AP2A2 (adaptor related protein complex 2 subunit alpha 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: AP2A2 (adaptor related protein complex 2 subunit alpha 2) Chlorocebus sabaeus
Analyze
Symbol: AP2A2
Name: adaptor related protein complex 2 subunit alpha 2
RGD ID: 18355139
Description: ENCODES a protein that exhibits disordered domain specific binding (ortholog); kinase binding (ortholog); phosphatidylinositol binding (ortholog); INVOLVED IN synaptic vesicle endocytosis (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ASSOCIATED WITH delta beta-thalassemia (ortholog); developmental and epileptic encephalopathy (ortholog); early infantile epileptic encephalopathy (ortholog); FOUND IN cytoplasmic vesicle (ortholog); synaptic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adaptor related protein complex 2 alpha 2 subunit; AP-2 complex subunit alpha-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11731,616 - 820,191 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1731,645 - 818,642 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603897,821,900 - 97,912,108 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AP2A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11731,616 - 820,191 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1731,645 - 818,642 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603897,821,900 - 97,912,108 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
AP2A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811925,870 - 1,012,240 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11924,881 - 1,012,245 (+)EnsemblGRCh38hg38GRCh38
GRCh3711925,870 - 1,012,240 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611915,841 - 1,002,240 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411915,880 - 1,000,919NCBI
Celera11993,301 - 1,080,635 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11740,785 - 828,407 (+)NCBIHuRef
CHM1_111924,861 - 1,011,169 (+)NCBICHM1_1
T2T-CHM13v2.011977,298 - 1,071,157 (+)NCBIT2T-CHM13v2.0
Ap2a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,142,093 - 141,212,924 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,142,086 - 141,212,924 (+)EnsemblGRCm39 Ensembl
GRCm387141,562,180 - 141,633,011 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,562,173 - 141,633,011 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,748,079 - 148,818,910 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,413,558 - 141,484,331 (+)NCBIMGSCv36mm8
Celera7141,382,192 - 141,426,917 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.94NCBI
Ap2a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,081,856 - 206,155,146 (+)NCBIGRCr8
mRatBN7.21196,652,315 - 196,725,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,652,337 - 196,725,603 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,997,575 - 205,069,879 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,126,225 - 212,198,337 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,800,374 - 204,872,485 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,534,217 - 214,607,497 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,534,284 - 214,606,169 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,451,352 - 221,524,612 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,741,585 - 201,813,472 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,894,982 - 201,967,871 (+)NCBI
Celera1194,285,764 - 194,357,691 (+)NCBICelera
Cytogenetic Map1q41NCBI
Ap2a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,185,223 - 11,229,409 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,184,944 - 11,229,385 (-)NCBIChiLan1.0ChiLan1.0
AP2A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,325,303 - 3,415,227 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,535,446 - 2,626,050 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011945,170 - 1,034,860 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,005,473 - 1,076,652 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,005,473 - 1,076,652 (+)Ensemblpanpan1.1panPan2
AP2A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,269,962 - 45,358,020 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1845,253,772 - 45,358,018 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1843,928,814 - 44,025,349 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01845,927,072 - 46,023,324 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1845,927,078 - 46,023,539 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11845,391,389 - 45,487,393 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01844,956,103 - 45,052,452 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,694,999 - 45,791,022 (+)NCBIUU_Cfam_GSD_1.0
Ap2a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947671,479 - 735,119 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936888689,727 - 733,541 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936888689,673 - 735,119 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AP2A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2580,182 - 628,087 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12580,169 - 628,098 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2249,080 - 94,085 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ap2a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,567,050 - 21,616,392 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476621,568,217 - 21,616,389 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 18 60
Low 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000008584   ⟹   ENSCSAP00000006728
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1731,645 - 818,642 (+)Ensembl
RefSeq Acc Id: XM_007997935   ⟹   XP_007996126
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11731,617 - 820,191 (+)NCBI
Vero_WHO_p1.0NW_02366603897,821,900 - 97,912,108 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007998011   ⟹   XP_007996202
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11731,617 - 820,191 (+)NCBI
Vero_WHO_p1.0NW_02366603897,821,900 - 97,912,108 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037998790   ⟹   XP_037854718
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603897,875,449 - 97,912,108 (+)NCBI
Protein Sequences
Protein RefSeqs XP_007996126 (Get FASTA)   NCBI Sequence Viewer  
  XP_007996202 (Get FASTA)   NCBI Sequence Viewer  
  XP_037854718 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000006728.1
Reference Protein Sequences
RefSeq Acc Id: XP_007996126   ⟸   XM_007997935
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RDN9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007996202   ⟸   XM_007998011
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RDN9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000006728   ⟸   ENSCSAT00000008584
RefSeq Acc Id: XP_037854718   ⟸   XM_037998790
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010503 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008584.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
  2.60.40.1230 UniProtKB/TrEMBL
  3.30.310.10 UniProtKB/TrEMBL
InterPro AP2_complex_asu UniProtKB/TrEMBL
  ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Clathrin/coatomer_adapt-like_N UniProtKB/TrEMBL
  Clathrin_a-adaptin_app_sub_C UniProtKB/TrEMBL
  Clathrin_a/b/g-adaptin_app_Ig UniProtKB/TrEMBL
  Clathrin_app_Ig-like_sf UniProtKB/TrEMBL
  Coatomer/calthrin_app_sub_C UniProtKB/TrEMBL
  TBP_dom_sf UniProtKB/TrEMBL
NCBI Gene AP2A2 ENTREZGENE
PANTHER ADAPTIN, ALPHA/GAMMA/EPSILON UniProtKB/TrEMBL
  AP-2 COMPLEX SUBUNIT ALPHA-2 UniProtKB/TrEMBL
Pfam Adaptin_N UniProtKB/TrEMBL
  Alpha_adaptin_C UniProtKB/TrEMBL
  Alpha_adaptinC2 UniProtKB/TrEMBL
PIRSF AP2_complex_alpha UniProtKB/TrEMBL
SMART Alpha_adaptinC2 UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF49348 UniProtKB/TrEMBL
  SSF55711 UniProtKB/TrEMBL
UniProt A0A0D9RDN9 ENTREZGENE, UniProtKB/TrEMBL