Ugt3a1 (UDP glycosyltransferase family 3 member A1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ugt3a1 (UDP glycosyltransferase family 3 member A1) Rattus norvegicus
Analyze
Symbol: Ugt3a1
Name: UDP glycosyltransferase family 3 member A1
RGD ID: 1564365
Description: Predicted to enable glucuronosyltransferase activity. Predicted to be involved in cellular response to genistein. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Orthologous to human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2); INTERACTS WITH bisphenol A; (1->4)-beta-D-glucan (ortholog); 17beta-estradiol (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC294793; RGD1564365; similar to Hypothetical protein MGC37820; UDP glycosyltransferase 3 family, polypeptide A2; UDP glycosyltransferases 3 family, polypeptide A2; UDP-glucuronosyltransferase 3A1; UDP-glucuronosyltransferase 3A2; Ugt3a2
RGD Orthologs
Human
Mouse
Bonobo
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8260,062,257 - 60,077,354 (+)NCBIGRCr8
mRatBN7.2258,327,058 - 58,350,186 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl258,334,603 - 58,350,186 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0258,666,337 - 58,682,212 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl258,668,157 - 58,681,747 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0277,756,134 - 77,775,205 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4258,955,159 - 58,997,290 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera253,936,376 - 53,959,955 (+)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ugt3a1RatNeurodevelopmental Disorders  ISORGD:16019338554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868

1 to 20 of 51 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ugt3a1Rat(1->4)-beta-D-glucan multiple interactionsISORGD:16157016480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of UGT3A1 mRNACTDPMID:36331819
Ugt3a1Rat17beta-estradiol decreases expressionISORGD:16019336480464Estradiol results in decreased expression of UGT3A1 mRNACTDPMID:20106945
Ugt3a1Rat17beta-estradiol decreases expressionISORGD:16157016480464Estradiol results in decreased expression of UGT3A1 mRNACTDPMID:39298647
Ugt3a1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:16157016480464Tetrachlorodibenzodioxin affects the expression of UGT3A1 mRNACTDPMID:24680724
Ugt3a1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISORGD:161570164804642,2',4,4',5-brominated diphenyl ether affects the expression of UGT3A1 mRNACTDPMID:38648751
Ugt3a1Rat3,3',4,4'-tetrachlorobiphenyl multiple interactionsISORGD:161570164804643,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of UGT3A1 mRNA]CTDPMID:19467301
Ugt3a1Rat4,4'-sulfonyldiphenol decreases expressionISORGD:16157016480464bisphenol S results in decreased expression of UGT3A1 mRNACTDPMID:39298647
Ugt3a1Rataflatoxin B1 decreases expressionISORGD:16019336480464Aflatoxin B1 results in decreased expression of UGT3A1 mRNACTDPMID:27153756
Ugt3a1Ratall-trans-retinoic acid increases expressionISORGD:16019336480464Tretinoin results in increased expression of UGT3A1 mRNACTDPMID:21934132
Ugt3a1Ratbelinostat increases expressionISORGD:16019336480464belinostat results in increased expression of UGT3A1 mRNACTDPMID:26272509
Ugt3a1Ratbelinostat multiple interactionsISORGD:16019336480464[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ...CTDPMID:27188386
Ugt3a1Ratbenzo[a]pyrene increases methylationISORGD:16019336480464Benzo(a)pyrene results in increased methylation of UGT3A1 promoterCTDPMID:27901495
Ugt3a1Ratbenzo[a]pyrene decreases expressionISORGD:16019336480464Benzo(a)pyrene results in decreased expression of UGT3A1 mRNACTDPMID:32234424
Ugt3a1Ratbis(2-ethylhexyl) phthalate increases expressionISORGD:16157016480464Diethylhexyl Phthalate results in increased expression of UGT3A1 mRNACTDPMID:19850644
Ugt3a1Ratbis(2-ethylhexyl) phthalate decreases expressionISORGD:16019336480464Diethylhexyl Phthalate results in decreased expression of UGT3A1 mRNACTDPMID:31163220
Ugt3a1Ratbis(2-ethylhexyl) phthalate multiple interactionsISORGD:16157016480464PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of UGT3A1 mRNA]CTDPMID:19850644
Ugt3a1Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of UGT3A2 mRNACTDPMID:25181051
Ugt3a1Ratbisphenol F increases expressionISORGD:16157016480464bisphenol F results in increased expression of UGT3A1 mRNACTDPMID:38685157
Ugt3a1RatCGP 52608 multiple interactionsISORGD:16019336480464CGP 52608 promotes the reaction [RORA protein binds to UGT3A1 gene]CTDPMID:28238834
Ugt3a1Ratchlorpyrifos increases expressionISORGD:16157016480464Chlorpyrifos results in increased expression of UGT3A1 mRNACTDPMID:32715474

1 to 20 of 51 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ugt3a1Ratcellular response to genistein acts_upstream_of_or_withinIEAUniProtKB:Q3SY77|ensembl:ENSP000002825071600115GO_REF:0000107EnsemblGO_REF:0000107

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ugt3a1Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Ugt3a1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Ugt3a1RatUDP-N-acetylglucosamine transferase complex part_ofISORGD:16019331624291 PMID:22621930RGDPMID:22621930
Ugt3a1RatUDP-N-acetylglucosamine transferase complex part_ofIBAPANTHER:PTN005360461|UniProtKB:Q6NUS81600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ugt3a1Ratglucuronosyltransferase activity enablesISORGD:16019331624291 PMID:22621930RGDPMID:22621930
Ugt3a1Ratglucuronosyltransferase activity enablesIBAPANTHER:PTN005360461|UniProtKB:Q6NUS81600115GO_REF:0000033GO_CentralGO_REF:0000033
Ugt3a1Ratglycosyltransferase activity enablesIEAUniProtKB-KW:KW-03281600115GO_REF:0000043UniProtGO_REF:0000043
Ugt3a1Rattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043
Ugt3a1RatUDP-glycosyltransferase activity enablesISORGD:16019331624291 PMID:22621930RGDPMID:22621930
Ugt3a1RatUDP-glycosyltransferase activity enablesIEAInterPro:IPR0022131600115GO_REF:0000002InterProGO_REF:0000002
Ugt3a1RatUDP-glycosyltransferase activity enablesIEAUniProtKB:Q3SY77|ensembl:ENSP000002825071600115GO_REF:0000107EnsemblGO_REF:0000107
Ugt3a1RatUDP-glycosyltransferase activity enablesISORGD:16157011624291 PMID:22621930RGDPMID:22621930


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:22621930  



Ugt3a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8260,062,257 - 60,077,354 (+)NCBIGRCr8
mRatBN7.2258,327,058 - 58,350,186 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl258,334,603 - 58,350,186 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0258,666,337 - 58,682,212 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl258,668,157 - 58,681,747 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0277,756,134 - 77,775,205 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4258,955,159 - 58,997,290 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera253,936,376 - 53,959,955 (+)NCBICelera
Cytogenetic Map2q16NCBI
UGT3A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38535,951,006 - 36,001,022 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl535,951,006 - 36,001,028 (-)EnsemblGRCh38hg38GRCh38
GRCh37535,951,108 - 36,001,124 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36535,988,967 - 36,027,256 (-)NCBINCBI36Build 36hg18NCBI36
Celera535,838,879 - 35,886,819 (-)NCBICelera
Cytogenetic Map5p13.2NCBI
HuRef535,903,464 - 35,951,406 (-)NCBIHuRef
CHM1_1535,955,886 - 36,003,836 (-)NCBICHM1_1
T2T-CHM13v2.0536,199,267 - 36,249,286 (-)NCBIT2T-CHM13v2.0
Ugt3a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39159,335,670 - 9,370,960 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl159,335,636 - 9,371,041 (+)EnsemblGRCm39 Ensembl
GRCm38159,335,551 - 9,370,955 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl159,335,550 - 9,370,955 (+)EnsemblGRCm38mm10GRCm38
MGSCv37159,265,353 - 9,300,625 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36159,267,771 - 9,315,584 (+)NCBIMGSCv36mm8
Celera159,136,088 - 9,171,085 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map154.01NCBI
UGT3A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2474,338,368 - 74,383,960 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1572,485,235 - 72,537,592 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0574,372,175 - 74,415,724 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1579,653,148 - 79,696,582 (+)NCBIpanpan1.1PanPan1.1panPan2
LOC103215128
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1434,799,857 - 34,841,195 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl434,795,751 - 34,839,803 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607125,120,691 - 25,161,211 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ugt3a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475918,972,089 - 18,991,063 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Ugt3a1
132 total Variants

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:140
Interacting mature miRNAs:149
Transcripts:ENSRNOT00000033513, ENSRNOT00000074076
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 47 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25666087974786777Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat

1 to 10 of 47 rows



alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 12 6 23 23 21 21 40 13 5 5 8 2



Ensembl Acc Id: ENSRNOT00000081192   ⟹   ENSRNOP00000073140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl258,334,603 - 58,350,186 (+)Ensembl
Rnor_6.0 Ensembl258,668,157 - 58,681,747 (+)Ensembl
RefSeq Acc Id: XM_039103898   ⟹   XP_038959826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,062,257 - 60,077,354 (+)NCBI
mRatBN7.2258,327,058 - 58,350,186 (+)NCBI
Protein RefSeqs XP_038959826 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073140
  ENSRNOP00000073140.2
Ensembl Acc Id: ENSRNOP00000073140   ⟸   ENSRNOT00000081192
RefSeq Acc Id: XP_038959826   ⟸   XM_039103898
- UniProtKB: A0A0G2K4R2 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K4R2-F1-model_v2 AlphaFold A0A0G2K4R2 1-424 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 15 of 15 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-54100 BioCyc
Ensembl Genes ENSRNOG00000059568 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081192 ENTREZGENE
  ENSRNOT00000081192.2 UniProtKB/TrEMBL
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/TrEMBL
InterPro UDP-glycosyltransferase UniProtKB/TrEMBL
  UDP_glucos_trans UniProtKB/TrEMBL
NCBI Gene 294793 ENTREZGENE
PANTHER EG:EG0003.4 PROTEIN-RELATED UniProtKB/TrEMBL
  UDP-GLUCURONOSYLTRANSFERASE 3A2 UniProtKB/TrEMBL
Pfam UDPGT UniProtKB/TrEMBL
PhenoGen Ugt3a1 PhenoGen
RatGTEx ENSRNOG00000059568 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/TrEMBL
UniProt A0A0G2K4R2 ENTREZGENE, UniProtKB/TrEMBL
1 to 15 of 15 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-10-12 Ugt3a1  UDP glycosyltransferase family 3 member A1  Ugt3a2  UDP glycosyltransferase 3 family, polypeptide A2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-07 Ugt3a2  UDP glycosyltransferase 3 family, polypeptide A2  Ugt3a2  UDP glycosyltransferases 3 family, polypeptide A2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Ugt3a2  UDP glycosyltransferases 3 family, polypeptide A2  RGD1564365_predicted  similar to Hypothetical protein MGC37820 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564365_predicted  similar to Hypothetical protein MGC37820 (predicted)  LOC294793  similar to Hypothetical protein MGC37820  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC294793  similar to Hypothetical protein MGC37820      Symbol and Name status set to provisional 70820 PROVISIONAL