CACNA1S (calcium voltage-gated channel subunit alpha1 S) - Rat Genome Database

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Gene: CACNA1S (calcium voltage-gated channel subunit alpha1 S) Chlorocebus sabaeus
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Symbol: CACNA1S
Name: calcium voltage-gated channel subunit alpha1 S
RGD ID: 18516185
Description: ENCODES a protein that exhibits high voltage-gated calcium channel activity (ortholog); molecular function activator activity (ortholog); small molecule binding (ortholog); INVOLVED IN calcium ion transport (ortholog); endoplasmic reticulum organization (ortholog); extraocular skeletal muscle development (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH centronuclear myopathy (ortholog); congenital myopathy 18 (ortholog); familial adult myoclonic epilepsy 5 (ortholog); FOUND IN dendritic spine head (ortholog); sarcolemma (ortholog); voltage-gated calcium channel complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: voltage-dependent L-type calcium channel subunit alpha-1S
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12528,288,483 - 28,363,231 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2528,289,342 - 28,363,327 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605529,088,659 - 29,162,753 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CACNA1S
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12528,288,483 - 28,363,231 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2528,289,342 - 28,363,327 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605529,088,659 - 29,162,753 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CACNA1S
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381201,039,512 - 201,112,426 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1201,039,512 - 201,112,451 (-)EnsemblGRCh38hg38GRCh38
GRCh371201,008,640 - 201,081,554 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361199,275,263 - 199,348,317 (-)NCBINCBI36Build 36hg18NCBI36
Build 341197,740,298 - 197,813,351NCBI
Celera1174,132,677 - 174,205,677 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1172,175,337 - 172,248,318 (-)NCBIHuRef
CHM1_11202,431,280 - 202,504,354 (-)NCBICHM1_1
T2T-CHM13v2.01200,296,459 - 200,369,410 (-)NCBIT2T-CHM13v2.0
Cacna1s
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,980,549 - 136,047,268 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,980,488 - 136,047,560 (+)EnsemblGRCm39 Ensembl
GRCm381136,052,806 - 136,119,822 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1136,052,750 - 136,119,822 (+)EnsemblGRCm38mm10GRCm38
MGSCv371137,949,478 - 138,016,399 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361137,869,312 - 137,936,233 (+)NCBIMGSCv36mm8
Celera1138,687,405 - 138,754,983 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map159.55NCBI
Cacna1s
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81350,045,668 - 50,115,903 (+)NCBIGRCr8
mRatBN7.21347,493,949 - 47,564,194 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1347,493,949 - 47,564,318 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1350,102,064 - 50,172,290 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01351,390,147 - 51,460,383 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01348,653,326 - 48,727,699 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01352,889,570 - 52,964,558 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1352,889,737 - 52,964,155 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01357,945,479 - 58,018,760 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41349,096,012 - 49,103,925 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1347,809,765 - 47,877,622 (+)NCBICelera
Cytogenetic Map13q13NCBI
Cacna1s
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540637,201,180 - 37,263,371 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540637,201,180 - 37,263,328 (-)NCBIChiLan1.0ChiLan1.0
CACNA1S
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2148,268,156 - 48,341,225 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1148,231,735 - 48,304,843 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01176,639,189 - 176,712,171 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11180,941,836 - 181,014,823 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1180,941,836 - 181,014,823 (-)Ensemblpanpan1.1panPan2
CACNA1S
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.172,108,716 - 2,172,246 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl72,108,455 - 2,303,220 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha71,793,187 - 1,856,620 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.071,755,440 - 1,818,918 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl71,755,328 - 1,818,919 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.171,738,797 - 1,802,223 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.071,841,461 - 1,904,933 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.071,871,249 - 1,934,698 (+)NCBIUU_Cfam_GSD_1.0
Cacna1s
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934474,034,420 - 74,097,190 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365673,269,355 - 3,331,460 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365673,269,283 - 3,331,858 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNA1S
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1023,502,898 - 23,568,058 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11023,503,701 - 23,567,797 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21027,934,779 - 27,999,415 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Cacna1s
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248079,559,954 - 9,619,132 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248079,560,004 - 9,618,942 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
33 1 17 17 17 33 1

Sequence


Ensembl Acc Id: ENSCSAT00000011932   ⟹   ENSCSAP00000009991
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2528,289,342 - 28,363,327 (+)Ensembl
RefSeq Acc Id: XM_007988996   ⟹   XP_007987187
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12528,288,483 - 28,363,231 (+)NCBI
Vero_WHO_p1.0NW_02366605529,088,659 - 29,162,753 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007987187 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009991.1
RefSeq Acc Id: XP_007987187   ⟸   XM_007988996
- UniProtKB: A0A0D9RN02 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000009991   ⟸   ENSCSAT00000011932


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013846 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011932.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
  6.10.250.2180 UniProtKB/TrEMBL
  6.10.250.2500 UniProtKB/TrEMBL
InterPro GPHH_dom UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  VDCC_a1su_IQ UniProtKB/TrEMBL
  VDCC_alpha-1_subunit UniProtKB/TrEMBL
  VDCC_L_a1ssu UniProtKB/TrEMBL
  VDCC_L_a1su UniProtKB/TrEMBL
  VDCCAlpha1 UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
NCBI Gene CACNA1S ENTREZGENE
PANTHER VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 UniProtKB/TrEMBL
  VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S UniProtKB/TrEMBL
Pfam Ca_chan_IQ UniProtKB/TrEMBL
  GPHH UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
PRINTS CACHANNEL UniProtKB/TrEMBL
  LVDCCALPHA1 UniProtKB/TrEMBL
  LVDCCALPHA1S UniProtKB/TrEMBL
SMART Ca_chan_IQ UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A0D9RN02 ENTREZGENE, UniProtKB/TrEMBL