Chrna2 (cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)) - Rat Genome Database

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Gene: Chrna2 (cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)) Mus musculus
Analyze
Symbol: Chrna2
Name: cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)
RGD ID: 735908
MGI Page MGI
Description: Predicted to enable acetylcholine-gated cation-selective channel activity and quaternary ammonium group binding activity. Predicted to contribute to acetylcholine receptor activity and heterocyclic compound binding activity. Predicted to be involved in several processes, including cholinergic synaptic transmission; response to acetylcholine; and response to nicotine. Predicted to act upstream of or within ion transport. Located in cell periphery. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and spinal cord. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 4. Orthologous to human CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ac; Acr; Acra-2; Acra2; BC011490; MGC18795; neuronal acetylcholine receptor subunit alpha-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,370,685 - 66,390,397 (+)NCBIGRCm39mm39
GRCm39 Ensembl1466,372,488 - 66,390,397 (+)Ensembl
GRCm381466,133,236 - 66,152,948 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1466,135,039 - 66,152,948 (+)EnsemblGRCm38mm10GRCm38
MGSCv371466,759,797 - 66,771,785 (+)NCBIGRCm37mm9NCBIm37
MGSCv361465,095,070 - 65,107,058 (+)NCBImm8
Celera1463,889,359 - 63,901,395 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1-dimethyl-4-phenylpiperazinium iodide  (ISO)
1-naphthyl isothiocyanate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,7-dihydropurine-6-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
acetamide  (ISO)
acetylcholine  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (ISO)
Aroclor 1254  (EXP)
atrazine  (ISO)
barium(0)  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bexarotene  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butan-2-ol  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (EXP)
carbachol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
crotyl alcohol  (ISO)
cytisine  (ISO)
dextran sulfate  (EXP)
diazinon  (ISO)
dichloroacetic acid  (EXP)
dieldrin  (ISO)
dihydro-beta-erythroidine  (ISO)
epibatidine  (ISO)
ethanol  (EXP)
fenofibrate  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
glyphosate  (ISO)
isobutanol  (ISO)
mercaptopurine  (ISO)
methapyrilene  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP)
Muraglitazar  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
paracetamol  (ISO)
pentan-1-ol  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
propan-1-ol  (ISO)
propan-2-ol  (ISO)
purine-6-thiol  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
tert-butanol  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP,ISO)
troglitazone  (EXP,ISO)
tubocurarine  (ISO)
valproic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1505988   PMID:2338144   PMID:8838678   PMID:9016344   PMID:10095079   PMID:10454512   PMID:12225896   PMID:12477932   PMID:15489334   PMID:17466021   PMID:18023270   PMID:19228980  
PMID:19279237   PMID:21267068   PMID:21873635   PMID:21884692   PMID:22647603   PMID:22949675   PMID:23637165   PMID:23811311   PMID:24260568   PMID:24952961   PMID:25131634   PMID:25641263  
PMID:26111579   PMID:27991860   PMID:28182735   PMID:28507032   PMID:29785025   PMID:31676717   PMID:32447811   PMID:32533922   PMID:34518365  


Genomics

Comparative Map Data
Chrna2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,370,685 - 66,390,397 (+)NCBIGRCm39mm39
GRCm39 Ensembl1466,372,488 - 66,390,397 (+)Ensembl
GRCm381466,133,236 - 66,152,948 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1466,135,039 - 66,152,948 (+)EnsemblGRCm38mm10GRCm38
MGSCv371466,759,797 - 66,771,785 (+)NCBIGRCm37mm9NCBIm37
MGSCv361465,095,070 - 65,107,058 (+)NCBImm8
Celera1463,889,359 - 63,901,395 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
CHRNA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38827,459,756 - 27,479,261 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl827,459,756 - 27,479,883 (-)EnsemblGRCh38hg38GRCh38
GRCh37827,317,273 - 27,336,778 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,373,195 - 27,392,730 (-)NCBINCBI36hg18NCBI36
Build 34827,374,181 - 27,392,675NCBI
Celera826,277,396 - 26,296,925 (-)NCBI
Cytogenetic Map8p21.2NCBI
HuRef825,862,340 - 25,881,872 (-)NCBIHuRef
CHM1_1827,519,147 - 27,538,678 (-)NCBICHM1_1
T2T-CHM13v2.0827,737,110 - 27,756,611 (-)NCBI
Chrna2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21540,342,317 - 40,358,601 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1540,342,317 - 40,358,601 (+)Ensembl
Rnor_6.01542,808,897 - 42,825,179 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,808,897 - 42,825,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,768,230 - 48,785,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,570,809 - 45,587,091 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11545,586,588 - 45,602,871 (+)NCBI
Celera1540,015,644 - 40,031,870 (+)NCBICelera
Cytogenetic Map15p12NCBI
Chrna2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540349,970,398 - 49,989,137 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540349,970,398 - 49,989,095 (-)NCBIChiLan1.0ChiLan1.0
CHRNA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1823,932,846 - 23,952,377 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl823,932,846 - 23,952,377 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0826,729,767 - 26,749,277 (-)NCBIMhudiblu_PPA_v0panPan3
CHRNA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12530,117,384 - 30,137,223 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2530,117,239 - 30,135,599 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2530,711,637 - 30,723,506 (+)NCBI
ROS_Cfam_1.02530,316,301 - 30,326,148 (+)NCBI
ROS_Cfam_1.0 Ensembl2530,307,340 - 30,325,726 (+)Ensembl
UMICH_Zoey_3.12530,245,712 - 30,257,580 (+)NCBI
UNSW_CanFamBas_1.02530,126,596 - 30,137,323 (+)NCBI
UU_Cfam_GSD_1.02530,292,990 - 30,304,860 (+)NCBI
Chrna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049438,251,532 - 8,258,650 (+)NCBI
SpeTri2.0NW_004936675327,501 - 334,493 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1411,191,842 - 11,207,381 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,193,732 - 11,204,334 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,374,481 - 12,388,291 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1825,571,958 - 25,591,982 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl825,571,863 - 25,591,788 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605216,552,356 - 16,572,243 (+)NCBIVero_WHO_p1.0
Chrna2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475822,182,468 - 22,200,076 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Chrna2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371466,767,695 - 66,767,792UniSTSGRCm37
Celera1463,897,305 - 63,897,402UniSTS
Cytogenetic Map14D1UniSTS
cM Map1420.0UniSTS
Chrna2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381466,148,858 - 66,148,955UniSTSGRCm38
MGSCv371466,767,695 - 66,767,792UniSTSGRCm37
Celera1463,897,305 - 63,897,402UniSTS
Cytogenetic Map14D1UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146239746096397680Mouse
10043888Cia51_mcollagen induced arthritis QTL 51 (mouse)Not determined146610389368785736Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:704
Count of miRNA genes:431
Interacting mature miRNAs:518
Transcripts:ENSMUST00000022620
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000022620   ⟹   ENSMUSP00000022620
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1466,378,382 - 66,390,397 (+)Ensembl
GRCm38.p6 Ensembl1466,140,933 - 66,152,948 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206455   ⟹   ENSMUSP00000145896
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1466,372,488 - 66,388,616 (+)Ensembl
GRCm38.p6 Ensembl1466,135,039 - 66,151,167 (+)Ensembl
RefSeq Acc Id: NM_144803   ⟹   NP_659052
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391466,378,409 - 66,390,397 (+)NCBI
GRCm381466,140,960 - 66,152,948 (+)NCBI
MGSCv371466,759,797 - 66,771,785 (+)RGD
Celera1463,889,359 - 63,901,395 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006518434   ⟹   XP_006518497
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391466,372,357 - 66,390,394 (+)NCBI
GRCm381466,134,908 - 66,152,945 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006518435   ⟹   XP_006518498
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391466,372,357 - 66,390,394 (+)NCBI
GRCm381466,134,908 - 66,152,945 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006518436   ⟹   XP_006518499
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391466,370,685 - 66,390,394 (+)NCBI
GRCm381466,133,236 - 66,152,945 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_659052   ⟸   NM_144803
- Peptide Label: precursor
- UniProtKB: Q91X60 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006518499   ⟸   XM_006518436
- Peptide Label: isoform X1
- UniProtKB: Q91X60 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006518498   ⟸   XM_006518435
- Peptide Label: isoform X1
- UniProtKB: Q91X60 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006518497   ⟸   XM_006518434
- Peptide Label: isoform X1
- UniProtKB: Q91X60 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000145896   ⟸   ENSMUST00000206455
RefSeq Acc Id: ENSMUSP00000022620   ⟸   ENSMUST00000022620

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91X60-F1-model_v2 AlphaFold Q91X60 1-512 view protein structure

Promoters
RGD ID:8682788
Promoter ID:EPDNEW_M19425
Type:multiple initiation site
Name:Chrna2_1
Description:Mus musculus cholinergic receptor, nicotinic, alpha polypeptide2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381466,140,950 - 66,141,010EPDNEW
RGD ID:6824775
Promoter ID:MM_KWN:17273
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_144803
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361466,759,441 - 66,759,941 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87886 AgrOrtholog
Ensembl Genes ENSMUSG00000022041 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000022620 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000145896 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022620 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000206455 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot
InterPro Neur_chan_lig-bd UniProtKB/Swiss-Prot
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot
  Neur_channel UniProtKB/Swiss-Prot
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot
  Neuro_actylchol_rec UniProtKB/Swiss-Prot
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot
  Nicotinic_acetylcholine_rcpt UniProtKB/Swiss-Prot
KEGG Report mmu:110902 UniProtKB/Swiss-Prot
MGD MGI:87886 ENTREZGENE
NCBI Gene 110902 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot
  Neur_chan_memb UniProtKB/Swiss-Prot
PharmGKB CHRNA2 RGD
PhenoGen Chrna2 PhenoGen
PRINTS NICOTINICR UniProtKB/Swiss-Prot
  NRIONCHANNEL UniProtKB/Swiss-Prot
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
TIGRFAMs LIC UniProtKB/Swiss-Prot
UniProt ACHA2_MOUSE UniProtKB/Swiss-Prot
  Q8VI12_MOUSE UniProtKB/TrEMBL
  Q91X60 ENTREZGENE