Smyd2 (SET and MYND domain containing 2) - Rat Genome Database

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Gene: Smyd2 (SET and MYND domain containing 2) Rattus norvegicus
Analyze
Symbol: Smyd2
Name: SET and MYND domain containing 2
RGD ID: 727785
Description: Predicted to enable RNA polymerase II complex binding activity; histone H3K36 methyltransferase activity; and p53 binding activity. Involved in heart development. Predicted to be located in cytosol. Predicted to be active in nucleus. Orthologous to human SMYD2 (SET and MYND domain containing 2); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; p53 signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: histone methyltransferase SMYD2; HSKM-B; N-lysine methyltransferase SMYD2; SET and MYND domain-containing protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813103,956,470 - 103,997,774 (-)NCBIGRCr8
mRatBN7.213101,425,270 - 101,466,576 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13101,425,273 - 101,466,576 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13103,940,656 - 103,981,564 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013105,329,429 - 105,370,669 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013102,534,981 - 102,578,302 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013108,642,156 - 108,686,293 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13108,642,156 - 108,686,290 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013113,261,746 - 113,302,399 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413106,160,147 - 106,201,473 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113106,349,462 - 106,390,567 (-)NCBI
Celera13100,910,865 - 100,950,701 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
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Original Reference(s)
Smyd2Ratgastrointestinal stromal tumor  ISOSMYD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Smyd2Ratparathyroid carcinoma  ISOSMYD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Object Symbol
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Original Reference(s)
Smyd2RatEsophageal Neoplasms  ISOSMYD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25825497

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Original Reference(s)
Smyd2Rat1,2-dimethylhydrazine increases expressionISOSmyd2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of SMYD2 mRNACTDPMID:22206623
Smyd2Rat1,2-dimethylhydrazine multiple interactionsISOSmyd2 (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of SMYD2 mRNA]CTDPMID:22206623
Smyd2Rat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in decreased expression of SMYD2 mRNACTDPMID:26496021
Smyd2Rat17beta-estradiol decreases expressionISOSMYD2 (Homo sapiens)6480464Estradiol results in decreased expression of SMYD2 mRNACTDPMID:32030086
Smyd2Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of SMYD2 mRNACTDPMID:32145629
Smyd2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of SMYD2 mRNACTDPMID:21215274
Smyd2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of SMYD2 mRNACTDPMID:33387578
Smyd2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOSmyd2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of SMYD2 mRNACTDPMID:21570461
Smyd2Rat5-aza-2'-deoxycytidine decreases methylationISOSmyd2 (Mus musculus)6480464Decitabine results in decreased methylation of SMYD2 geneCTDPMID:27923600
Smyd2Ratacrylamide decreases expressionISOSMYD2 (Homo sapiens)6480464Acrylamide results in decreased expression of SMYD2 mRNACTDPMID:32763439
Smyd2Ratall-trans-retinoic acid increases expressionISOSMYD2 (Homo sapiens)6480464Tretinoin results in increased expression of SMYD2 mRNACTDPMID:21934132
Smyd2Ratall-trans-retinoic acid decreases expressionISOSMYD2 (Homo sapiens)6480464Tretinoin results in decreased expression of SMYD2 mRNACTDPMID:33167477
Smyd2Ratantirheumatic drug increases expressionISOSMYD2 (Homo sapiens)6480464Antirheumatic Agents results in increased expression of SMYD2 mRNACTDPMID:24449571
Smyd2Rataristolochic acid A decreases expressionISOSMYD2 (Homo sapiens)6480464aristolochic acid I results in decreased expression of SMYD2 mRNACTDPMID:33212167
Smyd2Ratatrazine affects methylationEXP 6480464Atrazine affects the methylation of SMYD2 geneCTDPMID:35440735
Smyd2Ratbenzo[a]pyrene increases expressionEXP 6480464Benzo(a)pyrene results in increased expression of SMYD2 mRNACTDPMID:21839799
Smyd2Ratbis(2-ethylhexyl) phthalate increases expressionISOSMYD2 (Homo sapiens)6480464Diethylhexyl Phthalate results in increased expression of SMYD2 mRNACTDPMID:31163220
Smyd2Ratbisphenol A multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in decreased expression of SMYD2 mRNACTDPMID:26496021
Smyd2Ratbisphenol A decreases expressionISOSMYD2 (Homo sapiens)6480464bisphenol A results in decreased expression of SMYD2 mRNACTDPMID:29275510 and PMID:32030086
Smyd2Ratbisphenol A affects expressionISOSMYD2 (Homo sapiens)6480464bisphenol A affects the expression of SMYD2 mRNACTDPMID:30903817

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Biological Process
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Original Reference(s)
Smyd2Ratchromatin organization involved_inIEAUniProtKB-KW:KW-01561600115GO_REF:0000043UniProtGO_REF:0000043
Smyd2Ratchromatin remodeling involved_inIEAGO:00469751600115GO_REF:0000108GOCGO_REF:0000108
Smyd2Ratchromatin remodeling involved_inIEAGO:01409991600115GO_REF:0000108GOCGO_REF:0000108
Smyd2Ratchromatin remodeling involved_inIEAGO:00420541600115GO_REF:0000108GOCGO_REF:0000108
Smyd2Ratheart development  IEP 9586367 RGD 
Smyd2Ratmethylation involved_inIEAUniProtKB-KW:KW-04891600115GO_REF:0000043UniProtGO_REF:0000043
Smyd2Ratnegative regulation of cell population proliferation involved_inISSUniProtKB:Q8R5A01600115GO_REF:0000024UniProtGO_REF:0000024
Smyd2Ratnegative regulation of cell population proliferation involved_inIEAUniProtKB:Q8R5A0 and ensembl:ENSMUSP000000278971600115GO_REF:0000107EnsemblGO_REF:0000107
Smyd2Ratnegative regulation of cell population proliferation involved_inISOSmyd2 (Mus musculus)1624291 PMID:16805913RGDPMID:16805913
Smyd2Ratnegative regulation of transcription by RNA polymerase II involved_inISOSMYD2 (Homo sapiens)1624291 PMID:17108971RGDPMID:17108971
Smyd2Ratnegative regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:Q9NRG4 and ensembl:ENSP000003559241600115GO_REF:0000107EnsemblGO_REF:0000107
Smyd2Ratnegative regulation of transcription by RNA polymerase II involved_inISSUniProtKB:Q9NRG41600115GO_REF:0000024UniProtGO_REF:0000024
Smyd2Ratpeptidyl-lysine dimethylation involved_inISSUniProtKB:Q8R5A01600115GO_REF:0000024UniProtGO_REF:0000024
Smyd2Ratpeptidyl-lysine dimethylation involved_inISOSmyd2 (Mus musculus)1624291 PMID:16805913RGDPMID:16805913
Smyd2Ratpeptidyl-lysine monomethylation involved_inISSUniProtKB:Q9NRG41600115GO_REF:0000024UniProtGO_REF:0000024
Smyd2Ratpeptidyl-lysine monomethylation involved_inISOSMYD2 (Homo sapiens)1624291 PMID:17108971 and PMID:20870719RGDPMID:17108971 and PMID:20870719
Smyd2Ratregulation of DNA damage response, signal transduction by p53 class mediator involved_inISSUniProtKB:Q9NRG41600115GO_REF:0000024UniProtGO_REF:0000024
Smyd2Ratregulation of DNA damage response, signal transduction by p53 class mediator involved_inIEAUniProtKB:Q9NRG4 and ensembl:ENSP000003559241600115GO_REF:0000107EnsemblGO_REF:0000107
Smyd2Ratregulation of DNA damage response, signal transduction by p53 class mediator involved_inISOSMYD2 (Homo sapiens)1624291 PMID:17108971RGDPMID:17108971
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Cellular Component
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Original Reference(s)
Smyd2Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Smyd2Ratcytoplasm located_inIEAUniProtKB:Q8R5A0 and ensembl:ENSMUSP000000278971600115GO_REF:0000107EnsemblGO_REF:0000107
Smyd2Ratcytoplasm located_inISOSMYD2 (Homo sapiens)1624291 PMID:24880080RGDPMID:24880080
Smyd2Ratcytoplasm located_inISOSmyd2 (Mus musculus)1624291 PMID:16805913RGDPMID:16805913
Smyd2Ratcytoplasm located_inIEAUniProtKB:Q9NRG4 and ensembl:ENSP000003559241600115GO_REF:0000107EnsemblGO_REF:0000107
Smyd2Ratcytoplasm located_inISSUniProtKB:Q8R5A01600115GO_REF:0000024UniProtGO_REF:0000024
Smyd2Ratcytosol located_inISSUniProtKB:Q8R5A01600115GO_REF:0000024UniProtGO_REF:0000024
Smyd2Ratcytosol located_inIEAUniProtKB:Q8R5A0 and ensembl:ENSMUSP000000278971600115GO_REF:0000107EnsemblGO_REF:0000107
Smyd2Ratcytosol located_inISOSmyd2 (Mus musculus)1624291 PMID:20305823RGDPMID:20305823
Smyd2Ratcytosol located_inIEAUniProtKB-SubCell:SL-00911600115GO_REF:0000044UniProtGO_REF:0000044
Smyd2Ratnucleus located_inISOSmyd2 (Mus musculus)1624291 PMID:16805913 and PMID:20305823RGDPMID:16805913 and PMID:20305823
Smyd2Ratnucleus located_inIEAUniProtKB:Q8R5A0 and ensembl:ENSMUSP000000278971600115GO_REF:0000107EnsemblGO_REF:0000107
Smyd2Ratnucleus is_active_inIBAMGI:104790 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Smyd2Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Smyd2Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Smyd2Ratnucleus located_inISSUniProtKB:Q8R5A01600115GO_REF:0000024UniProtGO_REF:0000024
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Molecular Function
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Original Reference(s)
Smyd2Rathistone H3K36 methyltransferase activity enablesISOSmyd2 (Mus musculus)1624291 PMID:16805913 and PMID:22862948RGDPMID:16805913 and PMID:22862948
Smyd2Rathistone H3K36 methyltransferase activity enablesIEAUniProtKB:Q8R5A0 and ensembl:ENSMUSP000000278971600115GO_REF:0000107EnsemblGO_REF:0000107
Smyd2Rathistone H3K36 methyltransferase activity enablesISSUniProtKB:Q8R5A01600115GO_REF:0000024UniProtGO_REF:0000024
Smyd2Rathistone H3K4 trimethyltransferase activity enablesIEARHEA:602601600115GO_REF:0000116RHEAGO_REF:0000116
Smyd2Rathistone H3K4 trimethyltransferase activity enablesIEAEC:2.1.1.3541600115GO_REF:0000003UniProtGO_REF:0000003
Smyd2Rathistone methyltransferase activity enablesIEAInterPro:IPR0444191600115GO_REF:0000002InterProGO_REF:0000002
Smyd2Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Smyd2Ratmethyltransferase activity enablesIEAUniProtKB-KW:KW-04891600115GO_REF:0000043UniProtGO_REF:0000043
Smyd2Ratp53 binding enablesISOSMYD2 (Homo sapiens)1624291UniProtKB:P04637 and PMID:17108971RGDPMID:17108971
Smyd2Ratp53 binding enablesIEAUniProtKB:Q9NRG4 and ensembl:ENSP000003559241600115GO_REF:0000107EnsemblGO_REF:0000107
Smyd2Ratprotein binding enablesISOSmyd2 (Mus musculus)1624291UniProtKB:O09106 more ...RGDPMID:16805913 more ...
Smyd2Ratprotein binding enablesISOSMYD2 (Homo sapiens)1624291UniProtKB:P04637 more ...RGDPMID:17805299 more ...
Smyd2Ratprotein-lysine N-methyltransferase activity enablesISSUniProtKB:Q9NRG41600115GO_REF:0000024UniProtGO_REF:0000024
Smyd2Ratprotein-lysine N-methyltransferase activity enablesIEAUniProtKB:Q9NRG4 and ensembl:ENSP000003559241600115GO_REF:0000107EnsemblGO_REF:0000107
Smyd2Ratprotein-lysine N-methyltransferase activity enablesIEAInterPro:IPR0444191600115GO_REF:0000002InterProGO_REF:0000002
Smyd2Ratprotein-lysine N-methyltransferase activity enablesIEARHEA:517361600115GO_REF:0000116RHEAGO_REF:0000116
Smyd2Ratprotein-lysine N-methyltransferase activity enablesISOSMYD2 (Homo sapiens)1624291 PMID:17108971 and PMID:20870719RGDPMID:17108971 and PMID:20870719
Smyd2RatRNA polymerase II complex binding enablesISSUniProtKB:Q8R5A01600115GO_REF:0000024UniProtGO_REF:0000024
Smyd2RatRNA polymerase II complex binding enablesISOSmyd2 (Mus musculus)1624291 PMID:20305823RGDPMID:20305823
Smyd2RatRNA polymerase II complex binding enablesIEAUniProtKB:Q8R5A0 and ensembl:ENSMUSP000000278971600115GO_REF:0000107EnsemblGO_REF:0000107
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RGD Manual Annotations


  
Object Symbol
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Original Reference(s)
Smyd2Rathistone modification pathway   ISOSMYD2 (Homo sapiens)7242632 RGD 
Smyd2Ratmethionine cycle/metabolic pathway   ISOSMYD2 (Homo sapiens)7242554 RGD 
Smyd2Ratp53 signaling pathway   ISOSMYD2 (Homo sapiens)2316155 RGD 

Imported Annotations - PID (archival)

Object Symbol
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Original Reference(s)
Smyd2Ratp53 signaling pathway   ISOSMYD2 (Homo sapiens)6484113 PIDPID:200206

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#
Reference Title
Reference Citation
1. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
2. Dysregulation of CREB binding protein triggers thrombin-induced proliferation of vascular smooth muscle cells. Chen J, etal., Mol Cell Biochem. 2008 Aug;315(1-2):123-30. Epub 2008 May 23.
3. Cardiac deletion of Smyd2 is dispensable for mouse heart development. Diehl F, etal., PLoS One. 2010 Mar 17;5(3):e9748. doi: 10.1371/journal.pone.0009748.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Targeting protein lysine methylation and demethylation in cancers. He Y, etal., Acta Biochim Biophys Sin (Shanghai). 2012 Jan;44(1):70-9. doi: 10.1093/abbs/gmr109.
6. Modes of p53 regulation. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
7. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function. Voelkel T, etal., Biochim Biophys Acta. 2013 Apr;1833(4):812-22. doi: 10.1016/j.bbamcr.2012.09.012. Epub 2012 Oct 6.
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PMID:8889548   PMID:12783626   PMID:16805913   PMID:17108971   PMID:20870719   PMID:22862948   PMID:24880080   PMID:30337525   PMID:32096186   PMID:38770649  



Smyd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813103,956,470 - 103,997,774 (-)NCBIGRCr8
mRatBN7.213101,425,270 - 101,466,576 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13101,425,273 - 101,466,576 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13103,940,656 - 103,981,564 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013105,329,429 - 105,370,669 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013102,534,981 - 102,578,302 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013108,642,156 - 108,686,293 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13108,642,156 - 108,686,290 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013113,261,746 - 113,302,399 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413106,160,147 - 106,201,473 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113106,349,462 - 106,390,567 (-)NCBI
Celera13100,910,865 - 100,950,701 (-)NCBICelera
Cytogenetic Map13q26NCBI
SMYD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381214,281,159 - 214,337,131 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1214,281,102 - 214,337,131 (+)EnsemblGRCh38hg38GRCh38
GRCh371214,454,502 - 214,510,474 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361212,521,199 - 212,577,097 (+)NCBINCBI36Build 36hg18NCBI36
Build 341210,842,970 - 210,898,868NCBI
Celera1187,677,508 - 187,733,362 (+)NCBICelera
Cytogenetic Map1q32.3NCBI
HuRef1185,129,703 - 185,185,600 (+)NCBIHuRef
CHM1_11215,726,941 - 215,782,851 (+)NCBICHM1_1
T2T-CHM13v2.01213,520,680 - 213,576,627 (+)NCBIT2T-CHM13v2.0
Smyd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391189,612,689 - 189,654,758 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1189,612,689 - 189,654,560 (-)EnsemblGRCm39 Ensembl
GRCm381189,880,492 - 189,922,495 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1189,880,492 - 189,922,363 (-)EnsemblGRCm38mm10GRCm38
MGSCv371191,704,371 - 191,746,167 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361191,581,280 - 191,623,076 (-)NCBIMGSCv36mm8
Celera1196,790,858 - 196,832,656 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map195.03NCBI
Smyd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554063,465,924 - 3,509,156 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554063,467,123 - 3,509,156 (-)NCBIChiLan1.0ChiLan1.0
SMYD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2135,065,100 - 35,121,132 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1135,029,402 - 35,085,432 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01189,849,167 - 189,905,193 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11194,729,116 - 194,761,043 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1194,729,116 - 194,761,045 (+)Ensemblpanpan1.1panPan2
SMYD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1712,281,581 - 12,331,294 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl712,281,710 - 12,331,164 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha711,855,760 - 11,905,351 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0711,991,481 - 12,041,301 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl711,991,446 - 12,044,237 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1711,915,043 - 11,964,795 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0712,019,583 - 12,068,986 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0712,143,792 - 12,193,251 (+)NCBIUU_Cfam_GSD_1.0
Smyd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934461,907,871 - 61,955,361 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366283,918,230 - 3,965,387 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366283,917,898 - 3,965,382 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMYD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9129,263,526 - 129,316,349 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19129,263,524 - 129,316,226 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29142,158,967 - 142,212,600 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMYD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12515,236,773 - 15,293,154 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2515,235,653 - 15,293,153 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605515,711,719 - 15,767,873 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smyd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477119,441,456 - 19,487,793 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477119,441,452 - 19,485,897 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Smyd2
216 total Variants

Predicted Target Of
Summary Value
Count of predictions:173
Count of miRNA genes:123
Interacting mature miRNAs:133
Transcripts:ENSRNOT00000004783
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

RH130282  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213101,425,352 - 101,425,540 (-)MAPPERmRatBN7.2
Rnor_6.013108,686,023 - 108,686,210NCBIRnor6.0
Rnor_5.013113,302,129 - 113,302,316UniSTSRnor5.0
RGSC_v3.413106,160,230 - 106,160,417UniSTSRGSC3.4
Celera13100,910,948 - 100,911,135UniSTS
RH 3.4 Map13697.9UniSTS
Cytogenetic Map13q27UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000004783   ⟹   ENSRNOP00000004783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13101,425,273 - 101,466,576 (-)Ensembl
Rnor_6.0 Ensembl13108,642,156 - 108,686,290 (+)Ensembl
RefSeq Acc Id: NM_206851   ⟹   NP_996733
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813103,956,470 - 103,997,774 (-)NCBI
mRatBN7.213101,425,270 - 101,466,576 (-)NCBI
Rnor_6.013108,642,156 - 108,686,293 (+)NCBI
Rnor_5.013113,261,746 - 113,302,399 (+)NCBI
RGSC_v3.413106,160,147 - 106,201,473 (-)RGD
Celera13100,910,865 - 100,950,701 (-)RGD
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_996733 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein DAA01315 (Get FASTA)   NCBI Sequence Viewer  
  EDL94968 (Get FASTA)   NCBI Sequence Viewer  
  EDL94969 (Get FASTA)   NCBI Sequence Viewer  
  EDL94970 (Get FASTA)   NCBI Sequence Viewer  
  EDL94971 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004783
  ENSRNOP00000004783.4
GenBank Protein Q7M6Z3 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_996733   ⟸   NM_206851
- UniProtKB: Q7M6Z3 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004783   ⟸   ENSRNOT00000004783
MYND-type   SET

Name Modeler Protein Id AA Range Protein Structure
AF-Q7M6Z3-F1-model_v2 AlphaFold Q7M6Z3 1-433 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699106
Promoter ID:EPDNEW_R9631
Type:initiation region
Name:Smyd2_1
Description:SET and MYND domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013108,642,172 - 108,642,232EPDNEW


1 to 32 of 32 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-16899 BioCyc
Ensembl Genes ENSRNOG00000003583 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004783 ENTREZGENE
  ENSRNOT00000004783.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.220.160 UniProtKB/Swiss-Prot
  1.25.40.10 UniProtKB/Swiss-Prot
  2.170.270.10 UniProtKB/Swiss-Prot
  6.10.140.2220 UniProtKB/Swiss-Prot
InterPro H3K4_H4K5_MeTrfase UniProtKB/Swiss-Prot
  SET_dom UniProtKB/Swiss-Prot
  SET_dom_sf UniProtKB/Swiss-Prot
  SMYD2_SET UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
  Znf_MYND UniProtKB/Swiss-Prot
KEGG Report rno:289372 UniProtKB/Swiss-Prot
NCBI Gene 289372 ENTREZGENE
PANTHER HISTONE-LYSINE N-METHYLTRANSFERASE SMYD UniProtKB/Swiss-Prot
  N-LYSINE METHYLTRANSFERASE SMYD2 UniProtKB/Swiss-Prot
Pfam SET UniProtKB/Swiss-Prot
  zf-MYND UniProtKB/Swiss-Prot
PhenoGen Smyd2 PhenoGen
PROSITE SET UniProtKB/Swiss-Prot
  ZF_MYND_1 UniProtKB/Swiss-Prot
  ZF_MYND_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003583 RatGTEx
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot
  SSF82199 UniProtKB/Swiss-Prot
UniProt A6JGW2_RAT UniProtKB/TrEMBL
  A6JGW3_RAT UniProtKB/TrEMBL
  A6JGW4_RAT UniProtKB/TrEMBL
  A6JGW5_RAT UniProtKB/TrEMBL
  Q7M6Z3 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 32 of 32 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Smyd2  SET and MYND domain containing 2      Symbol and Name status set to approved 1299863 APPROVED