IFNL3 (interferon lambda 3) - Rat Genome Database

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Gene: IFNL3 (interferon lambda 3) Homo sapiens
Analyze
Symbol: IFNL3
Name: interferon lambda 3
RGD ID: 1348657
HGNC Page HGNC:18365
Description: Predicted to enable signaling receptor binding activity. Predicted to be involved in defense response to symbiont; mucosal immune response; and negative regulation of viral genome replication. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in cryoglobulinemia; hepatitis C; liver cirrhosis; and thrombocytopenia.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cytokine Zcyto22; IFN-lambda-3; IFN-lambda-4; IL-28B; IL-28C; IL28B; IL28C; interferon lambda-3; interferon lambda-4; interferon, lambda 3; interferon, lambda 4; interleukin 28B (interferon, lambda 3); interleukin 28C; interleukin-28B; interleukin-28C
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Related Pseudogenes: IFNL3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,243,455 - 39,245,250 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,243,455 - 39,245,250 (-)EnsemblGRCh38hg38GRCh38
GRCh371939,734,095 - 39,735,890 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,426,112 - 44,427,451 (-)NCBINCBI36Build 36hg18NCBI36
Build 341944,426,111 - 44,427,451NCBI
Celera1936,537,863 - 36,539,202 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,181,319 - 36,182,658 (-)NCBIHuRef
CHM1_11939,735,081 - 39,736,420 (-)NCBICHM1_1
T2T-CHM13v2.01942,047,720 - 42,049,515 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Interferon-λ4 (IFNL4) transcript expression in human liver tissue samples. Amanzada A, etal., PLoS One. 2013 Dec 20;8(12):e84026. doi: 10.1371/journal.pone.0084026. eCollection 2013.
2. Interleukin-1 receptor antagonist gene polymorphism and mortality in patients with severe sepsis. Arnalich F, etal., Clin Exp Immunol. 2002 Feb;127(2):331-6.
3. IFNL4 polymorphism predicts response to hepatitis C treatment after liver transplantation. Fernández-Carrillo C, etal., J Clin Virol. 2014 Oct;61(2):282-5. doi: 10.1016/j.jcv.2014.07.015. Epub 2014 Jul 30.
4. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
5. Association with Spontaneous Hepatitis C Viral Clearance and Genetic Differentiation of IL28B/IFNL4 Haplotypes in Populations from Mexico. Gonzalez-Aldaco K, etal., PLoS One. 2016 Jan 7;11(1):e0146258. doi: 10.1371/journal.pone.0146258. eCollection 2016.
6. Genetic variants in interferon-λ 4 influences HCV clearance in Chinese Han population. Huang P, etal., Sci Rep. 2017 Feb 10;7:42408. doi: 10.1038/srep42408.
7. Influence of IFNL3.rs12979860 and IFNL4.ss469415590 polymorphism on clearance of hepatitis C virus infection among Egyptians. Knapp S, etal., Hepatol Int. 2015 Apr;9(2):251-7. doi: 10.1007/s12072-015-9619-z. Epub 2015 Mar 12.
8. Interferon-related genetic markers of necroinflammatory activity in chronic hepatitis C. López-Rodríguez R, etal., PLoS One. 2017 Jul 12;12(7):e0180927. doi: 10.1371/journal.pone.0180927. eCollection 2017.
9. Interferon lambda 3 rs12979860 polymorphism in patients with haemophilia and HCV infection: a predictor of spontaneous viral clearance and sustained virological response. Mancuso ME, etal., Thromb Haemost. 2014 Jun;111(6):1067-76. doi: 10.1160/TH13-11-897. Epub 2014 Feb 13.
10. IFNL4 polymorphism effects on outcome of simeprevir, peginterferon, and ribavirin therapy for older patients with genotype 1 chronic hepatitis C. Mori N, etal., Hepatol Res. 2017 Mar;47(3):E5-E13. doi: 10.1111/hepr.12715. Epub 2016 Apr 21.
11. Effect of laparoscopic splenectomy in patients with Hepatitis C and cirrhosis carrying IL28B minor genotype. Motomura T, etal., BMC Gastroenterol. 2012 Nov 12;12:158. doi: 10.1186/1471-230X-12-158.
12. Genetic polymorphism in IFNL4 and response to pegylated interferon-alpha and ribavirin in Japanese chronic hepatitis C patients. Nozawa Y, etal., Tissue Antigens. 2014 Jan;83(1):45-8. doi: 10.1111/tan.12264.
13. IFNL4/IL-28B haplotype structure and its impact on susceptibility to hepatitis C virus and treatment response in the Japanese population. Ochi H, etal., J Gen Virol. 2014 Jun;95(Pt 6):1297-1306. doi: 10.1099/vir.0.060103-0. Epub 2014 Mar 19.
14. Valuable antiviral therapeutic options for the treatment of chronic hepatitis C patients with thrombocytopenia. Ogawa E, etal., J Viral Hepat. 2013 Dec;20(12):838-46. doi: 10.1111/jvh.12109. Epub 2013 May 26.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. IFNL3 polymorphisms and HCV infection in patients with beta thalassemia. Origa R, etal., Ann Hepatol. 2015 May-Jun;14(3):389-95.
17. Variation in genes encoding for interferon λ-3 and λ-4 in the prediction of HCV-1 treatment-induced viral clearance. Palmieri O, etal., Liver Int. 2014 Oct;34(9):1369-77. doi: 10.1111/liv.12411. Epub 2013 Dec 23.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Marked impact of IL28B genotype in the natural clearance of hepatitis C virus in patients with haemoglobinopathies. Renda MC, etal., Br J Haematol. 2011 Sep;154(5):659-61. doi: 10.1111/j.1365-2141.2011.08637.x. Epub 2011 May 25.
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. The impact of genetic variation in IL28B, IFNL4 and HLA genes on treatment responses against chronic hepatitis C virus infection. Sakhaee F, etal., Infect Genet Evol. 2017 Oct;54:330-337. doi: 10.1016/j.meegid.2017.07.023. Epub 2017 Jul 21.
22. Interleukin 28B gene polymorphisms in hepatitis C virus-related cryoglobulinemic vasculitis. Sansonno D, etal., J Rheumatol. 2014 Jan;41(1):91-8. doi: 10.3899/jrheum.130527. Epub 2013 Dec 1.
23. Role of IL28B and inosine triphosphatase polymorphisms in the treatment of chronic hepatitis C virus genotype 6 infection. Seto WK, etal., J Viral Hepat. 2013 Jul;20(7):470-7. doi: 10.1111/jvh.12047. Epub 2013 Apr 12.
24. Modeling Ribavirin-Induced Anemia in Patients with Chronic Hepatitis C Virus. Wu LS, etal., CPT Pharmacometrics Syst Pharmacol. 2016 Feb;5(2):65-73. doi: 10.1002/psp4.12058. Epub 2016 Feb 2.
25. Prevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C. Świątek-Kościelna B, etal., World J Gastroenterol. 2017 Jun 7;23(21):3815-3824. doi: 10.3748/wjg.v23.i21.3815.
Additional References at PubMed
PMID:12469119   PMID:12477932   PMID:12483210   PMID:16413080   PMID:16478884   PMID:16539846   PMID:16618774   PMID:18987645   PMID:19304895   PMID:19457860   PMID:19684573   PMID:19749757  
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PMID:30402710   PMID:30431653   PMID:30478788   PMID:30578289   PMID:30695542   PMID:30762338   PMID:30936491   PMID:31013168   PMID:31146794   PMID:31165537   PMID:31201901   PMID:31279176  
PMID:31318136   PMID:31383827   PMID:31465972   PMID:31551080   PMID:31561422   PMID:31568008   PMID:31619697   PMID:31642723   PMID:31645053   PMID:31793339   PMID:31826071   PMID:31838260  
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PMID:32749108   PMID:33116245   PMID:33308178   PMID:33334303   PMID:33528661   PMID:33612760   PMID:33725487   PMID:33768560   PMID:33799903   PMID:33806448   PMID:33807175   PMID:33961781  
PMID:34047252   PMID:34071309   PMID:34207750   PMID:34216268   PMID:34416803   PMID:34452889   PMID:34775984   PMID:34817649   PMID:35816926   PMID:36655749   PMID:36682084   PMID:36708570  
PMID:37812032   PMID:38193711   PMID:38406928  


Genomics

Comparative Map Data
IFNL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,243,455 - 39,245,250 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,243,455 - 39,245,250 (-)EnsemblGRCh38hg38GRCh38
GRCh371939,734,095 - 39,735,890 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,426,112 - 44,427,451 (-)NCBINCBI36Build 36hg18NCBI36
Build 341944,426,111 - 44,427,451NCBI
Celera1936,537,863 - 36,539,202 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,181,319 - 36,182,658 (-)NCBIHuRef
CHM1_11939,735,081 - 39,736,420 (-)NCBICHM1_1
T2T-CHM13v2.01942,047,720 - 42,049,515 (-)NCBIT2T-CHM13v2.0
Ifnl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,208,209 - 28,209,957 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,208,261 - 28,209,880 (-)EnsemblGRCm39 Ensembl
GRCm38728,508,784 - 28,510,532 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,508,836 - 28,510,455 (-)EnsemblGRCm38mm10GRCm38
MGSCv37729,293,880 - 29,295,379 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,217,621 - 28,219,120 (-)NCBIMGSCv36mm8
Celera723,071,574 - 23,073,073 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.8NCBI
Ifnl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,941,988 - 92,943,628 (+)NCBIGRCr8
mRatBN7.2183,814,456 - 83,816,096 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,814,564 - 83,816,096 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0185,236,243 - 85,237,775 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,236,243 - 85,237,775 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,450,831 - 86,452,363 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,617,808 - 83,619,340 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera178,209,346 - 78,210,878 (+)NCBICelera
Cytogenetic Map1q21NCBI
IFNL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,538,198 - 45,540,682 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,409,029 - 47,411,299 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01936,341,396 - 36,343,261 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IFNL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1113,356,570 - 113,358,011 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,553,957 - 114,555,398 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,553,847 - 114,555,398 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,112,719 - 114,114,160 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,745,246 - 113,746,687 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,740,713 - 114,742,154 (+)NCBIUU_Cfam_GSD_1.0
IL28B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,951,595 - 47,953,467 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,951,925 - 47,953,282 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214143,794,666 - 143,797,159 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IFNL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,843,140 - 33,845,444 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607311,865,640 - 11,867,069 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in IFNL3
27 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.12-13.2(chr19:37319377-42738688)x3 copy number gain See cases [RCV000050636] Chr19:37319377..42738688 [GRCh38]
Chr19:37810279..43242840 [GRCh37]
Chr19:42502119..47934680 [NCBI36]
Chr19:19q13.12-13.2		 pathogenic
NC_000019.10:g.39248147C>T single nucleotide variant boceprevir, peginterferon alfa-2a, peginterferon alfa-2b and ribavirin response - Efficacy [RCV001788072]|not specified [RCV000614473]|peginterferon alfa-2a, peginterferon alfa-2b, and ribavirin response - Efficacy [RCV000211399]|peginterferon alfa-2a, peginterferon alfa-2b, ribavirin, and telaprevir response - Efficacy [RCV000211184] Chr19:39248147 [GRCh38]
Chr19:39738787 [GRCh37]
Chr19:19q13.2		 benign|drug response
NC_000019.10:g.39252525T>G single nucleotide variant interferons, peginterferon alfa-2a, peginterferon alfa-2b, and ribavirin response - Efficacy [RCV000211192]|not provided [RCV000835188]|peginterferon alfa-2a, peginterferon alfa-2b, ribavirin, and telaprevir response - Efficacy [RCV000211316] Chr19:39252525 [GRCh38]
Chr19:39252525..39252526 [GRCh38]
Chr19:39743165 [GRCh37]
Chr19:39743165..39743166 [GRCh37]
Chr19:19q13.2		 benign|drug response
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31		 pathogenic
GRCh37/hg19 19q13.12-13.2(chr19:37582250-41630908)x3 copy number gain See cases [RCV000239839] Chr19:37582250..41630908 [GRCh37]
Chr19:19q13.12-13.2		 pathogenic
NM_172139.4(IFNL3):c.259-126T>C single nucleotide variant peginterferon alfa-2a response - Efficacy [RCV000417187]|peginterferon alfa-2b response - Efficacy [RCV000417140]|ribavirin response - Efficacy [RCV000417160] Chr19:39244283 [GRCh38]
Chr19:39734923 [GRCh37]
Chr19:19q13.2		 drug response
NM_172139.4(IFNL3):c.541C>T (p.Leu181Phe) single nucleotide variant not specified [RCV004312120] Chr19:39243682 [GRCh38]
Chr19:39734322 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_172139.4(IFNL3):c.451C>T (p.Leu151Phe) single nucleotide variant not specified [RCV004294283] Chr19:39243865 [GRCh38]
Chr19:39734505 [GRCh37]
Chr19:19q13.2		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
NM_172139.4(IFNL3):c.209A>G (p.Lys70Arg) single nucleotide variant not provided [RCV004704116]|not specified [RCV000612255] Chr19:39244466 [GRCh38]
Chr19:39735106 [GRCh37]
Chr19:19q13.2		 likely benign
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
NM_172139.4(IFNL3):c.491A>C (p.Lys164Thr) single nucleotide variant not specified [RCV004282517] Chr19:39243825 [GRCh38]
Chr19:39734465 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_172139.4(IFNL3):c.322A>G (p.Thr108Ala) single nucleotide variant not provided [RCV000971129] Chr19:39244094 [GRCh38]
Chr19:39734734 [GRCh37]
Chr19:19q13.2		 benign
NM_172139.4(IFNL3):c.215G>A (p.Arg72His) single nucleotide variant not provided [RCV000947941] Chr19:39244460 [GRCh38]
Chr19:39735100 [GRCh37]
Chr19:19q13.2		 benign
NM_172139.4(IFNL3):c.466C>T (p.His156Tyr) single nucleotide variant not provided [RCV000950845] Chr19:39243850 [GRCh38]
Chr19:39734490 [GRCh37]
Chr19:19q13.2		 benign
NM_172139.4(IFNL3):c.59G>C (p.Gly20Ala) single nucleotide variant not provided [RCV000966069] Chr19:39244909 [GRCh38]
Chr19:39735549 [GRCh37]
Chr19:19q13.2		 benign
NM_172139.4(IFNL3):c.283G>C (p.Glu95Gln) single nucleotide variant not provided [RCV000881665] Chr19:39244133 [GRCh38]
Chr19:39734773 [GRCh37]
Chr19:19q13.2		 benign
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33		 pathogenic
NC_000019.9:g.(?_39205089)_(40913839_?)dup duplication Type 2 diabetes mellitus [RCV003107444]|not provided [RCV003122562] Chr19:39205089..40913839 [GRCh37]
Chr19:19q13.2		 uncertain significance|no classifications from unflagged records
NM_172139.4(IFNL3):c.511G>A (p.Glu171Lys) single nucleotide variant not provided [RCV000949619] Chr19:39243712 [GRCh38]
Chr19:39734352 [GRCh37]
Chr19:19q13.2		 benign
GRCh37/hg19 19p13.11-q13.2(chr19:19546923-41313229)x3 copy number gain Specific learning disability [RCV001801194] Chr19:19546923..41313229 [GRCh37]
Chr19:19p13.11-q13.2		 pathogenic
NC_000019.9:g.(?_38375572)_(39738787_?)dup duplication RYR1-related disorder [RCV003111411] Chr19:38375572..39738787 [GRCh37]
Chr19:19q13.13-13.2		 uncertain significance
NM_172139.4(IFNL3):c.542T>G (p.Leu181Arg) single nucleotide variant not specified [RCV004102465] Chr19:39243681 [GRCh38]
Chr19:39734321 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_172139.4(IFNL3):c.17T>C (p.Met6Thr) single nucleotide variant not specified [RCV004188113] Chr19:39244951 [GRCh38]
Chr19:39735591 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_172139.4(IFNL3):c.449G>A (p.Arg150His) single nucleotide variant not specified [RCV004161239] Chr19:39243867 [GRCh38]
Chr19:39734507 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_172139.4(IFNL3):c.268C>T (p.Arg90Cys) single nucleotide variant not specified [RCV004168671] Chr19:39244148 [GRCh38]
Chr19:39734788 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_172139.4(IFNL3):c.443G>A (p.Arg148Gln) single nucleotide variant not specified [RCV004241555] Chr19:39243873 [GRCh38]
Chr19:39734513 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_172139.4(IFNL3):c.551G>A (p.Arg184Gln) single nucleotide variant not specified [RCV004120647] Chr19:39243672 [GRCh38]
Chr19:39734312 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_172139.4(IFNL3):c.133C>G (p.Leu45Val) single nucleotide variant not specified [RCV004279845] Chr19:39244835 [GRCh38]
Chr19:39735475 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_172139.4(IFNL3):c.487A>G (p.Lys163Glu) single nucleotide variant not specified [RCV004347092] Chr19:39243829 [GRCh38]
Chr19:39734469 [GRCh37]
Chr19:19q13.2		 uncertain significance
GRCh37/hg19 19q11-13.2(chr19:28271146-41508851)x3 copy number gain not specified [RCV003986115] Chr19:28271146..41508851 [GRCh37]
Chr19:19q11-13.2		 pathogenic
NM_172139.4(IFNL3):c.473T>C (p.Leu158Pro) single nucleotide variant not specified [RCV004400210] Chr19:39243843 [GRCh38]
Chr19:39734483 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_172139.4(IFNL3):c.563G>A (p.Cys188Tyr) single nucleotide variant not specified [RCV004400212] Chr19:39243660 [GRCh38]
Chr19:39734300 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_172139.4(IFNL3):c.252G>C (p.Gln84His) single nucleotide variant not specified [RCV004400207] Chr19:39244423 [GRCh38]
Chr19:39735063 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_172139.4(IFNL3):c.41C>T (p.Ala14Val) single nucleotide variant not specified [RCV004400209] Chr19:39244927 [GRCh38]
Chr19:39735567 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_172139.4(IFNL3):c.477G>C (p.Gln159His) single nucleotide variant not specified [RCV004400211] Chr19:39243839 [GRCh38]
Chr19:39734479 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_172139.4(IFNL3):c.80T>A (p.Leu27His) single nucleotide variant not specified [RCV004400213] Chr19:39244888 [GRCh38]
Chr19:39735528 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_172139.4(IFNL3):c.97G>C (p.Asp33His) single nucleotide variant not specified [RCV004400214] Chr19:39244871 [GRCh38]
Chr19:39735511 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_172139.4(IFNL3):c.455A>G (p.His152Arg) single nucleotide variant not specified [RCV004635616] Chr19:39243861 [GRCh38]
Chr19:39734501 [GRCh37]
Chr19:19q13.2		 uncertain significance
NM_172139.4(IFNL3):c.273C>T (p.Pro91=) single nucleotide variant not specified [RCV004635617] Chr19:39244143 [GRCh38]
Chr19:39734783 [GRCh37]
Chr19:19q13.2		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:110
Interacting mature miRNAs:112
Transcripts:ENST00000413851
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559110SCL22_HSerum cholesterol level QTL 22 (human)3.590.000241Lipid levelLDL cholesterol193190759457907594Human
407248551GWAS897527_Hchronic hepatitis C virus infection QTL GWAS897527 (human)1e-22chronic hepatitis C virus infection193924358039243581Human
407324027GWAS973003_Hinsomnia QTL GWAS973003 (human)2e-08insomnia193924358039243581Human
1331657COPD9_HChronic obstructive pulmonary disease QTL 9 (human)1.94Chronic airflow obstructionpost-bronchodilator FEV1193102176057021760Human

Markers in Region
G64446  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371939,757,234 - 39,757,509UniSTSGRCh37
GRCh371939,736,721 - 39,736,996UniSTSGRCh37
Build 361944,428,561 - 44,428,836RGDNCBI36
Celera1936,540,310 - 36,540,585RGD
Cytogenetic Map19q13.13UniSTS
HuRef1936,183,766 - 36,184,041UniSTS
HuRef1936,204,279 - 36,204,554UniSTS
SHGC-111908  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371939,757,224 - 39,757,526UniSTSGRCh37
GRCh371939,736,704 - 39,737,006UniSTSGRCh37
Build 361944,428,544 - 44,428,846RGDNCBI36
Celera1936,540,293 - 36,540,595RGD
Cytogenetic Map19q13.13UniSTS
HuRef1936,183,749 - 36,184,051UniSTS
HuRef1936,204,269 - 36,204,571UniSTS
TNG Radiation Hybrid Map1913916.0UniSTS
UniSTS:481139  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371939,734,272 - 39,735,611UniSTSGRCh37
Celera1936,537,863 - 36,539,202UniSTS
HuRef1936,181,319 - 36,182,658UniSTS
UniSTS:494905  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371939,734,246 - 39,735,646UniSTSGRCh37
Celera1936,537,837 - 36,539,237UniSTS
HuRef1936,181,293 - 36,182,693UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
207 408 852 328 2562 261 466 1 88 540 59 1009 1350 1225 2 1766 113 754 372 35

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_042193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001346937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_172139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC011445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY129149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY184374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY336714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY336717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC130314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC130316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS055925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS183957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS364718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB742072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GM040596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI658882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI659153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JB971261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000413851   ⟹   ENSP00000409000
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1939,243,553 - 39,245,006 (-)Ensembl
Ensembl Acc Id: ENST00000613087   ⟹   ENSP00000481633
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1939,243,455 - 39,245,250 (-)Ensembl
RefSeq Acc Id: NM_001346937   ⟹   NP_001333866
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381939,243,455 - 39,245,250 (-)NCBI
T2T-CHM13v2.01942,047,720 - 42,049,515 (-)NCBI
Sequence:
RefSeq Acc Id: NM_172139   ⟹   NP_742151
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381939,243,553 - 39,245,006 (-)NCBI
GRCh371939,734,272 - 39,735,916 (-)NCBI
Build 361944,426,112 - 44,427,451 (-)NCBI Archive
HuRef1936,181,319 - 36,182,658 (-)ENTREZGENE
CHM1_11939,735,081 - 39,736,420 (-)NCBI
T2T-CHM13v2.01942,047,818 - 42,049,271 (-)NCBI
Sequence:
RefSeq Acc Id: NP_742151   ⟸   NM_172139
- Peptide Label: isoform 2 precursor
- UniProtKB: Q7Z4J3 (UniProtKB/Swiss-Prot),   Q6VN56 (UniProtKB/Swiss-Prot),   A2BDE1 (UniProtKB/Swiss-Prot),   Q8IWL6 (UniProtKB/Swiss-Prot),   Q8IZI9 (UniProtKB/Swiss-Prot),   A0A7R8C2Z6 (UniProtKB/TrEMBL),   A0A7H1MG84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001333866   ⟸   NM_001346937
- Peptide Label: isoform 1 precursor
- UniProtKB: A0A0C4DGW8 (UniProtKB/TrEMBL),   A0A7H1MG84 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000409000   ⟸   ENST00000413851
Ensembl Acc Id: ENSP00000481633   ⟸   ENST00000613087

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8IZI9-F1-model_v2 AlphaFold Q8IZI9 1-196 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:18365 AgrOrtholog
COSMIC IFNL3 COSMIC
Ensembl Genes ENSG00000197110 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000291876 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000413851 ENTREZGENE
  ENST00000413851.3 UniProtKB/Swiss-Prot
  ENST00000613087 ENTREZGENE
  ENST00000613087.5 UniProtKB/TrEMBL
  ENST00000709042.1 UniProtKB/TrEMBL
  ENST00000709043.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000197110 GTEx
  ENSG00000291876 GTEx
HGNC ID HGNC:18365 ENTREZGENE
Human Proteome Map IFNL3 Human Proteome Map
InterPro IFN-lambda_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INF_lambda UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:282617 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 282617 ENTREZGENE
OMIM 607402 OMIM
PANTHER INTERFERON LAMBDA-2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR31943 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL28A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134952671 PharmGKB
UniProt A0A0C4DGW8 ENTREZGENE, UniProtKB/TrEMBL
  A0A7H1MG84 ENTREZGENE, UniProtKB/TrEMBL
  A0A7R8C2Z6 ENTREZGENE, UniProtKB/TrEMBL
  A2BDE1 ENTREZGENE
  IFNL3_HUMAN UniProtKB/Swiss-Prot
  Q6VN56 ENTREZGENE
  Q7Z4J3 ENTREZGENE
  Q8IWL6 ENTREZGENE
  Q8IZI9 ENTREZGENE
UniProt Secondary A2BDE1 UniProtKB/Swiss-Prot
  Q6VN56 UniProtKB/Swiss-Prot
  Q7Z4J3 UniProtKB/Swiss-Prot
  Q8IWL6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-21 IFNL3  interferon lambda 3  IFNL3  interferon, lambda 3  Symbol and/or name change 5135510 APPROVED
2012-11-28 IFNL3  interferon, lambda 3  IL28B  interleukin 28B (interferon, lambda 3)  Symbol and/or name change 5135510 APPROVED