SUFU (SUFU negative regulator of hedgehog signaling) - Rat Genome Database
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Gene: SUFU (SUFU negative regulator of hedgehog signaling) Canis lupus familiaris
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Symbol: SUFU
Name: SUFU negative regulator of hedgehog signaling
RGD ID: 12422745
Description: ENCODES a protein that exhibits beta-catenin binding (ortholog); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); cytoplasmic sequestering of transcription factor (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma (ortholog); basal cell carcinoma (ortholog); craniopharyngioma (ortholog); FOUND IN cilium (ortholog); cytoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: suppressor of fused homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2814,992,618 - 15,112,389 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12814,992,989 - 15,115,499 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
SUFU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2814,992,618 - 15,112,389 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12814,992,989 - 15,115,499 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
SUFU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10102,503,972 - 102,633,535 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl10102,503,987 - 102,633,535 (+)EnsemblGRCh38hg38GRCh38
GRCh3810102,502,801 - 102,633,535 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710104,263,719 - 104,393,214 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh3710104,263,729 - 104,393,292 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,253,754 - 104,383,199 (+)NCBINCBI36hg18NCBI36
Build 3410104,253,753 - 104,383,199NCBI
Celera1098,004,628 - 98,134,149 (+)NCBI
Cytogenetic Map10q24.32NCBI
HuRef1097,897,496 - 98,026,978 (+)NCBIHuRef
CHM1_110104,547,179 - 104,677,032 (+)NCBICHM1_1
Sufu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,385,335 - 46,477,243 (+)NCBIGRCm39mm39
GRCm381946,396,896 - 46,488,804 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,396,896 - 46,488,804 (+)EnsemblGRCm38mm10GRCm38
MGSCv371946,471,408 - 46,561,150 (+)NCBIGRCm37mm9NCBIm37
MGSCv361946,450,229 - 46,539,971 (+)NCBImm8
Celera1947,160,488 - 47,250,442 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.85NCBI
Sufu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21245,257,725 - 245,355,576 (+)NCBI
Rnor_6.0 Ensembl1266,143,818 - 266,239,016 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01266,143,766 - 266,241,742 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01273,574,697 - 273,672,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41251,612,377 - 251,708,109 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1241,040,495 - 241,135,358 (+)NCBICelera
Cytogenetic Map1q54NCBI
Sufu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554857,808,131 - 7,925,677 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554857,805,244 - 7,925,414 (-)NCBIChiLan1.0ChiLan1.0
SUFU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110102,571,886 - 102,696,472 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10102,571,886 - 102,696,472 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01099,107,516 - 99,231,761 (+)NCBIMhudiblu_PPA_v0panPan3
Sufu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366003,270,662 - 3,381,722 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SUFU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14113,500,842 - 113,614,517 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114113,500,001 - 113,628,064 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214123,356,101 - 123,481,988 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SUFU
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1995,532,228 - 95,660,594 (+)NCBI
ChlSab1.1 Ensembl995,532,242 - 95,657,290 (+)Ensembl
Sufu
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248311,882,114 - 2,012,341 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 10 2 10 7 5
Low 5 5 12 6 4 6 6 6 2 8 3 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000016234   ⟹   ENSCAFP00000015018
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2814,992,618 - 15,112,389 (+)Ensembl
RefSeq Acc Id: XM_005637674   ⟹   XP_005637731
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12814,992,989 - 15,115,499 (+)NCBI
Sequence:
RefSeq Acc Id: XM_846083   ⟹   XP_851176
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12814,992,990 - 15,115,499 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005637731   ⟸   XM_005637674
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_851176   ⟸   XM_846083
- Peptide Label: isoform X2
- UniProtKB: E2RAI7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000015018   ⟸   ENSCAFT00000016234
Protein Domains
SUFU   SUFU_C


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010221 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000015018 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000016234 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1360.230 UniProtKB/TrEMBL
InterPro SUFU-like_domain UniProtKB/TrEMBL
  SUFU_C UniProtKB/TrEMBL
  SUFU_C_sf UniProtKB/TrEMBL
  SUFU_N UniProtKB/TrEMBL
  Suppressor_of_fused UniProtKB/TrEMBL
  Suppressor_of_fused_euk UniProtKB/TrEMBL
NCBI Gene SUFU ENTREZGENE
PANTHER PTHR10928 UniProtKB/TrEMBL
Pfam SUFU UniProtKB/TrEMBL
  SUFU_C UniProtKB/TrEMBL
PIRSF Suppressor_of_fused_protein UniProtKB/TrEMBL
Superfamily-SCOP SSF103359 UniProtKB/TrEMBL
UniProt E2RAI7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:46971 ENTREZGENE