TOMM70 (translocase of outer mitochondrial membrane 70) - Rat Genome Database

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Gene: TOMM70 (translocase of outer mitochondrial membrane 70) Homo sapiens
Analyze
Symbol: TOMM70
Name: translocase of outer mitochondrial membrane 70
RGD ID: 1343038
HGNC Page HGNC:11985
Description: Enables molecular adaptor activity. Involved in several processes, including cellular response to virus; positive regulation of interferon-beta production; and regulation of defense response. Located in mitochondrion. Is active in mitochondrial membrane. Biomarker of congestive heart failure.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FLJ90470; mitochondrial import receptor subunit TOM70; mitochondrial precursor proteins import receptor; Tom70; TOMM70A; translocase of outer membrane 70 kDa subunit; translocase of outer mitochondrial membrane 70 homolog A; translocase of outer mitochondrial membrane 70 homolog a (yeast); translocase of outer mitochondrial membrane protein 70
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383100,363,431 - 100,401,089 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3100,363,431 - 100,401,089 (-)EnsemblGRCh38hg38GRCh38
GRCh373100,082,275 - 100,119,933 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363101,564,997 - 101,602,915 (-)NCBINCBI36Build 36hg18NCBI36
Build 343101,564,998 - 101,602,915NCBI
Celera398,473,164 - 98,511,084 (-)NCBICelera
Cytogenetic Map3q12.2NCBI
HuRef397,450,096 - 97,488,049 (-)NCBIHuRef
CHM1_13100,045,331 - 100,083,272 (-)NCBICHM1_1
T2T-CHM13v2.03103,068,774 - 103,106,448 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions. Alvarez-Dolado M, etal., J Neurochem. 1999 Dec;73(6):2240-9.
2. Biogenesis of mitochondrial outer membrane proteins, problems and diseases. Ellenrieder L, etal., Biol Chem. 2015 Oct 1;396(11):1199-213. doi: 10.1515/hsz-2015-0170.
3. Phosphoproteome mapping of cardiomyocyte mitochondria in a rat model of heart failure. Giorgianni F, etal., Mol Cell Biochem. 2014 Apr;389(1-2):159-67. doi: 10.1007/s11010-013-1937-7. Epub 2014 Jan 7.
4. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
5. Assembly of beta-barrel proteins in the mitochondrial outer membrane. Hohr AI, etal., Biochim Biophys Acta. 2015 Jan;1853(1):74-88. doi: 10.1016/j.bbamcr.2014.10.006. Epub 2014 Oct 8.
6. Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy. Li J, etal., Cell Res. 2014 Aug;24(8):977-93. doi: 10.1038/cr.2014.94. Epub 2014 Jul 15.
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy. Santos JM and Kowluru RA, Diabetes Metab Res Rev. 2013 Mar;29(3):204-13. doi: 10.1002/dmrr.2384.
9. Unlocking the presequence import pathway. Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.
10. Cooperation of protein machineries in mitochondrial protein sorting. Wenz LS, etal., Biochim Biophys Acta. 2015 May;1853(5):1119-29. doi: 10.1016/j.bbamcr.2015.01.012. Epub 2015 Jan 26.
Additional References at PubMed
PMID:9872452   PMID:12200962   PMID:12477932   PMID:12526792   PMID:15489334   PMID:15644312   PMID:16303743   PMID:16822835   PMID:16968702   PMID:17558393   PMID:18029348   PMID:18187620  
PMID:18331822   PMID:18570454   PMID:18669640   PMID:18852034   PMID:19946888   PMID:20504278   PMID:20531390   PMID:20628368   PMID:20877624   PMID:21412788   PMID:21771790   PMID:21781956  
PMID:21873635   PMID:21903422   PMID:22032846   PMID:22280891   PMID:22939629   PMID:23068103   PMID:23125841   PMID:23414517   PMID:23472196   PMID:23503661   PMID:23798571   PMID:23911537  
PMID:24149440   PMID:24244333   PMID:25277244   PMID:25544563   PMID:25591737   PMID:25609649   PMID:25609812   PMID:25737280   PMID:25921289   PMID:25963833   PMID:26344197   PMID:26972000  
PMID:27342126   PMID:27880917   PMID:28065597   PMID:28675297   PMID:29395920   PMID:29509190   PMID:29509794   PMID:29568061   PMID:30021884   PMID:30575818   PMID:30590033   PMID:30629163  
PMID:30833792   PMID:30948266   PMID:31046837   PMID:31073040   PMID:31280863   PMID:31527615   PMID:31536960   PMID:31586073   PMID:31617661   PMID:31723608   PMID:31907385   PMID:32142684  
PMID:32353859   PMID:32356556   PMID:32552912   PMID:32687490   PMID:32728199   PMID:32877691   PMID:32994395   PMID:33022573   PMID:33060197   PMID:33845483   PMID:33990585   PMID:34079125  
PMID:34228876   PMID:34232536   PMID:34502139   PMID:34519429   PMID:34591612   PMID:34709727   PMID:34798798   PMID:34942634   PMID:34964862   PMID:35007762   PMID:35025629   PMID:35253629  
PMID:35271311   PMID:35509820   PMID:35643212   PMID:35831314   PMID:35906200   PMID:35944360   PMID:36042349   PMID:36215168   PMID:36217030   PMID:36261009   PMID:36398858   PMID:36590901  
PMID:36896912   PMID:37616343   PMID:37682539   PMID:37827155   PMID:38297188  


Genomics

Comparative Map Data
TOMM70
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383100,363,431 - 100,401,089 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3100,363,431 - 100,401,089 (-)EnsemblGRCh38hg38GRCh38
GRCh373100,082,275 - 100,119,933 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363101,564,997 - 101,602,915 (-)NCBINCBI36Build 36hg18NCBI36
Build 343101,564,998 - 101,602,915NCBI
Celera398,473,164 - 98,511,084 (-)NCBICelera
Cytogenetic Map3q12.2NCBI
HuRef397,450,096 - 97,488,049 (-)NCBIHuRef
CHM1_13100,045,331 - 100,083,272 (-)NCBICHM1_1
T2T-CHM13v2.03103,068,774 - 103,106,448 (-)NCBIT2T-CHM13v2.0
Tomm70a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391656,942,077 - 56,974,893 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1656,942,066 - 56,977,068 (+)EnsemblGRCm39 Ensembl
GRCm381657,121,714 - 57,154,530 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1657,121,703 - 57,156,705 (+)EnsemblGRCm38mm10GRCm38
MGSCv371657,121,827 - 57,154,643 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361657,043,073 - 57,075,889 (+)NCBIMGSCv36mm8
Celera1657,455,013 - 57,487,868 (+)NCBICelera
Cytogenetic Map16C1.1NCBI
cM Map1634.22NCBI
Tomm70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81156,847,837 - 56,886,302 (-)NCBIGRCr8
mRatBN7.21143,378,719 - 43,417,166 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,377,216 - 43,417,202 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1152,153,913 - 52,192,339 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01144,815,517 - 44,853,943 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01143,939,611 - 43,978,037 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01145,477,053 - 45,511,409 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1145,480,250 - 45,510,961 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01148,669,804 - 48,706,365 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41144,302,535 - 44,341,250 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11144,360,417 - 44,398,702 (-)NCBI
Celera1143,168,344 - 43,206,551 (-)NCBICelera
Cytogenetic Map11q12NCBI
Tomm70
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554271,876,222 - 1,908,737 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554271,874,277 - 1,908,245 (-)NCBIChiLan1.0ChiLan1.0
TOMM70
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2298,306,633 - 98,344,497 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1398,311,415 - 98,348,981 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0397,459,180 - 97,497,175 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13104,139,473 - 104,177,061 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3104,139,473 - 104,178,074 (-)Ensemblpanpan1.1panPan2
TOMM70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1336,976,322 - 7,009,618 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl336,976,934 - 7,009,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha337,130,612 - 7,165,083 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0337,114,093 - 7,148,576 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl337,114,753 - 7,148,568 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1337,001,694 - 7,036,139 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0337,050,040 - 7,084,498 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0337,379,916 - 7,414,382 (-)NCBIUU_Cfam_GSD_1.0
Tomm70
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602150,008,687 - 150,042,592 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366302,906,581 - 2,940,608 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366302,906,573 - 2,938,837 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOMM70
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13158,577,379 - 158,628,262 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113158,577,026 - 158,629,878 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213168,193,917 - 168,218,856 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TOMM70
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12280,477,429 - 80,516,536 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2280,477,872 - 80,516,670 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604186,056,352 - 86,094,501 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tomm70
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478913,792,049 - 13,829,104 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478913,792,434 - 13,828,403 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TOMM70
14 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3q11.1-21.1(chr3:93886671-123216683)x1 copy number loss See cases [RCV000051543] Chr3:93886671..123216683 [GRCh38]
Chr3:93605515..122935530 [GRCh37]
Chr3:95088205..124418220 [NCBI36]
Chr3:3q11.1-21.1		 pathogenic
GRCh38/hg38 3q11.1-13.31(chr3:93819623-116887056)x1 copy number loss See cases [RCV000135320] Chr3:93819623..116887056 [GRCh38]
Chr3:93538467..116605903 [GRCh37]
Chr3:95021157..118088593 [NCBI36]
Chr3:3q11.1-13.31		 pathogenic
GRCh38/hg38 3q11.2-13.31(chr3:97795369-115663349)x1 copy number loss See cases [RCV000138186] Chr3:97795369..115663349 [GRCh38]
Chr3:97514213..115382196 [GRCh37]
Chr3:98996903..116864886 [NCBI36]
Chr3:3q11.2-13.31		 pathogenic|uncertain significance
GRCh38/hg38 3q12.1-12.2(chr3:99759385-100405781)x1 copy number loss See cases [RCV000139111] Chr3:99759385..100405781 [GRCh38]
Chr3:99478229..100124625 [GRCh37]
Chr3:100960919..101607315 [NCBI36]
Chr3:3q12.1-12.2		 uncertain significance
GRCh38/hg38 3q11.1-24(chr3:93800620-145695381)x3 copy number gain See cases [RCV000142340] Chr3:93800620..145695381 [GRCh38]
Chr3:93519464..145413168 [GRCh37]
Chr3:95002154..146895858 [NCBI36]
Chr3:3q11.1-24		 pathogenic
GRCh38/hg38 3q11.1-13.11(chr3:93819623-103888749)x3 copy number gain See cases [RCV000143259] Chr3:93819623..103888749 [GRCh38]
Chr3:93538467..103607593 [GRCh37]
Chr3:95021157..105090283 [NCBI36]
Chr3:3q11.1-13.11		 likely pathogenic|uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
NM_014820.5(TOMM70):c.945T>C (p.Ser315=) single nucleotide variant not provided [RCV000966877] Chr3:100377852 [GRCh38]
Chr3:100096696 [GRCh37]
Chr3:3q12.2		 benign
NM_014820.5(TOMM70):c.1820C>T (p.Thr607Ile) single nucleotide variant TOMM70-related neurodevelopmental disorder [RCV001090140] Chr3:100365571 [GRCh38]
Chr3:100084415 [GRCh37]
Chr3:3q12.2		 uncertain significance
NM_014820.5(TOMM70):c.794C>T (p.Thr265Met) single nucleotide variant not provided [RCV001267887] Chr3:100381705 [GRCh38]
Chr3:100100549 [GRCh37]
Chr3:3q12.2		 uncertain significance
NM_014820.5(TOMM70):c.1745C>T (p.Ala582Val) single nucleotide variant not provided [RCV001267888] Chr3:100365646 [GRCh38]
Chr3:100084490 [GRCh37]
Chr3:3q12.2		 uncertain significance
GRCh37/hg19 3q11.2-12.3(chr3:95563096-102371126)x1 copy number loss not provided [RCV001259224] Chr3:95563096..102371126 [GRCh37]
Chr3:3q11.2-12.3		 likely pathogenic
NM_014820.5(TOMM70):c.493C>T (p.Gln165Ter) single nucleotide variant TOMM70-related neurodevelopmental disorder [RCV001807927] Chr3:100386810 [GRCh38]
Chr3:100105654 [GRCh37]
Chr3:3q12.2		 uncertain significance
NM_014820.5(TOMM70):c.1612A>G (p.Ile538Val) single nucleotide variant See cases [RCV003151957] Chr3:100368105 [GRCh38]
Chr3:100086949 [GRCh37]
Chr3:3q12.2		 likely benign
NM_014820.5(TOMM70):c.1476del (p.Phe492fs) deletion See cases [RCV003151958] Chr3:100369112 [GRCh38]
Chr3:100087956 [GRCh37]
Chr3:3q12.2		 uncertain significance
NM_014820.5(TOMM70):c.1784C>G (p.Thr595Arg) single nucleotide variant Inborn genetic diseases [RCV002970009] Chr3:100365607 [GRCh38]
Chr3:100084451 [GRCh37]
Chr3:3q12.2		 uncertain significance
NM_014820.5(TOMM70):c.122T>G (p.Leu41Arg) single nucleotide variant Inborn genetic diseases [RCV002771883] Chr3:100400828 [GRCh38]
Chr3:100119672 [GRCh37]
Chr3:3q12.2		 uncertain significance
NM_014820.5(TOMM70):c.230T>G (p.Leu77Arg) single nucleotide variant Inborn genetic diseases [RCV002762705] Chr3:100400720 [GRCh38]
Chr3:100119564 [GRCh37]
Chr3:3q12.2		 uncertain significance
NM_014820.5(TOMM70):c.1367C>T (p.Ser456Leu) single nucleotide variant Inborn genetic diseases [RCV003003852] Chr3:100372691 [GRCh38]
Chr3:100091535 [GRCh37]
Chr3:3q12.2		 uncertain significance
NM_014820.5(TOMM70):c.1352C>T (p.Thr451Met) single nucleotide variant Inborn genetic diseases [RCV002747413] Chr3:100372706 [GRCh38]
Chr3:100091550 [GRCh37]
Chr3:3q12.2		 uncertain significance
NM_014820.5(TOMM70):c.1082C>G (p.Ala361Gly) single nucleotide variant Inborn genetic diseases [RCV002718644] Chr3:100377715 [GRCh38]
Chr3:100096559 [GRCh37]
Chr3:3q12.2		 uncertain significance
NM_014820.5(TOMM70):c.1193C>T (p.Pro398Leu) single nucleotide variant Inborn genetic diseases [RCV002679303] Chr3:100375052 [GRCh38]
Chr3:100093896 [GRCh37]
Chr3:3q12.2		 uncertain significance
GRCh38/hg38 3q11.1-21.2(chr3:93979547-124774010)x1 copy number loss Chromosome 3q13.31 deletion syndrome [RCV003327614] Chr3:93979547..124774010 [GRCh38]
Chr3:3q11.1-21.2		 pathogenic
GRCh37/hg19 3q11.1-12.3(chr3:93519465-101464485)x3 copy number gain not specified [RCV003986472] Chr3:93519465..101464485 [GRCh37]
Chr3:3q11.1-12.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:955
Count of miRNA genes:666
Interacting mature miRNAs:767
Transcripts:ENST00000284320, ENST00000483945, ENST00000492171
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH94012  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373100,121,790 - 100,121,972UniSTSGRCh37
Build 363101,604,480 - 101,604,662RGDNCBI36
Celera398,512,649 - 98,512,831RGD
Cytogenetic Map3q12.2UniSTS
HuRef397,489,597 - 97,489,779UniSTS
GeneMap99-GB4 RH Map3347.02UniSTS
RH91974  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373100,090,869 - 100,091,011UniSTSGRCh37
Build 363101,573,559 - 101,573,701RGDNCBI36
Celera398,481,728 - 98,481,870RGD
Cytogenetic Map3q12.2UniSTS
HuRef397,458,662 - 97,458,804UniSTS
GeneMap99-GB4 RH Map3357.67UniSTS
Bda09a02  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373100,082,943 - 100,083,057UniSTSGRCh37
Build 363101,565,633 - 101,565,747RGDNCBI36
Celera398,473,800 - 98,473,914RGD
Cytogenetic Map3q12.2UniSTS
HuRef397,450,736 - 97,450,850UniSTS
TNG Radiation Hybrid Map357984.0UniSTS
GeneMap99-GB4 RH Map3347.02UniSTS
RH47396  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373100,084,975 - 100,085,094UniSTSGRCh37
Build 363101,567,665 - 101,567,784RGDNCBI36
Celera398,475,832 - 98,475,951RGD
Cytogenetic Map3q12.2UniSTS
HuRef397,452,768 - 97,452,887UniSTS
GeneMap99-GB4 RH Map3358.77UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2426 2137 1715 619 1247 461 4357 2068 3408 402 1448 1607 172 1203 2788 4
Low 13 851 11 5 701 4 129 326 17 12 6 3 1 1 2 2
Below cutoff 3 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000284320   ⟹   ENSP00000284320
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3100,363,431 - 100,401,089 (-)Ensembl
RefSeq Acc Id: ENST00000483945
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3100,372,006 - 100,373,725 (-)Ensembl
RefSeq Acc Id: ENST00000492171
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3100,377,416 - 100,381,772 (-)Ensembl
RefSeq Acc Id: NM_014820   ⟹   NP_055635
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383100,363,431 - 100,401,089 (-)NCBI
GRCh373100,082,303 - 100,120,242 (-)NCBI
Build 363101,564,997 - 101,602,915 (-)NCBI Archive
HuRef397,450,096 - 97,488,049 (-)NCBI
CHM1_13100,045,331 - 100,083,272 (-)NCBI
T2T-CHM13v2.03103,068,774 - 103,106,448 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_055635   ⟸   NM_014820
- UniProtKB: D3DN48 (UniProtKB/Swiss-Prot),   O94826 (UniProtKB/Swiss-Prot),   B4DZ87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000284320   ⟸   ENST00000284320

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O94826-F1-model_v2 AlphaFold O94826 1-608 view protein structure

Promoters
RGD ID:6865116
Promoter ID:EPDNEW_H5723
Type:initiation region
Name:TOMM70_2
Description:translocase of outer mitochondrial membrane 70
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5725  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh383100,401,082 - 100,401,142EPDNEW
RGD ID:6865120
Promoter ID:EPDNEW_H5725
Type:initiation region
Name:TOMM70_1
Description:translocase of outer mitochondrial membrane 70
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5723  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh383100,401,408 - 100,401,468EPDNEW
RGD ID:6801816
Promoter ID:HG_KWN:45684
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_2Hour,   Jurkat
Transcripts:NM_014820
Position:
Human AssemblyChrPosition (strand)Source
Build 363101,602,196 - 101,602,857 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11985 AgrOrtholog
COSMIC TOMM70 COSMIC
Ensembl Genes ENSG00000154174 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000284320 ENTREZGENE
  ENST00000284320.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000154174 GTEx
HGNC ID HGNC:11985 ENTREZGENE
Human Proteome Map TOMM70 Human Proteome Map
InterPro TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:9868 UniProtKB/Swiss-Prot
NCBI Gene 9868 ENTREZGENE
OMIM 606081 OMIM
PANTHER MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70 UniProtKB/Swiss-Prot
  MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70 UniProtKB/Swiss-Prot
  MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70 UniProtKB/TrEMBL
  MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70 UniProtKB/TrEMBL
Pfam TPR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36669 PharmGKB
PROSITE TPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B4DZ87 ENTREZGENE, UniProtKB/TrEMBL
  D3DN48 ENTREZGENE
  O94826 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary D3DN48 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 TOMM70  translocase of outer mitochondrial membrane 70  TOMM70A  translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED