TOMM70 (translocase of outer mitochondrial membrane 70) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: TOMM70 (translocase of outer mitochondrial membrane 70) Canis lupus familiaris
Analyze
Symbol: TOMM70
Name: translocase of outer mitochondrial membrane 70
RGD ID: 12260644
Description: ENCODES a protein that exhibits molecular adaptor activity (inferred); INVOLVED IN negative regulation of cell growth involved in cardiac muscle cell development (ortholog); positive regulation of protein targeting to mitochondrion (ortholog); protein targeting to mitochondrion (ortholog); PARTICIPATES IN alpha-helical insertion pathway of mitochondrial protein import; beta-barrel pathway of mitochondrial protein import; carrier pathway of mitochondrial protein import; ASSOCIATED WITH Cardiomegaly (ortholog); congestive heart failure (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN mitochondrial membrane (ortholog); mitochondrial outer membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mitochondrial import receptor subunit TOM70
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1336,976,322 - 7,009,618 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl336,976,934 - 7,009,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha337,130,612 - 7,165,083 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0337,114,093 - 7,148,576 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl337,114,753 - 7,148,568 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1337,001,694 - 7,036,139 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0337,050,040 - 7,084,498 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0337,379,916 - 7,414,382 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
TOMM70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1336,976,322 - 7,009,618 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl336,976,934 - 7,009,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha337,130,612 - 7,165,083 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0337,114,093 - 7,148,576 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl337,114,753 - 7,148,568 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1337,001,694 - 7,036,139 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0337,050,040 - 7,084,498 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0337,379,916 - 7,414,382 (-)NCBIUU_Cfam_GSD_1.0
TOMM70
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383100,363,431 - 100,401,089 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3100,363,431 - 100,401,089 (-)EnsemblGRCh38hg38GRCh38
GRCh373100,082,275 - 100,119,933 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363101,564,997 - 101,602,915 (-)NCBINCBI36Build 36hg18NCBI36
Build 343101,564,998 - 101,602,915NCBI
Celera398,473,164 - 98,511,084 (-)NCBICelera
Cytogenetic Map3q12.2NCBI
HuRef397,450,096 - 97,488,049 (-)NCBIHuRef
CHM1_13100,045,331 - 100,083,272 (-)NCBICHM1_1
T2T-CHM13v2.03103,068,774 - 103,106,448 (-)NCBIT2T-CHM13v2.0
Tomm70a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391656,942,077 - 56,974,893 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1656,942,066 - 56,977,068 (+)EnsemblGRCm39 Ensembl
GRCm381657,121,714 - 57,154,530 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1657,121,703 - 57,156,705 (+)EnsemblGRCm38mm10GRCm38
MGSCv371657,121,827 - 57,154,643 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361657,043,073 - 57,075,889 (+)NCBIMGSCv36mm8
Celera1657,455,013 - 57,487,868 (+)NCBICelera
Cytogenetic Map16C1.1NCBI
cM Map1634.22NCBI
Tomm70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81156,847,837 - 56,886,302 (-)NCBIGRCr8
mRatBN7.21143,378,719 - 43,417,166 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,377,216 - 43,417,202 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1152,153,913 - 52,192,339 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01144,815,517 - 44,853,943 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01143,939,611 - 43,978,037 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01145,477,053 - 45,511,409 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1145,480,250 - 45,510,961 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01148,669,804 - 48,706,365 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41144,302,535 - 44,341,250 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11144,360,417 - 44,398,702 (-)NCBI
Celera1143,168,344 - 43,206,551 (-)NCBICelera
Cytogenetic Map11q12NCBI
Tomm70
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554271,876,222 - 1,908,737 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554271,874,277 - 1,908,245 (-)NCBIChiLan1.0ChiLan1.0
TOMM70
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2298,306,633 - 98,344,497 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1398,311,415 - 98,348,981 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0397,459,180 - 97,497,175 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13104,139,473 - 104,177,061 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3104,139,473 - 104,178,074 (-)Ensemblpanpan1.1panPan2
Tomm70
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602150,008,687 - 150,042,592 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366302,906,581 - 2,940,608 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366302,906,573 - 2,938,837 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOMM70
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13158,577,379 - 158,628,262 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113158,577,026 - 158,629,878 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213168,193,917 - 168,218,856 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TOMM70
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12280,477,429 - 80,516,536 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2280,477,872 - 80,516,670 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604186,056,352 - 86,094,501 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tomm70
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478913,792,049 - 13,829,104 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478913,792,434 - 13,828,403 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TOMM70
348 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022414015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038444742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038444743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038519068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038519069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038582602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038582603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038647024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038647025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_535719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005306196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005317120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005349261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005383207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005416855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000014803   ⟹   ENSCAFP00000013696
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl336,976,934 - 7,009,594 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000087460   ⟹   ENSCAFP00000050186
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl336,976,934 - 7,008,918 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845032540   ⟹   ENSCAFP00845025447
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl337,114,753 - 7,148,568 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845032640   ⟹   ENSCAFP00845025526
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl337,114,753 - 7,147,896 (-)Ensembl
RefSeq Acc Id: XM_022414015   ⟹   XP_022269723
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1336,976,322 - 7,009,616 (-)NCBI
Dog10K_Boxer_Tasha337,130,612 - 7,165,077 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038444742   ⟹   XP_038300670
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0337,114,093 - 7,148,576 (-)NCBI
RefSeq Acc Id: XM_038444743   ⟹   XP_038300671
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0337,114,093 - 7,148,569 (-)NCBI
RefSeq Acc Id: XM_038519068   ⟹   XP_038374996
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1337,001,694 - 7,036,139 (-)NCBI
RefSeq Acc Id: XM_038519069   ⟹   XP_038374997
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1337,001,694 - 7,036,132 (-)NCBI
RefSeq Acc Id: XM_038582602   ⟹   XP_038438530
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0337,379,916 - 7,414,382 (-)NCBI
RefSeq Acc Id: XM_038582603   ⟹   XP_038438531
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0337,379,916 - 7,414,375 (-)NCBI
RefSeq Acc Id: XM_038647024   ⟹   XP_038502952
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0337,050,040 - 7,084,498 (-)NCBI
RefSeq Acc Id: XM_038647025   ⟹   XP_038502953
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0337,050,040 - 7,084,491 (-)NCBI
RefSeq Acc Id: XM_535719   ⟹   XP_535719
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1336,976,322 - 7,009,618 (-)NCBI
Dog10K_Boxer_Tasha337,130,612 - 7,165,083 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005306196
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0337,114,093 - 7,148,576 (-)NCBI
RefSeq Acc Id: XR_005317120
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha337,130,612 - 7,165,083 (-)NCBI
RefSeq Acc Id: XR_005349261
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1337,001,694 - 7,036,139 (-)NCBI
RefSeq Acc Id: XR_005383207
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0337,379,916 - 7,414,382 (-)NCBI
RefSeq Acc Id: XR_005416855
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0337,050,040 - 7,084,498 (-)NCBI
RefSeq Acc Id: XP_535719   ⟸   XM_535719
- Peptide Label: isoform X1
- UniProtKB: A0A8C0K8N2 (UniProtKB/TrEMBL),   A0A8C0P4G2 (UniProtKB/TrEMBL),   A0A8I3P6B7 (UniProtKB/TrEMBL),   A0A8C0TLQ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022269723   ⟸   XM_022414015
- Peptide Label: isoform X2
- UniProtKB: A0A8C0THL1 (UniProtKB/TrEMBL),   A0A8I3S0H1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000050186   ⟸   ENSCAFT00000087460
Ensembl Acc Id: ENSCAFP00000013696   ⟸   ENSCAFT00000014803
RefSeq Acc Id: XP_038374996   ⟸   XM_038519068
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038374997   ⟸   XM_038519069
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038502952   ⟸   XM_038647024
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038502953   ⟸   XM_038647025
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038300670   ⟸   XM_038444742
- Peptide Label: isoform X1
- UniProtKB: A0A8C0K8N2 (UniProtKB/TrEMBL),   A0A8C0P4G2 (UniProtKB/TrEMBL),   A0A8I3P6B7 (UniProtKB/TrEMBL),   A0A8C0TLQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038300671   ⟸   XM_038444743
- Peptide Label: isoform X2
- UniProtKB: A0A8C0THL1 (UniProtKB/TrEMBL),   A0A8I3S0H1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038438530   ⟸   XM_038582602
- Peptide Label: isoform X1
- UniProtKB: A0A8C0K8N2 (UniProtKB/TrEMBL),   A0A8C0P4G2 (UniProtKB/TrEMBL),   A0A8C0TLQ3 (UniProtKB/TrEMBL),   A0A8I3P6B7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038438531   ⟸   XM_038582603
- Peptide Label: isoform X2
- UniProtKB: A0A8C0THL1 (UniProtKB/TrEMBL),   A0A8I3S0H1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845025526   ⟸   ENSCAFT00845032640
Ensembl Acc Id: ENSCAFP00845025447   ⟸   ENSCAFT00845032540

Promoters
RGD ID:13688779
Promoter ID:EPDNEW_C6847
Type:initiation region
Name:TOMM70_1
Description:translocase of outer mitochondrial membrane 70
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1337,009,610 - 7,009,670EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009301 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030021043 UniProtKB/TrEMBL
  ENSCAFG00040023005 UniProtKB/TrEMBL
  ENSCAFG00845018398 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000014803.5 UniProtKB/TrEMBL
  ENSCAFT00000087460.2 UniProtKB/TrEMBL
  ENSCAFT00030038669.1 UniProtKB/TrEMBL
  ENSCAFT00030038767.1 UniProtKB/TrEMBL
  ENSCAFT00040042758.1 UniProtKB/TrEMBL
  ENSCAFT00040042841.1 UniProtKB/TrEMBL
  ENSCAFT00845032540 ENTREZGENE
  ENSCAFT00845032540.1 UniProtKB/TrEMBL
  ENSCAFT00845032640 ENTREZGENE
  ENSCAFT00845032640.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
InterPro TPR-like_helical_dom_sf UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
NCBI Gene TOMM70 ENTREZGENE
PANTHER MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70 UniProtKB/TrEMBL
  MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70 UniProtKB/TrEMBL
Pfam TPR_1 UniProtKB/TrEMBL
  TPR_8 UniProtKB/TrEMBL
PROSITE TPR UniProtKB/TrEMBL
  TPR_REGION UniProtKB/TrEMBL
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt A0A8C0K8N2 ENTREZGENE
  A0A8C0P4G2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0THL1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TLQ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P6B7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S0H1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:49630 ENTREZGENE