Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: DNASE2 (deoxyribonuclease 2, lysosomal) Homo sapiens
Analyze
Symbol: DNASE2
Name: deoxyribonuclease 2, lysosomal
Description: This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acid DNase; deoxyribonuclease II alpha; deoxyribonuclease II, lysosomal; deoxyribonuclease-2-alpha; DNase II alpha; DNase II, lysosomal; DNASE2A; DNL; DNL2; lysosomal DNase II; R31240_2
Orthologs:
Mus musculus (house mouse) : Dnase2a (deoxyribonuclease II alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dnase2 (deoxyribonuclease 2, lysosomal)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnase2 (deoxyribonuclease 2, lysosomal)
Pan paniscus (bonobo/pygmy chimpanzee) : DNASE2 (deoxyribonuclease 2, lysosomal)
Canis lupus familiaris (dog) : DNASE2 (deoxyribonuclease 2, lysosomal)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnase2 (deoxyribonuclease 2, lysosomal)
Sus scrofa (pig) : DNASE2 (deoxyribonuclease 2, lysosomal)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,875,209 - 12,881,449 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371912,986,025 - 12,992,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,847,023 - 12,853,335 (-)NCBINCBI36hg18NCBI36
Build 341912,847,024 - 12,853,335NCBI
Celera1912,875,733 - 12,882,043 (-)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,557,881 - 12,564,200 (-)NCBIHuRef
CHM1_11912,986,545 - 12,992,854 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
  
More on DNASE2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1343662
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



Contact Us |  About Us |  License CC BY 4.0 |  Legal Disclaimer |  © Medical College of Wisconsin
NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.