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Gene: AP2A2 (adaptor related protein complex 2 subunit alpha 2) Canis lupus familiaris

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Symbol:

AP2A2

Name:

adaptor related protein complex 2 subunit alpha 2

RGD ID:

12247439

Description:

ENCODES a protein that exhibits phosphatidylinositol binding (ortholog); protein serine/threonine kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN clathrin-dependent endocytosis (inferred); intracellular protein transport (inferred); protein transport (inferred); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ASSOCIATED WITH Breast Cancer, Familial (ortholog); cholangiocarcinoma (ortholog); head and neck squamous cell carcinoma (ortholog); FOUND IN synapse (ortholog); synaptic vesicle (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

adaptor related protein complex 2 alpha 2 subunit; AP-2 complex subunit alpha-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	45,269,962 - 45,358,020 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	45,253,772 - 45,358,018 (+)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	43,928,814 - 44,025,349 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	45,927,072 - 46,023,324 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	45,927,078 - 46,023,539 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	45,391,389 - 45,487,393 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	44,956,103 - 45,052,452 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	45,694,999 - 45,791,022 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Cancer, Familial (ISO)

cholangiocarcinoma (ISO)

head and neck squamous cell carcinoma (ISO)

hepatocellular carcinoma (ISO)

ovarian serous cystadenocarcinoma (ISO)

sarcoma (ISO)

thymoma (ISO)

Thyroid Carcinoma, Nonmedullary 1 (ISO)

uterine carcinosarcoma (ISO)

uterine corpus endometrial carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

clathrin-dependent endocytosis (IBA,IEA)

intracellular protein transport (IEA)

protein transport (IEA)

synaptic vesicle endocytosis (IEA)

vesicle-mediated transport (IEA)

Cellular Component

AP-2 adaptor complex (IBA,IEA)

clathrin adaptor complex (IEA)

cytoplasmic vesicle (IEA)

membrane (IEA)

membrane coat (IEA)

plasma membrane (IEA)

presynapse (IEA)

synapse (ISO)

synaptic vesicle (ISO)

Molecular Function

clathrin-cargo adaptor activity (IBA,IEA)

disordered domain specific binding (IEA)

kinase binding (IEA)

phosphatidylinositol binding (ISO)

protein binding (ISO)

protein domain specific binding (IEA)

protein kinase binding (IEA)

protein serine/threonine kinase binding (ISO)

protein-containing complex binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

clathrin-dependent synaptic vesicle endocytosis (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

AP2A2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	45,269,962 - 45,358,020 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	45,253,772 - 45,358,018 (+)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	43,928,814 - 44,025,349 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	45,927,072 - 46,023,324 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	45,927,078 - 46,023,539 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	45,391,389 - 45,487,393 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	44,956,103 - 45,052,452 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	45,694,999 - 45,791,022 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

AP2A2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	925,870 - 1,012,240 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	924,881 - 1,012,245 (+)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	11	925,870 - 1,012,240 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	915,841 - 1,002,240 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	915,880 - 1,000,919	NCBI
Celera	11	993,301 - 1,080,635 (+)	NCBI		Celera
Cytogenetic Map	11	p15.5	NCBI
HuRef	11	740,785 - 828,407 (+)	NCBI		HuRef
CHM1_1	11	924,861 - 1,011,169 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	977,298 - 1,071,157 (+)	NCBI		T2T-CHM13v2.0

Ap2a2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	141,142,093 - 141,212,924 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	141,142,031 - 141,249,132 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	141,562,180 - 141,633,011 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	141,562,173 - 141,633,011 (+)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	7	148,748,079 - 148,818,910 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	141,413,558 - 141,484,331 (+)	NCBI		MGSCv36	mm8
Celera	7	141,382,192 - 141,426,917 (+)	NCBI		Celera
Cytogenetic Map	7	F5	NCBI
cM Map	7	86.94	NCBI

Ap2a2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	206,081,856 - 206,155,146 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	206,081,878 - 206,155,150 (+)	Ensembl				GRCr8
mRatBN7.2	1	196,652,315 - 196,725,609 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	196,652,337 - 196,725,603 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	204,997,575 - 205,069,879 (+)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	212,126,225 - 212,198,337 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	204,800,374 - 204,872,485 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	1	205,450,923 - 205,523,224 (+)	NCBI
Lyon_Normotensive	1	210,397,252 - 210,469,404 (+)	NCBI
Lyon_Hypertensive	1	207,096,069 - 207,168,371 (+)	NCBI
F344_StmMcwi	1	205,350,488 - 205,422,789 (+)	NCBI
Rnor_6.0	1	214,534,217 - 214,607,497 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	214,534,284 - 214,606,169 (+)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	1	221,451,352 - 221,524,612 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	201,741,585 - 201,813,472 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	194,285,764 - 194,357,691 (+)	NCBI		Celera
RGSC_v3.1	1	201,894,982 - 201,967,871 (+)	NCBI
Cytogenetic Map	1	q41	NCBI

Ap2a2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955476	11,185,223 - 11,229,409 (-)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955476	11,184,944 - 11,229,385 (-)	NCBI	ChiLan1.0	ChiLan1.0

AP2A2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	3,325,303 - 3,415,227 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	2,535,446 - 2,626,050 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	945,170 - 1,034,860 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	1,005,473 - 1,076,652 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	1,005,473 - 1,076,652 (+)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

Ap2a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	4	749,026 - 814,040 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024404947	671,479 - 735,119 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936888	689,727 - 733,541 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936888	689,673 - 735,119 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AP2A2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	580,182 - 628,087 (+)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	2	580,169 - 628,098 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	49,080 - 94,085 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AP2A2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	1	753,974 - 845,195 (+)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666038	97,821,900 - 97,912,108 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	1	731,616 - 820,191 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	731,645 - 818,642 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Ap2a2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624766	21,568,217 - 21,616,389 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624766	21,567,050 - 21,616,392 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl

Ap2a2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	7,860,612 - 7,933,551 (-)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Variants

Variants in AP2A2
921 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_022405507	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022405508	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022405509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022405510	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038424605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038424606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038424607	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038424608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038453888	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038453889	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038453890	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038500870	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038500871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038500872	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038500873	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038563533	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038563534	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038563535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038563536	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038627655	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038627656	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038627657	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038627658	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000176	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000015398 ⟹ ENSCAFP00000014249

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	18	45,269,977 - 45,358,018 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000083847 ⟹ ENSCAFP00000044197

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	18	45,253,772 - 45,358,018 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845012775 ⟹ ENSCAFP00845009963

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	18	45,927,078 - 46,023,539 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845012836 ⟹ ENSCAFP00845010004

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	18	45,927,078 - 46,023,310 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845012908 ⟹ ENSCAFP00845010060

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	18	45,985,065 - 46,023,309 (+)	Ensembl

RefSeq Acc Id:

XM_022405510 ⟹ XP_022261218

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	18	45,303,836 - 45,358,020 (+)	NCBI
Dog10K_Boxer_Tasha	18	43,971,179 - 44,025,349 (+)	NCBI

Sequence:

show sequence

GTCATCGTGGACTCCAGCTCATTTTGGACAGCCAGGGTTTTCTCTTGAACCTCCTCCACACCAG
GAATCTCAAGGATGCTGGGGGTGACTGGGTAAAAGTAAAGAAGCAGAAATAAAGAGAATAAACA
AAGAACTGGCAAACATTAGATCAAAATTTAAAGGTGACAAGGCTCTTGATGGCTATAGTAAAAA
AAAGTACGTCTGCAAGTTGCTCTTCATCTTCCTCCTGGGTCATGACATTGACTTTGGGCACATG
GAGGCCGTGAACCTGCTGAGCTCCAACAGATACACGGAGAAGCAGATCGGCTACCTCTTCATCT
CTGTGCTGGTGAACTCCAACAGTGAGCTCATCCGGCTCATCAACAATGCCATCAAGAATGACCT
GGCCAGTCGGAACCCCACCTTCATGGGCCTGGCCCTGCACTGCATCGCCAACGTGGGCAGCCGA
GAGATGGCCGAGGCCTTCGCTGGGGAGATTCCAAAAATCCTTGTAGCTGGAGACACCATGGACA
GCGTGAAGCAGAGTGCCGCCCTTTGTTTGCTGCGTTTGTATAGAACATCTCCTGATCTCGTCCC
CATGGGTGACTGGACATCCCGAGTTGTGCACCTTCTCAACGACCAGCATTTGGGCGTGGTGACT
GCTGCCACTAGTCTCATCACCACCTTGGCACAGAAGAATCCTGAGGAGTTCAAGACCTCTGTCT
CTCTGGCCGTCTCCAGATTAAGCAGGATTGTGACATCTGCATCCACAGACCTTCAGGATTATAC
CTACTATTTTGTCCCGGCTCCCTGGCTGTCCGTAAAACTTCTGAGGTTGCTACAGTGCTATCCA
CCCCCAGAAGACCCCGCAGTGCGAGGCCGCCTGACCGAGTGCCTGGAGACGATTCTGAACAAAG
CCCAGGAACCACCAAAGTCAAAAAAAGTGCAGCATTCCAACGCTAAGAACGCCGTGCTCTTTGA
GGCGATCAGCCTGATCATTCACCACGATAGTGAGCCAAACCTGCTCGTCCGCGCCTGTAACCAG
CTTGGCCAGTTCCTGCAGCATCGGGAGACCAACCTGCGCTACCTGGCCCTGGAGAGCATGTGCA
CGCTAGCCAGCTCCGAGTTCTCCCACGAGGCAGTCAAGACACACATCGAGACAGTCATCAATGC
TCTGAAGACGGAGCGGGACGTGAGTGTCCGGCAGCGGGCTGTGGACCTCCTCTACGCCATGTGT
GACCGCAGCAATGCTCAGCAGATTGTGGCCGAGATGCTGAGCTACCTGGAGACGGCTGACTACT
CTATCCGGGAGGAGATCGTGCTGAAGGTTGCCATCTTGGCGGAGAAGTATGCTGTGGACTACAC
GTGGTACGTGGACACCATCCTCAACCTGATCCGGATTGCTGGTGACTATGTGAGTGAAGAGGTG
TGGTACCGTGTCATTCAGATTGTCATCAACCGGGACGATGTGCAGGGCTATGCTGCCAAGACGG
TGTTCGAGGCTCTCCAGGCTCCGGCGTGCCATGAGAACCTGGTCAAAGTGGGTGGCTACATCCT
GGGGGAGTTTGGAAACTTGATAGCTGGGGACCCGAGATCCAGCCCCCTGATCCAGTTCAACTTG
TTACACTCCAAGTTCCACCTGTGCAGCGTCCCCACCAGGGCGCTGCTCTTGTCTACCTACATCA
AATTTGTGAACCTCTTTCCGGAGGTGAAAACCACCATTCAGGATGTGCTGCGCAGCGACAGCCA
GCTGAAGAACGCGGATGTAGAGCTGCAGCAGCGGGCCGTGGAGTATCTGAGGCTCAGCACAGTG
GCCAGCACCGACATCCTGGCAACCGTCCTGGAGGAGATGCCGCCTTTTCCAGAGCGTGAGTCTT
CCATCCTGGCCAAGCTCAAGAAGAAGAAGGGCCCAAACACTGTGACAGACCTGGAGGATGCTAA
GCGGGAGAGGAGCGCAGATGTCAATGGGGGCCCTGAGCCTGCCCCGGCCAGCGCCGCGTCCACA
CCTTCTCCATCCGCAGACCTCTTGGGTCTGGGGGCTGCACCACCTGCCCCTGTGGGCCCCCCAC
CTTCCTCTGGCGGGCTGCTTGTGGATGTGTTCTCAGACTCACCCTCCGCGGTTGCACCGCTGGC
TCCCGGCTCTGAAGACAACTTTGCCAGATTCGTCTGTAAAAATAACGGTGTGCTGTTTGAAAAT
CAGCTGCTTCAAATTGGACTGAAGTCTGAATTCCGGCAGAATTTGGGTCGGATGTTTATATTTT
ATGGAAATAAGACCTCCACGCAGTTTTTAAATTTCACTCCAACACTGATCTGTTCAGACGACCT
TCAGACGAATCTGAGCTTGCAGACCAAGCCCGTGGACCCGACTGTGGATGGTGGAGCCCAGGTG
CAACAGGTTGTGAACATAGAGTGTGTGTCTGACTTCACGGAGGCACCAGTCCTCAACATCCAGT
TCAGGTATGGGGGAACCTTTCAGAATGTGTCCGTTAAGCTGCCTATCACACTCAACAAATTTTT
CCAGCCCACAGAAATGGCTTCTCAGGATTTCTTTCAGCGTTGGAAGCAGCTGAGCAGTCCCCAA
CAGGAAGTGCAGAACATTTTCAAAGCAAAGCACCCGATGGACACAGAAATCACCAAAGCCAAGA
TCATTGGGTTTGGTTCTGCACTCCTTGAAGACGTAGATCCTAATCCTGCAAATTTCGTGGGGGC
TGGTATCATACACACCAAAACCACCCAAATTGGATGCTTACTGCGTTTGGAACCAAATCTGCAA
GCCCAGATGTACCGACTCACGCTGCGCACGAGTAAAGAGACCGTCTCTCAGAGGTTGTGTGAAT
TGCTGTCAGAACAGTTTTGATCCACGAGGATGGAGGATCAGGCTCCTGTGTCTTGCATTTTTCT
TCATCTGTGTCATTTGTCTTCATTGCTGTGCTGCAAATAAACAGCCCTGTGTACAGGCGTCTCT
CAGC

hide sequence

RefSeq Acc Id:

XM_038424605 ⟹ XP_038280533

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	18	45,927,073 - 46,023,324 (+)	NCBI

RefSeq Acc Id:

XM_038424606 ⟹ XP_038280534

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	18	45,927,073 - 46,023,324 (+)	NCBI

RefSeq Acc Id:

XM_038424607 ⟹ XP_038280535

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	18	45,927,072 - 46,023,324 (+)	NCBI

RefSeq Acc Id:

XM_038424608 ⟹ XP_038280536

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	18	45,969,068 - 46,023,324 (+)	NCBI

RefSeq Acc Id:

XM_038453888 ⟹ XP_038309816

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	18	43,928,815 - 44,025,349 (+)	NCBI

RefSeq Acc Id:

XM_038453889 ⟹ XP_038309817

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	18	43,928,815 - 44,025,349 (+)	NCBI

RefSeq Acc Id:

XM_038453890 ⟹ XP_038309818

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	18	43,928,814 - 44,025,349 (+)	NCBI

RefSeq Acc Id:

XM_038500870 ⟹ XP_038356798

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	18	45,391,390 - 45,487,393 (+)	NCBI

RefSeq Acc Id:

XM_038500871 ⟹ XP_038356799

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	18	45,391,390 - 45,487,393 (+)	NCBI

RefSeq Acc Id:

XM_038500872 ⟹ XP_038356800

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	18	45,391,389 - 45,487,393 (+)	NCBI

RefSeq Acc Id:

XM_038500873 ⟹ XP_038356801

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	18	45,433,144 - 45,487,393 (+)	NCBI

RefSeq Acc Id:

XM_038563533 ⟹ XP_038419461

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	18	45,695,000 - 45,791,022 (+)	NCBI

RefSeq Acc Id:

XM_038563534 ⟹ XP_038419462

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	18	45,695,000 - 45,791,022 (+)	NCBI

RefSeq Acc Id:

XM_038563535 ⟹ XP_038419463

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	18	45,694,999 - 45,791,022 (+)	NCBI

RefSeq Acc Id:

XM_038563536 ⟹ XP_038419464

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	18	45,736,790 - 45,791,022 (+)	NCBI

RefSeq Acc Id:

XM_038627655 ⟹ XP_038483583

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	18	44,956,104 - 45,052,452 (+)	NCBI

RefSeq Acc Id:

XM_038627656 ⟹ XP_038483584

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	18	44,956,104 - 45,052,452 (+)	NCBI

RefSeq Acc Id:

XM_038627657 ⟹ XP_038483585

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	18	44,956,103 - 45,052,452 (+)	NCBI

RefSeq Acc Id:

XM_038627658 ⟹ XP_038483586

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	18	44,998,231 - 45,052,452 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_022261218	(Get FASTA)	NCBI Sequence Viewer
	XP_038280533	(Get FASTA)	NCBI Sequence Viewer
	XP_038280534	(Get FASTA)	NCBI Sequence Viewer
	XP_038280535	(Get FASTA)	NCBI Sequence Viewer
	XP_038280536	(Get FASTA)	NCBI Sequence Viewer
	XP_038309816	(Get FASTA)	NCBI Sequence Viewer
	XP_038309817	(Get FASTA)	NCBI Sequence Viewer
	XP_038309818	(Get FASTA)	NCBI Sequence Viewer
	XP_038356798	(Get FASTA)	NCBI Sequence Viewer
	XP_038356799	(Get FASTA)	NCBI Sequence Viewer
	XP_038356800	(Get FASTA)	NCBI Sequence Viewer
	XP_038356801	(Get FASTA)	NCBI Sequence Viewer
	XP_038419461	(Get FASTA)	NCBI Sequence Viewer
	XP_038419462	(Get FASTA)	NCBI Sequence Viewer
	XP_038419463	(Get FASTA)	NCBI Sequence Viewer
	XP_038419464	(Get FASTA)	NCBI Sequence Viewer
	XP_038483583	(Get FASTA)	NCBI Sequence Viewer
	XP_038483584	(Get FASTA)	NCBI Sequence Viewer
	XP_038483585	(Get FASTA)	NCBI Sequence Viewer
	XP_038483586	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00845009963
	ENSCAFP00845009963.1
	ENSCAFP00845010004
	ENSCAFP00845010004.1
	ENSCAFP00845010060.1

RefSeq Acc Id:	XP_022261218 ⟸ XM_022405510
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I3RTT7 (UniProtKB/TrEMBL), A0A8I3MWF6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIANVGS REMAEAFAGEIPKILVAGDTMDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHLLNDQHLGVV TAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCY PPPEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACN QLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAM CDRSNAQQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIRIAGDYVSEE VWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFN LLHSKFHLCSVPTRALLLSTYIKFVNLFPEVKTTIQDVLRSDSQLKNADVELQQRAVEYLRLST VASTDILATVLEEMPPFPERESSILAKLKKKKGPNTVTDLEDAKRERSADVNGGPEPAPASAAS TPSPSADLLGLGAAPPAPVGPPPSSGGLLVDVFSDSPSAVAPLAPGSEDNFARFVCKNNGVLFE NQLLQIGLKSEFRQNLGRMFIFYGNKTSTQFLNFTPTLICSDDLQTNLSLQTKPVDPTVDGGAQ VQQVVNIECVSDFTEAPVLNIQFRYGGTFQNVSVKLPITLNKFFQPTEMASQDFFQRWKQLSSP QQEVQNIFKAKHPMDTEITKAKIIGFGSALLEDVDPNPANFVGAGIIHTKTTQIGCLLRLEPNL QAQMYRLTLRTSKETVSQRLCELLSEQF hide sequence

Ensembl Acc Id:

ENSCAFP00000014249 ⟸ ENSCAFT00000015398

Ensembl Acc Id:

ENSCAFP00000044197 ⟸ ENSCAFT00000083847

RefSeq Acc Id:	XP_038356800 ⟸ XM_038500872
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038356798 ⟸ XM_038500870
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038356799 ⟸ XM_038500871
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038356801 ⟸ XM_038500873
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038483585 ⟸ XM_038627657
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038483583 ⟸ XM_038627655
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038483584 ⟸ XM_038627656
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038483586 ⟸ XM_038627658
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038280535 ⟸ XM_038424607
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I3MWF6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038280533 ⟸ XM_038424605
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I3MWF6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038280534 ⟸ XM_038424606
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KYT5 (UniProtKB/TrEMBL), A0A8I3MWF6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038280536 ⟸ XM_038424608
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I3RTT7 (UniProtKB/TrEMBL), A0A8I3MWF6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038309818 ⟸ XM_038453890
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I3MWF6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038309816 ⟸ XM_038453888
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I3MWF6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038309817 ⟸ XM_038453889
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KYT5 (UniProtKB/TrEMBL), A0A8I3MWF6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038419463 ⟸ XM_038563535
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I3MWF6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038419461 ⟸ XM_038563533
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I3MWF6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038419462 ⟸ XM_038563534
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KYT5 (UniProtKB/TrEMBL), A0A8I3MWF6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038419464 ⟸ XM_038563536
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I3MWF6 (UniProtKB/TrEMBL), A0A8I3RTT7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845009963 ⟸ ENSCAFT00845012775

Ensembl Acc Id:

ENSCAFP00845010060 ⟸ ENSCAFT00845012908

Ensembl Acc Id:

ENSCAFP00845010004 ⟸ ENSCAFT00845012836

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000009691	Ensembl
	ENSCAFG00845007202	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00845012775	ENTREZGENE
	ENSCAFT00845012775.1	UniProtKB/TrEMBL
	ENSCAFT00845012836	ENTREZGENE
	ENSCAFT00845012836.1	UniProtKB/TrEMBL
	ENSCAFT00845012908.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.10.10	UniProtKB/TrEMBL
	2.60.40.1230	UniProtKB/TrEMBL
	3.30.310.10	UniProtKB/TrEMBL
InterPro	Adaptor_Complx_Large_Subunit	UniProtKB/TrEMBL
	AP2_complex_asu	UniProtKB/TrEMBL
	ARM-like	UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/TrEMBL
	Clathrin/coatomer_adapt-like_N	UniProtKB/TrEMBL
	Clathrin_a-adaptin_app_sub_C	UniProtKB/TrEMBL
	Clathrin_a/b/g-adaptin_app_Ig	UniProtKB/TrEMBL
	Clathrin_app_Ig-like_sf	UniProtKB/TrEMBL
	Coatomer/calthrin_app_sub_C	UniProtKB/TrEMBL
	TBP_dom_sf	UniProtKB/TrEMBL
KEGG Report	cfa:475994	UniProtKB/TrEMBL
NCBI Gene	AP2A2	ENTREZGENE
PANTHER	ADAPTIN, ALPHA/GAMMA/EPSILON	UniProtKB/TrEMBL
Pfam	Adaptin_N	UniProtKB/TrEMBL
	Alpha_adaptin_C	UniProtKB/TrEMBL
	Alpha_adaptinC2	UniProtKB/TrEMBL
PIRSF	AP2_complex_alpha	UniProtKB/TrEMBL
SMART	Alpha_adaptinC2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48371	UniProtKB/TrEMBL
	SSF49348	UniProtKB/TrEMBL
	SSF55711	UniProtKB/TrEMBL
UniProt	A0A8C0KYT5	ENTREZGENE
	A0A8I3MWF6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3N7P9_CANLF	UniProtKB/TrEMBL
	A0A8I3RTT7	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:37959	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-01	AP2A2	adaptor related protein complex 2 subunit alpha 2		adaptor related protein complex 2 alpha 2 subunit	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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