CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit) Sus scrofa
Analyze
Symbol: CHRNA2
Name: cholinergic receptor nicotinic alpha 2 subunit
RGD ID: 14217744
Description: ENCODES a protein that exhibits acetylcholine receptor activity (ortholog); acetylcholine-gated cation-selective channel activity (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN response to acetylcholine (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH autosomal dominant nocturnal frontal lobe epilepsy (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 4 (ortholog); epilepsy (ortholog); FOUND IN cell periphery (ortholog); membrane (ortholog); protein-containing complex (ortholog); INTERACTS WITH (S)-nicotine; carbon dioxide; dioxygen
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: neuronal acetylcholine receptor subunit alpha-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1411,191,842 - 11,207,381 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,193,732 - 11,204,334 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,374,481 - 12,388,291 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
CHRNA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1411,191,842 - 11,207,381 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,193,732 - 11,204,334 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,374,481 - 12,388,291 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl827,459,756 - 27,479,883 (-)EnsemblGRCh38hg38GRCh38
GRCh38827,459,756 - 27,479,285 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37827,317,273 - 27,336,778 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,373,195 - 27,392,730 (-)NCBINCBI36hg18NCBI36
Build 34827,374,181 - 27,392,675NCBI
Celera826,277,396 - 26,296,925 (-)NCBI
Cytogenetic Map8p21.2NCBI
HuRef825,862,340 - 25,881,872 (-)NCBIHuRef
CHM1_1827,519,147 - 27,538,678 (-)NCBICHM1_1
Chrna2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,370,685 - 66,390,397 (+)NCBIGRCm39mm39
GRCm39 Ensembl1466,372,488 - 66,390,397 (+)Ensembl
GRCm381466,133,236 - 66,152,948 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1466,135,039 - 66,152,948 (+)EnsemblGRCm38mm10GRCm38
MGSCv371466,759,797 - 66,771,785 (+)NCBIGRCm37mm9NCBIm37
MGSCv361465,095,070 - 65,107,058 (+)NCBImm8
Celera1463,889,359 - 63,901,395 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
Chrna2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21540,342,317 - 40,358,601 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1540,342,317 - 40,358,601 (+)Ensembl
Rnor_6.01542,808,897 - 42,825,179 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,808,897 - 42,825,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,768,230 - 48,785,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,570,809 - 45,587,091 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11545,586,588 - 45,602,871 (+)NCBI
Celera1540,015,644 - 40,031,870 (+)NCBICelera
Cytogenetic Map15p12NCBI
Chrna2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540349,970,398 - 49,989,137 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540349,970,398 - 49,989,095 (-)NCBIChiLan1.0ChiLan1.0
CHRNA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1823,932,846 - 23,952,377 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl823,932,846 - 23,952,377 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0826,729,767 - 26,749,277 (-)NCBIMhudiblu_PPA_v0panPan3
CHRNA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12530,117,384 - 30,137,223 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2530,117,239 - 30,135,599 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2530,711,637 - 30,723,506 (+)NCBI
ROS_Cfam_1.02530,316,301 - 30,326,148 (+)NCBI
UMICH_Zoey_3.12530,245,712 - 30,257,580 (+)NCBI
UNSW_CanFamBas_1.02530,126,596 - 30,137,323 (+)NCBI
UU_Cfam_GSD_1.02530,292,990 - 30,304,860 (+)NCBI
Chrna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049438,251,532 - 8,258,650 (+)NCBI
SpeTri2.0NW_004936675327,501 - 334,493 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1825,571,958 - 25,591,982 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl825,571,863 - 25,591,788 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605216,552,356 - 16,572,243 (+)NCBIVero_WHO_p1.0
Chrna2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475822,182,468 - 22,200,076 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system hemolymphoid system nervous system respiratory system
High
Medium
Low 1 6
Below cutoff 2 4 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010597   ⟹   ENSSSCP00000010321
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1411,191,842 - 11,207,381 (-)Ensembl
RefSeq Acc Id: XM_021073187   ⟹   XP_020928846
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11411,193,732 - 11,204,334 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020928846 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020928846   ⟸   XM_021073187
- Sequence:
RefSeq Acc Id: ENSSSCP00000010321   ⟸   ENSSSCT00000010597
Protein Domains
Neur_chan_LBD   Neur_chan_memb


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009665 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000010321 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010597 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.70.170.10 UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/TrEMBL
  Neur_channel UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/TrEMBL
NCBI Gene CHRNA2 ENTREZGENE
PANTHER PTHR18945 UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/TrEMBL
PRINTS NICOTINICR UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/TrEMBL
  SSF90112 UniProtKB/TrEMBL
TIGRFAMs LIC UniProtKB/TrEMBL
UniProt F1RJS5_PIG UniProtKB/TrEMBL
VGNC ID VGNC:86668 ENTREZGENE