Sufu (SUFU negative regulator of hedgehog signaling) - Rat Genome Database

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Gene: Sufu (SUFU negative regulator of hedgehog signaling) Mus musculus
Analyze
Symbol: Sufu
Name: SUFU negative regulator of hedgehog signaling
RGD ID: 1556878
MGI Page MGI
Description: Enables beta-catenin binding activity. Involved in negative regulation of smoothened signaling pathway. Acts upstream of with a negative effect on smoothened signaling pathway. Acts upstream of or within several processes, including circulatory system development; regulation of DNA-templated transcription; and smoothened signaling pathway involved in ventral spinal cord patterning. Located in cilium; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; sensory organ; and testis. Used to study nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome 2. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2810026F04Rik; b2b273C; b2b273Clo; Su(Fu; Su(fu); suppressor of fused homolog; suppressor of fused homolog (Drosophila)
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,385,335 - 46,477,243 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,385,335 - 46,477,243 (+)EnsemblGRCm39 Ensembl
GRCm381946,396,896 - 46,488,804 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,396,896 - 46,488,804 (+)EnsemblGRCm38mm10GRCm38
MGSCv371946,471,408 - 46,561,150 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361946,450,229 - 46,539,971 (+)NCBIMGSCv36mm8
Celera1947,160,488 - 47,250,442 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cilium  (IDA)
cytoplasm  (IBA,IDA,ISO)
cytosol  (TAS)
GLI-SUFU complex  (ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal coat/hair pigmentation  (IAGP)
abnormal coronary artery morphology  (IEA)
abnormal craniofacial morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal direction of heart looping  (IAGP)
abnormal dorsal-ventral axis patterning  (IAGP)
abnormal embryo size  (IEA)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal eye morphology  (IEA)
abnormal floor plate morphology  (IAGP)
abnormal forebrain development  (IAGP)
abnormal head shape  (IEA)
abnormal heart morphology  (IAGP)
abnormal hindbrain development  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal limb bud morphology  (IEA)
abnormal limb morphology  (IAGP)
abnormal liver size  (IEA)
abnormal midbrain development  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal neural tube closure  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal placenta size  (IEA)
abnormal primitive node morphology  (IAGP)
abnormal skin appearance  (IAGP)
abnormal somite development  (IAGP)
abnormal stomach morphology  (IEA)
abnormal white adipose tissue morphology  (IAGP)
abnormal white adipose tissue physiology  (IAGP)
abnormal white fat cell morphology  (IAGP)
alopecia  (IAGP)
brain aneurysm  (IAGP)
cardiovascular system phenotype  (IEA)
cleft palate  (IEA)
coronary fistula  (IEA)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased total body fat amount  (IEA)
decreased white adipose tissue amount  (IAGP)
decreased white fat cell number  (IAGP)
decreased white fat cell size  (IAGP)
descending aorta dilation  (IAGP)
double outlet right ventricle  (IEA)
edema  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality prior to tooth bud stage  (IEA)
enlarged lymph nodes  (IEA)
exencephaly  (IAGP)
failure of initiation of embryo turning  (IAGP)
hemorrhage  (IAGP)
incomplete embryo turning  (IAGP)
increased lymphoma incidence  (IAGP)
increased medulloblastoma incidence  (IAGP)
increased rhabdomyosarcoma incidence  (IAGP)
increased startle reflex  (IEA)
intracranial hemorrhage  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
microcephaly  (IEA)
micrognathia  (IEA)
muscular ventricular septal defect  (IEA)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
overriding aortic valve  (IEA)
pale liver  (IEA)
pale yolk sac  (IEA)
pallor  (IEA)
perimembraneous ventricular septal defect  (IEA)
polydactyly  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
small lung  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Dynamic changes of Sonic Hedgehog signaling pathway in gastric mucosa of rats with MNNG-induced gastric precancerous lesions. Cai D, etal., J Cell Physiol. 2019 Jul;234(7):10827-10834. doi: 10.1002/jcp.27908. Epub 2018 Dec 7.
2. SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation. Ding X, etal., J Exp Clin Cancer Res. 2019 Sep 13;38(1):404. doi: 10.1186/s13046-019-1411-9.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Impact of surgeon laparoscopic training and case volume of laparoscopic surgery on conversion during elective laparoscopic colorectal surgery. Massarotti H, etal., Colorectal Dis. 2017 Jan;19(1):76-85. doi: 10.1111/codi.13402.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies. Mimeault M and Batra SK, Pharmacol Rev. 2010 Sep;62(3):497-524.
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Oroxylin A increases the sensitivity of temozolomide on glioma cells by hypoxia-inducible factor 1α/hedgehog pathway under hypoxia. Wei M, etal., J Cell Physiol. 2019 Aug;234(10):17392-17404. doi: 10.1002/jcp.28361. Epub 2019 Feb 20.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10433824   PMID:10531011   PMID:10564661   PMID:10920228   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11252182   PMID:11477086   PMID:11557033  
PMID:11960000   PMID:12477932   PMID:12520002   PMID:14610273   PMID:14611647   PMID:14681479   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16155214   PMID:16254602  
PMID:16316410   PMID:16459297   PMID:16459298   PMID:16602821   PMID:16958114   PMID:17182001   PMID:17452975   PMID:17967808   PMID:18488998   PMID:18590716   PMID:18781608   PMID:18799693  
PMID:18827223   PMID:18997815   PMID:19076778   PMID:19223390   PMID:19286674   PMID:19371734   PMID:19592253   PMID:19622347   PMID:19666565   PMID:19684109   PMID:19684112   PMID:20074523  
PMID:20360384   PMID:20463034   PMID:20956384   PMID:21076395   PMID:21098272   PMID:21209331   PMID:21209912   PMID:21289193   PMID:21317289   PMID:21451052   PMID:21543335   PMID:21677750  
PMID:21795282   PMID:21816948   PMID:21873635   PMID:22051878   PMID:22182519   PMID:22275805   PMID:22666390   PMID:22930757   PMID:22958902   PMID:23026747   PMID:23034632   PMID:23166838  
PMID:23686138   PMID:24194600   PMID:24726283   PMID:24854174   PMID:24886827   PMID:25403183   PMID:25531316   PMID:25581370   PMID:25760946   PMID:25807483   PMID:25834022   PMID:26001200  
PMID:26120032   PMID:26261006   PMID:26387942   PMID:27046536   PMID:27234298   PMID:27340223   PMID:27626380   PMID:27802276   PMID:27849569   PMID:28412462   PMID:28560839   PMID:28688895  
PMID:28781964   PMID:28794157   PMID:28945232   PMID:29487109   PMID:29515120   PMID:29739868   PMID:29923621   PMID:30206138   PMID:30554998   PMID:30791390   PMID:30973324   PMID:31000813  
PMID:31142467   PMID:31167144   PMID:31604927   PMID:31932349   PMID:32155439   PMID:32226648   PMID:32325033   PMID:32350360   PMID:32737167   PMID:34260378   PMID:34321999   PMID:36103394  
PMID:36252002   PMID:36598878   PMID:37441604   PMID:37577930   PMID:38355793   PMID:38358805   PMID:38602877   PMID:39217245  


Genomics

Comparative Map Data
Sufu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,385,335 - 46,477,243 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,385,335 - 46,477,243 (+)EnsemblGRCm39 Ensembl
GRCm381946,396,896 - 46,488,804 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,396,896 - 46,488,804 (+)EnsemblGRCm38mm10GRCm38
MGSCv371946,471,408 - 46,561,150 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361946,450,229 - 46,539,971 (+)NCBIMGSCv36mm8
Celera1947,160,488 - 47,250,442 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.85NCBI
SUFU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810102,502,819 - 102,633,535 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10102,503,972 - 102,633,535 (+)EnsemblGRCh38hg38GRCh38
GRCh3710104,263,729 - 104,393,292 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,253,754 - 104,383,199 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410104,253,753 - 104,383,199NCBI
Celera1098,004,628 - 98,134,149 (+)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1097,897,496 - 98,026,978 (+)NCBIHuRef
CHM1_110104,547,179 - 104,677,032 (+)NCBICHM1_1
T2T-CHM13v2.010103,387,806 - 103,518,575 (+)NCBIT2T-CHM13v2.0
Sufu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81255,199,108 - 255,296,983 (+)NCBIGRCr8
mRatBN7.21245,257,725 - 245,355,576 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,257,768 - 245,355,577 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1253,379,193 - 253,479,376 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01260,073,830 - 260,172,100 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,725,633 - 252,823,412 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01266,143,766 - 266,241,742 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,143,818 - 266,239,016 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01273,574,697 - 273,672,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41251,612,377 - 251,708,109 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1241,040,495 - 241,135,358 (+)NCBICelera
Cytogenetic Map1q54NCBI
Sufu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554857,808,131 - 7,925,677 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554857,805,244 - 7,925,414 (-)NCBIChiLan1.0ChiLan1.0
SUFU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28114,389,841 - 114,515,759 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110114,395,163 - 114,521,085 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01099,107,516 - 99,231,761 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110102,571,886 - 102,696,472 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10102,571,886 - 102,696,472 (+)Ensemblpanpan1.1panPan2
SUFU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12814,992,989 - 15,115,499 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2814,992,618 - 15,112,389 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2815,165,295 - 15,287,811 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02815,467,025 - 15,589,735 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2815,466,996 - 15,589,728 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12815,011,961 - 15,134,129 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02815,051,335 - 15,173,877 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02815,183,706 - 15,305,945 (+)NCBIUU_Cfam_GSD_1.0
Sufu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721331,665,075 - 31,778,513 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366003,268,260 - 3,381,781 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366003,270,662 - 3,381,722 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SUFU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14113,500,842 - 113,626,003 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114113,500,001 - 113,628,064 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214123,356,101 - 123,481,988 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SUFU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1995,532,228 - 95,660,594 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl995,532,242 - 95,657,290 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604856,639,722 - 56,772,532 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sufu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248311,882,077 - 2,012,341 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248311,882,114 - 2,012,341 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sufu
3025 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2822
Count of miRNA genes:818
Interacting mature miRNAs:1131
Transcripts:ENSMUST00000039922, ENSMUST00000111867, ENSMUST00000118440, ENSMUST00000120778, ENSMUST00000123252, ENSMUST00000144341
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193959606661420004Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193601694446761521Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
1300585Pgia12_mproteoglycan induced arthritis 12 (mouse)Not determined194258685961420004Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001025391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_015752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC156982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF134893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ131692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ308624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ308625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ308626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ308627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ308628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ308629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ308630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ308631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ308632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ308633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ308634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ308635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ308636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK015885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK016976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK047603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB732695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC056997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01041484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000039922   ⟹   ENSMUSP00000049109
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1946,385,335 - 46,477,243 (+)Ensembl
GRCm38.p6 Ensembl1946,396,896 - 46,488,804 (+)Ensembl
Ensembl Acc Id: ENSMUST00000111867   ⟹   ENSMUSP00000107498
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1946,385,357 - 46,474,487 (+)Ensembl
GRCm38.p6 Ensembl1946,396,918 - 46,486,048 (+)Ensembl
Ensembl Acc Id: ENSMUST00000118440   ⟹   ENSMUSP00000113073
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1946,385,465 - 46,465,393 (+)Ensembl
GRCm38.p6 Ensembl1946,397,026 - 46,476,954 (+)Ensembl
Ensembl Acc Id: ENSMUST00000120778   ⟹   ENSMUSP00000112653
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1946,385,443 - 46,444,146 (+)Ensembl
GRCm38.p6 Ensembl1946,397,004 - 46,455,707 (+)Ensembl
Ensembl Acc Id: ENSMUST00000123252
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1946,446,345 - 46,464,073 (+)Ensembl
GRCm38.p6 Ensembl1946,457,906 - 46,475,634 (+)Ensembl
Ensembl Acc Id: ENSMUST00000144341
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1946,471,536 - 46,474,421 (+)Ensembl
GRCm38.p6 Ensembl1946,483,097 - 46,485,982 (+)Ensembl
Ensembl Acc Id: ENSMUST00000235166
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1946,389,563 - 46,442,482 (+)Ensembl
GRCm38.p6 Ensembl1946,401,124 - 46,454,043 (+)Ensembl
RefSeq Acc Id: NM_001025391   ⟹   NP_001020562
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391946,385,335 - 46,477,243 (+)NCBI
GRCm381946,396,896 - 46,488,804 (+)NCBI
MGSCv371946,471,408 - 46,561,150 (+)RGD
Celera1947,160,466 - 47,252,586 (+)NCBI
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_015752   ⟹   NP_056567
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391946,385,335 - 46,477,243 (+)NCBI
GRCm381946,396,896 - 46,488,804 (+)NCBI
MGSCv371946,471,408 - 46,561,150 (+)RGD
Celera1947,160,466 - 47,252,586 (+)NCBI
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_056567   ⟸   NM_015752
- Peptide Label: isoform 1
- UniProtKB: Q3U0Z8 (UniProtKB/TrEMBL),   D3Z7B6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001020562   ⟸   NM_001025391
- Peptide Label: isoform 2
- UniProtKB: Q9D521 (UniProtKB/Swiss-Prot),   Q99JG0 (UniProtKB/Swiss-Prot),   Q8C8B4 (UniProtKB/Swiss-Prot),   Q9JLU1 (UniProtKB/Swiss-Prot),   Q9Z0P7 (UniProtKB/Swiss-Prot),   D3Z7B6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000107498   ⟸   ENSMUST00000111867
Ensembl Acc Id: ENSMUSP00000113073   ⟸   ENSMUST00000118440
Ensembl Acc Id: ENSMUSP00000112653   ⟸   ENSMUST00000120778
Ensembl Acc Id: ENSMUSP00000049109   ⟸   ENSMUST00000039922
Protein Domains
Suppressor of fused C-terminal   Suppressor of fused-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0P7-F1-model_v2 AlphaFold Q9Z0P7 1-484 view protein structure

Promoters
RGD ID:13679688
Promoter ID:EPDNEW_M23993
Type:initiation region
Name:Sufu_1
Description:Mus musculus SUFU negative regulator of hedgehog signaling ,transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381946,396,929 - 46,396,989EPDNEW
RGD ID:6830443
Promoter ID:MM_KWN:27244
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000111866,   ENSMUST00000111867,   ENSMUST00000118440,   OTTMUST00000075541,   UC008HTN.1,   UC008HTO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361946,471,239 - 46,471,739 (+)MPROMDB
RGD ID:6830446
Promoter ID:MM_KWN:27246
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:OTTMUST00000075546
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361946,532,334 - 46,532,834 (+)MPROMDB
RGD ID:6830444
Promoter ID:MM_KWN:27247
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000075545
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361946,557,171 - 46,557,671 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1345643 AgrOrtholog
Ensembl Genes ENSMUSG00000025231 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000039922 ENTREZGENE
  ENSMUST00000039922.13 UniProtKB/Swiss-Prot
  ENSMUST00000111867 ENTREZGENE
  ENSMUST00000111867.9 UniProtKB/Swiss-Prot
  ENSMUST00000118440.3 UniProtKB/TrEMBL
  ENSMUST00000120778.8 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1360.230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro SUFU-like_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUFU_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUFU_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUFU_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Suppressor_of_fused UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Suppressor_of_fused_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:24069 UniProtKB/Swiss-Prot
MGD MGI:1345643 ENTREZGENE
NCBI Gene 24069 ENTREZGENE
PANTHER PTHR10928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUPPRESSOR OF FUSED HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SUFU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUFU_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sufu PhenoGen
PIRSF Suppressor_of_fused_protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103359 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J1M0_MOUSE UniProtKB/TrEMBL
  D3Z7B6 ENTREZGENE, UniProtKB/TrEMBL
  Q3U0Z8 ENTREZGENE, UniProtKB/TrEMBL
  Q8C8B4 ENTREZGENE
  Q99JG0 ENTREZGENE
  Q9D521 ENTREZGENE
  Q9JLU1 ENTREZGENE
  Q9Z0P7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8C8B4 UniProtKB/Swiss-Prot
  Q99JG0 UniProtKB/Swiss-Prot
  Q9D521 UniProtKB/Swiss-Prot
  Q9JLU1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-24 Sufu  SUFU negative regulator of hedgehog signaling    suppressor of fused homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED