Ap2a2 (adaptor related protein complex 2 subunit alpha 2) - Rat Genome Database

Send us a Message



Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Grant Resources Citing RGD About Us Contact Us
Search by Genomic Position Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quantitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ap2a2 (adaptor related protein complex 2 subunit alpha 2) Heterocephalus glaber
Analyze
Symbol: Ap2a2
Name: adaptor related protein complex 2 subunit alpha 2
RGD ID: 18926770
Description: ENCODES a protein that exhibits clathrin-cargo adaptor activity (ortholog); disordered domain specific binding (ortholog); kinase binding (ortholog); INVOLVED IN synaptic vesicle endocytosis (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ASSOCIATED WITH Breast Cancer, Familial (ortholog); cholangiocarcinoma (ortholog); head and neck squamous cell carcinoma (ortholog); FOUND IN cytoplasmic vesicle (ortholog); plasma membrane (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adaptor related protein complex 2 alpha 2 subunit; AP-2 complex subunit alpha-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476621,568,217 - 21,616,389 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462476621,567,050 - 21,616,392 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ap2a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476621,568,217 - 21,616,389 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462476621,567,050 - 21,616,392 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
AP2A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811925,870 - 1,012,240 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11924,881 - 1,012,245 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh3711925,870 - 1,012,240 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611915,841 - 1,002,240 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411915,880 - 1,000,919NCBI
Celera11993,301 - 1,080,635 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11740,785 - 828,407 (+)NCBIHuRef
CHM1_111924,861 - 1,011,169 (+)NCBICHM1_1
T2T-CHM13v2.011977,298 - 1,071,157 (+)NCBIT2T-CHM13v2.0
Ap2a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,142,093 - 141,212,924 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,142,031 - 141,249,132 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387141,562,180 - 141,633,011 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,562,173 - 141,633,011 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv377148,748,079 - 148,818,910 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367141,413,558 - 141,484,331 (+)NCBIMGSCv36mm8
Celera7141,382,192 - 141,426,917 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.94NCBI
Ap2a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,081,856 - 206,155,146 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1206,081,878 - 206,155,150 (+)EnsemblGRCr8
mRatBN7.21196,652,315 - 196,725,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,652,337 - 196,725,603 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1204,997,575 - 205,069,879 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,126,225 - 212,198,337 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,800,374 - 204,872,485 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1205,450,923 - 205,523,224 (+)NCBI
Lyon_Normotensive1210,397,252 - 210,469,404 (+)NCBI
Lyon_Hypertensive1207,096,069 - 207,168,371 (+)NCBI
F344_StmMcwi1205,350,488 - 205,422,789 (+)NCBI
Rnor_6.01214,534,217 - 214,607,497 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,534,284 - 214,606,169 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01221,451,352 - 221,524,612 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41201,741,585 - 201,813,472 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1194,285,764 - 194,357,691 (+)NCBICelera
RGSC_v3.11201,894,982 - 201,967,871 (+)NCBI
Cytogenetic Map1q41NCBI
Ap2a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,185,223 - 11,229,409 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495547611,184,944 - 11,229,385 (-)NCBIChiLan1.0ChiLan1.0
AP2A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,325,303 - 3,415,227 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,535,446 - 2,626,050 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011945,170 - 1,034,860 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,005,473 - 1,076,652 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,005,473 - 1,076,652 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
AP2A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,269,962 - 45,358,020 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1845,253,772 - 45,358,018 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1843,928,814 - 44,025,349 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01845,927,072 - 46,023,324 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1845,927,078 - 46,023,539 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11845,391,389 - 45,487,393 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01844,956,103 - 45,052,452 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,694,999 - 45,791,022 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ap2a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap14749,026 - 814,040 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_024404947671,479 - 735,119 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936888689,727 - 733,541 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936888689,673 - 735,119 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AP2A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2580,182 - 628,087 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.12580,169 - 628,098 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2249,080 - 94,085 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AP2A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap11753,974 - 845,195 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366603897,821,900 - 97,912,108 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.11731,616 - 820,191 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1731,645 - 818,642 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Ap2a2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v127,860,612 - 7,933,551 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000006089   ⟹   ENSHGLP00000006015
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476621,567,050 - 21,616,392 (-)Ensembl
RefSeq Acc Id: XM_004851628   ⟹   XP_004851685
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476621,568,291 - 21,616,388 (-)NCBI
RefSeq Acc Id: XM_004851629   ⟹   XP_004851686
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476621,568,291 - 21,616,388 (-)NCBI
RefSeq Acc Id: XM_021264020   ⟹   XP_021119679
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476621,568,217 - 21,616,389 (-)NCBI
RefSeq Acc Id: XM_021264022   ⟹   XP_021119681
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476621,568,217 - 21,616,389 (-)NCBI
RefSeq Acc Id: XM_021264023   ⟹   XP_021119682
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476621,568,217 - 21,601,209 (-)NCBI
RefSeq Acc Id: XM_021264024   ⟹   XP_021119683
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476621,568,217 - 21,606,018 (-)NCBI
RefSeq Acc Id: XP_021119681   ⟸   XM_021264022
- Peptide Label: isoform X2
- UniProtKB: A0AAX6TEU9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021119679   ⟸   XM_021264020
- Peptide Label: isoform X1
- UniProtKB: A0AAX6TDR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021119683   ⟸   XM_021264024
- Peptide Label: isoform X4
- UniProtKB: A0AAX6THV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021119682   ⟸   XM_021264023
- Peptide Label: isoform X3
- UniProtKB: A0AAX6TBE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004851686   ⟸   XM_004851629
- Peptide Label: isoform X6
- UniProtKB: A0A0P6J6M9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004851685   ⟸   XM_004851628
- Peptide Label: isoform X5
- UniProtKB: A0AAX6PGK1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000006015   ⟸   ENSHGLT00000006089


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000004399 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000006089 ENTREZGENE
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
  2.60.40.1230 UniProtKB/TrEMBL
  3.30.310.10 UniProtKB/TrEMBL
InterPro Adaptor_Complx_Large_Subunit UniProtKB/TrEMBL
  AP2_complex_asu UniProtKB/TrEMBL
  ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Clathrin/coatomer_adapt-like_N UniProtKB/TrEMBL
  Clathrin_a-adaptin_app_sub_C UniProtKB/TrEMBL
  Clathrin_a/b/g-adaptin_app_Ig UniProtKB/TrEMBL
  Clathrin_app_Ig-like_sf UniProtKB/TrEMBL
  Coatomer/calthrin_app_sub_C UniProtKB/TrEMBL
  TBP_dom_sf UniProtKB/TrEMBL
KEGG Report hgl:101719967 UniProtKB/TrEMBL
NCBI Gene Ap2a2 ENTREZGENE
PANTHER ADAPTIN, ALPHA/GAMMA/EPSILON UniProtKB/TrEMBL
Pfam Adaptin_N UniProtKB/TrEMBL
  Alpha_adaptin_C UniProtKB/TrEMBL
  Alpha_adaptinC2 UniProtKB/TrEMBL
PIRSF AP2_complex_alpha UniProtKB/TrEMBL
SMART Alpha_adaptinC2 UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF49348 UniProtKB/TrEMBL
  SSF55711 UniProtKB/TrEMBL
UniProt A0A0P6J6M9 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6PGK1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6TBE6 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6TDR5 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6TEU9 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6THV7 ENTREZGENE, UniProtKB/TrEMBL