Polr3g (RNA polymerase III subunit G) - Rat Genome Database

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Gene: Polr3g (RNA polymerase III subunit G) Rattus norvegicus
Analyze
Symbol: Polr3g
Name: RNA polymerase III subunit G
RGD ID: 1593792
Description: Predicted to enable chromatin binding activity. Predicted to be involved in several processes, including positive regulation of innate immune response; positive regulation of interferon-beta production; and transcription by RNA polymerase III. Predicted to act upstream of or within epithelial cell proliferation. Predicted to be located in cytosol and nuclear body. Predicted to be part of RNA polymerase III complex. Predicted to be active in nucleus. Orthologous to human POLR3G (RNA polymerase III subunit G); PARTICIPATES IN RNA polymerase III transcription pathway; purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH 3-chloropropane-1,2-diol; 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA-directed RNA polymerase III subunit RPC7; DNA-directed RNA polymerase III subunit RPC7-like; LOC103691413; LOC685465; polymerase (RNA) III (DNA directed) polypeptide G; polymerase (RNA) III (DNA directed) polypeptide G (32kD); polymerase (RNA) III subunit G; similar to DNA-directed RNA polymerase III 32 kDa polypeptide (RNA polymerase III C32 subunit)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2211,945,215 - 11,986,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl211,945,217 - 11,986,125 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx219,058,971 - 19,099,261 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0217,158,491 - 17,198,782 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0211,813,031 - 11,853,624 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.029,537,642 - 9,578,551 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl29,537,642 - 9,578,310 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.029,417,663 - 9,458,293 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.429,763,378 - 9,804,285 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera28,304,852 - 8,345,111 (-)NCBICelera
Cytogenetic Map2q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diclofenac  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
irinotecan  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
panobinostat  (ISO)
paraquat  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
trichostatin A  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Dumay-Odelot H, etal., Cell Cycle. 2010 Sep 15;9(18):3687-99. Epub 2010 Sep 1.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. Hu P, etal., Mol Cell Biol. 2002 Nov;22(22):8044-55.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:19609254   PMID:19631370   PMID:20154270   PMID:24107381  


Genomics

Comparative Map Data
Polr3g
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2211,945,215 - 11,986,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl211,945,217 - 11,986,125 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx219,058,971 - 19,099,261 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0217,158,491 - 17,198,782 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0211,813,031 - 11,853,624 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.029,537,642 - 9,578,551 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl29,537,642 - 9,578,310 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.029,417,663 - 9,458,293 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.429,763,378 - 9,804,285 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera28,304,852 - 8,345,111 (-)NCBICelera
Cytogenetic Map2q11NCBI
POLR3G
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38590,473,929 - 90,514,557 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl590,471,748 - 90,514,557 (+)EnsemblGRCh38hg38GRCh38
GRCh37589,769,746 - 89,810,374 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36589,806,437 - 89,846,125 (+)NCBINCBI36Build 36hg18NCBI36
Build 34589,806,481 - 89,843,881NCBI
Celera585,672,528 - 85,712,495 (+)NCBICelera
Cytogenetic Map5q14.3NCBI
HuRef584,981,329 - 85,021,025 (+)NCBIHuRef
CHM1_1589,203,359 - 89,243,046 (+)NCBICHM1_1
T2T-CHM13v2.0590,960,487 - 91,001,143 (+)NCBIT2T-CHM13v2.0
Polr3g
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391381,821,956 - 81,859,132 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1381,821,962 - 81,859,132 (-)EnsemblGRCm39 Ensembl
GRCm381381,673,837 - 81,711,013 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1381,673,843 - 81,711,013 (-)EnsemblGRCm38mm10GRCm38
MGSCv371381,812,836 - 81,850,012 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361382,151,174 - 82,188,912 (-)NCBIMGSCv36mm8
Celera1383,934,554 - 83,971,713 (-)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1343.68NCBI
Polr3g
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541821,116,812 - 21,149,818 (-)NCBIChiLan1.0ChiLan1.0
POLR3G
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1523,033,851 - 23,073,989 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0524,855,517 - 24,896,051 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1524,989,905 - 25,030,180 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl524,992,158 - 25,019,272 (-)Ensemblpanpan1.1panPan2
POLR3G
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1318,426,169 - 18,529,304 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl318,427,985 - 18,467,801 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha319,793,797 - 19,896,582 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0318,332,611 - 18,433,936 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl318,332,616 - 18,374,264 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1318,306,259 - 18,409,054 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0318,271,553 - 18,374,844 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0318,560,360 - 18,663,292 (-)NCBIUU_Cfam_GSD_1.0
Polr3g
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213174,015,683 - 174,051,672 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364698,574,120 - 8,611,643 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLR3G
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1297,646,112 - 97,688,255 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22100,726,267 - 100,766,345 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POLR3G
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1484,418,692 - 84,459,920 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604933,477,530 - 33,519,561 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Polr3g
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247439,733,372 - 9,765,967 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Polr3g
312 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:309
Count of miRNA genes:183
Interacting mature miRNAs:229
Transcripts:ENSRNOT00000021804
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777212654247Rat
61368Mcs1Mammary carcinoma susceptibility QTL 14.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777223319447Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 14 12 4 12 10 13 19
Low 3 41 43 29 15 29 8 9 64 22 21 11 8
Below cutoff 2 1

Sequence


RefSeq Acc Id: ENSRNOT00000021804   ⟹   ENSRNOP00000021804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl211,945,217 - 11,986,125 (-)Ensembl
Rnor_6.0 Ensembl29,537,642 - 9,578,310 (-)Ensembl
RefSeq Acc Id: NM_001109468   ⟹   NP_001102938
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2211,945,217 - 11,986,125 (-)NCBI
Rnor_6.029,537,644 - 9,578,551 (-)NCBI
Rnor_5.029,417,663 - 9,458,293 (-)NCBI
RGSC_v3.429,763,378 - 9,804,285 (-)RGD
Celera28,304,852 - 8,345,111 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231729   ⟹   XP_006231791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2211,945,215 - 11,985,652 (-)NCBI
Rnor_6.029,537,642 - 9,577,983 (-)NCBI
Rnor_5.029,417,663 - 9,458,293 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039103140   ⟹   XP_038959068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2211,945,215 - 11,985,652 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102938 (Get FASTA)   NCBI Sequence Viewer  
  XP_006231791 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959068 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09948 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021804
  ENSRNOP00000021804.5
RefSeq Acc Id: NP_001102938   ⟸   NM_001109468
- UniProtKB: D4A1K1 (UniProtKB/TrEMBL),   A6I4J0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231791   ⟸   XM_006231729
- Peptide Label: isoform X1
- UniProtKB: D4A1K1 (UniProtKB/TrEMBL),   A6I4J0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021804   ⟸   ENSRNOT00000021804
RefSeq Acc Id: XP_038959068   ⟸   XM_039103140
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A1K1-F1-model_v2 AlphaFold D4A1K1 1-223 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691045
Promoter ID:EPDNEW_R1570
Type:single initiation site
Name:Polr3g_1
Description:RNA polymerase III subunit G
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.029,578,335 - 9,578,395EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593792 AgrOrtholog
BioCyc Gene G2FUF-55014 BioCyc
Ensembl Genes ENSRNOG00000016260 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021804 ENTREZGENE
  ENSRNOT00000021804.7 UniProtKB/TrEMBL
InterPro RNA_pol_III_Rpc31 UniProtKB/TrEMBL
KEGG Report rno:685465 UniProtKB/TrEMBL
NCBI Gene 685465 ENTREZGENE
PANTHER DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 UniProtKB/TrEMBL
  PTHR15367 UniProtKB/TrEMBL
Pfam RNA_pol_3_Rpc31 UniProtKB/TrEMBL
PhenoGen Polr3g PhenoGen
RatGTEx ENSRNOG00000016260 RatGTEx
UniProt A6I4J0 ENTREZGENE, UniProtKB/TrEMBL
  D4A1K1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Polr3g  RNA polymerase III subunit G  LOC103691413  DNA-directed RNA polymerase III subunit RPC7-like  Data merged from RGD:9124045 737654 PROVISIONAL
2016-07-21 Polr3g  RNA polymerase III subunit G  Polr3g  polymerase (RNA) III subunit G  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-11 Polr3g  polymerase (RNA) III subunit G  Polr3g  polymerase (RNA) III (DNA directed) polypeptide G  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103691413  DNA-directed RNA polymerase III subunit RPC7-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-10-22 Polr3g  polymerase (RNA) III (DNA directed) polypeptide G  Polr3g  polymerase (RNA) III (DNA directed) polypeptide G (32kD)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Polr3g  polymerase (RNA) III (DNA directed) polypeptide G (32kD)  Polr3g  polymerase (RNA) III (DNA directed) polypeptide G  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Polr3g  polymerase (RNA) III (DNA directed) polypeptide G  LOC685465  similar to DNA-directed RNA polymerase III 32 kDa polypeptide (RNA polymerase III C32 subunit)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC685465  similar to DNA-directed RNA polymerase III 32 kDa polypeptide (RNA polymerase III C32 subunit)  LOC682370  similar to DNA-directed RNA polymerase III 32 kDa polypeptide (RNA polymerase III C32 subunit)  Data merged from RGD:1584579 1643240 APPROVED
2006-11-20 LOC685465  similar to DNA-directed RNA polymerase III 32 kDa polypeptide (RNA polymerase III C32 subunit)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC682370  similar to DNA-directed RNA polymerase III 32 kDa polypeptide (RNA polymerase III C32 subunit)      Symbol and Name status set to provisional 70820 PROVISIONAL