Gene: CACNA1S (calcium voltage-gated channel subunit alpha1 S) Homo sapiens
Symbol: CACNA1S
Name: calcium voltage-gated channel subunit alpha1 S
Description: This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CACNL1A3; calcium channel, L type, alpha 1 polypeptide, isoform 3 (skeletal muscle, hypokalemic periodic paralysis); calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; calcium channel, voltage-dependent, L type, alpha 1S subunit; Cav1.1; CCHL1A3; dihydropyridine receptor; dihydropyridine receptor alpha 1 subunit; dihydropyridine-sensitive L-type calcium channel alpha-1 subunit; HOKPP; HOKPP1; hypoPP; MHS5; OTTHUMP00000033931; OTTHUMP00000033932; TTPP1; voltage-dependent L-type calcium channel subunit alpha-1S; voltage-gated calcium channel subunit alpha Cav1.1
Mus musculus (house mouse) : Cacna1s (calcium channel, voltage-dependent, L type, alpha 1S subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cacna1s (calcium voltage-gated channel subunit alpha1 S)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cacna1s (calcium voltage-gated channel subunit alpha1 S)
Pan paniscus (bonobo/pygmy chimpanzee) : CACNA1S (calcium voltage-gated channel subunit alpha1 S)
Canis lupus familiaris (dog) : CACNA1S (calcium voltage-gated channel subunit alpha1 S)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cacna1s (calcium voltage-gated channel subunit alpha1 S)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381201,039,509 - 201,112,566 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371201,008,635 - 201,081,694 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361199,275,263 - 199,348,317 (-)NCBINCBI36hg18NCBI36
Build 341197,740,298 - 197,813,351NCBI
Celera1174,132,677 - 174,205,677 (-)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1172,175,337 - 172,248,318 (-)NCBIHuRef
CHM1_11202,431,280 - 202,504,354 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CACNA1S
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736857
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2018-03-13
Status: ACTIVE