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Gene: Sufu (SUFU negative regulator of hedgehog signaling) Mus musculus
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Symbol: Sufu
Name: SUFU negative regulator of hedgehog signaling
Description: Exhibits beta-catenin binding activity. Involved in several processes, including animal organ development; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; and regulation of transcription, DNA-templated. Localizes to the cilium; cytoplasm; and nucleus. Used to study nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and testis. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling); PARTICIPATES IN Hedgehog signaling pathway; basal cell carcinoma pathway; INTERACTS WITH 4-hydroxyphenyl retinamide; acrylamide; ethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2810026F04Rik; b2b273Clo; Su(fu); suppressor of fused homolog; suppressor of fused homolog (Drosophila)
Orthologs:
Homo sapiens (human) : SUFU (SUFU negative regulator of hedgehog signaling)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sufu (SUFU negative regulator of hedgehog signaling)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sufu (SUFU negative regulator of hedgehog signaling)
Pan paniscus (bonobo/pygmy chimpanzee) : SUFU (SUFU negative regulator of hedgehog signaling)
Canis lupus familiaris (dog) : SUFU (SUFU negative regulator of hedgehog signaling)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sufu (SUFU negative regulator of hedgehog signaling)
Sus scrofa (pig) : SUFU (SUFU negative regulator of hedgehog signaling)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1946,396,896 - 46,488,804 (+)Ensembl
GRCm381946,396,896 - 46,488,804 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371946,471,408 - 46,561,150 (+)NCBIGRCm37mm9NCBIm37
MGSCv361946,450,229 - 46,539,971 (+)NCBImm8
Celera1947,160,466 - 47,252,586 (+)NCBICelera
Cytogenetic Map19 C3NCBI
cM Map1938.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Sufu
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1556878
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.