Oprm1 (opioid receptor mu 1) - Rat Genome Database

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Gene: Oprm1 (opioid receptor mu 1) Heterocephalus glaber
Analyze
Symbol: Oprm1
Name: opioid receptor mu 1
RGD ID: 18909113
Description: ENCODES a protein that exhibits G protein-coupled opioid receptor activity (ortholog); G protein-coupled receptor activity (ortholog); G-protein beta-subunit binding (ortholog); INVOLVED IN acute inflammatory response to antigenic stimulus (ortholog); adenylate cyclase-activating dopamine receptor signaling pathway (ortholog); adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH AIDS Dementia Complex (ortholog); amphetamine abuse (ortholog); anxiety disorder (ortholog); FOUND IN dendrite (ortholog); dendrite cytoplasm (ortholog); dendrite membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mu-opioid receptor; mu-type opioid receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247854,032,689 - 4,196,186 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247854,147,079 - 4,195,712 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response to antigenic stimulus  (ISO)
adenylate cyclase-activating dopamine receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting opioid receptor signaling pathway  (ISO)
behavioral response to ethanol  (ISO)
cellular response to morphine  (IEA)
eating behavior  (ISO)
estrous cycle  (ISO)
excitatory postsynaptic potential  (ISO)
G protein-coupled opioid receptor signaling pathway  (IEA)
G protein-coupled receptor signaling pathway  (IEA,ISO)
locomotory behavior  (ISO)
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
negative regulation of cAMP-mediated signaling  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of luteinizing hormone secretion  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of Wnt protein secretion  (ISO)
neuropeptide signaling pathway  (IEA)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of appetite  (ISO)
positive regulation of cAMP-mediated signaling  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
presynaptic modulation of chemical synaptic transmission  (ISO)
regulation of cellular response to stress  (ISO)
regulation of NMDA receptor activity  (ISO)
response to cocaine  (ISO)
response to ethanol  (ISO)
response to food  (ISO)
response to growth factor  (ISO)
response to lipopolysaccharide  (ISO)
sensory perception of pain  (IEA)
social behavior  (ISO)
sperm ejaculation  (ISO)
transmission of nerve impulse  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacokinetics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
heroin pharmacokinetics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
interleukin-4 signaling pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Oprm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247854,032,689 - 4,196,186 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247854,147,079 - 4,195,712 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
OPRM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386154,010,496 - 154,246,867 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6154,010,496 - 154,246,867 (+)EnsemblGRCh38hg38GRCh38
GRCh376154,331,631 - 154,568,001 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366154,402,136 - 154,609,693 (+)NCBINCBI36Build 36hg18NCBI36
Build 346154,452,556 - 154,660,114NCBI
Celera6155,066,098 - 155,302,376 (+)NCBICelera
Cytogenetic Map6q25.2NCBI
HuRef6151,895,214 - 152,131,143 (+)NCBIHuRef
CHM1_16154,595,701 - 154,831,638 (+)NCBICHM1_1
T2T-CHM13v2.06155,212,511 - 155,448,859 (+)NCBIT2T-CHM13v2.0
Oprm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39106,708,593 - 6,988,209 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl106,708,506 - 6,988,198 (+)EnsemblGRCm39 Ensembl
GRCm38106,758,593 - 7,038,209 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl106,758,506 - 7,038,198 (+)EnsemblGRCm38mm10GRCm38
MGSCv37103,308,332 - 3,557,940 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36103,309,340 - 3,557,732 (-)NCBIMGSCv36mm8
Celera106,736,075 - 7,000,690 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map101.85NCBI
Oprm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,565,371 - 45,818,722 (+)NCBIGRCr8
mRatBN7.2143,160,057 - 43,413,409 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl143,160,057 - 43,413,409 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx143,700,986 - 43,954,675 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0149,688,216 - 49,941,908 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0143,776,469 - 44,030,156 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0143,454,803 - 43,704,948 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl143,454,803 - 43,704,948 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0144,804,181 - 45,034,145 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4137,535,416 - 37,779,392 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1137,538,384 - 37,591,800 (+)NCBI
Celera138,804,246 - 39,057,359 (+)NCBICelera
RH 3.4 Map1468.6RGD
Cytogenetic Map1q11NCBI
Oprm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554397,757,569 - 7,923,817 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554397,870,563 - 7,923,817 (-)NCBIChiLan1.0ChiLan1.0
OPRM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25174,001,918 - 174,144,256 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16171,893,526 - 172,035,890 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06151,827,323 - 151,937,658 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16156,517,666 - 156,627,758 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6156,517,661 - 157,088,251 (+)Ensemblpanpan1.1panPan2
OPRM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1143,972,915 - 44,037,477 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl143,972,219 - 44,141,238 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha144,810,592 - 44,875,131 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0144,157,040 - 44,221,809 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl144,156,501 - 44,325,450 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1144,023,836 - 44,088,390 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0143,896,066 - 43,961,450 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0144,471,346 - 44,490,044 (+)NCBIUU_Cfam_GSD_1.0
Oprm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946139,253,997 - 139,325,813 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364896,506,207 - 6,548,946 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364896,506,207 - 6,567,136 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPRM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl112,528,672 - 12,702,443 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1112,634,125 - 12,702,295 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2114,770,415 - 14,819,354 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1pNCBI
OPRM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11381,568,295 - 81,650,005 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1381,568,732 - 81,625,088 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604053,917,647 - 54,030,223 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000007524   ⟹   ENSHGLP00000007439
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247854,032,689 - 4,195,706 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000007525   ⟹   ENSHGLP00000007440
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247854,147,079 - 4,196,186 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000007526   ⟹   ENSHGLP00000007441
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247854,153,520 - 4,195,706 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000007527   ⟹   ENSHGLP00000007442
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247854,154,430 - 4,195,706 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000007528   ⟹   ENSHGLP00000007443
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247854,161,273 - 4,195,706 (-)Ensembl
RefSeq Acc Id: NM_001267590   ⟹   NP_001254519
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247854,147,079 - 4,195,712 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001254519 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AEX59148 (Get FASTA)   NCBI Sequence Viewer  
  EHB11430 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000007440
  ENSHGLP00100004580
RefSeq Acc Id: NP_001254519   ⟸   NM_001267590
- UniProtKB: G5BQ62 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000007440   ⟸   ENSHGLT00000007525
Ensembl Acc Id: ENSHGLP00000007441   ⟸   ENSHGLT00000007526
Ensembl Acc Id: ENSHGLP00000007439   ⟸   ENSHGLT00000007524
Ensembl Acc Id: ENSHGLP00000007443   ⟸   ENSHGLT00000007528
Ensembl Acc Id: ENSHGLP00000007442   ⟸   ENSHGLT00000007527


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000005417 Ensembl, ENTREZGENE
  ENSHGLG00100003461 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000007525 ENTREZGENE
  ENSHGLT00100004649 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Mu_opioid_rcpt UniProtKB/TrEMBL
  Opioid_rcpt UniProtKB/TrEMBL
KEGG Report hgl:100897068 UniProtKB/TrEMBL
NCBI Gene Oprm1 ENTREZGENE
PANTHER MU-TYPE OPIOID RECEPTOR UniProtKB/TrEMBL
  NEUROPEPTIDES RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  MUOPIOIDR UniProtKB/TrEMBL
  OPIOIDR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt G5BQ62 ENTREZGENE, UniProtKB/TrEMBL