PDGFRA (platelet derived growth factor receptor alpha) - Rat Genome Database

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Gene: PDGFRA (platelet derived growth factor receptor alpha) Chlorocebus sabaeus
Analyze
Symbol: PDGFRA
Name: platelet derived growth factor receptor alpha
RGD ID: 18406317
Description: ENCODES a protein that exhibits phosphatidylinositol 3-kinase binding (ortholog); platelet-derived growth factor alpha-receptor activity (ortholog); INVOLVED IN adrenal gland development (ortholog); anatomical structure morphogenesis (ortholog); animal organ morphogenesis (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma (ortholog); Brain Injuries (ortholog); brain stem glioma (ortholog); FOUND IN axon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: platelet-derived growth factor receptor alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1714,243,291 - 14,307,373 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl714,241,070 - 14,307,422 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606615,086,695 - 15,149,115 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
B-lymphoblastic leukemia/lymphoma  (ISO)
Brain Injuries  (ISO)
brain stem glioma  (ISO)
breast carcinoma  (ISO)
Chronic Allograft Nephropathy  (ISO)
chronic ulcer of skin  (ISO)
cleft palate  (ISO)
colon carcinoma  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation type IIk  (ISO)
congestive heart failure  (ISO)
Craniofacial Abnormalities  (ISO)
craniopharyngioma  (ISO)
Diabetic Nephropathies  (ISO)
Endometrioid Carcinomas  (ISO)
Eosinophilia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fetal Death  (ISO)
gastrointestinal stromal tumor  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypereosinophilic syndrome  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
in situ carcinoma  (ISO)
isolated cleft palate  (ISO)
Kidney Reperfusion Injury  (ISO)
leukemia  (ISO)
Leydig cell tumor  (ISO)
lung disease  (ISO)
lung sarcomatoid carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
mesenchymal chondrosarcoma  (ISO)
middle cerebral artery infarction  (ISO)
Multiple Polyps and Recurrent Inflammatory Fibroid, Gastrointestinal  (ISO)
myeloid leukemia  (ISO)
myeloid sarcoma  (ISO)
myeloproliferative neoplasm  (ISO)
Neointima  (ISO)
oligohydramnios  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
Pdgfra-Associated Chronic Eosinophilic Leukemia  (ISO)
prostate adenocarcinoma  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
Respiratory System Abnormalities  (ISO)
sciatic neuropathy  (ISO)
scimitar syndrome  (ISO)
seminoma  (ISO)
spina bifida  (ISO)
Stroke  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
Uterine Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IEA,ISO)
anatomical structure morphogenesis  (IEA,ISO)
animal organ morphogenesis  (IEA,ISO)
brain-derived neurotrophic factor receptor signaling pathway  (IEA)
cardiac myofibril assembly  (IEA)
cell chemotaxis  (IEA)
cell migration  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to growth factor stimulus  (IEA)
cellular response to interleukin-1  (ISO)
cellular response to reactive oxygen species  (IEA,ISO)
chemotaxis  (IEA)
chromatin remodeling  (IEA)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA)
embryonic cranial skeleton morphogenesis  (IEA)
embryonic digestive tract morphogenesis  (IEA)
ephrin receptor signaling pathway  (IEA)
epidermal growth factor receptor signaling pathway  (IEA)
estrogen metabolic process  (IEA,ISO)
extracellular matrix organization  (IEA,ISO)
face morphogenesis  (IEA,ISO)
female gonad development  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (IEA)
hematopoietic progenitor cell differentiation  (IEA,ISO)
hepatocyte growth factor receptor signaling pathway  (IEA)
in utero embryonic development  (IEA,ISO)
inner ear development  (ISO)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
Kit signaling pathway  (IEA)
Leydig cell differentiation  (IEA,ISO)
lung development  (IEA,ISO)
lung growth  (ISO)
luteinization  (IEA,ISO)
macrophage colony-stimulating factor signaling pathway  (IEA)
male genitalia development  (IEA,ISO)
male gonad development  (ISO)
metanephric glomerular capillary formation  (IEA)
negative regulation of platelet activation  (IEA)
odontogenesis of dentin-containing tooth  (IEA,ISO)
peptidyl-tyrosine phosphorylation  (ISO)
platelet aggregation  (IEA)
platelet-derived growth factor receptor signaling pathway  (IEA,ISO)
platelet-derived growth factor receptor-alpha signaling pathway  (IEA)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
positive regulation of branching involved in lung morphogenesis  (ISO)
positive regulation of calcium-mediated signaling  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway  (IEA)
positive regulation of chemotaxis  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of fibroblast proliferation  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
protein autophosphorylation  (ISO)
regulation of cell population proliferation  (IEA)
regulation of mesenchymal stem cell differentiation  (IEA)
response to cytokine  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to formaldehyde  (ISO)
response to hormone  (ISO)
response to hyperoxia  (ISO)
retina vasculature development in camera-type eye  (IEA)
roof of mouth development  (IEA,ISO)
signal transduction involved in regulation of gene expression  (IEA,ISO)
skeletal system morphogenesis  (IEA,ISO)
vascular endothelial growth factor receptor-1 signaling pathway  (IEA)
white fat cell differentiation  (IEA,ISO)
wound healing  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PDGFRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1714,243,291 - 14,307,373 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl714,241,070 - 14,307,422 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606615,086,695 - 15,149,115 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PDGFRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38454,229,293 - 54,298,245 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl454,229,280 - 54,298,245 (+)EnsemblGRCh38hg38GRCh38
GRCh37455,095,460 - 55,164,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36454,790,204 - 54,859,169 (+)NCBINCBI36Build 36hg18NCBI36
Build 34454,936,129 - 55,005,339NCBI
Celera452,596,023 - 52,665,170 (+)NCBICelera
Cytogenetic Map4q12NCBI
HuRef451,043,324 - 51,112,555 (+)NCBIHuRef
CHM1_1455,130,846 - 55,199,987 (+)NCBICHM1_1
T2T-CHM13v2.0457,718,046 - 57,786,996 (+)NCBIT2T-CHM13v2.0
Pdgfra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39575,311,988 - 75,358,867 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl575,312,953 - 75,358,876 (+)EnsemblGRCm39 Ensembl
GRCm38575,151,322 - 75,198,206 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl575,152,292 - 75,198,215 (+)EnsemblGRCm38mm10GRCm38
MGSCv37575,548,316 - 75,594,229 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36575,434,045 - 75,479,893 (+)NCBIMGSCv36mm8
Celera572,441,591 - 72,487,596 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map539.55NCBI
Pdgfra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81433,360,027 - 33,408,604 (-)NCBIGRCr8
mRatBN7.21433,005,838 - 33,054,347 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1433,005,839 - 33,054,335 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1433,356,581 - 33,405,000 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01434,664,393 - 34,712,811 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01433,149,650 - 33,198,062 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01435,527,926 - 35,581,130 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1435,527,927 - 35,581,031 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01435,356,434 - 35,409,311 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41435,369,422 - 35,418,126 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11435,369,672 - 35,418,126 (-)NCBI
Celera1432,273,077 - 32,324,887 (-)NCBICelera
RH 3.4 Map14432.47RGD
Cytogenetic Map14p11NCBI
Pdgfra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544716,569,909 - 16,612,373 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544716,570,652 - 16,613,410 (-)NCBIChiLan1.0ChiLan1.0
PDGFRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2375,493,805 - 75,564,589 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1475,697,777 - 75,768,556 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0469,639,081 - 69,709,870 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1476,200,871 - 76,271,105 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl476,199,382 - 76,271,097 (-)Ensemblpanpan1.1panPan2
PDGFRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11346,729,722 - 46,775,828 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1346,730,703 - 46,773,278 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1346,687,151 - 46,733,378 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01347,339,954 - 47,386,179 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1347,340,084 - 47,386,176 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11347,012,519 - 47,058,684 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01346,544,815 - 46,590,877 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01347,418,193 - 47,464,247 (+)NCBIUU_Cfam_GSD_1.0
Pdgfra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528529,444,794 - 29,494,171 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648216,807,569 - 16,853,587 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648216,804,129 - 16,853,539 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDGFRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl840,967,493 - 41,021,441 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1840,966,568 - 41,021,440 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2843,067,784 - 43,081,654 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pdgfra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476115,225,356 - 15,269,810 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476115,223,789 - 15,269,685 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 18 34 34 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000003021   ⟹   ENSCSAP00000001309
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl714,241,070 - 14,307,422 (-)Ensembl
RefSeq Acc Id: XM_007998695   ⟹   XP_007996886
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1714,243,291 - 14,307,373 (-)NCBI
Vero_WHO_p1.0NW_02366606615,086,695 - 15,149,115 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007998697   ⟹   XP_007996888
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1714,243,291 - 14,307,373 (-)NCBI
Vero_WHO_p1.0NW_02366606615,086,695 - 15,148,899 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037989438   ⟹   XP_037845366
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366606615,086,695 - 15,146,122 (-)NCBI
RefSeq Acc Id: XM_037989439   ⟹   XP_037845367
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366606615,086,695 - 15,145,065 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007996886 (Get FASTA)   NCBI Sequence Viewer  
  XP_007996888 (Get FASTA)   NCBI Sequence Viewer  
  XP_037845366 (Get FASTA)   NCBI Sequence Viewer  
  XP_037845367 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000001309.1
RefSeq Acc Id: XP_007996886   ⟸   XM_007998695
- UniProtKB: A0A0D9QY70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007996888   ⟸   XM_007998697
- UniProtKB: A0A0D9QY70 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000001309   ⟸   ENSCSAT00000003021
RefSeq Acc Id: XP_037845366   ⟸   XM_037989438
- UniProtKB: A0A0D9QY70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037845367   ⟸   XM_037989439
- UniProtKB: A0A0D9QY70 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000004987 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000003021.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PDGFRA UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RTK UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_rcpt_3_CS UniProtKB/TrEMBL
KEGG Report csab:103235675 UniProtKB/TrEMBL
NCBI Gene PDGFRA ENTREZGENE
PANTHER PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
  PF00047 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PIRSF Alpha-PDGF_receptor UniProtKB/TrEMBL
  TyrPK_CSF1-R UniProtKB/TrEMBL
PRINTS VEGFRECEPTOR UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_III UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9QY70 ENTREZGENE, UniProtKB/TrEMBL