Ndufa3 (NADH:ubiquinone oxidoreductase subunit A3) - Rat Genome Database

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Gene: Ndufa3 (NADH:ubiquinone oxidoreductase subunit A3) Mus musculus
Analyze
Symbol: Ndufa3
Name: NADH:ubiquinone oxidoreductase subunit A3
RGD ID: 1323448
MGI Page MGI
Description: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Is expressed in brown fat. Orthologous to human NDUFA3 (NADH:ubiquinone oxidoreductase subunit A3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1010001M12Rik; 1700022J01Rik; CI-B9; Complex I-B9; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3; NADH-ubiquinone oxidoreductase B9 subunit
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3973,620,372 - 3,623,162 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl73,620,372 - 3,623,326 (+)EnsemblGRCm39 Ensembl
GRCm3873,617,347 - 3,620,165 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl73,617,373 - 3,620,327 (+)EnsemblGRCm38mm10GRCm38
MGSCv3773,568,975 - 3,571,763 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3673,220,460 - 3,223,248 (+)NCBIMGSCv36mm8
Celera73,529,176 - 3,531,956 (+)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.08NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butan-1-ol  (ISO)
chloropicrin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
disodium selenite  (ISO)
diuron  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
ethylparaben  (ISO)
fenthion  (EXP)
flutamide  (EXP)
folic acid  (EXP)
gallic acid  (ISO)
gentamycin  (ISO)
glyphosate  (EXP)
hydralazine  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
lipopolysaccharide  (EXP,ISO)
methidathion  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
ochratoxin A  (ISO)
oxybenzone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phlorizin  (EXP)
pirinixic acid  (EXP,ISO)
quercetin  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
triphenyl phosphate  (ISO)
tungsten  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12865426   PMID:14681479   PMID:16141072   PMID:16141073   PMID:18614015   PMID:18799693  
PMID:21267068   PMID:21556144   PMID:21873635   PMID:25863250   PMID:26876175   PMID:27407143   PMID:30030361   PMID:30550785   PMID:31097699   PMID:32325033   PMID:36220812  


Genomics

Comparative Map Data
Ndufa3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3973,620,372 - 3,623,162 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl73,620,372 - 3,623,326 (+)EnsemblGRCm39 Ensembl
GRCm3873,617,347 - 3,620,165 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl73,617,373 - 3,620,327 (+)EnsemblGRCm38mm10GRCm38
MGSCv3773,568,975 - 3,571,763 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3673,220,460 - 3,223,248 (+)NCBIMGSCv36mm8
Celera73,529,176 - 3,531,956 (+)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.08NCBI
NDUFA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381954,102,855 - 54,107,568 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1954,102,728 - 54,109,257 (+)EnsemblGRCh38hg38GRCh38
GRCh371954,606,163 - 54,610,875 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361959,297,972 - 59,302,080 (+)NCBINCBI36Build 36hg18NCBI36
Build 341959,297,971 - 59,302,078NCBI
Celera1951,645,840 - 51,649,962 (+)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1950,922,024 - 50,926,151 (+)NCBIHuRef
CHM1_11954,607,871 - 54,611,993 (+)NCBICHM1_1
T2T-CHM13v2.01957,180,922 - 57,186,265 (+)NCBIT2T-CHM13v2.0
Ndufa3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8174,512,928 - 74,515,558 (-)NCBIGRCr8
mRatBN7.2165,597,567 - 65,600,197 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,597,578 - 65,600,235 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx171,045,692 - 71,048,322 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,468,668 - 79,471,298 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0172,795,531 - 72,798,151 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0164,172,462 - 64,175,174 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl164,172,540 - 64,175,099 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0163,164,744 - 63,167,429 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4163,910,487 - 63,913,120 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera163,322,486 - 63,325,198 (-)NCBICelera
Cytogenetic Map1q12NCBI
Ndufa3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955604139,844 - 141,578 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955604139,844 - 141,578 (-)NCBIChiLan1.0ChiLan1.0
NDUFA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22060,106,633 - 60,113,906 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11962,028,541 - 62,035,997 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01951,034,675 - 51,041,025 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11959,878,237 - 59,885,049 (+)NCBIpanpan1.1PanPan1.1panPan2
NDUFA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11103,098,639 - 103,101,226 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1103,160,460 - 103,163,047 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,743,822 - 103,746,409 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1103,743,825 - 103,746,061 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11103,381,701 - 103,384,288 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01103,143,107 - 103,145,694 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,857,234 - 103,859,821 (-)NCBIUU_Cfam_GSD_1.0
Ndufa3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,702,862 - 2,704,933 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936994232,936 - 234,939 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936994232,913 - 234,939 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDUFA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1656,018,221 - 56,021,318 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2653,196,363 - 53,199,447 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NDUFA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1646,779,015 - 46,782,564 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607326,867,931 - 26,871,530 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndufa3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248322,459,430 - 2,461,527 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248322,459,430 - 2,461,590 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1250
Count of miRNA genes:534
Interacting mature miRNAs:613
Transcripts:ENSMUST00000076657, ENSMUST00000108644, ENSMUST00000134683, ENSMUST00000148403, ENSMUST00000150497, ENSMUST00000156712
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12904948Tammq5_mtibialis anterior muscle mass QTL 5 (mouse)7121821047Mouse
1302115Abhr3_mallergen-induced bronchial hyperresponsiveness 3 (mouse)Not determined7331599616637423Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7335204824879418Mouse
12904941Edlmmq6_mextensor digitorum longus muscle mass QTL 6 (mouse)7121821047Mouse
25394570Skmw58_mskeletal muscle weight 58, TA (mouse)735524286281481Mouse
1301177Vent3_mventricular size 3 (mouse)Not determined7120511925Mouse
10054067Sle20_msystematic lupus erythematosus susceptibility 20 (mouse)Not determined7120511925Mouse
12904953Gmmq5_mgastrocnemius muscle mass QTL 5 (mouse)7121821047Mouse
1302188Lxw6_mlupus BXSB x NZW 6 (mouse)Not determined7121698146Mouse

Markers in Region
AI450389  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3873,620,492 - 3,620,588UniSTSGRCm38
MGSCv3773,572,094 - 3,572,190UniSTSGRCm37
Celera73,532,287 - 3,532,383UniSTS
Cytogenetic Map7A1UniSTS
Whitehead/MRC_RH728.93UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000076657   ⟹   ENSMUSP00000075953
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl73,620,372 - 3,623,326 (+)Ensembl
GRCm38.p6 Ensembl73,617,373 - 3,620,327 (+)Ensembl
Ensembl Acc Id: ENSMUST00000108644   ⟹   ENSMUSP00000104284
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl73,620,385 - 3,623,127 (+)Ensembl
GRCm38.p6 Ensembl73,617,386 - 3,620,128 (+)Ensembl
Ensembl Acc Id: ENSMUST00000134683   ⟹   ENSMUSP00000116828
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl73,620,616 - 3,623,084 (+)Ensembl
GRCm38.p6 Ensembl73,617,617 - 3,620,085 (+)Ensembl
Ensembl Acc Id: ENSMUST00000148403   ⟹   ENSMUSP00000116988
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl73,620,390 - 3,623,162 (+)Ensembl
GRCm38.p6 Ensembl73,617,391 - 3,620,163 (+)Ensembl
Ensembl Acc Id: ENSMUST00000150497
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl73,620,379 - 3,623,151 (+)Ensembl
GRCm38.p6 Ensembl73,617,380 - 3,620,152 (+)Ensembl
Ensembl Acc Id: ENSMUST00000156712
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl73,620,384 - 3,620,718 (+)Ensembl
GRCm38.p6 Ensembl73,617,385 - 3,617,719 (+)Ensembl
RefSeq Acc Id: NM_025348   ⟹   NP_079624
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3973,620,372 - 3,623,162 (+)NCBI
GRCm3873,617,373 - 3,620,163 (+)NCBI
MGSCv3773,568,975 - 3,571,763 (+)RGD
Celera73,529,176 - 3,531,956 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_079624   ⟸   NM_025348
- UniProtKB: Q0VBA7 (UniProtKB/Swiss-Prot),   Q9CQ91 (UniProtKB/Swiss-Prot),   D3Z670 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000075953   ⟸   ENSMUST00000076657
Ensembl Acc Id: ENSMUSP00000116988   ⟸   ENSMUST00000148403
Ensembl Acc Id: ENSMUSP00000116828   ⟸   ENSMUST00000134683
Ensembl Acc Id: ENSMUSP00000104284   ⟸   ENSMUST00000108644

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CQ91-F1-model_v2 AlphaFold Q9CQ91 1-84 view protein structure

Promoters
RGD ID:6841625
Promoter ID:MM_KWN:48383
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000108644,   NM_025348,   OTTMUST00000056821,   OTTMUST00000056822,   OTTMUST00000056824,   OTTMUST00000069088,   UC009EVD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3673,568,784 - 3,569,284 (+)MPROMDB
RGD ID:6891612
Promoter ID:EPDNEW_M9257
Type:multiple initiation site
Name:Ndufa3_1
Description:Mus musculus NADH dehydrogenase 1 alpha subcomplex, 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3873,617,380 - 3,617,440EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913341 AgrOrtholog
Ensembl Genes ENSMUSG00000035674 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000076657 ENTREZGENE
  ENSMUST00000076657.11 UniProtKB/Swiss-Prot
  ENSMUST00000108644.8 UniProtKB/TrEMBL
  ENSMUST00000134683.2 UniProtKB/TrEMBL
  ENSMUST00000148403.2 UniProtKB/TrEMBL
InterPro NDUFA3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:66091 UniProtKB/Swiss-Prot
MGD MGI:1913341 ENTREZGENE
NCBI Gene 66091 ENTREZGENE
PANTHER NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15221 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NADHdh_A3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ndufa3 PhenoGen
UniProt D3Z670 ENTREZGENE, UniProtKB/TrEMBL
  D6RGT3_MOUSE UniProtKB/TrEMBL
  F7BLS8_MOUSE UniProtKB/TrEMBL
  NDUA3_MOUSE UniProtKB/Swiss-Prot
  Q0VBA7 ENTREZGENE
  Q9CQ91 ENTREZGENE
  Q9DA27_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q0VBA7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-22 Ndufa3  NADH:ubiquinone oxidoreductase subunit A3    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3  Symbol and/or name change 5135510 APPROVED