Gene: Cacna1s (calcium channel, voltage-dependent, L type, alpha 1S subunit) Mus musculus
Symbol: Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Description: ENCODES a protein that exhibits voltage-gated calcium channel activity; high voltage-gated calcium channel activity (ortholog); INVOLVED IN calcium ion transport; endoplasmic reticulum organization; extraocular skeletal muscle development; PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; Alzheimer disease pathway; ASSOCIATED WITH abnormal axial skeleton morphology; abnormal calcium ion homeostasis; abnormal cartilage morphology; ASSOCIATED WITH cutaneous malignant melanoma, susceptibility to, 1 (ortholog); hyperkalemic periodic paralysis (ortholog); Hypokalemic Periodic Paralysis (ortholog); FOUND IN sarcoplasmic reticulum; T-tubule; cytoplasm (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW493108; calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; Cav1.1; Cchl1a3; DHPR; DHPR alpha1s; dihydropyridine receptor alpha 1S; fmd; mdg; muscle dysgenesis; OTTMUSP00000045912; OTTMUSP00000045913; OTTMUSP00000045914; sj; voltage-dependent L-type calcium channel subunit alpha-1S; voltage-gated calcium channel subunit alpha Cav1.1
Homo sapiens (human) : CACNA1S (calcium voltage-gated channel subunit alpha1 S)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cacna1s (calcium voltage-gated channel subunit alpha1 S)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cacna1s (calcium voltage-gated channel subunit alpha1 S)
Pan paniscus (bonobo/pygmy chimpanzee) : CACNA1S (calcium voltage-gated channel subunit alpha1 S)
Canis lupus familiaris (dog) : CACNA1S (calcium voltage-gated channel subunit alpha1 S)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cacna1s (calcium voltage-gated channel subunit alpha1 S)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381136,052,805 - 136,119,822 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371137,949,478 - 138,016,399 (+)NCBIGRCm37mm9NCBIm37
MGSCv361137,869,312 - 137,936,233 (+)NCBImm8
Celera1138,687,405 - 138,754,983 (+)NCBICelera
Cytogenetic Map1 E4NCBI
cM Map159.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cacna1s
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733918
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2018-02-27
Status: ACTIVE