		ENTREZGENE

Sequence:

show sequence

ATGATATGGCCTGGACTCAAAGTCACGCTTGCAGACTCTGGATGGGCTGCAGAGAGACAGGGCCTTGAAGAAGCCAGCTCCTTGTAGTCCAACAGAAACCAGGACCCTCTGAAGCCATGGCCCCCTCC
CATCCTGCTTTCCAGTTCTGGATACATCTTTATCTCTGGTGTCTGCTTCTGATGCCAGCAGTGTTGGCCCAGCAAGGCTCGCACACCCATGCCGAGGACCGCCTGTTCAAACACCTCTTTGGAGGCTA
CAATCGCTGGGCACGGCCAGTGCCCAACACTTCCGATGTGGTCATCGTGCGCTTTGGACTATCCATTGCACAGCTCATAGATGTGGATGAGAAGAATCAAATGATGACCACCAATGTCTGGCTAAAGC
AGGAATGGAATGACTACAAGCTGCGCTGGGACCCGGCTGAGTTTGGCAACATCACCTCCCTCCGCGTCCCCTCAGAGATGATCTGGATCCCAGACATTGTTCTCTACAACAATGCAGACGGGGAGTTT
GCGGTGACCCACATGACCAAGGCCCACCTCTTCTTCACGGGCACTGTGCACTGGGTGCCCCCAGCCATCTACAAGAGCTCCTGCAGCATCGACGTGACTTTCTTCCCCTTCGACCAGCAGAACTGCAA
GATGAAGTTTGGCTCCTGGACATACGACAAGGCCAAGATCGACCTGGAGCAGATGGAGCGGACGGTGGACCTGAAGGACTACTGGGAGAGCGGCGAGTGGGCCATTATCAACGCCACCGGAACCTATA
ACAGCAAGAAGTACGACTGCTGCGCGGAGATCTACCCCGACGTCACCTACTACTTCGTTATCCGCCGGCTGCCGCTGTTCTACACCATCAACCTCATTATCCCGTGCCTGCTCATCTCCTGCCTCACC
GTGCTCGTGTTCTACTTGCCCTCTGAGTGTGGAGAGAAGATCACGCTGTGCATCTCGGTGCTGCTCTCCCTCACTGTCTTCCTGCTGCTCATCACAGAAATTATCCCATCCACCTCACTGGTCATCCC
ACTCATCGGCGAGTACCTGCTCTTCACCATGATCTTCGTCACCCTCTCTATTGTGATCACAGTCTTCGTGCTCAATGTCCACCACCGTTCCCCTAGCACGCACAACATGCCCAACTGGGTGAGGGTGG
CCCTGCTAGGCCGGGTGCCCCGGTGGCTGATGATGAATCGGCCCCTGCCGCCCATGGAGCTCCATGGCTCTCCAGGTCTGAAGCTCAGCCCCACTTATCATTGGCTGGAGACCAACATGGATGCTGAA
GAAAGGGAGGAGACAGAGGAAGAGGAGGAGGAGGAAGAAGATGAAAACATATGTATGTGTGCAGGCCTCCCAGACTCTTCCATGGGTGTCCTCTATGGCCATGGCAGCCTGCATCTGAGGGCCATGGG
GCCTGAGGCCAAGACTCCATCCCAGGCTAGTGAGATCCTGCTGTCACCTCAAATACAGAAAGCACTAGAAGGTGTACACTACATTGCTGACCACCTGAGGTCTGAGGATGCTGACTCTTCGGTGAAGG
AAGATTGGAAGTATGTGGCCATGGTGGTAGACCGGATCTTCCTCTGGCTGTTCATTATCGTCTGCTTCCTGGGGACCATCGGGCTCTTCCTCCCTCCGTTCCTGGCTGGAATGATCTGACTTGATGTC
CCTCATGTTGGCTCCAAGGTGGCCTGGACAACCATCTTCTGCTCTTCTGTGACTGGAGCCATCTCTAGAATATTCTTTTGACTTAATGCCACCTGCCTGCGATGTTTCTACGAGGCCCCTGATCTAGC
CTGGACTTCATATCCTCCTTGTCAACAGTTCATGGTGCCATTGCGGTGACAAGCACTGAGACCACTCAACATGACAACTATTTAGGGATGCTGAGGAACTAGAAGAGGTGAAGGCTGCTCTGTAGGTG
ATGACAACATGGTGGTGATATGGGGGGAGAGCAAGATAGTTCTGAAAGAGCATATAGGAGTTGTCTATGGCAAAAGGGTCAAACAAAGGGATGGAGGGGTCAGACCAGGACAAAGGGAAATAGAACAC
TGGCCCAAAGATGGGCACAAGGGGACAATGGGAGTGCCTGGTGTGGAAGAGTTCTGCACAACACTGTGGATTCAGAATGTCAGAGAGGACAGCCAGCTGGGGTGGGGAGGCTGGGAGGCAAGTTGGGA
TATTTTTGACCCAGGCCCAAGAAGAAGCTCAGAGTCTGCACTGAACCTGTCTCTATGCACTTTGCAGGAAATGTCAGAGGGACAGGGGTACTTCCCAAAGGAGTGGGGCACAAAGAAAGTTCTAGAGC
AGTGGCTTTCAACCTGTGTCGTGGGTTGCAACCCTTCAGGGAGTCAAACGACCCTTTCACAGGGGTCACATATCAGATATCCTGCATATCAGATGTTTTACATGACAGTCCATAACAATATCAAAATT
ACTGTTATGAAGTTGAAATGAAAACAATTTTGTGGTTGGGGTCACAACATGAGGAACTGTAAAGGGTCATAGCATTAGGAAGGTTGAGAACCACTGATCTAGGTGCCCTGGTGGATGCTTGAGGCAGA
ATAGCAACATTGGGTATAAGTTGCTGGGCCATTATTCAACCAAAAGCACTTTGGAGCCTTCAAGTTCCCCTCAGTGTCATGTCTCACTGTTCTATGCTACAAAAAAAGAGGTATAGCAATTTCTACAA
GGGATCAGGGCTACCTTCAAATCAAGAGGACAAAGTAAGAAGGCAGTCTCCAATGTTGGCACCCTTCTTGCTGTCCACAGGGACCTGGTCCTCAATTCCTGGCTCTGTCAGCATGCCTCACATAGGAA
CTGAGATCTTTGCATCAAGCTCTTTCAATTGTGTGCTCCTTCAGGGCAGAGTCTCTGCTCTTGTTGCTTTCACTCATCCTGAGCTGGGTGAGAGAGCTCAGTAGCTGGACCCTCCATCGTGAGTAGTG
GAGAGAAACCAACCTGGTAGCTTTAGGCTCCAGAACTGCTACATAATACCAAAGCTTTGGGGGAGGACTCTTCCCCAGTCTTCCCAGGGCCCCATCAGGTGACTAACCTGCTCTGAACTGTCCTGTGT
AGCTTGTTCTTTTACTTGTAATATTCCACGACCCTTCATTGCATAGAAGCCCAGCGGATTGGGCCTTTCAGAACATTCTGCAGTCCCCAAGGAATTAGGTCCCAGACGCTAACAGCAATGAGATTCAG
GGTCACTAAGAGATATAGAGACCAAGTTTGTTCTCTGTCTTGGGGTGCTCTCCTTCCGAACCCCACACACAGCACCTCGACAGACCTAGGAGATCTGCTTGTCGGAGGCCTTACCCAGACTTCCTGTT
ACCAGTTCTAATGATACCCACTCAGTCTCAGGCCTTGGCTCCCCCTTTCTCCACTGAATGCAGCCGGCACCTCTTTTCTCTGTGTCAAACCCCAAGACATGATTTCCTGATGCAGAGATGCTTGTTGG
ATGATCCCTACCCCCCATCCTCCTTGCATGTGAGTGAAATGTCAAAATAAAGCTAAAATGTCTGCCGTCAA

hide sequence

RefSeq Acc Id:

XM_006518435 ⟹ XP_006518498

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	14	66,372,357 - 66,390,394 (+)	NCBI
GRCm38	14	66,134,908 - 66,152,945 (+)	NCBI

Sequence:

show sequence

GAGAGAGAGAGAGAGAGAGAGAGAGAGAATAGTCTGCAGAAGCCGTAGTGCTGGTGGCTCTCCAAAATAGCCTCTTCTGTGGCACCTACATAAGCCTCTGCTGTCTCCTGGAGCTGAGCAGCCCCAGG
AAAACTGACCACTCTTGAACTGGACCACCTATCCCCAGGAAGCTAGCCTGAGTCCCTCATCCTTACAGTGCCTCCTCCCAAACCTTCCAGTTTCTGTGTCTGTGCAACCATGAGCTGCAGCGACTGAG
CTCCGACCTGCACCTGTCACTGCTTCCAAGGGACCCTCATCAGCTACCCCCAACTCCAGCTGGCTGGTTCTCTGCATCCCTCGAGGGCCCTGTGTCCTATGACCACAGGGCACTGACATCCACAGAGC
AACCCAGTGCCTGGCCCCCCTCCTCAGTGTTCTGGAGCTCACATACAGACTCCTATGACTCCACTGGACTATGAACCTGTTCTGGGAGCTGCAGAGAGACAGGGCCTTGAAGAAGCCAGCTCCTTGTA
GTCCAACAGAAACCAGGACCCTCTGAAGCCATGGCCCCCTCCCATCCTGCTTTCCAGTTCTGGATACATCTTTATCTCTGGTGTCTGCTTCTGATGCCAGCAGTGTTGGCCCAGCAAGGCTCGCACAC
CCATGCCGAGGACCGCCTGTTCAAACACCTCTTTGGAGGCTACAATCGCTGGGCACGGCCAGTGCCCAACACTTCCGATGTGGTCATCGTGCGCTTTGGACTATCCATTGCACAGCTCATAGATGTGG
ATGAGAAGAATCAAATGATGACCACCAATGTCTGGCTAAAGCAGGAATGGAATGACTACAAGCTGCGCTGGGACCCGGCTGAGTTTGGCAACATCACCTCCCTCCGCGTCCCCTCAGAGATGATCTGG
ATCCCAGACATTGTTCTCTACAACAATGCAGACGGGGAGTTTGCGGTGACCCACATGACCAAGGCCCACCTCTTCTTCACGGGCACTGTGCACTGGGTGCCCCCAGCCATCTACAAGAGCTCCTGCAG
CATCGACGTGACTTTCTTCCCCTTCGACCAGCAGAACTGCAAGATGAAGTTTGGCTCCTGGACATACGACAAGGCCAAGATCGACCTGGAGCAGATGGAGCGGACGGTGGACCTGAAGGACTACTGGG
AGAGCGGCGAGTGGGCCATTATCAACGCCACCGGAACCTATAACAGCAAGAAGTACGACTGCTGCGCGGAGATCTACCCCGACGTCACCTACTACTTCGTTATCCGCCGGCTGCCGCTGTTCTACACC
ATCAACCTCATTATCCCGTGCCTGCTCATCTCCTGCCTCACCGTGCTCGTGTTCTACTTGCCCTCTGAGTGTGGAGAGAAGATCACGCTGTGCATCTCGGTGCTGCTCTCCCTCACTGTCTTCCTGCT
GCTCATCACAGAAATTATCCCATCCACCTCACTGGTCATCCCACTCATCGGCGAGTACCTGCTCTTCACCATGATCTTCGTCACCCTCTCTATTGTGATCACAGTCTTCGTGCTCAATGTCCACCACC
GTTCCCCTAGCACGCACAACATGCCCAACTGGGTGAGGGTGGCCCTGCTAGGCCGGGTGCCCCGGTGGCTGATGATGAATCGGCCCCTGCCGCCCATGGAGCTCCATGGCTCTCCAGGTCTGAAGCTC
AGCCCCACTTATCATTGGCTGGAGACCAACATGGATGCTGAAGAAAGGGAGGAGACAGAGGAAGAGGAGGAGGAGGAAGAAGATGAAAACATATGTATGTGTGCAGGCCTCCCAGACTCTTCCATGGG
TGTCCTCTATGGCCATGGCAGCCTGCATCTGAGGGCCATGGGGCCTGAGGCCAAGACTCCATCCCAGGCTAGTGAGATCCTGCTGTCACCTCAAATACAGAAAGCACTAGAAGGTGTACACTACATTG
CTGACCACCTGAGGTCTGAGGATGCTGACTCTTCGGTGAAGGAAGATTGGAAGTATGTGGCCATGGTGGTAGACCGGATCTTCCTCTGGCTGTTCATTATCGTCTGCTTCCTGGGGACCATCGGGCTC
TTCCTCCCTCCGTTCCTGGCTGGAATGATCTGACTTGATGTCCCTCATGTTGGCTCCAAGGTGGCCTGGACAACCATCTTCTGCTCTTCTGTGACTGGAGCCATCTCTAGAATATTCTTTTGACTTAA
TGCCACCTGCCTGCGATGTTTCTACGAGGCCCCTGATCTAGCCTGGACTTCATATCCTCCTTGTCAACAGTTCATGGTGCCATTGCGGTGACAAGCACTGAGACCACTCAACATGACAACTATTTAGG
GATGCTGAGGAACTAGAAGAGGTGAAGGCTGCTCTGTAGGTGATGACAACATGGTGGTGATATGGGGGGAGAGCAAGATAGTTCTGAAAGAGCATATAGGAGTTGTCTATGGCAAAAGGGTCAAACAA
AGGGATGGAGGGGTCAGACCAGGACAAAGGGAAATAGAACACTGGCCCAAAGATGGGCACAAGGGGACAATGGGAGTGCCTGGTGTGGAAGAGTTCTGCACAACACTGTGGATTCAGAATGTCAGAGA
GGACAGCCAGCTGGGGTGGGGAGGCTGGGAGGCAAGTTGGGATATTTTTGACCCAGGCCCAAGAAGAAGCTCAGAGTCTGCACTGAACCTGTCTCTATGCACTTTGCAGGAAATGTCAGAGGGACAGG
GGTACTTCCCAAAGGAGTGGGGCACAAAGAAAGTTCTAGAGCAGTGGCTTTCAACCTGTGTCGTGGGTTGCAACCCTTCAGGGAGTCAAACGACCCTTTCACAGGGGTCACATATCAGATATCCTGCA
TATCAGATGTTTTACATGACAGTCCATAACAATATCAAAATTACTGTTATGAAGTTGAAATGAAAACAATTTTGTGGTTGGGGTCACAACATGAGGAACTGTAAAGGGTCATAGCATTAGGAAGGTTG
AGAACCACTGATCTAGGTGCCCTGGTGGATGCTTGAGGCAGAATAGCAACATTGGGTATAAGTTGCTGGGCCATTATTCAACCAAAAGCACTTTGGAGCCTTCAAGTTCCCCTCAGTGTCATGTCTCA
CTGTTCTATGCTACAAAAAAAGAGGTATAGCAATTTCTACAAGGGATCAGGGCTACCTTCAAATCAAGAGGACAAAGTAAGAAGGCAGTCTCCAATGTTGGCACCCTTCTTGCTGTCCACAGGGACCT
GGTCCTCAATTCCTGGCTCTGTCAGCATGCCTCACATAGGAACTGAGATCTTTGCATCAAGCTCTTTCAATTGTGTGCTCCTTCAGGGCAGAGTCTCTGCTCTTGTTGCTTTCACTCATCCTGAGCTG
GGTGAGAGAGCTCAGTAGCTGGACCCTCCATCGTGAGTAGTGGAGAGAAACCAACCTGGTAGCTTTAGGCTCCAGAACTGCTACATAATACCAAAGCTTTGGGGGAGGACTCTTCCCCAGTCTTCCCA
GGGCCCCATCAGGTGACTAACCTGCTCTGAACTGTCCTGTGTAGCTTGTTCTTTTACTTGTAATATTCCACGACCCTTCATTGCATAGAAGCCCAGCGGATTGGGCCTTTCAGAACATTCTGCAGTCC
CCAAGGAATTAGGTCCCAGACGCTAACAGCAATGAGATTCAGGGTCACTAAGAGATATAGAGACCAAGTTTGTTCTCTGTCTTGGGGTGCTCTCCTTCCGAACCCCACACACAGCACCTCGACAGACC
TAGGAGATCTGCTTGTCGGAGGCCTTACCCAGACTTCCTGTTACCAGTTCTAATGATACCCACTCAGTCTCAGGCCTTGGCTCCCCCTTTCTCCACTGAATGCAGCCGGCACCTCTTTTCTCTGTGTC
AAACCCCAAGACATGATTTCCTGATGCAGAGATGCTTGTTGGATGATCCCTACCCCCCATCCTCCTTGCATGTGAGTGAAATGTCAAAATAAAGCTAAAATGTCTGCCGT

hide sequence

RefSeq Acc Id:

XM_006518436 ⟹ XP_006518499

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	14	66,370,685 - 66,390,394 (+)	NCBI
GRCm38	14	66,133,236 - 66,152,945 (+)	NCBI

Sequence:

show sequence

GCAACAGCAGGGCTGATTTCCAGGGTTGAGGTAGCAGTATCAGCGATGCTTAAGTTCTGGTGCCTGGCTCTGTAGCAGGGGCCTACCACGAAGGCAACCAAGCTGCTCTGGGCTGAAGTGGAGCTGAC
ACCTCCTTTGTTCCCACCCGGCCTCCAAGCAGTCCCTCCAATTTTTTTCTGTGTCTGTGCAACCATGAGCTGCAGCGACTGAGCTCCGACCTGCACCTGTCACTGCTTCCAAGGGACCCTCATCAGCT
ACCCCCAACTCCAGCTGGCTGGTTCTCTGCATCCCTCGAGGGCCCTGTGTCCTATGACCACAGCTGCAGAGAGACAGGGCCTTGAAGAAGCCAGCTCCTTGTAGTCCAACAGAAACCAGGACCCTCTG
AAGCCATGGCCCCCTCCCATCCTGCTTTCCAGTTCTGGATACATCTTTATCTCTGGTGTCTGCTTCTGATGCCAGCAGTGTTGGCCCAGCAAGGCTCGCACACCCATGCCGAGGACCGCCTGTTCAAA
CACCTCTTTGGAGGCTACAATCGCTGGGCACGGCCAGTGCCCAACACTTCCGATGTGGTCATCGTGCGCTTTGGACTATCCATTGCACAGCTCATAGATGTGGATGAGAAGAATCAAATGATGACCAC
CAATGTCTGGCTAAAGCAGGAATGGAATGACTACAAGCTGCGCTGGGACCCGGCTGAGTTTGGCAACATCACCTCCCTCCGCGTCCCCTCAGAGATGATCTGGATCCCAGACATTGTTCTCTACAACA
ATGCAGACGGGGAGTTTGCGGTGACCCACATGACCAAGGCCCACCTCTTCTTCACGGGCACTGTGCACTGGGTGCCCCCAGCCATCTACAAGAGCTCCTGCAGCATCGACGTGACTTTCTTCCCCTTC
GACCAGCAGAACTGCAAGATGAAGTTTGGCTCCTGGACATACGACAAGGCCAAGATCGACCTGGAGCAGATGGAGCGGACGGTGGACCTGAAGGACTACTGGGAGAGCGGCGAGTGGGCCATTATCAA
CGCCACCGGAACCTATAACAGCAAGAAGTACGACTGCTGCGCGGAGATCTACCCCGACGTCACCTACTACTTCGTTATCCGCCGGCTGCCGCTGTTCTACACCATCAACCTCATTATCCCGTGCCTGC
TCATCTCCTGCCTCACCGTGCTCGTGTTCTACTTGCCCTCTGAGTGTGGAGAGAAGATCACGCTGTGCATCTCGGTGCTGCTCTCCCTCACTGTCTTCCTGCTGCTCATCACAGAAATTATCCCATCC
ACCTCACTGGTCATCCCACTCATCGGCGAGTACCTGCTCTTCACCATGATCTTCGTCACCCTCTCTATTGTGATCACAGTCTTCGTGCTCAATGTCCACCACCGTTCCCCTAGCACGCACAACATGCC
CAACTGGGTGAGGGTGGCCCTGCTAGGCCGGGTGCCCCGGTGGCTGATGATGAATCGGCCCCTGCCGCCCATGGAGCTCCATGGCTCTCCAGGTCTGAAGCTCAGCCCCACTTATCATTGGCTGGAGA
CCAACATGGATGCTGAAGAAAGGGAGGAGACAGAGGAAGAGGAGGAGGAGGAAGAAGATGAAAACATATGTATGTGTGCAGGCCTCCCAGACTCTTCCATGGGTGTCCTCTATGGCCATGGCAGCCTG
CATCTGAGGGCCATGGGGCCTGAGGCCAAGACTCCATCCCAGGCTAGTGAGATCCTGCTGTCACCTCAAATACAGAAAGCACTAGAAGGTGTACACTACATTGCTGACCACCTGAGGTCTGAGGATGC
TGACTCTTCGGTGAAGGAAGATTGGAAGTATGTGGCCATGGTGGTAGACCGGATCTTCCTCTGGCTGTTCATTATCGTCTGCTTCCTGGGGACCATCGGGCTCTTCCTCCCTCCGTTCCTGGCTGGAA
TGATCTGACTTGATGTCCCTCATGTTGGCTCCAAGGTGGCCTGGACAACCATCTTCTGCTCTTCTGTGACTGGAGCCATCTCTAGAATATTCTTTTGACTTAATGCCACCTGCCTGCGATGTTTCTAC
GAGGCCCCTGATCTAGCCTGGACTTCATATCCTCCTTGTCAACAGTTCATGGTGCCATTGCGGTGACAAGCACTGAGACCACTCAACATGACAACTATTTAGGGATGCTGAGGAACTAGAAGAGGTGA
AGGCTGCTCTGTAGGTGATGACAACATGGTGGTGATATGGGGGGAGAGCAAGATAGTTCTGAAAGAGCATATAGGAGTTGTCTATGGCAAAAGGGTCAAACAAAGGGATGGAGGGGTCAGACCAGGAC
AAAGGGAAATAGAACACTGGCCCAAAGATGGGCACAAGGGGACAATGGGAGTGCCTGGTGTGGAAGAGTTCTGCACAACACTGTGGATTCAGAATGTCAGAGAGGACAGCCAGCTGGGGTGGGGAGGC
TGGGAGGCAAGTTGGGATATTTTTGACCCAGGCCCAAGAAGAAGCTCAGAGTCTGCACTGAACCTGTCTCTATGCACTTTGCAGGAAATGTCAGAGGGACAGGGGTACTTCCCAAAGGAGTGGGGCAC
AAAGAAAGTTCTAGAGCAGTGGCTTTCAACCTGTGTCGTGGGTTGCAACCCTTCAGGGAGTCAAACGACCCTTTCACAGGGGTCACATATCAGATATCCTGCATATCAGATGTTTTACATGACAGTCC
ATAACAATATCAAAATTACTGTTATGAAGTTGAAATGAAAACAATTTTGTGGTTGGGGTCACAACATGAGGAACTGTAAAGGGTCATAGCATTAGGAAGGTTGAGAACCACTGATCTAGGTGCCCTGG
TGGATGCTTGAGGCAGAATAGCAACATTGGGTATAAGTTGCTGGGCCATTATTCAACCAAAAGCACTTTGGAGCCTTCAAGTTCCCCTCAGTGTCATGTCTCACTGTTCTATGCTACAAAAAAAGAGG
TATAGCAATTTCTACAAGGGATCAGGGCTACCTTCAAATCAAGAGGACAAAGTAAGAAGGCAGTCTCCAATGTTGGCACCCTTCTTGCTGTCCACAGGGACCTGGTCCTCAATTCCTGGCTCTGTCAG
CATGCCTCACATAGGAACTGAGATCTTTGCATCAAGCTCTTTCAATTGTGTGCTCCTTCAGGGCAGAGTCTCTGCTCTTGTTGCTTTCACTCATCCTGAGCTGGGTGAGAGAGCTCAGTAGCTGGACC
CTCCATCGTGAGTAGTGGAGAGAAACCAACCTGGTAGCTTTAGGCTCCAGAACTGCTACATAATACCAAAGCTTTGGGGGAGGACTCTTCCCCAGTCTTCCCAGGGCCCCATCAGGTGACTAACCTGC
TCTGAACTGTCCTGTGTAGCTTGTTCTTTTACTTGTAATATTCCACGACCCTTCATTGCATAGAAGCCCAGCGGATTGGGCCTTTCAGAACATTCTGCAGTCCCCAAGGAATTAGGTCCCAGACGCTA
ACAGCAATGAGATTCAGGGTCACTAAGAGATATAGAGACCAAGTTTGTTCTCTGTCTTGGGGTGCTCTCCTTCCGAACCCCACACACAGCACCTCGACAGACCTAGGAGATCTGCTTGTCGGAGGCCT
TACCCAGACTTCCTGTTACCAGTTCTAATGATACCCACTCAGTCTCAGGCCTTGGCTCCCCCTTTCTCCACTGAATGCAGCCGGCACCTCTTTTCTCTGTGTCAAACCCCAAGACATGATTTCCTGAT
GCAGAGATGCTTGTTGGATGATCCCTACCCCCCATCCTCCTTGCATGTGAGTGAAATGTCAAAATAAAGCTAAAATGTCTGCCGT

hide sequence


Protein RefSeqs	NP_001412497	(Get FASTA)	NCBI Sequence Viewer
	NP_659052	(Get FASTA)	NCBI Sequence Viewer
	XP_006518498	(Get FASTA)	NCBI Sequence Viewer
	XP_006518499	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH11490	(Get FASTA)	NCBI Sequence Viewer
	AAL37361	(Get FASTA)	NCBI Sequence Viewer
	AAS90357	(Get FASTA)	NCBI Sequence Viewer
	EDL36004	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000022620
	ENSMUSP00000022620.10
	ENSMUSP00000145896
	ENSMUSP00000145896.2
GenBank Protein	Q91X60	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_659052 ⟸ NM_144803
- Peptide Label:	precursor
- UniProtKB:	Q91X60 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAPSHPAFQFWIHLYLWCLLLMPAVLAQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNITSLRVPSEMIWIPDIVLYNNA DGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLI SCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRPLPPMELHGSPGLKLSPTYHWLETN MDAEEREETEEEEEEEEDENICMCAGLPDSSMGVLYGHGSLHLRAMGPEAKTPSQASEILLSPQIQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFLPPFLAGMI hide sequence

RefSeq Acc Id:	XP_006518499 ⟸ XM_006518436
- Peptide Label:	isoform X1
- UniProtKB:	Q91X60 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAPSHPAFQFWIHLYLWCLLLMPAVLAQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNITSLRVPSEMIWIPDIVLYNNA DGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLI SCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRPLPPMELHGSPGLKLSPTYHWLETN MDAEEREETEEEEEEEEDENICMCAGLPDSSMGVLYGHGSLHLRAMGPEAKTPSQASEILLSPQIQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFLPPFLAGMI hide sequence

RefSeq Acc Id:	XP_006518498 ⟸ XM_006518435
- Peptide Label:	isoform X1
- UniProtKB:	Q91X60 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAPSHPAFQFWIHLYLWCLLLMPAVLAQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNITSLRVPSEMIWIPDIVLYNNA DGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLI SCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRPLPPMELHGSPGLKLSPTYHWLETN MDAEEREETEEEEEEEEDENICMCAGLPDSSMGVLYGHGSLHLRAMGPEAKTPSQASEILLSPQIQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFLPPFLAGMI hide sequence

Ensembl Acc Id:

ENSMUSP00000145896 ⟸ ENSMUST00000206455

Ensembl Acc Id:

ENSMUSP00000022620 ⟸ ENSMUST00000022620

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q91X60-F1-model_v2	AlphaFold	Q91X60	1-512	view protein structure

RGD ID:

8682788

Promoter ID:

EPDNEW_M19425

Type:

multiple initiation site

Name:

Chrna2_1

Description:

Mus musculus cholinergic receptor, nicotinic, alpha polypeptide2 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	14	66,140,950 - 66,141,010	EPDNEW

RGD ID:

6824775

Promoter ID:

MM_KWN:17273

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Liver

Transcripts:

NM_144803

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	14	66,759,441 - 66,759,941 (+)	MPROMDB

Database	Acc Id	Source(s)
Ensembl Genes	ENSMUSG00000022041	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000022620	ENTREZGENE
	ENSMUST00000022620.11	UniProtKB/Swiss-Prot
	ENSMUST00000206455	ENTREZGENE
	ENSMUST00000206455.2	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.58.390	UniProtKB/Swiss-Prot
	2.70.170.10	UniProtKB/Swiss-Prot
InterPro	Neur_chan_lig-bd	UniProtKB/Swiss-Prot
	Neur_chan_lig-bd_sf	UniProtKB/Swiss-Prot
	Neur_channel	UniProtKB/Swiss-Prot
	Neuro-gated_channel_TM_sf	UniProtKB/Swiss-Prot
	Neuro_actylchol_rec	UniProtKB/Swiss-Prot
	Neurotrans-gated_channel_TM	UniProtKB/Swiss-Prot
	Neurotransmitter_ion_chnl_CS	UniProtKB/Swiss-Prot
	Nicotinic_acetylcholine_rcpt	UniProtKB/Swiss-Prot
KEGG Report	mmu:110902	UniProtKB/Swiss-Prot
MGD	MGI:87886	ENTREZGENE
NCBI Gene	Chrna2	ENTREZGENE
PANTHER	PTHR18945	UniProtKB/Swiss-Prot
Pfam	Neur_chan_LBD	UniProtKB/Swiss-Prot
	Neur_chan_memb	UniProtKB/Swiss-Prot
PharmGKB	CHRNA2	RGD
PhenoGen	Chrna2	PhenoGen
PRINTS	NICOTINICR	UniProtKB/Swiss-Prot
	NRIONCHANNEL	UniProtKB/Swiss-Prot
PROSITE	NEUROTR_ION_CHANNEL	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF63712	UniProtKB/Swiss-Prot
	SSF90112	UniProtKB/Swiss-Prot
UniProt	ACHA2_MOUSE	UniProtKB/Swiss-Prot
	Q8VI12_MOUSE	UniProtKB/TrEMBL
	Q91X60	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-08-27	Chrna2	cholinergic receptor nicotinic alpha 2 subunit	Chrna2	cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)	Symbol and/or name change	5135510	APPROVED
2024-08-21	Chrna2	cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)	Chrna2	cholinergic receptor nicotinic alpha 2 subunit	Symbol and/or name change	5135510	APPROVED
2023-07-04	Chrna2	cholinergic receptor nicotinic alpha 2 subunit	Chrna2	cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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