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Gene: PTPN4 (protein tyrosine phosphatase non-receptor type 4) Homo sapiens

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Symbol:

PTPN4

Name:

protein tyrosine phosphatase non-receptor type 4

RGD ID:

1316480

HGNC Page

HGNC:9656

Description:

Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation. Located in cytoplasm and cytoplasmic side of plasma membrane.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

MEG; megakaryocyte phosphatase; megakaryocyte protein-tyrosine phosphatase; protein tyrosine phosphatase MEG1; protein-tyrosine phosphatase MEG1; PTPase-MEG1; PTPMEG; PTPMEG1; tyrosine-protein phosphatase non-receptor type 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Related Pseudogenes:

LOC100422495

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	119,759,922 - 119,984,899 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	119,759,922 - 119,984,899 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	120,517,498 - 120,742,475 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	120,233,677 - 120,451,507 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	120,233,436 - 120,451,267	NCBI
Celera	2	113,842,942 - 114,061,903 (+)	NCBI		Celera
Cytogenetic Map	2	q14.2	NCBI
HuRef	2	112,841,586 - 113,066,878 (+)	NCBI		HuRef
CHM1_1	2	120,520,785 - 120,746,914 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	120,193,967 - 120,419,641 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PTPN4	Human	genetic disease		IAGP	(Homo sapiens) more ...	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar
PTPN4	Human	intellectual disability		IAGP	(Homo sapiens)	8554872	ClinVar Annotator: match by term: Intellectual disability	ClinVar
PTPN4	Human	Neurodevelopmental Disorders		IAGP	(Homo sapiens)	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868
PTPN4	Human	Neurodevelopmental Disorders		IAGP	(Homo sapiens) and (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868 and PMID:34527963

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PTPN4	Human	(-)-epigallocatechin 3-gallate	multiple interactions	EXP		6480464	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PTPN4 mRNA	CTD	PMID:22079256
PTPN4	Human	1,2-dichloroethane	decreases expression	ISO	Ptpn4 (Mus musculus)	6480464	ethylene dichloride results in decreased expression of PTPN4 mRNA	CTD	PMID:28960355
PTPN4	Human	1-naphthyl isothiocyanate	decreases expression	ISO	Ptpn4 (Rattus norvegicus)	6480464	1-Naphthylisothiocyanate results in decreased expression of PTPN4 mRNA	CTD	PMID:30723492
PTPN4	Human	2,2',4,4',5,5'-hexachlorobiphenyl	multiple interactions	ISO	Ptpn4 (Mus musculus)	6480464	[2 more ...	CTD	PMID:25510870
PTPN4	Human	2,2',5,5'-tetrachlorobiphenyl	multiple interactions	ISO	Ptpn4 (Mus musculus)	6480464	[2 more ...	CTD	PMID:25510870
PTPN4	Human	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	Ptpn4 (Mus musculus)	6480464	Tetrachlorodibenzodioxin affects the expression of PTPN4 mRNA	CTD	PMID:24680724
PTPN4	Human	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	Ptpn4 (Rattus norvegicus)	6480464	Tetrachlorodibenzodioxin results in increased expression of PTPN4 mRNA	CTD	PMID:34747641
PTPN4	Human	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	Ptpn4 (Rattus norvegicus)	6480464	Tetrachlorodibenzodioxin results in decreased expression of PTPN4 mRNA	CTD	PMID:32109520 and PMID:33387578
PTPN4	Human	2,3,7,8-Tetrachlorodibenzofuran	decreases expression	ISO	Ptpn4 (Rattus norvegicus)	6480464	2 more ...	CTD	PMID:32109520
PTPN4	Human	3,4-methylenedioxymethamphetamine	decreases expression	ISO	Ptpn4 (Mus musculus)	6480464	N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of PTPN4 mRNA	CTD	PMID:26251327
PTPN4	Human	4-hydroxyphenyl retinamide	decreases expression	ISO	Ptpn4 (Mus musculus)	6480464	Fenretinide results in decreased expression of PTPN4 mRNA	CTD	PMID:28973697
PTPN4	Human	6-propyl-2-thiouracil	decreases expression	ISO	Ptpn4 (Rattus norvegicus)	6480464	Propylthiouracil results in decreased expression of PTPN4 mRNA	CTD	PMID:24780913
PTPN4	Human	acetamide	decreases expression	ISO	Ptpn4 (Rattus norvegicus)	6480464	acetamide results in decreased expression of PTPN4 mRNA	CTD	PMID:31881176
PTPN4	Human	aflatoxin B1	decreases methylation	EXP		6480464	Aflatoxin B1 results in decreased methylation of PTPN4 gene	CTD	PMID:27153756
PTPN4	Human	amphetamine	decreases expression	ISO	Ptpn4 (Rattus norvegicus)	6480464	Amphetamine results in decreased expression of PTPN4 mRNA	CTD	PMID:30779732
PTPN4	Human	aristolochic acid A	decreases expression	EXP		6480464	aristolochic acid I results in decreased expression of PTPN4 mRNA	CTD	PMID:33212167
PTPN4	Human	benzo[a]pyrene	decreases expression	EXP		6480464	Benzo(a)pyrene results in decreased expression of PTPN4 mRNA	CTD	PMID:21632981
PTPN4	Human	bisphenol A	affects methylation	ISO	Ptpn4 (Mus musculus)	6480464	bisphenol A affects the methylation of PTPN4 promoter	CTD	PMID:27334623
PTPN4	Human	bisphenol A	decreases expression	ISO	Ptpn4 (Rattus norvegicus)	6480464	bisphenol A results in decreased expression of PTPN4 mRNA	CTD	PMID:34947998
PTPN4	Human	bisphenol A	increases expression	ISO	Ptpn4 (Rattus norvegicus)	6480464	bisphenol A results in increased expression of PTPN4 mRNA	CTD	PMID:30816183 and PMID:33296240
PTPN4	Human	bisphenol A	increases methylation	ISO	Ptpn4 (Rattus norvegicus)	6480464	bisphenol A results in increased methylation of PTPN4 gene	CTD	PMID:28505145
PTPN4	Human	bisphenol F	increases expression	ISO	Ptpn4 (Mus musculus)	6480464	bisphenol F results in increased expression of PTPN4 mRNA	CTD	PMID:38685157
PTPN4	Human	cadmium atom	multiple interactions	EXP		6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PTPN4 mRNA	CTD	PMID:35301059
PTPN4	Human	cadmium dichloride	multiple interactions	EXP		6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PTPN4 mRNA	CTD	PMID:35301059
PTPN4	Human	CGP 52608	multiple interactions	EXP		6480464	CGP 52608 promotes the reaction [RORA protein binds to PTPN4 gene]	CTD	PMID:28238834
PTPN4	Human	chloroprene	increases expression	ISO	Ptpn4 (Rattus norvegicus)	6480464	Chloroprene results in increased expression of PTPN4 mRNA	CTD	PMID:23125180
PTPN4	Human	chlorpyrifos	decreases expression	ISO	Ptpn4 (Mus musculus)	6480464	Chlorpyrifos results in decreased expression of PTPN4 mRNA	CTD	PMID:37019170
PTPN4	Human	crocin-1	multiple interactions	EXP		6480464	MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein] and PTPN4 protein affects the reaction [crocin results in increased activity of CASP3 protein]	CTD	PMID:35085590
PTPN4	Human	crocin-1	increases expression	EXP		6480464	crocin results in increased expression of PTPN4 protein	CTD	PMID:35085590
PTPN4	Human	dicrotophos	decreases expression	EXP		6480464	dicrotophos results in decreased expression of PTPN4 mRNA	CTD	PMID:28302478
PTPN4	Human	doxorubicin	decreases expression	EXP		6480464	Doxorubicin results in decreased expression of PTPN4 mRNA	CTD	PMID:29803840
PTPN4	Human	ethanol	decreases expression	ISO	Ptpn4 (Mus musculus)	6480464	Ethanol results in decreased expression of PTPN4 mRNA	CTD	PMID:29018328
PTPN4	Human	flutamide	increases expression	ISO	Ptpn4 (Rattus norvegicus)	6480464	Flutamide results in increased expression of PTPN4 mRNA	CTD	PMID:24793618
PTPN4	Human	maneb	affects activity	EXP		6480464	Maneb affects the activity of PTPN4 protein	CTD	PMID:23611293
PTPN4	Human	methidathion	decreases expression	ISO	Ptpn4 (Mus musculus)	6480464	methidathion results in decreased expression of PTPN4 mRNA	CTD	PMID:34813904
PTPN4	Human	methylmercury chloride	decreases expression	EXP		6480464	methylmercuric chloride results in decreased expression of PTPN4 mRNA	CTD	PMID:28001369
PTPN4	Human	oxybenzone	increases expression	EXP		6480464	oxybenzone results in increased expression of PTPN4 mRNA	CTD	PMID:36581016
PTPN4	Human	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of PTPN4 mRNA	CTD	PMID:26690555
PTPN4	Human	paracetamol	increases expression	ISO	Ptpn4 (Rattus norvegicus)	6480464	Acetaminophen results in increased expression of PTPN4 mRNA	CTD	PMID:33387578
PTPN4	Human	PCB138	multiple interactions	ISO	Ptpn4 (Mus musculus)	6480464	[2 more ...	CTD	PMID:25510870
PTPN4	Human	pirinixic acid	multiple interactions	EXP		6480464	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PTPN4 mRNA	CTD	PMID:19710929
PTPN4	Human	pirinixic acid	increases expression	ISO	Ptpn4 (Mus musculus)	6480464	pirinixic acid results in increased expression of PTPN4 mRNA	CTD	PMID:18301758
PTPN4	Human	potassium chromate	decreases expression	EXP		6480464	potassium chromate(VI) results in decreased expression of PTPN4 mRNA	CTD	PMID:22079256
PTPN4	Human	potassium chromate	multiple interactions	EXP		6480464	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PTPN4 mRNA	CTD	PMID:22079256
PTPN4	Human	raloxifene	affects expression	EXP		6480464	Raloxifene Hydrochloride affects the expression of PTPN4 mRNA	CTD	PMID:14699072
PTPN4	Human	silicon dioxide	decreases expression	EXP		6480464	Silicon Dioxide results in decreased expression of PTPN4 mRNA	CTD	PMID:25351596
PTPN4	Human	tamoxifen	affects expression	EXP		6480464	Tamoxifen affects the expression of PTPN4 mRNA	CTD	PMID:14699072
PTPN4	Human	testosterone enanthate	affects expression	EXP		6480464	testosterone enanthate affects the expression of PTPN4 mRNA	CTD	PMID:17440010
PTPN4	Human	tetrachloromethane	increases expression	ISO	Ptpn4 (Rattus norvegicus)	6480464	Carbon Tetrachloride results in increased expression of PTPN4 mRNA	CTD	PMID:31150632
PTPN4	Human	thimerosal	increases expression	EXP		6480464	Thimerosal results in increased expression of PTPN4 mRNA	CTD	PMID:27188386
PTPN4	Human	thiram	decreases expression	EXP		6480464	Thiram results in decreased expression of PTPN4 mRNA	CTD	PMID:38568856
PTPN4	Human	titanium dioxide	decreases methylation	ISO	Ptpn4 (Mus musculus)	6480464	titanium dioxide results in decreased methylation of PTPN4 promoter	CTD	PMID:35295148
PTPN4	Human	triphenyl phosphate	affects expression	EXP		6480464	triphenyl phosphate affects the expression of PTPN4 mRNA	CTD	PMID:37042841
PTPN4	Human	triptonide	increases expression	ISO	Ptpn4 (Mus musculus)	6480464	triptonide results in increased expression of PTPN4 mRNA	CTD	PMID:33045310
PTPN4	Human	valproic acid	decreases expression	EXP		6480464	Valproic Acid results in decreased expression of PTPN4 mRNA	CTD	PMID:23179753 and PMID:28001369
PTPN4	Human	valproic acid	decreases expression	ISO	Ptpn4 (Rattus norvegicus)	6480464	Valproic Acid results in decreased expression of PTPN4 mRNA	CTD	PMID:29427782
PTPN4	Human	valproic acid	affects splicing	ISO	Ptpn4 (Rattus norvegicus)	6480464	Valproic Acid affects the splicing of PTPN4 mRNA	CTD	PMID:29427782
PTPN4	Human	vinclozolin	increases expression	ISO	Ptpn4 (Rattus norvegicus)	6480464	vinclozolin results in increased expression of PTPN4 mRNA	CTD	PMID:23034163
PTPN4	Human	vorinostat	increases expression	EXP		6480464	vorinostat results in increased expression of PTPN4 mRNA	CTD	PMID:27188386

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PTPN4	Human	peptidyl-tyrosine phosphorylation	acts_upstream_of_or_within	ISO	Ptpn4 (Mus musculus)	9068941	PMID:33158444	MGI	PMID:33158444
PTPN4	Human	protein dephosphorylation	involved_in	TAS		150520179	PMID:1648233	PINC	PMID:1648233

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PTPN4	Human	cytoplasm	located_in	TAS		150520179	PMID:1648233	PINC	PMID:1648233
PTPN4	Human	cytoplasm	is_active_in	IBA	PANTHER:PTN001057123 more ...	150520179		GO_Central	GO_REF:0000033
PTPN4	Human	cytoplasm	located_in	IEA	UniProtKB-KW:KW-0963	150520179		UniProt	GO_REF:0000043
PTPN4	Human	cytoplasm	located_in	IDA		150520179	PMID:10940933	UniProt	PMID:10940933
PTPN4	Human	cytoplasm	located_in	IEA	UniProtKB-SubCell:SL-0086	150520179		UniProt	GO_REF:0000044
PTPN4	Human	cytoplasmic side of plasma membrane	located_in	IDA		150520179	PMID:10940933	UniProt	PMID:10940933
PTPN4	Human	cytoplasmic side of plasma membrane	is_active_in	IBA	PANTHER:PTN001057123 more ...	150520179		GO_Central	GO_REF:0000033
PTPN4	Human	cytoskeleton	located_in	IEA	InterPro:IPR000299	150520179		InterPro	GO_REF:0000002
PTPN4	Human	cytoskeleton	located_in	IEA	UniProtKB-SubCell:SL-0090	150520179		UniProt	GO_REF:0000044
PTPN4	Human	cytoskeleton	located_in	IEA	UniProtKB-KW:KW-0206	150520179		UniProt	GO_REF:0000043
PTPN4	Human	cytosol	located_in	TAS		150520179		Reactome	Reactome:R-HSA-9006585
PTPN4	Human	membrane	located_in	IEA	UniProtKB:Q9WU22 and ensembl:ENSMUSP00000067614	150520179		Ensembl	GO_REF:0000107
PTPN4	Human	membrane	located_in	IEA	UniProtKB-KW:KW-0472	150520179		UniProt	GO_REF:0000043
PTPN4	Human	nucleoplasm	located_in	TAS		150520179		Reactome	Reactome:R-HSA-9008894
PTPN4	Human	plasma membrane	located_in	IEA	UniProtKB-KW:KW-1003	150520179		UniProt	GO_REF:0000043
PTPN4	Human	plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0039	150520179		UniProt	GO_REF:0000044

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PTPN4	Human	cytoskeletal protein binding	enables	IEA	InterPro:IPR000798 and InterPro:IPR012151	150520179		InterPro	GO_REF:0000002
PTPN4	Human	glutamate receptor binding	enables	IEA	UniProtKB:Q9WU22 and ensembl:ENSMUSP00000067614	150520179		Ensembl	GO_REF:0000107
PTPN4	Human	hydrolase activity	enables	IEA	UniProtKB-KW:KW-0378	150520179		UniProt	GO_REF:0000043
PTPN4	Human	non-membrane spanning protein tyrosine phosphatase activity	enables	TAS		150520179	PMID:1648233	PINC	PMID:1648233
PTPN4	Human	non-membrane spanning protein tyrosine phosphatase activity	enables	IEA	UniProtKB:Q9WU22 and ensembl:ENSMUSP00000067614	150520179		Ensembl	GO_REF:0000107
PTPN4	Human	phosphoprotein phosphatase activity	enables	IEA	UniProtKB-KW:KW-0904	150520179		UniProt	GO_REF:0000043
PTPN4	Human	protein binding	enables	IPI	UniProtKB:O75400-2 more ...	150520179	PMID:32814053	IntAct	PMID:32814053
PTPN4	Human	protein binding	enables	IPI	UniProtKB:P46108	150520179	PMID:21988832	IntAct	PMID:21988832
PTPN4	Human	protein binding	enables	IPI	UniProtKB:Q92993	150520179	PMID:16169070	IntAct	PMID:16169070
PTPN4	Human	protein binding	enables	IPI	UniProtKB:P16333	150520179	PMID:17474147	IntAct	PMID:17474147
PTPN4	Human	protein binding	enables	IPI	UniProtKB:P53778	150520179	PMID:25158884	IntAct	PMID:25158884
PTPN4	Human	protein tyrosine phosphatase activity	enables	IEA	RHEA:10684	150520179		RHEA	GO_REF:0000116
PTPN4	Human	protein tyrosine phosphatase activity	enables	IEA	EC:3.1.3.48	150520179		UniProt	GO_REF:0000003
PTPN4	Human	protein tyrosine phosphatase activity	enables	IBA	FB:FBgn0261985 more ...	150520179		GO_Central	GO_REF:0000033
PTPN4	Human	protein tyrosine phosphatase activity	enables	IEA	InterPro:IPR000242 and InterPro:IPR012151	150520179		InterPro	GO_REF:0000002

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PTPN4	Human	Intellectual disability		IAGP	(Homo sapiens)	8554872	ClinVar Annotator: match by term: Intellectual disability	ClinVar

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:1648233	PMID:8910369	PMID:8917530	PMID:10748123	PMID:10940933	PMID:11054567	PMID:12477932	PMID:15489334	PMID:16169070	PMID:16226712	PMID:17474147	PMID:18614237
PMID:21873635	PMID:21900206	PMID:21988832	PMID:22000519	PMID:23666597	PMID:25158884	PMID:25424712	PMID:26053890	PMID:26186194	PMID:27246854	PMID:27432908	PMID:27880917
PMID:27923202	PMID:28330616	PMID:28514442	PMID:28611215	PMID:28675297	PMID:28801650	PMID:30021884	PMID:31025789	PMID:31586073	PMID:32814053	PMID:33961781	PMID:35089587
PMID:36042375	PMID:37747937	PMID:38630149	PMID:38761175

PTPN4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	119,759,922 - 119,984,899 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	119,759,922 - 119,984,899 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	120,517,498 - 120,742,475 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	120,233,677 - 120,451,507 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	120,233,436 - 120,451,267	NCBI
Celera	2	113,842,942 - 114,061,903 (+)	NCBI		Celera
Cytogenetic Map	2	q14.2	NCBI
HuRef	2	112,841,586 - 113,066,878 (+)	NCBI		HuRef
CHM1_1	2	120,520,785 - 120,746,914 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	120,193,967 - 120,419,641 (+)	NCBI		T2T-CHM13v2.0

Ptpn4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	119,580,197 - 119,765,281 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	119,580,197 - 119,765,343 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	119,652,467 - 119,837,585 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	119,652,467 - 119,837,613 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	121,554,669 - 121,733,648 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	121,487,291 - 121,630,021 (-)	NCBI		MGSCv36	mm8
Celera	1	122,316,986 - 122,496,376 (-)	NCBI		Celera
Cytogenetic Map	1	E2.3	NCBI
cM Map	1	52.39	NCBI

Ptpn4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	33,324,808 - 33,504,957 (-)	NCBI		GRCr8
mRatBN7.2	13	30,772,012 - 30,952,340 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	30,776,682 - 30,952,170 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	33,353,328 - 33,533,288 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	34,641,168 - 34,821,122 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	31,915,258 - 32,095,209 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	35,678,240 - 35,858,414 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	35,678,240 - 35,858,390 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	40,792,728 - 40,972,784 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	32,430,875 - 32,611,163 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	32,475,262 - 32,484,043 (-)	NCBI
Celera	13	30,666,333 - 30,846,454 (-)	NCBI		Celera
Cytogenetic Map	13	q11	NCBI

Ptpn4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955459	9,803,421 - 9,981,392 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955459	9,803,421 - 9,981,392 (-)	NCBI	ChiLan1.0	ChiLan1.0

PTPN4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	21,735,494 - 21,982,547 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	21,750,466 - 21,998,093 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	6,694,192 - 6,917,265 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	120,320,591 - 120,492,423 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	120,320,610 - 120,485,676 (+)	Ensembl	panpan1.1		panPan2

PTPN4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	30,079,221 - 30,285,126 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	30,086,832 - 30,241,064 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	30,335,314 - 30,541,476 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	31,454,630 - 31,662,707 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	31,461,882 - 31,663,169 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	30,140,713 - 30,349,797 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	30,310,819 - 30,517,448 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	31,493,639 - 31,702,636 (-)	NCBI		UU_Cfam_GSD_1.0

Ptpn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	90,976,332 - 91,149,472 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	50,470,256 - 50,594,357 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	50,463,473 - 50,641,419 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTPN4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	31,307,447 - 31,502,923 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	31,305,394 - 31,502,978 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	36,235,035 - 36,459,764 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PTPN4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	10,325,263 - 10,554,381 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	10,328,766 - 10,554,258 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666061	12,136,097 - 12,365,467 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ptpn4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	25,108,192 - 25,278,948 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624732	25,099,327 - 25,301,610 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in PTPN4
100 total Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 2q14.1-21.3(chr2:118086324-134964738)x1	copy number loss	See cases [RCV000054058]	Chr2:118086324..134964738 [GRCh38] Chr2:118843900..135722308 [GRCh37] Chr2:118560370..135438778 [NCBI36] Chr2:2q14.1-21.3	pathogenic
NM_002830.3(PTPN4):c.138+19627T>G	single nucleotide variant	Lung cancer [RCV000091239]	Chr2:119829618 [GRCh38] Chr2:120587194 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.3(PTPN4):c.139-8631G>A	single nucleotide variant	Lung cancer [RCV000091240]	Chr2:119853905 [GRCh38] Chr2:120611481 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1355+1G>A	single nucleotide variant	not provided [RCV003104336]	Chr2:119934959 [GRCh38] Chr2:120692535 [GRCh37] Chr2:2q14.2	likely pathogenic
NM_002830.4(PTPN4):c.1738G>T (p.Asp580Tyr)	single nucleotide variant	Intellectual disability [RCV001293771]	Chr2:119952054 [GRCh38] Chr2:120709630 [GRCh37] Chr2:2q14.2	likely pathogenic
GRCh38/hg38 2q14.2(chr2:119745184-120469045)x1	copy number loss	See cases [RCV000137836]	Chr2:119745184..120469045 [GRCh38] Chr2:120502760..121226621 [GRCh37] Chr2:120219230..120943091 [NCBI36] Chr2:2q14.2	uncertain significance
GRCh38/hg38 2q14.1-14.3(chr2:115302067-129071130)x1	copy number loss	See cases [RCV000141584]	Chr2:115302067..129071130 [GRCh38] Chr2:116059643..129828703 [GRCh37] Chr2:115776113..129545173 [NCBI36] Chr2:2q14.1-14.3	pathogenic
GRCh38/hg38 2q14.2-14.3(chr2:118687829-121621814)x1	copy number loss	See cases [RCV000143725]	Chr2:118687829..121621814 [GRCh38] Chr2:119445405..122379390 [GRCh37] Chr2:119161875..122095860 [NCBI36] Chr2:2q14.2-14.3	pathogenic
GRCh37/hg19 2q12.3-14.3(chr2:109798247-125658380)x1	copy number loss	See cases [RCV000240485]	Chr2:109798247..125658380 [GRCh37] Chr2:2q12.3-14.3	pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3	copy number gain	not provided [RCV000752802]	Chr2:14238..243048760 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2q14.2-14.3(chr2:120715409-126676946)x3	copy number gain	See cases [RCV000448127]	Chr2:120715409..126676946 [GRCh37] Chr2:2q14.2-14.3	uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)	copy number gain	See cases [RCV000512056]	Chr2:12771..242783384 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2q13-14.3(chr2:114056441-123673800)x1	copy number loss	See cases [RCV000511150]	Chr2:114056441..123673800 [GRCh37] Chr2:2q13-14.3	pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3	copy number gain	See cases [RCV000511212]	Chr2:12771..242783384 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2q12.1-24.3(chr2:104172062-168223828)x1	copy number loss	Poly (ADP-Ribose) polymerase inhibitor response [RCV000626436]	Chr2:104172062..168223828 [GRCh37] Chr2:2q12.1-24.3	drug response
NM_002830.4(PTPN4):c.1513A>G (p.Thr505Ala)	single nucleotide variant	Inborn genetic diseases [RCV003295002]	Chr2:119945238 [GRCh38] Chr2:120702814 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1539T>G (p.Asp513Glu)	single nucleotide variant	Inborn genetic diseases [RCV003250945]	Chr2:119946364 [GRCh38] Chr2:120703940 [GRCh37] Chr2:2q14.2	uncertain significance
GRCh37/hg19 2q14.1-14.3(chr2:116754600-123897370)x1	copy number loss	See cases [RCV000512514]	Chr2:116754600..123897370 [GRCh37] Chr2:2q14.1-14.3	pathogenic
GRCh37/hg19 2q14.2-22.1(chr2:120571363-141627287)x1	copy number loss	See cases [RCV000512348]	Chr2:120571363..141627287 [GRCh37] Chr2:2q14.2-22.1	pathogenic
GRCh37/hg19 2q14.2(chr2:120669888-120735581)x1	copy number loss	not provided [RCV000681983]	Chr2:120669888..120735581 [GRCh37] Chr2:2q14.2	uncertain significance
Single allele	deletion	not provided [RCV000714264]	Chr2:40608411..146900718 [GRCh37] Chr2:2p22.1-q22.3	likely pathogenic
GRCh37/hg19 2q14.1-14.3(chr2:114707932-124328692)x1	copy number loss	not provided [RCV000682164]	Chr2:114707932..124328692 [GRCh37] Chr2:2q14.1-14.3	pathogenic
GRCh37/hg19 2q14.1-14.3(chr2:117070953-126303416)x1	copy number loss	not provided [RCV000753106]	Chr2:117070953..126303416 [GRCh37] Chr2:2q14.1-14.3	pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3	copy number gain	not provided [RCV000752804]	Chr2:15672..243101834 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2q14.1-14.2(chr2:115416190-122399064)x1	copy number loss	not provided [RCV001005308]	Chr2:115416190..122399064 [GRCh37] Chr2:2q14.1-14.2	pathogenic
NM_002830.4(PTPN4):c.2311A>G (p.Thr771Ala)	single nucleotide variant	Inborn genetic diseases [RCV003275121]	Chr2:119962646 [GRCh38] Chr2:120720222 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1472T>A (p.Ile491Asn)	single nucleotide variant	Inborn genetic diseases [RCV003274891]	Chr2:119945197 [GRCh38] Chr2:120702773 [GRCh37] Chr2:2q14.2	uncertain significance
GRCh37/hg19 2q14.2-14.3(chr2:118903294-123099547)x1	copy number loss	not provided [RCV001005310]	Chr2:118903294..123099547 [GRCh37] Chr2:2q14.2-14.3	pathogenic
NM_002830.4(PTPN4):c.1694A>G (p.Gln565Arg)	single nucleotide variant	Inborn genetic diseases [RCV003247804]	Chr2:119952010 [GRCh38] Chr2:120709586 [GRCh37] Chr2:2q14.2	uncertain significance
GRCh37/hg19 2q14.2(chr2:120729215-121383896)x3	copy number gain	not provided [RCV002473599]	Chr2:120729215..121383896 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1656+16G>T	single nucleotide variant	not provided [RCV001714242]	Chr2:119946590 [GRCh38] Chr2:120704166 [GRCh37] Chr2:2q14.2	benign
NM_002830.4(PTPN4):c.2491C>A (p.Leu831Ile)	single nucleotide variant	PTPN4-related Neurodevelopmental Disorder [RCV004799412]	Chr2:119965578 [GRCh38] Chr2:120723154 [GRCh37] Chr2:2q14.2	uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373)	copy number gain	Mosaic trisomy 2 [RCV002280628]	Chr2:1..243199373 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
NM_002830.4(PTPN4):c.393_396del (p.Gln132fs)	deletion	not provided [RCV001264843]	Chr2:119881808..119881811 [GRCh38] Chr2:120639384..120639387 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.715G>A (p.Gly239Arg)	single nucleotide variant	not provided [RCV001264844]	Chr2:119900757 [GRCh38] Chr2:120658333 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.2423G>A (p.Arg808His)	single nucleotide variant	not provided [RCV001265121]	Chr2:119965510 [GRCh38] Chr2:120723086 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.2512C>T (p.Arg838Ter)	single nucleotide variant	not provided [RCV001265216]	Chr2:119965599 [GRCh38] Chr2:120723175 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.191T>G (p.Leu64Trp)	single nucleotide variant	not provided [RCV001267875]	Chr2:119862588 [GRCh38] Chr2:120620164 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.588-2A>G	single nucleotide variant	not provided [RCV001280698]	Chr2:119885793 [GRCh38] Chr2:120643369 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.2338C>T (p.Gln780Ter)	single nucleotide variant	Neurodevelopmental disorder [RCV002273316]	Chr2:119962673 [GRCh38] Chr2:120720249 [GRCh37] Chr2:2q14.2	pathogenic\|likely pathogenic
NM_002830.4(PTPN4):c.2465G>A (p.Gly822Glu)	single nucleotide variant	not provided [RCV001754705]	Chr2:119965552 [GRCh38] Chr2:120723128 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.659A>C (p.Glu220Ala)	single nucleotide variant	not provided [RCV001769340]	Chr2:119885866 [GRCh38] Chr2:120643442 [GRCh37] Chr2:2q14.2	uncertain significance
GRCh37/hg19 2q13-14.3(chr2:113188197-128144700)	copy number loss	not specified [RCV002053220]	Chr2:113188197..128144700 [GRCh37] Chr2:2q13-14.3	pathogenic
GRCh37/hg19 2q14.2-14.3(chr2:120715409-126676946)	copy number gain	not specified [RCV002053222]	Chr2:120715409..126676946 [GRCh37] Chr2:2q14.2-14.3	uncertain significance
GRCh37/hg19 2q13-22.3(chr2:111484468-146333604)x3	copy number gain	not provided [RCV001832896]	Chr2:111484468..146333604 [GRCh37] Chr2:2q13-22.3	pathogenic
GRCh37/hg19 2q14.2(chr2:119967365-121555029)x3	copy number gain	not provided [RCV001829193]	Chr2:119967365..121555029 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1253A>G (p.His418Arg)	single nucleotide variant	not provided [RCV001953074]	Chr2:119934856 [GRCh38] Chr2:120692432 [GRCh37] Chr2:2q14.2	uncertain significance
GRCh37/hg19 2q13-22.3(chr2:112475655-145691999)x3	copy number gain	2q13q22.3 microduplication syndrome [RCV002226436]	Chr2:112475655..145691999 [GRCh37] Chr2:2q13-22.3	pathogenic
NM_002830.4(PTPN4):c.863T>C (p.Met288Thr)	single nucleotide variant	Inborn genetic diseases [RCV003278066]	Chr2:119920103 [GRCh38] Chr2:120677679 [GRCh37] Chr2:2q14.2	uncertain significance
GRCh37/hg19 2q14.2-14.3(chr2:120628484-127658188)x1	copy number loss	not provided [RCV002279758]	Chr2:120628484..127658188 [GRCh37] Chr2:2q14.2-14.3	pathogenic
NM_002830.4(PTPN4):c.745C>T (p.Arg249Ter)	single nucleotide variant	Inborn genetic diseases [RCV002686810]\|PTPN4-related disorder [RCV003994510]	Chr2:119900787 [GRCh38] Chr2:120658363 [GRCh37] Chr2:2q14.2	pathogenic
GRCh37/hg19 2q14.1-14.3(chr2:116761476-123897262)x1	copy number loss	not provided [RCV002475758]	Chr2:116761476..123897262 [GRCh37] Chr2:2q14.1-14.3	pathogenic
NM_002830.4(PTPN4):c.312C>A (p.Asn104Lys)	single nucleotide variant	Inborn genetic diseases [RCV002865751]	Chr2:119877486 [GRCh38] Chr2:120635062 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1142A>G (p.Asp381Gly)	single nucleotide variant	Inborn genetic diseases [RCV002981790]	Chr2:119932495 [GRCh38] Chr2:120690071 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.2244G>A (p.Met748Ile)	single nucleotide variant	Inborn genetic diseases [RCV002949789]	Chr2:119960917 [GRCh38] Chr2:120718493 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.2387A>G (p.Lys796Arg)	single nucleotide variant	Inborn genetic diseases [RCV002692955]	Chr2:119962722 [GRCh38] Chr2:120720298 [GRCh37] Chr2:2q14.2	likely benign
NM_002830.4(PTPN4):c.141A>T (p.Lys47Asn)	single nucleotide variant	Inborn genetic diseases [RCV002911259]	Chr2:119862538 [GRCh38] Chr2:120620114 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.2507A>G (p.His836Arg)	single nucleotide variant	Inborn genetic diseases [RCV002822109]	Chr2:119965594 [GRCh38] Chr2:120723170 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1327G>A (p.Ala443Thr)	single nucleotide variant	Inborn genetic diseases [RCV002768598]	Chr2:119934930 [GRCh38] Chr2:120692506 [GRCh37] Chr2:2q14.2	likely benign
NM_002830.4(PTPN4):c.95A>C (p.Asn32Thr)	single nucleotide variant	Inborn genetic diseases [RCV002713594]	Chr2:119809948 [GRCh38] Chr2:120567524 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.2066C>T (p.Ser689Leu)	single nucleotide variant	Inborn genetic diseases [RCV002697745]	Chr2:119956929 [GRCh38] Chr2:120714505 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1927A>T (p.Met643Leu)	single nucleotide variant	Inborn genetic diseases [RCV002787847]	Chr2:119955270 [GRCh38] Chr2:120712846 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1939G>A (p.Ala647Thr)	single nucleotide variant	Inborn genetic diseases [RCV002698859]	Chr2:119955282 [GRCh38] Chr2:120712858 [GRCh37] Chr2:2q14.2	likely benign\|uncertain significance
NM_002830.4(PTPN4):c.748A>C (p.Met250Leu)	single nucleotide variant	Inborn genetic diseases [RCV002763063]	Chr2:119900790 [GRCh38] Chr2:120658366 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.926G>A (p.Arg309His)	single nucleotide variant	Inborn genetic diseases [RCV002989572]	Chr2:119920166 [GRCh38] Chr2:120677742 [GRCh37] Chr2:2q14.2	likely benign
NM_002830.4(PTPN4):c.1535A>T (p.His512Leu)	single nucleotide variant	Inborn genetic diseases [RCV002718257]	Chr2:119946360 [GRCh38] Chr2:120703936 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1919G>A (p.Arg640Gln)	single nucleotide variant	Inborn genetic diseases [RCV002964481]	Chr2:119955262 [GRCh38] Chr2:120712838 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.137A>G (p.Asn46Ser)	single nucleotide variant	Inborn genetic diseases [RCV002896465]	Chr2:119809990 [GRCh38] Chr2:120567566 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.115A>G (p.Thr39Ala)	single nucleotide variant	Inborn genetic diseases [RCV002648438]	Chr2:119809968 [GRCh38] Chr2:120567544 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.138+2T>C	single nucleotide variant	not provided [RCV002648009]	Chr2:119809993 [GRCh38] Chr2:120567569 [GRCh37] Chr2:2q14.2	likely pathogenic
NM_002830.4(PTPN4):c.1060G>A (p.Val354Ile)	single nucleotide variant	Inborn genetic diseases [RCV003203857]	Chr2:119926656 [GRCh38] Chr2:120684232 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1822G>A (p.Asp608Asn)	single nucleotide variant	Inborn genetic diseases [RCV003206628]	Chr2:119955165 [GRCh38] Chr2:120712741 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.2431A>G (p.Thr811Ala)	single nucleotide variant	Inborn genetic diseases [RCV003213595]	Chr2:119965518 [GRCh38] Chr2:120723094 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1172G>A (p.Arg391Gln)	single nucleotide variant	Inborn genetic diseases [RCV003373382]	Chr2:119932525 [GRCh38] Chr2:120690101 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.752A>G (p.Asn251Ser)	single nucleotide variant	Inborn genetic diseases [RCV003373798]	Chr2:119900794 [GRCh38] Chr2:120658370 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.2120C>G (p.Ala707Gly)	single nucleotide variant	PTPN4-related disorder [RCV004536705]	Chr2:119957064 [GRCh38] Chr2:120714640 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1658C>A (p.Ala553Asp)	single nucleotide variant	PTPN4-related disorder [RCV004536736]	Chr2:119951974 [GRCh38] Chr2:120709550 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.879A>G (p.Ala293=)	single nucleotide variant	not provided [RCV003429255]	Chr2:119920119 [GRCh38] Chr2:120677695 [GRCh37] Chr2:2q14.2	likely benign
NM_002830.4(PTPN4):c.399C>A (p.Asp133Glu)	single nucleotide variant	PTPN4-related disorder [RCV004527870]	Chr2:119881816 [GRCh38] Chr2:120639392 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.2075A>T (p.Asp692Val)	single nucleotide variant	PTPN4-associated disorder [RCV003494084]	Chr2:119957019 [GRCh38] Chr2:120714595 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.2748del (p.Phe916fs)	deletion	not provided [RCV003491389]	Chr2:119977035 [GRCh38] Chr2:120734611 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1983A>G (p.Gln661=)	single nucleotide variant	not provided [RCV003699187]	Chr2:119956846 [GRCh38] Chr2:120714422 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.722T>C (p.Ile241Thr)	single nucleotide variant	Neurodevelopmental disorder [RCV003994666]	Chr2:119900764 [GRCh38] Chr2:120658340 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.246+1G>T	single nucleotide variant	not provided [RCV003711271]	Chr2:119862644 [GRCh38] Chr2:120620220 [GRCh37] Chr2:2q14.2	likely pathogenic
GRCh37/hg19 2q14.2(chr2:120273496-120842237)x3	copy number gain	not specified [RCV003986365]	Chr2:120273496..120842237 [GRCh37] Chr2:2q14.2	uncertain significance
GRCh37/hg19 2q14.1-14.3(chr2:116646793-126388760)x1	copy number loss	not specified [RCV003986356]	Chr2:116646793..126388760 [GRCh37] Chr2:2q14.1-14.3	likely pathogenic
GRCh37/hg19 2q12.2-21.2(chr2:106755586-134302739)x1	copy number loss	not specified [RCV003986380]	Chr2:106755586..134302739 [GRCh37] Chr2:2q12.2-21.2	pathogenic
NM_002830.4(PTPN4):c.1020A>G (p.Gln340=)	single nucleotide variant	PTPN4-related disorder [RCV004539328]	Chr2:119926616 [GRCh38] Chr2:120684192 [GRCh37] Chr2:2q14.2	likely benign
NM_002830.4(PTPN4):c.2203A>G (p.Thr735Ala)	single nucleotide variant	Inborn genetic diseases [RCV004445104]	Chr2:119960876 [GRCh38] Chr2:120718452 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.595T>C (p.Ser199Pro)	single nucleotide variant	Inborn genetic diseases [RCV004445108]	Chr2:119885802 [GRCh38] Chr2:120643378 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.635G>A (p.Arg212His)	single nucleotide variant	Inborn genetic diseases [RCV004445109]	Chr2:119885842 [GRCh38] Chr2:120643418 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1143C>G (p.Asp381Glu)	single nucleotide variant	Inborn genetic diseases [RCV004445098]	Chr2:119932496 [GRCh38] Chr2:120690072 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.860A>G (p.Asn287Ser)	single nucleotide variant	Inborn genetic diseases [RCV004445110]	Chr2:119920100 [GRCh38] Chr2:120677676 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.43G>A (p.Val15Ile)	single nucleotide variant	Inborn genetic diseases [RCV004445107]	Chr2:119809896 [GRCh38] Chr2:120567472 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.472C>A (p.Leu158Ile)	single nucleotide variant	PTPN4-related disorder [RCV004532200]	Chr2:119882508 [GRCh38] Chr2:120640084 [GRCh37] Chr2:2q14.2	likely benign
NM_002830.4(PTPN4):c.252G>T (p.Trp84Cys)	single nucleotide variant	not specified [RCV004526470]	Chr2:119877328 [GRCh38] Chr2:120634904 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1814-4_1814-3dup	duplication	PTPN4-related disorder [RCV004532158]	Chr2:119955142..119955143 [GRCh38] Chr2:120712718..120712719 [GRCh37] Chr2:2q14.2	likely benign
NM_002830.4(PTPN4):c.1814-3dup	duplication	PTPN4-related disorder [RCV004542551]	Chr2:119955142..119955143 [GRCh38] Chr2:120712718..120712719 [GRCh37] Chr2:2q14.2	benign
NM_002830.4(PTPN4):c.784T>G (p.Ser262Ala)	single nucleotide variant	PTPN4-related disorder [RCV004537091]	Chr2:119915198 [GRCh38] Chr2:120672774 [GRCh37] Chr2:2q14.2	likely benign
NM_002830.4(PTPN4):c.1347_1355+6del	deletion	not provided [RCV004555102]	Chr2:119934948..119934962 [GRCh38] Chr2:120692524..120692538 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.2024A>G (p.Lys675Arg)	single nucleotide variant	Inborn genetic diseases [RCV004662566]	Chr2:119956887 [GRCh38] Chr2:120714463 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.2421T>A (p.Ser807Arg)	single nucleotide variant	Inborn genetic diseases [RCV004669200]	Chr2:119965508 [GRCh38] Chr2:120723084 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1207A>G (p.Thr403Ala)	single nucleotide variant	Inborn genetic diseases [RCV004669201]	Chr2:119934810 [GRCh38] Chr2:120692386 [GRCh37] Chr2:2q14.2	likely benign
NM_002830.4(PTPN4):c.1367C>T (p.Thr456Ile)	single nucleotide variant	Inborn genetic diseases [RCV004662564]	Chr2:119945092 [GRCh38] Chr2:120702668 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.149del (p.Gln50fs)	deletion	Neurodevelopmental disorder [RCV004594847]	Chr2:119862546 [GRCh38] Chr2:120620122 [GRCh37] Chr2:2q14.2	likely pathogenic
NM_002830.4(PTPN4):c.679C>T (p.Gln227Ter)	single nucleotide variant	PTPN4-related disorder [RCV004731728]	Chr2:119900721 [GRCh38] Chr2:120658297 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.202G>A (p.Asp68Asn)	single nucleotide variant	PTPN4-related disorder [RCV004730451]	Chr2:119862599 [GRCh38] Chr2:120620175 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1580G>A (p.Arg527Lys)	single nucleotide variant	Inborn genetic diseases [RCV004957339]	Chr2:119946405 [GRCh38] Chr2:120703981 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1564C>A (p.Pro522Thr)	single nucleotide variant	Inborn genetic diseases [RCV004957343]	Chr2:119946389 [GRCh38] Chr2:120703965 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1229G>A (p.Arg410Gln)	single nucleotide variant	Inborn genetic diseases [RCV004957346]	Chr2:119934832 [GRCh38] Chr2:120692408 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1556G>A (p.Arg519Lys)	single nucleotide variant	Inborn genetic diseases [RCV004957351]	Chr2:119946381 [GRCh38] Chr2:120703957 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1331A>G (p.Asn444Ser)	single nucleotide variant	Inborn genetic diseases [RCV004957342]	Chr2:119934934 [GRCh38] Chr2:120692510 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.116C>G (p.Thr39Ser)	single nucleotide variant	Inborn genetic diseases [RCV004957341]	Chr2:119809969 [GRCh38] Chr2:120567545 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1744G>A (p.Val582Ile)	single nucleotide variant	Inborn genetic diseases [RCV004957348]	Chr2:119952060 [GRCh38] Chr2:120709636 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.83A>C (p.Glu28Ala)	single nucleotide variant	Inborn genetic diseases [RCV004957350]	Chr2:119809936 [GRCh38] Chr2:120567512 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.65G>A (p.Arg22Gln)	single nucleotide variant	Inborn genetic diseases [RCV004957340]	Chr2:119809918 [GRCh38] Chr2:120567494 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1714C>T (p.Arg572Trp)	single nucleotide variant	Inborn genetic diseases [RCV004957344]	Chr2:119952030 [GRCh38] Chr2:120709606 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.436G>A (p.Ala146Thr)	single nucleotide variant	Inborn genetic diseases [RCV004957345]	Chr2:119882119 [GRCh38] Chr2:120639695 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.235A>G (p.Thr79Ala)	single nucleotide variant	Inborn genetic diseases [RCV004957349]	Chr2:119862632 [GRCh38] Chr2:120620208 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.538C>T (p.Gln180Ter)	single nucleotide variant	PTPN4-related aberrant neurodevelopment and growth [RCV005054988]	Chr2:119882574 [GRCh38] Chr2:120640150 [GRCh37] Chr2:2q14.2	likely pathogenic
NM_002830.4(PTPN4):c.1141G>A (p.Asp381Asn)	single nucleotide variant	Inborn genetic diseases [RCV004957347]	Chr2:119932494 [GRCh38] Chr2:120690070 [GRCh37] Chr2:2q14.2	uncertain significance
GRCh37/hg19 2q14.2(chr2:120079538-120626557)x4	copy number gain	not provided [RCV002473829]	Chr2:120079538..120626557 [GRCh37] Chr2:2q14.2	uncertain significance
GRCh37/hg19 2q14.2-14.3(chr2:118872395-128069813)x1	copy number loss	not provided [RCV001005309]	Chr2:118872395..128069813 [GRCh37] Chr2:2q14.2-14.3	pathogenic
GRCh37/hg19 2q14.2(chr2:120613138-121287716)x1	copy number loss	not provided [RCV001005313]	Chr2:120613138..121287716 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1496C>T (p.Ser499Phe)	single nucleotide variant	Inborn genetic diseases [RCV003256630]	Chr2:119945221 [GRCh38] Chr2:120702797 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.710T>C (p.Met237Thr)	single nucleotide variant	not provided [RCV003436133]	Chr2:119900752 [GRCh38] Chr2:120658328 [GRCh37] Chr2:2q14.2	benign
NM_002830.4(PTPN4):c.1478A>G (p.Glu493Gly)	single nucleotide variant	Inborn genetic diseases [RCV004445101]	Chr2:119945203 [GRCh38] Chr2:120702779 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.172G>A (p.Val58Ile)	single nucleotide variant	Inborn genetic diseases [RCV004445102]	Chr2:119862569 [GRCh38] Chr2:120620145 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.2272C>T (p.Arg758Cys)	single nucleotide variant	Inborn genetic diseases [RCV004445105]	Chr2:119960945 [GRCh38] Chr2:120718521 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.271A>G (p.Ile91Val)	single nucleotide variant	Inborn genetic diseases [RCV004445106]	Chr2:119877347 [GRCh38] Chr2:120634923 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.1183G>C (p.Gly395Arg)	single nucleotide variant	Inborn genetic diseases [RCV004445099]	Chr2:119932536 [GRCh38] Chr2:120690112 [GRCh37] Chr2:2q14.2	uncertain significance
NM_002830.4(PTPN4):c.2170A>G (p.Ile724Val)	single nucleotide variant	Inborn genetic diseases [RCV004445103]	Chr2:119960843 [GRCh38] Chr2:120718419 [GRCh37] Chr2:2q14.2	uncertain significance

Predicted Target Of

	Summary Value
Count of predictions:	4775
Count of miRNA genes:	1348
Interacting mature miRNAs:	1785
Transcripts:	ENST00000263708, ENST00000420482, ENST00000430976, ENST00000431283, ENST00000433888, ENST00000441089, ENST00000460162, ENST00000460289, ENST00000469511, ENST00000485247, ENST00000488279, ENST00000488896, ENST00000544261
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
407222839	GWAS871815_H	lymphocyte count QTL GWAS871815 (human)		8e-16	lymphocyte count	blood lymphocyte count (CMO:0000031)	2	119922642	119922643	Human
597337512	GWAS1433586_H	severe acute respiratory syndrome, COVID-19 QTL GWAS1433586 (human)		2e-09	severe acute respiratory syndrome, COVID-19		2	119961803	119961804	Human
597060821	GWAS1156895_H	FEV/FVC ratio QTL GWAS1156895 (human)		3e-08	FEV/FVC ratio	forced expiratory volume to forced vital capacity ratio (CMO:0000241)	2	119925053	119925054	Human
597318195	GWAS1414269_H	smoking initiation QTL GWAS1414269 (human)		1e-10	smoking initiation		2	119848851	119848852	Human
597136892	GWAS1232966_H	neuroimaging measurement QTL GWAS1232966 (human)		1e-09	neuroimaging measurement		2	119870887	119870888	Human
597295953	GWAS1392027_H	lymphocyte count QTL GWAS1392027 (human)		2e-10	lymphocyte count	blood lymphocyte count (CMO:0000031)	2	119922642	119922643	Human
407249882	GWAS898858_H	lymphocyte count QTL GWAS898858 (human)		2e-18	lymphocyte count	blood lymphocyte count (CMO:0000031)	2	119922642	119922643	Human
597246404	GWAS1342478_H	platelet-to-lymphocyte ratio QTL GWAS1342478 (human)		5e-08	platelet-to-lymphocyte ratio		2	119782648	119782649	Human
597139289	GWAS1235363_H	5alpha-pregnan-3beta,20beta-diol monosulfate (1) measurement QTL GWAS1235363 (human)		0.000002	5alpha-pregnan-3beta,20beta-diol monosulfate (1) measurement		2	119874083	119874084	Human
597082185	GWAS1178259_H	lymphocyte count QTL GWAS1178259 (human)		3e-16	lymphocyte count	blood lymphocyte count (CMO:0000031)	2	119922642	119922643	Human

RH65502

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	120,741,848 - 120,741,928	UniSTS	GRCh37
Build 36	2	120,458,318 - 120,458,398	RGD	NCBI36
Celera	2	114,068,715 - 114,068,795	RGD
Cytogenetic Map	2	q14.2	UniSTS
HuRef	2	113,066,251 - 113,066,331	UniSTS

RH91837

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	120,742,283 - 120,742,461	UniSTS	GRCh37
Build 36	2	120,458,753 - 120,458,931	RGD	NCBI36
Celera	2	114,069,150 - 114,069,328	RGD
Cytogenetic Map	2	q14.2	UniSTS
HuRef	2	113,066,686 - 113,066,864	UniSTS
GeneMap99-GB4 RH Map	2	437.47	UniSTS

RH120908

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	120,712,501 - 120,712,817	UniSTS	GRCh37
Build 36	2	120,428,971 - 120,429,287	RGD	NCBI36
Celera	2	114,039,358 - 114,039,674	RGD
Cytogenetic Map	2	q14.2	UniSTS
HuRef	2	113,036,899 - 113,037,215	UniSTS
TNG Radiation Hybrid Map	2	69663.0	UniSTS

RH68765

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	120,659,020 - 120,659,171	UniSTS	GRCh37
Build 36	2	120,375,490 - 120,375,641	RGD	NCBI36
Celera	2	113,985,871 - 113,986,022	RGD
Cytogenetic Map	2	q14.2	UniSTS
HuRef	2	112,983,414 - 112,983,565	UniSTS
GeneMap99-GB4 RH Map	2	437.54	UniSTS

SHGC-35144

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	120,659,051 - 120,659,178	UniSTS	GRCh37
Build 36	2	120,375,521 - 120,375,648	RGD	NCBI36
Celera	2	113,985,902 - 113,986,029	RGD
Cytogenetic Map	2	q14.2	UniSTS
HuRef	2	112,983,445 - 112,983,572	UniSTS
GeneMap99-GB4 RH Map	2	438.07	UniSTS
Whitehead-RH Map	2	696.6	UniSTS

SHGC-33019

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	120,663,633 - 120,663,763	UniSTS	GRCh37
Build 36	2	120,380,103 - 120,380,233	RGD	NCBI36
Celera	2	113,990,484 - 113,990,614	RGD
Cytogenetic Map	2	q14.2	UniSTS
HuRef	2	112,988,028 - 112,988,158	UniSTS
TNG Radiation Hybrid Map	2	69622.0	UniSTS
Stanford-G3 RH Map	2	4955.0	UniSTS
GeneMap99-GB4 RH Map	2	437.44	UniSTS
Whitehead-RH Map	2	698.4	UniSTS
GeneMap99-G3 RH Map	2	5868.0	UniSTS

PTPN4_3121

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	120,734,576 - 120,735,115	UniSTS	GRCh37
Build 36	2	120,451,046 - 120,451,585	RGD	NCBI36
Celera	2	114,061,442 - 114,061,981	RGD
HuRef	2	113,058,978 - 113,059,517	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
1204	2439	2788	2253	4973	1726	2351	6	624	1951	465	2269	7306	6472	53	3734	1	852	1744	1617	175	1


RefSeq Transcripts	NM_002830	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC016691	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC069154	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC092455	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC104061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC104668	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC116632	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK025546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK301218	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK314836	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC010674	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC037838	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX648614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068276	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KF456698	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KF456699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KF456700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M68941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000263708 ⟹ ENSP00000263708

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	119,759,922 - 119,984,899 (+)	Ensembl

Ensembl Acc Id:

ENST00000420482 ⟹ ENSP00000405763

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	119,760,177 - 119,862,622 (+)	Ensembl

Ensembl Acc Id:

ENST00000430976 ⟹ ENSP00000395603

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	119,882,503 - 119,977,461 (+)	Ensembl

Ensembl Acc Id:

ENST00000431283 ⟹ ENSP00000387457

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	119,932,476 - 119,946,670 (+)	Ensembl

Ensembl Acc Id:

ENST00000433888 ⟹ ENSP00000411364

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	119,877,323 - 119,934,960 (+)	Ensembl

Ensembl Acc Id:

ENST00000441089 ⟹ ENSP00000394706

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	119,960,824 - 119,977,083 (+)	Ensembl

Ensembl Acc Id:

ENST00000460162

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	119,759,954 - 119,809,884 (+)	Ensembl

Ensembl Acc Id:

ENST00000460289

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	119,760,220 - 119,880,117 (+)	Ensembl

Ensembl Acc Id:

ENST00000469511

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	119,960,792 - 119,967,872 (+)	Ensembl

Ensembl Acc Id:

ENST00000485247

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	119,760,275 - 119,882,579 (+)	Ensembl

Ensembl Acc Id:

ENST00000488279 ⟹ ENSP00000438445

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	119,760,224 - 119,882,146 (+)	Ensembl

Ensembl Acc Id:

ENST00000488896

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	119,932,280 - 119,935,104 (+)	Ensembl

RefSeq Acc Id:

NM_002830 ⟹ NP_002821

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	119,759,922 - 119,984,899 (+)	NCBI
GRCh37	2	120,517,207 - 120,742,496 (+)	NCBI
Build 36	2	120,233,677 - 120,451,507 (+)	NCBI Archive
Celera	2	113,842,942 - 114,061,903 (+)	RGD
HuRef	2	112,841,586 - 113,066,878 (+)	NCBI
CHM1_1	2	120,520,785 - 120,746,914 (+)	NCBI
T2T-CHM13v2.0	2	120,193,967 - 120,419,641 (+)	NCBI

Sequence:

show sequence

AGGATTACCCGCCAGCTCACGCCGCGCAGTGCGCTTTTCCGCTCCTCGCGCCCCACCACCAACATTGTTCTCTCAGGACTCCTGGGTCCCAGGGGCCGGAATTGGGCCTGAGCGGGAGAGGAAAGAGA
CTTGGCTTTGGCCGCGGGGTCGGAGGATTGGGGCCAGGCCCCCTCCCCCACGCACTTTTGGGGGTGTGGATTATCTCATCCCTGCAGGGAGGTAGGAGAGGTCGCCGGCTGCCCGCCTCCCTGCCACC
TCCCCAGCGGCGCCGGCCCGCGGCTGCCCAGCAGCATGAGGTGGTGCTGGCGGCTCCGGGTCGTGGCGCGACCGCTGCGGCGGCGGCTGCTCGGGGGGCGCTGAGGTAGCCCCCCGGAGCGGCACGGA
GGACGCGCTTCTCCTCTGCGCGCCGGGGCCTCGAGGCTTTTTTTCTCCAGCCGAGAGGACGCGGCTGTGATATACGAAGACTTTGTGTGGACAGTAATGACCTCACGTTTCCGATTGCCTGCTGGCAG
AACCTACAATGTACGAGCATCAGAGTTGGCCCGAGACAGACAGCATACTGAAGTGGTTTGCAACATCCTTCTTCTGGATAACACTGTACAAGCTTTCAAAGTCAATAAACATGATCAGGGGCAAGTCT
TGTTGGATGTCGTCTTCAAGCATCTAGATTTGACTGAGCAGGACTATTTTGGTTTACAGTTGGCTGATGATTCCACAGATAACCCAAGGTGGCTGGATCCAAACAAACCAATAAGGAAGCAGCTAAAG
AGAGGATCTCCTTACAGTTTGAACTTTAGAGTCAAATTTTTTGTAAGTGACCCCAACAAGTTACAAGAAGAATATACAAGGTACCAGTATTTTTTGCAAATTAAACAAGACATTCTTACTGGAAGATT
ACCCTGTCCTTCTAATACTGCTGCCCTTTTAGCTTCATTTGCTGTTCAGTCTGAACTTGGAGACTACGATCAGTCAGAGAACTTGTCAGGCTACCTCTCAGATTATTCTTTCATTCCTAATCAACCTC
AAGATTTTGAAAAAGAAATTGCAAAATTACATCAGCAACACATAGGCTTATCTCCTGCAGAAGCAGAATTTAATTACCTAAACACAGCACGTACCTTAGAACTCTATGGAGTTGAATTCCACTATGCA
AGGGATCAGAGTAACAATGAAATTATGATTGGAGTGATGTCAGGAGGAATTCTGATTTATAAGAACAGGGTACGAATGAATACCTTTCCATGGTTGAAGATTGTAAAAATTTCTTTTAAGTGCAAACA
GTTTTTTATTCAACTTAGAAAAGAATTGCATGAATCTAGAGAAACATTATTGGGATTTAATATGGTGAATTACAGAGCATGTAAAAATTTGTGGAAAGCATGTGTAGAACATCACACATTCTTCCGTT
TGGACAGACCACTTCCACCTCAAAAGAATTTTTTTGCACATTATTTTACATTAGGTTCAAAATTCCGGTACTGTGGGAGAACTGAAGTCCAATCAGTTCAGTATGGCAAAGAAAAGGCAAATAAAGAC
AGGGTATTTGCAAGATCCCCAAGTAAGCCCTTGGCACGGAAATTAATGGATTGGGAAGTAGTAAGCAGAAATTCAATATCTGATGACAGGTTAGAAACACAAAGTCTTCCATCACGATCTCCACCGGG
AACTCCTAATCATCGAAATTCTACATTCACGCAGGAAGGAACCCGGTTACGACCATCTTCAGTTGGTCATTTGGTAGACCATATGGTTCATACTTCCCCAAGCGAAGTGTTTGTAAATCAGAGATCTC
CGTCATCAACACAAGCTAATAGCATTGTTCTGGAATCATCACCATCACAAGAGACCCCTGGAGATGGGAAGCCTCCAGCTTTACCACCCAAACAGTCAAAGAAAAACAGTTGGAACCAAATTCATTAT
TCACATTCGCAACAAGATCTAGAAAGTCATATTAATGAAACATTTGATATTCCATCTTCTCCTGAAAAACCCACTCCTAATGGTGGTATTCCACATGATAATCTTGTCCTAATCAGAATGAAACCTGA
TGAAAATGGGAGGTTTGGATTCAATGTAAAGGGAGGATATGATCAGAAGATGCCTGTGATTGTGTCTCGAGTAGCACCAGGAACACCTGCTGACCTCTGTGTCCCTAGACTGAATGAAGGGGACCAAG
TTGTACTGATCAATGGTCGGGACATTGCAGAACACACTCATGATCAGGTTGTGCTGTTTATTAAAGCTAGTTGTGAGAGACATTCTGGGGAACTCATGCTTCTAGTTCGACCTAATGCTGTATATGAT
GTAGTGGAAGAAAAGCTAGAAAATGAGCCAGATTTCCAGTATATTCCTGAGAAAGCCCCACTAGATAGTGTGCATCAGGATGACCATTCCCTGCGGGAGTCAATGATCCAGCTAGCTGAGGGGCTTAT
CACTGGAACAGTCCTGACACAGTTTGATCAACTGTATCGGAAAAAACCTGGAATGACAATGTCCTGTGCCAAATTACCTCAGAATATTTCCAAAAATAGATACAGAGATATTTCGCCTTATGATGCCA
CACGGGTCATTTTAAAAGGTAATGAAGACTACATCAATGCGAACTATATAAATATGGAAATTCCTTCTTCCAGCATTATAAATCAGTACATTGCTTGTCAAGGGCCATTACCACACACTTGTACAGAT
TTTTGGCAGATGACTTGGGAACAAGGCTCCTCTATGGTTGTAATGTTGACCACACAAGTTGAACGTGGCAGAGTTAAATGTCACCAATATTGGCCAGAACCCACAGGCAGTTCATCTTATGGATGCTA
CCAAGTTACCTGCCACTCTGAAGAAGGAAACACTGCCTATATCTTCAGGAAGATGACCCTATTTAACCAAGAGAAAAATGAAAGTCGTCCACTCACTCAGATCCAGTACATAGCCTGGCCTGACCATG
GAGTCCCTGATGATTCGAGTGACTTTCTAGATTTTGTTTGTCATGTACGAAACAAGAGGGCTGGCAAGGAAGAACCCGTTGTTGTCCATTGCAGTGCTGGAATCGGAAGAACTGGGGTTCTTATTACT
ATGGAAACAGCCATGTGTCTCATTGAATGCAATCAGCCAGTTTATCCACTAGATATTGTAAGAACAATGAGAGATCAGCGAGCCATGATGATCCAAACACCTAGTCAATACAGATTTGTATGTGAAGC
TATTTTGAAAGTTTATGAAGAAGGCTTTGTTAAACCCTTAACAACATCAACAAATAAATAAGAAAGCAAAAAGATCTGGGATATGTGTTGGAAAACTGCTTTCCCTTATGTTCACTGTGCCATAATGC
TGCTCGCAGGAAATGGCATTTTACAAAAAAAAAATGAAGAACTCAAAAAAACTTTGAAAACTTCAGCACTGTTGCACTTTATGTTTTAAAAAATGTCACTCTTTCAAAATCTATAACTCATGTATTTG
AAGACTGTTTCATGCTTTGCTCCGAACAAATAGTAAATAACTGAGTATGTTCAGGGTAATTTATGAAATTTTGTGGTGGTGCCATGCAATCCCCTTTTGGTAGAATTGCCACAAACAAGGCTCAAAAT
TCTCATCATCTCTGTTATACACCTGTATCATGAAAGCAAAAAGAAGTAAACATCAGGAGTCAGCTCTGGTCTTTTGCAGTGGTTTGCGTACTTACTATACTGATTACCAGATTTTATTTTTAAAATTT
TAGCAATATCGTTCTTAATATTAGCCAATACACTGCCTATGGATGCAGCACATTTTTCCCTGCACACCCCCTGTAGAGACCTGCCTGCTGCTCAGAAGAAGAAAGATGGAATTTGCTGTTCCCAGGAA
ATGCTGCACATTGTCCATTTACCAGCATCTTATAGAAAATATAAATATGAATCTACAAATTCTCTTGGATTTAATAATGTAACTTATATTTATCATAAGGTTGGCTTATTCCAAATCATGTGATTTCA
CATACTTGATGTAAAGGAATGCATGCATTGTGTCTTAACCCCTTAAGTGCCTTGAGACGTCCTTGTATGTCTAACGAAAAGGCACTCATTTGACCCCACTAGGAGGTATATATGTATATTGTACATTC
GTATATTTTTATGCATTTTGAATAAGTTCACATTTTAAAAAACAGCTATATTGAGTGTTATACAGTCAAAGAAGGGTAAGGAAATTCTGTTTCTTACTCAGTACTCGTGATTTGCTATAAGAAGCAAA
GATAATTTGTGTTCTACTGAGTGCACACTGCTGCTATGGAATTGTTCAAAATCTGCACATTCCTTTACTTGAGGGACTGAGGGGTTACGGTTTAGCAGCTCAACTTTAAAAGATGCTTTTATGCTTCA
AATTTCATATTTATTTCATCCCTAACTTTAGGAAGACATCTAACATGCAGATTAATGTTAAACATATTGATAATCTAAGCTAAAGTTAGAGCAAATAATTGTGATTTATTCATGTCCATAACTAAAAT
ATTATTCTTTAGCACTCATTTCAGTTAATATCAAGCTTTGTTCACACTGATATATTGATTGGGATTCTTCAAACGAAGAATGAAACATTATTGACTTATTTCTAAGTGTAATAACTCAATAACTAAAT
TGAGAATTTTCTTGTTTTTTTGTGTACAATTAAATTATTCCATTTTATATATACTTATTAAGTTATAAGCATGTTAATAAGGAGACTTTTGACTGTCCAGCCTAATGGAGGATCTGATTCCCATTAAG
GATGTGGGAATTCCCGTATTTTCCTCTTCAGGTTTTTTTGTTTTTAAGTCTACAGAGAGATAGAACCTTAACATTGCCCAGTTTGATAAAAGTGAAAATTTGCTCACCTATACAAATGTTATTTTACA
CAATTATTTTATGTGGATTGGGGTTTTAAAAGATTCATTTCCTAGCAGTTTCTGAATATTTCTGTAAGATCTTGATAAAGTTTAGAGTCAAATGGCAGATATTTTGGAAAGCCATTTAGTATGAGGGG
AAGAGTACACATTTTAAATCTTTGGTATAATCTAAACGATGTCATTTCAGACATTCAAAACTCATAATAATAAATTTCAGGAAATCAAGCTCCTAAACATTAATAGCCAAGATACCAAATAAATTATC
ATATTAAAATATTTAAGTTTATTTAAAGAGAGAAGTAAACATAAACTTATGTCAAAGAGAAATTCTCTTAATCTATTTCCTGACTTCACAGTCAAAACAGTATAAGATAGTGAAGTAACTTATAATCT
TATTTGGTCATTCTGTTCTATAAACAGACAAATATAATTTAGGCTGCTATATGACATGATAAATTAAAAACTGAGAAAGTAAAATTATGTCGGGGTCTACACATTAAATGACTGTTTTGGCAGTTTTT
CACCTGAATTTAAAAATAAAATTTGTCTGTTCTATCTGTATGGACAGAATATGACAACCATAGACCAAAAGATATCATTGTATAGATGTAAAGAGACAAAAGTCATGGTTGGCATGTTCTTTAATTTA
GGGCCTTGTTTATACTTGTGAGTTTAATAATTTCTTGGCAATGAGCACTGCTGCCTTTTTAAATCATCAATGCCTGTCTTTAAATGCCAATCATTAGAAGTTTAGAATTACATTTAAATTTCTCATAT
ATGAATTTTTCATCTGGGAACTACCCACTGTCGTCATTTTTATGTGCAGAAAAGATCCTTTTTGAAAACCATATTTATTGGGATCTTATTTAAATTTAAATTATCCTTTACAACTTCTTAAAATGAAT
ATGCTAATAGATAAGACTTTATCCATTACATCTAAGAACTTTTTAACCTGTATATCAATCTAAATAGGTTTCTAGAAATAATCCTAGCTTTCATACACCATGTAGTTCTAGACTCCGTCCATATCAGT
GTAACATTGTGTGATAAAATGCCAAATGTCTTGTATCTAAGCTACGCTCCCACTCTTCCAGCCACCCCTACCTCCCACCTTGACACCCTTAAGAAAGCAATGCTGACTTTTATTCTGACAAGTGGAAA
TCAATAGTGGTTAATCAAGTGGATTTTGTAAATGCTAAGAAGTGTTTGTGAAAACCTTCCCTTTCTGAGTTAGGATTGTTTTTTCCTGTTCATTTCAGGTGTTTTATTGAGCATCTGATTTGTGTCAG
CACCATGTAAATATGATGAGGAGTATTTGGAATAGACTTTACATTCACCAGAAAATTGATAGTATTTGTTAAACCAATGCATCCATTCAAAATAGAGGCAGAGTAAACAGCCTAAGAAATGATTTCCT
TTCTACAGTCTGCTAGGAGAAAGAGGTGAGAGGGGAGTGGTTGATGATTTTAATCAAGAGTAAAGGGAACATTTATTACATGAAATCTGACTTCAGTTGTGCAAAGGTATGTTAAGACATTAAGACAA
TTGCTGGAAGGTTTCAAATATGTGTACACACACATAGAGCTACTTTTGTGTGTTTATTTATATGTATATTTCACAAAGGCTAATGCCCACAGAGGAAAATGATTATTTTAACTTCTGGGTTATCATCT
GCTGGCAGGGTCTGATCAGGTCTAGAGTATTTAAGGAAAAGTCTCCTGTCTTCTATCTCCACTAGAAGTACTGCAGCTTGAGAGCTGAAAGGAACTTGAAAAATGTTATCCAGTCTTCACTTAGCCCA
TTTTTATCGGCATTAGGAAATAGGGTTCAGCAATGGTTATTGATTTAGCAGTCTGGTCTTATATGATCTGCTTTCTAATTATCTATCTAGTATTCCTATATTATACTGGAACTTCAATAAATTATAAC
CTATGTGAATATCATAAATTCTTGTGAATTTTTGTCTATTTCCAGTAGAGAAGCATACTCAGCCAATGTTTTCACTTAATAACTATGACAACCTTAAAGGATGTCACTTAAGTTAGAAAATAAGCAGG
CTTAAGAAGTGATTCTAATTAGGACCCCCACTCAGTTTGCTAGTCATGCCTGCCTGACAGAACATAAGCTTTTGTAAAGTATTTAGACTGATAACACATGCAGTATGAAAACATTATAGACTGCAGTT
AGAAGACTAATTTTTTAAAAGCACTCAAAACATAGAACTAAGATTTAGAATATATGTCCATTTATAATGAAATAATTTGTGTTCATAATGTGAACATGTAAGATAAGTAAATAAAGCATTACTTGTTT
TATAATATCAGGAAGAGAGAAGGAAACATTAGTTTATAACAATGTGCTATTTAATATCTGTATTTTGAACATTTAAAATACTCTGATGGTAAGGTTGCCAAAGTAATTTTGAATTCATAAAAATTGTT
TATACCACAATAATGTGGGATATGTTTACAGGCTCTTTTATTTTGTGGTAGTTACTTTATAGTTCAGATGAATTTGCATTTCAGTCACTTATAGTAAATAAAGTATATTAAATATTTGTTGGAATAAA
AATCTCAATGTAATAGGACATAGATAAATTATGCAACAGCCTGCTTTGATGAAAGCTGGTGCATTATGTGAGCTGCCACAGTTAATACTTTGTATTAACATTGCTTACTTCCCCCATTTGCTTCACCT
ATCTGACTACAATTGCTGGAATCATTCTTTTTGTGGTGCTTCCTCCAAGTGAAATAACTATGTTATTAAAACCTACTGGATTAATTTTATCAAATATCAGACTTACTGATCTCTTGGCAGAGATTTAT
TGGTGTCTCAGTGTGATCACAATACAAGTTGTAGCAACCATTTTATAAAACTCTTAGAGAATTATGTAGATAAAATGGAAATTACATAATCCTAAAACATTTTTGAGGGCTAATTGATAATAATTTCA
GCAATTTTATTAAGAACCCAGTAAATTAATCCCTAATTTGTATGTTTTTTGTTCAACTTACCGTGTCTGCAACCATTATATAGACTTCATTGATACTCAGCAATTACTACAGTGTGTCTTACAATGTT
ATAAAAAACAAACAGCAATCTCTGTTTCTGCCAGAAGTTAGATATTTTTTTATAGTCCTGATGAATTTGTTGTGAGTAGACACCACATAGTTATTTCTGTTTGCATATAAATTTGCTGCTATTTATTT
GTATGTTTTTCTACTGTAGTATGCTATTGATTTCTGAAGTTATAATCATAATTTTTATTTTAGTAATCCAAGCTAAATGGGCAACCAGAAGTAATATCTGCTAGGGTGCAATCCATCAGCATTGGTTC
AGTGCATATACATAAGTAAACCAGTTTAAAAAAATTTTACTAAGCAAAAGGTAGTAGCAATATTGCTAGTTAAAGATTACCATTTTAGGGGAAAGTTCAAAGGTTTAACTTCCTGAAACCTTTTAAAC
TTTTCAGTGCAAGAATGAAAATGTTTGAAAGCCTTGTTAAGCTCATAAAAGTTTCATTTAAACACTGTAGAGTTTCCTACCTTTGTTGTGTAAAGGATATAGAAAATATTTTTCTATGGACAGAAGGT
TGAAACTGTTAACTTCTTTAATTTCATTGTTTAAAGGAGATAAAATGTTATTTGTGTGTCTTTCATGCTGTAAAGAAAATGAATGTATCTTTCAAATGTCATTAGAATTATGGCTTGATTCTAAGGAT
ACTCTATTTGTTTTAAAGTCTACACGGGATTGAAAAGAAAGGGAAGAGTATTACACTTCATTGTACAAAATGTAATTTTAGAAGAAAAACATTTTCATTATAAACAAGAGCAATCATTGAAGCATTTT
CAGATATAATGTACATTCTTTTTCATTTTGCTTTGCCTCTAGAATAGAAACTTTTCAGAAAATTTGCACATACTGTTTGTAAGTATAAAATAATTGAATTCTAGACTTTTGGAGTGTGGAAGGGTGTT
TGTGTGTGAAGGTAATAAATGTGTTGCTGCATGTGTTTACCATAGAGAACGTTGCCAGGCTTTGTCAAATGAGGACATTGTTGTGAGGGTGTGACTTTTGTGAAGCCAGAAAACTGTGCCTAAGATTC
ATTACAGTGAGTATGTGCAGAGGCCCCTGACCCAGTAAATGCTTTTTGCCTTTTTATTCCCAATGTCTTGGACAGTTGAGACAACTTGGCCCAACTCTGAATTGTAGCAGTGATGTCTTATATGCTTA
CGAGTTTATATTAATTCAGCTGAACAAGAACTACATCTTAAACCACCTTTGTAGGTATGATTAATACGTGCAACAGCTGCTTTAAAAGGTGGTATTTATTATTCATCACTCATGAAACTTGACTCAGT
GAGGACTTCATTATTTTTATTTCTCTTTCCACGTCTCCAACTTTTTAAAAATCACTAATTTAACTCTTTGTTAAGTACTCAAGTACAAAGTGATCTCTTCTTTCATGAACTTTGCTATAACTGTTGAA
AGGATTGGTGTCAGGCTCTCTCAACCCTGGGAGTTTCCAAAATTTAGCAAATATTACTTGTGATAAGCTTAAATGCCACATCGCTAAGTACAATTATTACCAGGAATCCGTCAAGGGGGAGATAGCCC
CGCTCACACCCTTAGACCCAAACAGGTGCTGGTTCATGCTTTCTCCACAAATTGGCAGTTGGGTACTTCCCCACTGTCATCACAGTTGAGCTCATTTTAACATATATTCAAAGAAGCTTTTTAGTTTC
TACTCCTGAATTGTAGTGTTCAAGTTATTTGCCTTCCTGGGTAAGAAAATTTTAACCCAAGTCTGGGATTCTCTGGCACCTGTCTTTTCCCATCTTTTAATGAGTTGGCAAGATTAGGTCAAATTTCA
ATGCTAAATTTGATTTTTTGAATTTTAAATAGTTGCACTTTATTTCATGCTGACCACCAACTTAATTTATACATTTTAAAATAAAATTATCCTAGAAGTGTTGTAAACGTGGGAAAATTTTAATTAGT
GTTGGAGGTCATTAGATTGGACCCAGGTTTAAATATAATGATCTCTTCACAGCTTATTTGATGTTTAAGAGCAACTTGTGTGATCTTAGCTTTGCAGGTTTTCTGTAATTTATGTAGCACAATAAAGG
ATAACCAGTTGACTGTGTTACTGGACTCTGAGTTCTCACAGCTAGTTTCATCTAAGCTTGGTTTATTATCATTTCTGCTTTGGATTTTTTTGTGCATCACATGAATACTTAGAAATCCATTTGTTTTC
AGTGTAGTACCTAGGGTGAAGTAGATGCTGCACAAGTAAGTTTAAGGGAATAAAAGTCCCGACACTTTATATACATGTTGAGGGGCACGATTTAAGAGACTGAAACAGTTTACATTAAACTGTTTTTA
TTTTCTGCCAGTAGACTCTATCTGCTTAAAAAAATAAAAATTGTTCAACCCAGTGTTCTCCAGCATCAGGACATTACAGTTGTAATCTATGTTGTAATCTTTTCAAATAAGAAAAGCTACTCCTTATT
CTCTACAGTGTAGGCTTAATTTTAGAACCGATAATTTACTATATCTGCATTATTGATATTTTTAAGTAGTAGTTTTAAAAATAATTATTTCTATGTGGAGGGTGTTTTAATTTGGGATTTTTTTTTTC
TTGTAACAGGTGCTATTTGTAAATATGAAGGGGAAAAGTCACTTAGTTAAAAGTCTAGCTTATGTCATAATTAAGATACAATTATTCATTTCATGTTTGATTCTATTAAACTAGTGGCAAAACAGAAT
TGGTCCCTTAGTTTTTTAGATTACCTTTCCCCCTATATCACAAAAATATCTCTTTCCATATGATCTCATAATTGAGGCAAAGAAGCTAAGGGTTTATTTAAAATGTGTATAAGCTTGAATTTGGTCAA
CACTGCATAATTTGAAATCACTCTGCATTTGTCACTGCAGCTTACTGTATGCTTGAAAGGCCTTGTGTGTTTGTCTTAATTTTAGTGAAAAAATTAGAATTTCTGCCATTCATGTACAAAAAAATTAC
AACTACAGCAAACAAGATAAAAATGCTGGTTTGCATTAATACTGTTTTAGTCTTAAGAGCAATTTATATTATGTGAAATGCTGTTACACATATTTTGTTGGCCATATTTCATTTTGAGAAACAGTTGT
TCAGGTACAAACATGACAAACAACTCTAGCTATGACTCTTAATGTTCAATTGCAAAATAAAGATGTGCTTTAGTAATCTAAA

hide sequence


Protein RefSeqs	NP_002821	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA36530	(Get FASTA)	NCBI Sequence Viewer
	AAH10674	(Get FASTA)	NCBI Sequence Viewer
	AAX82012	(Get FASTA)	NCBI Sequence Viewer
	AAX88858	(Get FASTA)	NCBI Sequence Viewer
	AAY14805	(Get FASTA)	NCBI Sequence Viewer
	AAY24016	(Get FASTA)	NCBI Sequence Viewer
	BAG37355	(Get FASTA)	NCBI Sequence Viewer
	BAH13435	(Get FASTA)	NCBI Sequence Viewer
	EAW95231	(Get FASTA)	NCBI Sequence Viewer
	EAW95232	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000263708
	ENSP00000263708.2
GenBank Protein	P29074	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_002821 ⟸ NM_002830

- UniProtKB:

B2RBV8 (UniProtKB/Swiss-Prot), Q9UDA7 (UniProtKB/Swiss-Prot), P29074 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFL
QIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWL
KIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSISDDRLE
TQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNGGIPH
DNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVRPNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLR
ESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWP
EPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQ
TPSQYRFVCEAILKVYEEGFVKPLTTSTNK

hide sequence

Ensembl Acc Id:

ENSP00000394706 ⟸ ENST00000441089

Ensembl Acc Id:

ENSP00000395603 ⟸ ENST00000430976

Ensembl Acc Id:

ENSP00000387457 ⟸ ENST00000431283

Ensembl Acc Id:

ENSP00000411364 ⟸ ENST00000433888

Protein Domains

FERM PDZ Tyrosine specific protein phosphatases Tyrosine-protein phosphatase

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P29074-F1-model_v2	AlphaFold	P29074	1-926	view protein structure

RGD ID:

6861446

Promoter ID:

EPDNEW_H3888

Type:

initiation region

Name:

PTPN4_2

Description:

protein tyrosine phosphatase, non-receptor type 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H3889

Experiment Methods:

Single-end sequencing.; Paired-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	119,759,604 - 119,759,664	EPDNEW

RGD ID:

6861448

Promoter ID:

EPDNEW_H3889

Type:

initiation region

Name:

PTPN4_1

Description:

protein tyrosine phosphatase, non-receptor type 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H3888

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	119,759,954 - 119,760,014	EPDNEW

RGD ID:

6798033

Promoter ID:

HG_KWN:34741

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4

Transcripts:

OTTHUMT00000254233, OTTHUMT00000332673, OTTHUMT00000332674, OTTHUMT00000337186, OTTHUMT00000337188, OTTHUMT00000337271

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	2	120,233,514 - 120,234,014 (+)	MPROMDB

Database	Acc Id	Source(s)
COSMIC	PTPN4	COSMIC
Ensembl Genes	ENSG00000088179	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000263708	ENTREZGENE
	ENST00000263708.7	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.80.10	UniProtKB/Swiss-Prot
	2.30.29.30	UniProtKB/Swiss-Prot
	2.30.42.10	UniProtKB/Swiss-Prot
	3.90.190.10	UniProtKB/Swiss-Prot
	Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1	UniProtKB/Swiss-Prot
GTEx	ENSG00000088179	GTEx
HGNC ID	HGNC:9656	ENTREZGENE
Human Proteome Map	PTPN4	Human Proteome Map
InterPro	Band_41_domain	UniProtKB/Swiss-Prot
	FERM-adjacent	UniProtKB/Swiss-Prot
	FERM/acyl-CoA-bd_prot_sf	UniProtKB/Swiss-Prot
	FERM_2	UniProtKB/Swiss-Prot
	FERM_central	UniProtKB/Swiss-Prot
	FERM_CS	UniProtKB/Swiss-Prot
	FERM_domain	UniProtKB/Swiss-Prot
	FERM_N	UniProtKB/Swiss-Prot
	FERM_PH-like_C	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	PDZ_sf	UniProtKB/Swiss-Prot
	PH-like_dom_sf	UniProtKB/Swiss-Prot
	Prot-tyrosine_phosphatase-like	UniProtKB/Swiss-Prot
	PTPase_domain	UniProtKB/Swiss-Prot
	PTPN3/4_FERM_C	UniProtKB/Swiss-Prot
	Tyr_Pase_AS	UniProtKB/Swiss-Prot
	Tyr_Pase_cat	UniProtKB/Swiss-Prot
	Tyr_Pase_non-rcpt_typ-3/4	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_dom	UniProtKB/Swiss-Prot
	Ubiquitin-like_domsf	UniProtKB/Swiss-Prot
KEGG Report	hsa:5775	UniProtKB/Swiss-Prot
NCBI Gene	5775	ENTREZGENE
OMIM	176878	OMIM
PANTHER	TYROSINE-PROTEIN PHOSPHATASE	UniProtKB/Swiss-Prot
	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 4	UniProtKB/Swiss-Prot
Pfam	FERM_C	UniProtKB/Swiss-Prot
	FERM_M	UniProtKB/Swiss-Prot
	FERM_N	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	PF08736	UniProtKB/Swiss-Prot
	Y_phosphatase	UniProtKB/Swiss-Prot
PharmGKB	PA34000	PharmGKB
PIRSF	Tyr-Ptase_nr3	UniProtKB/Swiss-Prot
PRINTS	BAND41	UniProtKB/Swiss-Prot
	PRTYPHPHTASE	UniProtKB/Swiss-Prot
PROSITE	FERM_1	UniProtKB/Swiss-Prot
	FERM_2	UniProtKB/Swiss-Prot
	FERM_3	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_1	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_2	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_PTP	UniProtKB/Swiss-Prot
SMART	B41	UniProtKB/Swiss-Prot
	FERM_C	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	PTPc	UniProtKB/Swiss-Prot
	PTPc_motif	UniProtKB/Swiss-Prot
	SM01195	UniProtKB/Swiss-Prot
Superfamily-SCOP	PH domain-like	UniProtKB/Swiss-Prot
	SSF47031	UniProtKB/Swiss-Prot
	SSF50156	UniProtKB/Swiss-Prot
	SSF52799	UniProtKB/Swiss-Prot
	SSF54236	UniProtKB/Swiss-Prot
UniProt	B2RBV8	ENTREZGENE
	F5H020_HUMAN	UniProtKB/TrEMBL
	J3KQD3_HUMAN	UniProtKB/TrEMBL
	J3KQP5_HUMAN	UniProtKB/TrEMBL
	J3QT41_HUMAN	UniProtKB/TrEMBL
	J3QT59_HUMAN	UniProtKB/TrEMBL
	J3QT89_HUMAN	UniProtKB/TrEMBL
	P29074	ENTREZGENE, UniProtKB/Swiss-Prot
	Q4ZG31_HUMAN	UniProtKB/TrEMBL
	Q53Q76_HUMAN	UniProtKB/TrEMBL
	Q53QV5_HUMAN	UniProtKB/TrEMBL
	Q580X3_HUMAN	UniProtKB/TrEMBL
	Q9UDA7	ENTREZGENE
UniProt Secondary	B2RBV8	UniProtKB/Swiss-Prot
	Q9UDA7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-02-19	PTPN4	protein tyrosine phosphatase non-receptor type 4		protein tyrosine phosphatase, non-receptor type 4	Symbol and/or name change	5135510	APPROVED
2016-01-19	PTPN4	protein tyrosine phosphatase, non-receptor type 4		protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

Imported Disease Annotations - ClinVar

Imported Human Phenotype Annotations - ClinVar

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Imported Disease Annotations - ClinVar

Imported Human Phenotype Annotations - ClinVar