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Gene: Cacna1s (calcium channel, voltage-dependent, L type, alpha 1S subunit) Mus musculus
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Symbol: Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Description: Exhibits voltage-gated calcium channel activity. Involved in several processes, including extraocular skeletal muscle development; myotube differentiation; and skeletal muscle adaptation. Localizes to the T-tubule and sarcoplasmic reticulum. Used to study hypokalemic periodic paralysis. Human ortholog(s) of this gene implicated in hypokalemic periodic paralysis and malignant hyperthermia. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Orthologous to human CACNA1S (calcium voltage-gated channel subunit alpha1 S); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; Alzheimer's disease pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW493108; calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; Cav1.1; Cchl1a3; DHPR; DHPR alpha1s; dihydropyridine receptor alpha 1S; fmd; mdg; muscle dysgenesis; sj; voltage-dependent L-type calcium channel subunit alpha-1S; voltage-gated calcium channel subunit alpha Cav1.1
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381136,052,806 - 136,119,822 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371137,949,478 - 138,016,399 (+)NCBIGRCm37mm9NCBIm37
MGSCv361137,869,312 - 137,936,233 (+)NCBImm8
Celera1138,687,405 - 138,754,983 (+)NCBICelera
Cytogenetic Map1 E4NCBI
cM Map159.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on Cacna1s
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733918
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.