Ptpn4 (protein tyrosine phosphatase non-receptor type 4) - Rat Genome Database

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Gene: Ptpn4 (protein tyrosine phosphatase non-receptor type 4) Chinchilla lanigera
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Symbol: Ptpn4
Name: protein tyrosine phosphatase non-receptor type 4
RGD ID: 8834882
Description: ENCODES a protein that exhibits glutamate receptor binding (ortholog); non-membrane spanning protein tyrosine phosphatase activity (ortholog); ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic side of plasma membrane (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein phosphatase non-receptor type 4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554599,803,421 - 9,981,392 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554599,803,421 - 9,981,392 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ptpn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554599,803,421 - 9,981,392 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554599,803,421 - 9,981,392 (-)NCBIChiLan1.0ChiLan1.0
PTPN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382119,759,922 - 119,984,899 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2119,759,922 - 119,984,899 (+)EnsemblGRCh38hg38GRCh38
GRCh372120,517,498 - 120,742,475 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362120,233,677 - 120,451,507 (+)NCBINCBI36Build 36hg18NCBI36
Build 342120,233,436 - 120,451,267NCBI
Celera2113,842,942 - 114,061,903 (+)NCBICelera
Cytogenetic Map2q14.2NCBI
HuRef2112,841,586 - 113,066,878 (+)NCBIHuRef
CHM1_12120,520,785 - 120,746,914 (+)NCBICHM1_1
T2T-CHM13v2.02120,193,967 - 120,419,641 (+)NCBIT2T-CHM13v2.0
Ptpn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391119,580,197 - 119,765,281 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1119,580,197 - 119,765,343 (-)EnsemblGRCm39 Ensembl
GRCm381119,652,467 - 119,837,585 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1119,652,467 - 119,837,613 (-)EnsemblGRCm38mm10GRCm38
MGSCv371121,554,669 - 121,733,648 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361121,487,291 - 121,630,021 (-)NCBIMGSCv36mm8
Celera1122,316,986 - 122,496,376 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.39NCBI
Ptpn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81333,324,808 - 33,504,957 (-)NCBIGRCr8
mRatBN7.21330,772,012 - 30,952,340 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1330,776,682 - 30,952,170 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1333,353,328 - 33,533,288 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01334,641,168 - 34,821,122 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01331,915,258 - 32,095,209 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01335,678,240 - 35,858,414 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1335,678,240 - 35,858,390 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01340,792,728 - 40,972,784 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41332,430,875 - 32,611,163 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11332,475,262 - 32,484,043 (-)NCBI
Celera1330,666,333 - 30,846,454 (-)NCBICelera
Cytogenetic Map13q11NCBI
PTPN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21321,735,494 - 21,982,547 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B21,750,466 - 21,998,093 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B6,694,192 - 6,917,265 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B120,320,591 - 120,492,423 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B120,320,610 - 120,485,676 (+)Ensemblpanpan1.1panPan2
PTPN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11930,079,221 - 30,285,126 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1930,086,832 - 30,241,064 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1930,335,314 - 30,541,476 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01931,454,630 - 31,662,707 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1931,461,882 - 31,663,169 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11930,140,713 - 30,349,797 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01930,310,819 - 30,517,448 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01931,493,639 - 31,702,636 (-)NCBIUU_Cfam_GSD_1.0
Ptpn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530390,976,332 - 91,149,472 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646950,470,256 - 50,594,357 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646950,463,473 - 50,641,419 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1531,307,447 - 31,502,923 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11531,305,394 - 31,502,978 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21536,235,035 - 36,459,764 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11010,325,263 - 10,554,381 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1010,328,766 - 10,554,258 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606112,136,097 - 12,365,467 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473225,108,192 - 25,278,948 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473225,099,327 - 25,301,610 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000003985   ⟹   ENSCLAP00000003909
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554599,803,421 - 9,981,392 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000003986   ⟹   ENSCLAP00000003910
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554599,883,934 - 9,943,696 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000003987   ⟹   ENSCLAP00000003911
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554599,890,217 - 9,943,696 (-)Ensembl
RefSeq Acc Id: XM_005397664   ⟹   XP_005397721
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554599,803,421 - 9,981,392 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013521057   ⟹   XP_013376511
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554599,803,421 - 9,981,392 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013521058   ⟹   XP_013376512
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554599,803,421 - 9,981,392 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013521059   ⟹   XP_013376513
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554599,803,421 - 9,981,392 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005397721   ⟸   XM_005397664
- Peptide Label: isoform X4
- UniProtKB: A0A8C2UR20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013376513   ⟸   XM_013521059
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013376512   ⟸   XM_013521058
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013376511   ⟸   XM_013521057
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCLAP00000003910   ⟸   ENSCLAT00000003986
RefSeq Acc Id: ENSCLAP00000003911   ⟸   ENSCLAT00000003987
RefSeq Acc Id: ENSCLAP00000003909   ⟸   ENSCLAT00000003985

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002781 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000003985 ENTREZGENE
  ENSCLAT00000003985.1 UniProtKB/TrEMBL
  ENSCLAT00000003986.1 UniProtKB/TrEMBL
  ENSCLAT00000003987.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM-adjacent UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_CS UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTP_cat UniProtKB/TrEMBL
  PTPN3/4_FERM_C UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL
  Tyr_Pase_non-rcpt_typ-3/4 UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene Ptpn4 ENTREZGENE
PANTHER TYROSINE-PROTEIN PHOSPHATASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 4 UniProtKB/TrEMBL
Pfam FERM_C UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PF08736 UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PIRSF Tyr-Ptase_nr3 UniProtKB/TrEMBL
PRINTS BAND41 UniProtKB/TrEMBL
  PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE FERM_1 UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_3 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
  SM01195 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8C2UR20 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YJT5_CHILA UniProtKB/TrEMBL
  A0A8C2YJU2_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 Ptpn4  protein tyrosine phosphatase non-receptor type 4    protein tyrosine phosphatase, non-receptor type 4  Symbol and/or name change 5135510 APPROVED
2016-08-03 Ptpn4  protein tyrosine phosphatase, non-receptor type 4    protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)  Symbol and/or name change 5135510 APPROVED