Prmt5 (protein arginine methyltransferase 5) - Rat Genome Database

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Gene: Prmt5 (protein arginine methyltransferase 5) Rattus norvegicus
Analyze
Symbol: Prmt5
Name: protein arginine methyltransferase 5
RGD ID: 1309053
Description: Predicted to enable several functions, including p53 binding activity; protein-arginine N-methyltransferase activity; and sequence-specific DNA binding activity. Involved in several processes, including liver regeneration; negative regulation of gene expression via chromosomal CpG island methylation; and positive regulation of oligodendrocyte differentiation. Part of protein-containing complex. Biomarker of asthma. Orthologous to human PRMT5 (protein arginine methyltransferase 5); PARTICIPATES IN histone modification pathway; homocysteine metabolic pathway; methionine cycle/metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: HMT1 hnRNP methyltransferase-like 5; Hrmt1l5; LOC364382; protein arginine N-methyltransferase 5; Skb1; SKB1 homolog; SKB1 homolog (S. pombe)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81531,938,927 - 31,948,318 (-)NCBIGRCr8
mRatBN7.21527,968,893 - 27,978,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1527,968,910 - 27,978,296 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1529,808,255 - 29,817,654 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01530,955,476 - 30,964,875 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,205,536 - 29,214,734 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,156,508 - 33,165,893 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,156,492 - 33,165,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,041,740 - 37,051,125 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41532,574,951 - 32,584,336 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11532,590,652 - 32,600,343 (-)NCBI
Celera1527,551,512 - 27,560,897 (-)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
clofibric acid  (EXP)
cocaine  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
Nutlin-3  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
ribavirin  (ISO)
rotenone  (EXP)
S-adenosyl-L-homocysteine  (ISO)
selenium atom  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
T-2 toxin  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF. Andreu-Perez P, etal., Sci Signal. 2011 Sep 13;4(190):ra58. doi: 10.1126/scisignal.2001936.
2. Arginine methylation an emerging regulator of protein function. Bedford MT and Richard S, Mol Cell 2005 Apr 29;18(3):263-72.
3. Histone arginine methylation. Di Lorenzo A and Bedford MT, FEBS Lett. 2011 Jul 7;585(13):2024-31. doi: 10.1016/j.febslet.2010.11.010. Epub 2010 Nov 11.
4. Negative regulation of transcription by the type II arginine methyltransferase PRMT5. Fabbrizio E, etal., EMBO Rep. 2002 Jul;3(7):641-5.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Readers of histone methylarginine marks. Gayatri S and Bedford MT, Biochim Biophys Acta. 2014 Aug;1839(8):702-710. doi: 10.1016/j.bbagrm.2014.02.015. Epub 2014 Feb 28.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Type II arginine methyltransferase PRMT5 regulates gene expression of inhibitors of differentiation/DNA binding Id2 and Id4 during glial cell differentiation. Huang J, etal., J Biol Chem. 2011 Dec 30;286(52):44424-32. doi: 10.1074/jbc.M111.277046. Epub 2011 Oct 31.
9. The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors. Liang JJ, etal., J Urol. 2007 May;177(5):1918-22.
10. Multimerization of expressed protein-arginine methyltransferases during the growth and differentiation of rat liver. Lim Y, etal., Biochim Biophys Acta. 2005 May 25;1723(1-3):240-7. Epub 2005 Mar 17.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. [Expression of protein arginine N-methyltransferases in E3 rat models of acute asthma]. Sun QZ, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2010 Apr;30(4):716-9.
Additional References at PubMed
PMID:8889548   PMID:11756452   PMID:12477932   PMID:15369763   PMID:16787967   PMID:17709427   PMID:18347060   PMID:18495660   PMID:18984161   PMID:19011621   PMID:20421892   PMID:21081503  
PMID:22143770   PMID:22269951   PMID:22365833   PMID:22871113   PMID:22952863   PMID:23048031   PMID:23071334   PMID:23133559   PMID:25284789   PMID:26554819   PMID:26700805   PMID:30858101  
PMID:32739429   PMID:35352799   PMID:37390022  


Genomics

Comparative Map Data
Prmt5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81531,938,927 - 31,948,318 (-)NCBIGRCr8
mRatBN7.21527,968,893 - 27,978,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1527,968,910 - 27,978,296 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1529,808,255 - 29,817,654 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01530,955,476 - 30,964,875 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,205,536 - 29,214,734 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,156,508 - 33,165,893 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,156,492 - 33,165,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,041,740 - 37,051,125 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41532,574,951 - 32,584,336 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11532,590,652 - 32,600,343 (-)NCBI
Celera1527,551,512 - 27,560,897 (-)NCBICelera
Cytogenetic Map15p13NCBI
PRMT5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381422,920,529 - 22,929,376 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1422,920,525 - 22,929,408 (-)EnsemblGRCh38hg38GRCh38
GRCh371423,389,738 - 23,398,585 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,459,573 - 22,468,501 (-)NCBINCBI36Build 36hg18NCBI36
Build 341422,459,578 - 22,468,501NCBI
Celera143,252,630 - 3,261,553 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,506,765 - 3,515,687 (-)NCBIHuRef
CHM1_11423,388,351 - 23,397,277 (-)NCBICHM1_1
T2T-CHM13v2.01417,118,607 - 17,127,453 (-)NCBIT2T-CHM13v2.0
Prmt5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391454,744,639 - 54,754,927 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1454,744,644 - 54,754,982 (-)EnsemblGRCm39 Ensembl
GRCm381454,507,182 - 54,517,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,507,187 - 54,517,525 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,126,019 - 55,136,307 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,461,664 - 53,471,620 (-)NCBIMGSCv36mm8
Celera1452,302,644 - 52,312,943 (-)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1427.82NCBI
Prmt5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540937,369,234 - 37,378,093 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540937,369,507 - 37,378,034 (+)NCBIChiLan1.0ChiLan1.0
PRMT5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,350,371 - 24,359,212 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11423,566,859 - 23,576,070 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0143,737,741 - 3,746,646 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11421,836,984 - 21,846,018 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1421,836,984 - 21,846,018 (-)Ensemblpanpan1.1panPan2
PRMT5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,248,349 - 3,257,567 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,248,404 - 3,257,456 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,196,693 - 3,205,933 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,356,162 - 3,365,422 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,356,165 - 3,365,310 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,047,415 - 3,056,657 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,108,945 - 3,118,202 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,371,200 - 3,380,454 (-)NCBIUU_Cfam_GSD_1.0
Prmt5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,000,952 - 35,009,330 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367221,379,515 - 1,388,546 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367221,379,515 - 1,388,538 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRMT5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl776,110,951 - 76,124,989 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1776,110,956 - 76,119,619 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PRMT5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,288,458 - 23,297,746 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,288,835 - 23,297,518 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605923,123,104 - 23,132,411 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prmt5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248209,599,734 - 9,608,703 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248209,599,867 - 9,608,578 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prmt5
29 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:89
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000016302
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000016302   ⟹   ENSRNOP00000016302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1527,968,911 - 27,978,296 (-)Ensembl
Rnor_6.0 Ensembl1533,156,492 - 33,165,895 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096842   ⟹   ENSRNOP00000097566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1527,968,910 - 27,978,264 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097219   ⟹   ENSRNOP00000080060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1527,968,910 - 27,978,262 (-)Ensembl
RefSeq Acc Id: NM_001108867   ⟹   NP_001102337
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81531,938,927 - 31,948,312 (-)NCBI
mRatBN7.21527,968,893 - 27,978,278 (-)NCBI
Rnor_6.01533,156,508 - 33,165,893 (-)NCBI
Rnor_5.01537,041,740 - 37,051,125 (-)NCBI
RGSC_v3.41532,574,951 - 32,584,336 (-)RGD
Celera1527,551,512 - 27,560,897 (-)RGD
Sequence:
RefSeq Acc Id: XM_039093546   ⟹   XP_038949474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81531,939,195 - 31,948,318 (-)NCBI
mRatBN7.21527,968,898 - 27,978,291 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102337 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949474 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM14174 (Get FASTA)   NCBI Sequence Viewer  
  EDM14175 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016302.3
  ENSRNOP00000080060.1
  ENSRNOP00000097566.1
RefSeq Acc Id: NP_001102337   ⟸   NM_001108867
- UniProtKB: D4A0E8 (UniProtKB/TrEMBL),   A6KGU5 (UniProtKB/TrEMBL),   A0A8I6ANJ2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016302   ⟸   ENSRNOT00000016302
RefSeq Acc Id: XP_038949474   ⟸   XM_039093546
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZP89 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097566   ⟸   ENSRNOT00000096842
Ensembl Acc Id: ENSRNOP00000080060   ⟸   ENSRNOT00000097219
Protein Domains
PRMT5 arginine-N-methyltransferase   PRMT5 oligomerisation   PRMT5 TIM barrel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A0E8-F1-model_v2 AlphaFold D4A0E8 1-637 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699652
Promoter ID:EPDNEW_R10175
Type:multiple initiation site
Name:Prmt5_1
Description:protein arginine methyltransferase 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01533,165,884 - 33,165,944EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309053 AgrOrtholog
BioCyc Gene G2FUF-13797 BioCyc
Ensembl Genes ENSRNOG00000012046 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016302.5 UniProtKB/TrEMBL
  ENSRNOT00000096842.1 UniProtKB/TrEMBL
  ENSRNOT00000097219.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
  Divalent-metal-dependent TIM barrel enzymes UniProtKB/TrEMBL
  Hnrnp arginine n-methyltransferase1 UniProtKB/TrEMBL
InterPro Arg_MeTrfase UniProtKB/TrEMBL
  PRMT5 UniProtKB/TrEMBL
  PRMT5_C UniProtKB/TrEMBL
  PRMT5_TIM UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
  Skb1_MeTrfase UniProtKB/TrEMBL
KEGG Report rno:364382 UniProtKB/TrEMBL
NCBI Gene 364382 ENTREZGENE
PANTHER PROTEIN ARGININE N-METHYLTRANSFERASE 5 UniProtKB/TrEMBL
  Skb1_mtfrase UniProtKB/TrEMBL
Pfam PRMT5 UniProtKB/TrEMBL
  PRMT5_C UniProtKB/TrEMBL
  PRMT5_TIM UniProtKB/TrEMBL
PhenoGen Prmt5 PhenoGen
PIRSF Skb1_MeTrfase UniProtKB/TrEMBL
PROSITE SAM_MT_PRMT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012046 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A8I5ZP89 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ANJ2 ENTREZGENE, UniProtKB/TrEMBL
  A6KGU5 ENTREZGENE, UniProtKB/TrEMBL
  D4A0E8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-24 Prmt5  protein arginine methyltransferase 5  Prmt5  protein arginine N-methyltransferase 5   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Prmt5  protein arginine N-methyltransferase 5   Prmt5_predicted  protein arginine N-methyltransferase 5 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Prmt5_predicted  protein arginine N-methyltransferase 5 (predicted)  Skb1_predicted  SKB1 homolog (S. pombe) (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Skb1_predicted  SKB1 homolog (S. pombe) (predicted)      Symbol and Name status set to approved 70820 APPROVED