Symbol:
APH1A
Name:
aph-1 homolog A, gamma-secretase subunit
RGD ID:
1349695
HGNC Page
HGNC:29509
Description:
Enables endopeptidase activator activity and protein-macromolecule adaptor activity. Involved in Notch receptor processing; amyloid-beta formation; and proteolysis. Located in Golgi apparatus; endoplasmic reticulum; and plasma membrane. Part of gamma-secretase complex.
Type:
protein-coding
RefSeq Status:
REVIEWED
Previously known as:
6530402N02Rik; anterior pharynx defective 1 homolog A; APH-1; aph-1 homolog A, gamma secretase subunit; APH-1A; aph-1alpha; APH1A gamma secretase subunit; CGI-78; gamma-secretase subunit APH-1A; presenilin-stabilization factor
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Aph1a (aph1 homolog A, gamma secretase subunit) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Aph1a (aph-1 homolog A, gamma secretase subunit) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Chinchilla lanigera (long-tailed chinchilla):
Aph1a (aph-1 homolog A, gamma-secretase subunit) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
APH1A (aph-1 homolog A, gamma-secretase subunit) NCBI
Ortholog
Canis lupus familiaris (dog):
APH1A (aph-1 homolog A, gamma-secretase subunit) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Aph1a (aph-1 homolog A, gamma-secretase subunit) NCBI
Ortholog
Sus scrofa (pig):
APH1A (aph-1 homolog A, gamma-secretase subunit) HGNC
EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):
APH1A (aph-1 homolog A, gamma-secretase subunit) NCBI
Ortholog
Heterocephalus glaber (naked mole-rat):
Aph1a (aph-1 homolog A, gamma-secretase subunit) NCBI
Ortholog
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Aph1a (aph-1 homolog A, gamma secretase subunit)
Alliance
DIOPT (HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Aph1a (aph1 homolog A, gamma secretase subunit)
Alliance
DIOPT (HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
aph1b (APH1B gamma secretase subunit)
Alliance
DIOPT (InParanoid|OMA|OrthoInspector|SonicParanoid)
Drosophila melanogaster (fruit fly):
aph-1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Caenorhabditis elegans (roundworm):
aph-1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus laevis (African clawed frog):
aph1a.S
Alliance
DIOPT (Xenbase)
Xenopus laevis (African clawed frog):
aph1a.L
Alliance
DIOPT (Xenbase)
Xenopus tropicalis (tropical clawed frog):
aph1a
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 1 150,265,404 - 150,269,016 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 1 150,265,399 - 150,269,580 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 1 150,237,804 - 150,241,416 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 1 148,504,423 - 148,508,156 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 1 147,050,878 - 147,054,384 NCBI Celera 1 123,353,530 - 123,357,263 (-) NCBI Celera Cytogenetic Map 1 q21.2 NCBI HuRef 1 121,616,466 - 121,620,276 (-) NCBI HuRef CHM1_1 1 151,633,525 - 151,637,335 (-) NCBI CHM1_1 T2T-CHM13v2.0 1 149,390,321 - 149,393,933 (-) NCBI T2T-CHM13v2.0
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - KEGG (archival)
Imported Annotations - PID (archival)
Biological Process
amyloid precursor protein catabolic process (IDA,IGI,IMP,ISS,TAS) amyloid precursor protein metabolic process (IDA) amyloid-beta formation (IDA,IGI,IMP) membrane protein ectodomain proteolysis (IDA) membrane protein intracellular domain proteolysis (IDA,IMP,ISS) metanephros development (IEA) Notch receptor processing (IBA,IDA,IEA,IMP,NAS,TAS) Notch signaling pathway (IBA,IEA) protein processing (IBA,IDA,IEA,IGI,IMP)
Cellular Component
early endosome (IEA,ISO) endoplasmic reticulum (IBA,IDA,IEA) endoplasmic reticulum membrane (IEA,NAS) endosome membrane (TAS) gamma-secretase complex (IBA,IDA,IEA,IPI,ISS) Golgi apparatus (IDA,IEA) Golgi cisterna membrane (IEA) Golgi membrane (NAS) membrane (HDA,IDA,IEA) plasma membrane (IDA,ISS,TAS) presynaptic membrane (IEA) synaptic membrane (IEA,ISO) synaptic vesicle (IEA,ISO)
APH1A Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 1 150,265,404 - 150,269,016 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 1 150,265,399 - 150,269,580 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 1 150,237,804 - 150,241,416 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 1 148,504,423 - 148,508,156 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 1 147,050,878 - 147,054,384 NCBI Celera 1 123,353,530 - 123,357,263 (-) NCBI Celera Cytogenetic Map 1 q21.2 NCBI HuRef 1 121,616,466 - 121,620,276 (-) NCBI HuRef CHM1_1 1 151,633,525 - 151,637,335 (-) NCBI CHM1_1 T2T-CHM13v2.0 1 149,390,321 - 149,393,933 (-) NCBI T2T-CHM13v2.0
Aph1a Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 3 95,801,233 - 95,805,904 (+) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 3 95,801,281 - 95,805,600 (+) Ensembl GRCm39 Ensembl GRCm38 3 95,893,921 - 95,898,592 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 3 95,893,969 - 95,898,288 (+) Ensembl GRCm38 mm10 GRCm38 MGSCv37 3 95,697,919 - 95,702,226 (+) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 3 95,979,401 - 95,983,708 (+) NCBI MGSCv36 mm8 Celera 3 97,327,550 - 97,331,856 (+) NCBI Celera Cytogenetic Map 3 F2.1 NCBI cM Map 3 41.47 NCBI
Aph1a Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 2 186,123,023 - 186,130,886 (+) NCBI GRCr8 mRatBN7.2 2 183,437,676 - 183,443,113 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 2 183,438,434 - 183,441,955 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 2 191,103,181 - 191,106,690 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 2 188,906,757 - 188,910,266 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 2 183,735,718 - 183,739,227 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 2 198,006,247 - 198,009,837 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 2 198,006,316 - 198,009,830 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 2 217,496,424 - 217,499,992 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 2 190,679,692 - 190,683,202 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 2 190,642,445 - 190,645,954 (+) NCBI Celera 2 175,967,700 - 175,971,210 (+) NCBI Celera Cytogenetic Map 2 q34 NCBI
Aph1a Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955413 506,297 - 509,787 (+) Ensembl ChiLan1.0 ChiLan1.0 NW_004955413 506,297 - 509,787 (+) NCBI ChiLan1.0 ChiLan1.0
APH1A Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 1 99,556,319 - 99,573,297 (+) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 1 99,323,843 - 99,326,806 (+) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 1 125,610,649 - 125,614,261 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 1 129,262,002 - 129,278,517 (-) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 1 129,262,002 - 129,265,810 (-) Ensembl panpan1.1 panPan2
APH1A Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 17 59,510,805 - 59,514,431 (-) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 17 59,502,523 - 59,514,403 (-) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 17 58,957,162 - 58,960,794 (-) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 17 60,526,236 - 60,529,875 (-) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 17 60,526,235 - 60,529,849 (-) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 17 59,356,688 - 59,360,320 (-) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 17 59,440,418 - 59,444,051 (-) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 17 60,168,413 - 60,172,045 (-) NCBI UU_Cfam_GSD_1.0
Aph1a
APH1A
APH1A Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Vero_WHO_p1.0 NW_023666038 13,022,908 - 13,026,804 (+) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Aph1a
.
Confirmed Target Of
MIR145 hsa-miR-145-5p Tarbase external_info Microarray POSITIVE
Predicted Target Of
Count of predictions: 2970 Count of miRNA genes: 938 Interacting mature miRNAs: 1110 Transcripts: ENST00000236017, ENST00000360244, ENST00000369109, ENST00000414276, ENST00000461320, ENST00000476538, ENST00000486308, ENST00000486720, ENST00000493092 Prediction methods: Microtar, Miranda, Rnahybrid Result types: miRGate_prediction
1357381 BW57_H Body weight QTL 57 (human) 1 0.0001 Body weight fat free mass after exercise training 1 140630236 166630236 Human
SGC31751
Human Assembly Chr Position (strand) Source JBrowse GRCh37 1 150,237,829 - 150,237,958 UniSTS GRCh37 Build 36 1 148,504,453 - 148,504,582 RGD NCBI36 Celera 1 123,353,560 - 123,353,689 RGD Cytogenetic Map 1 q21 UniSTS Cytogenetic Map 1 p36.13-q31.3 UniSTS HuRef 1 121,616,496 - 121,616,625 UniSTS GeneMap99-GB4 RH Map 1 542.76 UniSTS GeneMap99-GB4 RH Map 1 540.36 UniSTS Whitehead-RH Map 1 634.9 UniSTS
SHGC-32182
Human Assembly Chr Position (strand) Source JBrowse GRCh37 1 150,237,331 - 150,237,433 UniSTS GRCh37 Build 36 1 148,503,955 - 148,504,057 RGD NCBI36 Celera 1 123,353,062 - 123,353,164 RGD Cytogenetic Map 1 q21 UniSTS Cytogenetic Map 1 p36.13-q31.3 UniSTS HuRef 1 121,615,998 - 121,616,100 UniSTS GeneMap99-GB4 RH Map 1 537.26 UniSTS GeneMap99-GB4 RH Map 1 553.37 UniSTS Whitehead-RH Map 1 627.7 UniSTS NCBI RH Map 1 1003.6 UniSTS
D13S1659
Human Assembly Chr Position (strand) Source JBrowse GRCh37 1 150,238,285 - 150,238,427 UniSTS GRCh37 Build 36 1 148,504,909 - 148,505,051 RGD NCBI36 Celera 1 123,354,016 - 123,354,158 RGD Cytogenetic Map 1 p36.13-q31.3 UniSTS HuRef 1 121,616,952 - 121,617,094 UniSTS GeneMap99-G3 RH Map 1 1761.0 UniSTS
A004F41
Human Assembly Chr Position (strand) Source JBrowse GRCh37 1 150,237,873 - 150,238,086 UniSTS GRCh37 Build 36 1 148,504,497 - 148,504,710 RGD NCBI36 Celera 1 123,353,604 - 123,353,817 RGD Cytogenetic Map 1 p36.13-q31.3 UniSTS HuRef 1 121,616,540 - 121,616,753 UniSTS GeneMap99-GB4 RH Map 1 536.8 UniSTS
APH-1A__4340
Human Assembly Chr Position (strand) Source JBrowse GRCh37 1 150,237,641 - 150,238,436 UniSTS GRCh37 Build 36 1 148,504,265 - 148,505,060 RGD NCBI36 Celera 1 123,353,372 - 123,354,167 RGD HuRef 1 121,616,308 - 121,617,103 UniSTS
MARC_7139-7140:992008251:1
Human Assembly Chr Position (strand) Source JBrowse GRCh37 1 150,239,003 - 150,239,791 UniSTS GRCh37 Celera 1 123,354,734 - 123,355,522 UniSTS HuRef 1 121,617,670 - 121,618,458 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
entire extraembryonic component
1204
2439
2788
2253
4974
1726
2351
6
624
1951
465
2270
7306
6472
53
3734
1
852
1744
1617
175
1
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENST00000236017 ⟹ ENSP00000236017
Type:
CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38.p14 Ensembl 1 150,266,645 - 150,269,023 (-) Ensembl
Ensembl Acc Id:
ENST00000360244 ⟹ ENSP00000353380
Type:
CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38.p14 Ensembl 1 150,265,406 - 150,269,303 (-) Ensembl
Ensembl Acc Id:
ENST00000369109 ⟹ ENSP00000358105
Type:
CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38.p14 Ensembl 1 150,265,404 - 150,269,016 (-) Ensembl
Ensembl Acc Id:
ENST00000414276 ⟹ ENSP00000397473
Type:
CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38.p14 Ensembl 1 150,265,399 - 150,269,209 (-) Ensembl
Ensembl Acc Id:
ENST00000461320
Type:
CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38.p14 Ensembl 1 150,266,349 - 150,269,015 (-) Ensembl
Ensembl Acc Id:
ENST00000476538
Type:
CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38.p14 Ensembl 1 150,267,370 - 150,268,566 (-) Ensembl
Ensembl Acc Id:
ENST00000486308
Type:
CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38.p14 Ensembl 1 150,266,956 - 150,267,766 (-) Ensembl
Ensembl Acc Id:
ENST00000486720
Type:
CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38.p14 Ensembl 1 150,267,097 - 150,267,696 (-) Ensembl
Ensembl Acc Id:
ENST00000493092
Type:
CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38.p14 Ensembl 1 150,268,901 - 150,269,580 (-) Ensembl
RefSeq Acc Id:
NM_001077628 ⟹ NP_001071096
RefSeq Status:
REVIEWED
Type:
CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38 1 150,265,404 - 150,269,016 (-) NCBI GRCh37 1 150,237,799 - 150,241,609 (-) NCBI Build 36 1 148,504,423 - 148,508,156 (-) NCBI Archive HuRef 1 121,616,466 - 121,620,276 (-) NCBI CHM1_1 1 151,633,525 - 151,637,335 (-) NCBI T2T-CHM13v2.0 1 149,390,321 - 149,393,933 (-) NCBI
Sequence:
CTCTTCGGCTTCCGTAGAGGAAGTGGCGCGGACCTTCATTTGGGGTTTCGGTTCCCCCCCTTCCCCTTCCCCGGGGTCTGGGGGTGACATTGCACCGCGCCCCTCGTGGGGTCGCGTTGCCACCCCAC
hide sequence
RefSeq Acc Id:
NM_001243771 ⟹ NP_001230700
RefSeq Status:
REVIEWED
Type:
CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38 1 150,265,404 - 150,269,016 (-) NCBI GRCh37 1 150,237,799 - 150,241,609 (-) NCBI HuRef 1 121,616,466 - 121,620,276 (-) NCBI CHM1_1 1 151,633,525 - 151,637,335 (-) NCBI T2T-CHM13v2.0 1 149,390,321 - 149,393,933 (-) NCBI
Sequence:
CTCTTCGGCTTCCGTAGAGGAAGTGGCGCGGACCTTCATTTGGGGTTTCGGTTCCCCCCCTTCCCCTTCCCCGGGGTCTGGGGGTGACATTGCACCGCGCCCCTCGTGGGGTCGCGTTGCCACCCCAC
hide sequence
RefSeq Acc Id:
NM_001243772 ⟹ NP_001230701
RefSeq Status:
REVIEWED
Type:
CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38 1 150,265,404 - 150,269,016 (-) NCBI GRCh37 1 150,237,799 - 150,241,609 (-) NCBI HuRef 1 121,616,466 - 121,620,276 (-) NCBI CHM1_1 1 151,633,525 - 151,637,335 (-) NCBI T2T-CHM13v2.0 1 149,390,321 - 149,393,933 (-) NCBI
Sequence:
CTCTTCGGCTTCCGTAGAGGAAGTGGCGCGGACCTTCATTTGGGGTTTCGGTTCCCCCCCTTCCCCTTCCCCGGGGTCTGGGGGTGACATTGCACCGCGCCCCTCGTGGGGTCGCGTTGCCACCCCAC
hide sequence
RefSeq Acc Id:
NM_016022 ⟹ NP_057106
RefSeq Status:
REVIEWED
Type:
CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38 1 150,265,404 - 150,269,016 (-) NCBI GRCh37 1 150,237,799 - 150,241,609 (-) NCBI Build 36 1 148,504,423 - 148,508,156 (-) NCBI Archive HuRef 1 121,616,466 - 121,620,276 (-) NCBI CHM1_1 1 151,633,525 - 151,637,335 (-) NCBI T2T-CHM13v2.0 1 149,390,321 - 149,393,933 (-) NCBI
Sequence:
CTCTTCGGCTTCCGTAGAGGAAGTGGCGCGGACCTTCATTTGGGGTTTCGGTTCCCCCCCTTCCCCTTCCCCGGGGTCTGGGGGTGACATTGCACCGCGCCCCTCGTGGGGTCGCGTTGCCACCCCAC
hide sequence
RefSeq Acc Id:
NR_045033
RefSeq Status:
REVIEWED
Type:
NON-CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38 1 150,265,404 - 150,269,016 (-) NCBI GRCh37 1 150,237,799 - 150,241,609 (-) NCBI HuRef 1 121,616,466 - 121,620,276 (-) NCBI CHM1_1 1 151,633,525 - 151,637,335 (-) NCBI T2T-CHM13v2.0 1 149,390,321 - 149,393,933 (-) NCBI
Sequence:
CTCTTCGGCTTCCGTAGAGGAAGTGGCGCGGACCTTCATTTGGGGTTTCGGTTCCCCCCCTTCC
hide sequence
RefSeq Acc Id:
NR_045034
RefSeq Status:
REVIEWED
Type:
NON-CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38 1 150,265,404 - 150,269,016 (-) NCBI GRCh37 1 150,237,799 - 150,241,609 (-) NCBI HuRef 1 121,616,466 - 121,620,276 (-) NCBI CHM1_1 1 151,633,525 - 151,637,335 (-) NCBI T2T-CHM13v2.0 1 149,390,321 - 149,393,933 (-) NCBI
Sequence:
CTCTTCGGCTTCCGTAGAGGAAGTGGCGCGGACCTTCATTTGGGGTTTCGGTTCCCCCCCTTCCCCTTCCCCGGGGTCTGGGGGTGACATTGCACCGCGCCCCTCGTGGGGTCGCGTTGCCACCCCAC
hide sequence
RefSeq Acc Id:
NR_045035
RefSeq Status:
REVIEWED
Type:
NON-CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38 1 150,265,404 - 150,269,016 (-) NCBI GRCh37 1 150,237,799 - 150,241,609 (-) NCBI HuRef 1 121,616,466 - 121,620,276 (-) NCBI CHM1_1 1 151,633,525 - 151,637,335 (-) NCBI T2T-CHM13v2.0 1 149,390,321 - 149,393,933 (-) NCBI
Sequence:
CTCTTCGGCTTCCGTAGAGGAAGTGGCGCGGACCTTCATTTGGGGTTTCGGTTCCCCCCCTTCC
hide sequence
RefSeq Acc Id:
XM_047422066 ⟹ XP_047278022
Type:
CODING
Position:
Human Assembly Chr Position (strand) Source GRCh38 1 150,265,404 - 150,269,016 (-) NCBI
RefSeq Acc Id:
XM_054336892 ⟹ XP_054192867
Type:
CODING
Position:
Human Assembly Chr Position (strand) Source T2T-CHM13v2.0 1 149,390,321 - 149,393,933 (-) NCBI
RefSeq Acc Id:
NP_001071096 ⟸ NM_001077628
- Peptide Label:
isoform 1
- UniProtKB:
Q9BVG0 (UniProtKB/Swiss-Prot), Q969R6 (UniProtKB/Swiss-Prot), Q5TB23 (UniProtKB/Swiss-Prot), Q5TB22 (UniProtKB/Swiss-Prot), B4DQK0 (UniProtKB/Swiss-Prot), Q9Y386 (UniProtKB/Swiss-Prot), Q96BI3 (UniProtKB/Swiss-Prot), B3KQT0 (UniProtKB/TrEMBL)
- Sequence:
MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGII
hide sequence
RefSeq Acc Id:
NP_057106 ⟸ NM_016022
- Peptide Label:
isoform 2
- UniProtKB:
B3KQT0 (UniProtKB/TrEMBL)
- Sequence:
MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSD
hide sequence
RefSeq Acc Id:
NP_001230700 ⟸ NM_001243771
- Peptide Label:
isoform 3
- UniProtKB:
B4DUG7 (UniProtKB/TrEMBL)
- Sequence:
MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGKADEGLASLSEDGRSPISIRQMAYVS
hide sequence
RefSeq Acc Id:
NP_001230701 ⟸ NM_001243772
- Peptide Label:
isoform 4
- UniProtKB:
Q96BI3 (UniProtKB/Swiss-Prot)
- Sequence:
MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGRCSALPTTSCLISGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHL
hide sequence
Ensembl Acc Id:
ENSP00000353380 ⟸ ENST00000360244
Ensembl Acc Id:
ENSP00000397473 ⟸ ENST00000414276
Ensembl Acc Id:
ENSP00000236017 ⟸ ENST00000236017
Ensembl Acc Id:
ENSP00000358105 ⟸ ENST00000369109
RefSeq Acc Id:
XP_047278022 ⟸ XM_047422066
- Peptide Label:
isoform X1
RefSeq Acc Id:
XP_054192867 ⟸ XM_054336892
- Peptide Label:
isoform X1
RGD ID: 6786348 Promoter ID: HG_KWN:4912 Type: CpG-Island SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: K562 Transcripts: ENST00000236017, NM_001077628, OTTHUMT00000035047, OTTHUMT00000035049, OTTHUMT00000035050, OTTHUMT00000035051, OTTHUMT00000035052, OTTHUMT00000095846, OTTHUMT00000095847, UC001EUA.1, UC001EUB.1 Position: Human Assembly Chr Position (strand) Source Build 36 1 148,507,846 - 148,508,346 (-) MPROMDB
RGD ID: 6856956 Promoter ID: EPDNEW_H1643 Type: initiation region Name: APH1A_1 Description: aph-1 homolog A, gamma-secretase subunit SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Alternative Promoters: null; see alsoEPDNEW_H1644 EPDNEW_H1645 EPDNEW_H1647 Experiment Methods: Single-end sequencing. Position: Human Assembly Chr Position (strand) Source GRCh38 1 150,269,014 - 150,269,074 EPDNEW
RGD ID: 6856958 Promoter ID: EPDNEW_H1644 Type: initiation region Name: APH1A_3 Description: aph-1 homolog A, gamma-secretase subunit SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Alternative Promoters: null; see alsoEPDNEW_H1643 EPDNEW_H1645 EPDNEW_H1647 Experiment Methods: Single-end sequencing. Position: Human Assembly Chr Position (strand) Source GRCh38 1 150,269,344 - 150,269,404 EPDNEW
RGD ID: 6856960 Promoter ID: EPDNEW_H1645 Type: multiple initiation site Name: APH1A_4 Description: aph-1 homolog A, gamma-secretase subunit SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Alternative Promoters: null; see alsoEPDNEW_H1643 EPDNEW_H1644 EPDNEW_H1647 Experiment Methods: Single-end sequencing.; Paired-end sequencing. Position: Human Assembly Chr Position (strand) Source GRCh38 1 150,272,370 - 150,272,430 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2016-05-19
APH1A
aph-1 homolog A, gamma-secretase subunit
aph-1 homolog A, gamma secretase subunit
Symbol and/or name change
5135510 APPROVED
2015-12-01
APH1A
aph-1 homolog A, gamma secretase subunit
APH1A gamma secretase subunit
Symbol and/or name change
5135510 APPROVED
2013-07-09
APH1A
APH1A gamma secretase subunit
anterior pharynx defective 1 homolog A (C. elegans)
Symbol and/or name change
5135510 APPROVED
