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Gene: DNASE2 (deoxyribonuclease 2, lysosomal) Homo sapiens
Symbol: DNASE2
Name: deoxyribonuclease 2, lysosomal
Description: This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acid DNase; deoxyribonuclease II alpha; deoxyribonuclease II, lysosomal; deoxyribonuclease-2-alpha; DNase II alpha; DNase II, lysosomal; DNASE2A; DNL; DNL2; lysosomal DNase II; R31240_2
Mus musculus (house mouse) : Dnase2a (deoxyribonuclease II alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dnase2 (deoxyribonuclease 2, lysosomal)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnase2 (deoxyribonuclease 2, lysosomal)
Pan paniscus (bonobo/pygmy chimpanzee) : DNASE2 (deoxyribonuclease 2, lysosomal)
Canis lupus familiaris (dog) : DNASE2 (deoxyribonuclease 2, lysosomal)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnase2 (deoxyribonuclease 2, lysosomal)
Sus scrofa (pig) : DNASE2 (deoxyribonuclease 2, lysosomal)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381912,875,209 - 12,881,449 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371912,986,025 - 12,992,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,847,023 - 12,853,335 (-)NCBINCBI36hg18NCBI36
Build 341912,847,024 - 12,853,335NCBI
Celera1912,875,733 - 12,882,043 (-)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,557,881 - 12,564,200 (-)NCBIHuRef
CHM1_11912,986,545 - 12,992,854 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DNASE2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1343662
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.