Pfas (phosphoribosylformylglycinamidine synthase) - Rat Genome Database

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Gene: Pfas (phosphoribosylformylglycinamidine synthase) Rattus norvegicus
Analyze
Symbol: Pfas
Name: phosphoribosylformylglycinamidine synthase
RGD ID: 1304926
Description: Predicted to enable phosphoribosylformylglycinamidine synthase activity. Involved in glutamine metabolic process and response to xenobiotic stimulus. Predicted to be active in cytoplasm. Biomarker of hepatocellular carcinoma. Orthologous to human PFAS (phosphoribosylformylglycinamidine synthase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 6-propyl-2-thiouracil; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FGAM synthetase; LOC287420; phosphoribosylformylglycinamidine synthase (FGAR amidotransferase); similar to phosphoribosylformylglycinamidine synthase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,189,157 - 54,210,685 (-)NCBIGRCr8
mRatBN7.21053,690,301 - 53,711,811 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1053,691,626 - 53,708,420 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,352,061 - 58,370,245 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01057,840,655 - 57,858,839 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,349,123 - 53,367,092 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01055,571,881 - 55,593,384 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,571,118 - 55,589,978 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,314,680 - 55,336,185 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41055,745,617 - 55,761,944 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11055,759,631 - 55,771,591 (-)NCBI
Celera1052,858,284 - 52,874,638 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PfasRatcolon adenocarcinoma  ISORGD:13126485135276 RGD 
PfasRatExperimental Diabetes Mellitus  IEP 5135485protein:increased activity:liver (rat)RGD 
PfasRathepatocellular carcinoma  IEP 5135276protein:increased activity:hepatoma (rat)RGD 
PfasRatlung carcinoma  ISORGD:16141545135276 RGD 
PfasRatrenal cell carcinoma  ISORGD:13126485135276 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PfasRatAutosomal Recessive Dyskeratosis Congenita  ISORGD:13126488554872ClinVar Annotator: match by term: Dyskeratosis Congenita, RecessiveClinVarPMID:25741868
PfasRatCerebroretinal Microangiopathy with Calcifications and Cysts 1  ISORGD:13126488554872ClinVar Annotator: match by term: CTC1-related condition | ClinVar Annotator: match by term: Cerebroretinal microangiopathy more ...ClinVarPMID:22267198|PMID:22387016|PMID:24115768|PMID:25741868|PMID:28492532|PMID:29481669
PfasRatDiamond-Blackfan anemia  ISORGD:13126488554872ClinVar Annotator: match by term: Diamond-Blackfan anemiaClinVarPMID:20522432|PMID:21056402|PMID:22267198|PMID:22387016|PMID:22431104|PMID:23172776|PMID:28492532
PfasRatdyskeratosis congenita  ISORGD:13126488554872ClinVar Annotator: match by term: Dyskeratosis congenitaClinVarPMID:16199547|PMID:17576681|PMID:20522432|PMID:21056402|PMID:22267198|PMID:22387016|PMID:23172776|PMID:24115768|PMID:25741868|PMID:28492532|PMID:29481669|PMID:9536098
PfasRatgenetic disease  ISORGD:13126488554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868|PMID:28492532
PfasRatLi-Fraumeni syndrome  ISORGD:13126488554872ClinVar Annotator: match by term: Li-Fraumeni syndromeClinVarPMID:20522432|PMID:21056402|PMID:22267198|PMID:22387016|PMID:23172776|PMID:26681312|PMID:28369373|PMID:28492532
PfasRatvery long chain acyl-CoA dehydrogenase deficiency  ISORGD:13126488554872ClinVar Annotator: match by term: Very long chain acyl-CoA dehydrogenase deficiencyClinVarPMID:11590124|PMID:28492532|PMID:9973285

1 to 20 of 103 rows

  
Object Symbol
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Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
PfasRat(-)-demecolcine decreases expressionISORGD:13126486480464Demecolcine results in decreased expression of PFAS mRNACTDPMID:23649840
PfasRat1,2-dichloroethane increases expressionISORGD:16141546480464ethylene dichloride results in increased expression of PFAS mRNACTDPMID:28960355
PfasRat1,2-dimethylhydrazine decreases expressionISORGD:161415464804641,2-Dimethylhydrazine results in decreased expression of PFAS mRNACTDPMID:22206623
PfasRat17beta-estradiol multiple interactionsISORGD:13126486480464[Progesterone co-treated with Estradiol] results in decreased expression of PFAS mRNACTDPMID:17404688
PfasRat17beta-estradiol increases expressionISORGD:13126486480464Estradiol results in increased expression of PFAS mRNACTDPMID:23019147|PMID:31614463
PfasRat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISORGD:131264864804642,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PFAS proteinCTDPMID:31675489
PfasRat2,3',4,4',5-Pentachlorobiphenyl decreases expressionISORGD:161415464804642,3',4,4',5-pentachlorobiphenyl results in decreased expression of PFAS mRNACTDPMID:31388691
PfasRat2,4,6-tribromophenol decreases expressionISORGD:131264864804642,4,6-tribromophenol results in decreased expression of PFAS mRNACTDPMID:31675489
PfasRat3,3',5,5'-tetrabromobisphenol A decreases expressionISORGD:13126486480464tetrabromobisphenol A results in decreased expression of PFAS proteinCTDPMID:31675489
PfasRat4,4'-sulfonyldiphenol decreases expressionISORGD:16141546480464bisphenol S results in decreased expression of PFAS mRNACTDPMID:39298647
PfasRat4,4'-sulfonyldiphenol decreases methylationISORGD:16141546480464bisphenol S results in decreased methylation of PFAS promoterCTDPMID:33297965
PfasRat5-aza-2'-deoxycytidine affects expressionISORGD:13126486480464Decitabine affects the expression of PFAS mRNACTDPMID:23300844
PfasRat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of PFAS mRNACTDPMID:30047161
PfasRatacrylamide decreases expressionISORGD:13126486480464Acrylamide results in decreased expression of PFAS mRNACTDPMID:32763439
PfasRataflatoxin B1 decreases methylationISORGD:13126486480464Aflatoxin B1 results in decreased methylation of PFAS geneCTDPMID:27153756
PfasRatall-trans-retinoic acid decreases expressionISORGD:13126486480464Tretinoin results in decreased expression of PFAS mRNACTDPMID:33167477
PfasRatamphetamine decreases expressionEXP 6480464Amphetamine results in decreased expression of PFAS mRNACTDPMID:30779732
PfasRatarsane affects methylationISORGD:13126486480464Arsenic affects the methylation of PFAS geneCTDPMID:25304211
PfasRatarsenic atom affects methylationISORGD:13126486480464Arsenic affects the methylation of PFAS geneCTDPMID:25304211
PfasRatarsenite(3-) multiple interactionsISORGD:13126486480464arsenite inhibits the reaction [G3BP1 protein binds to PFAS mRNA]CTDPMID:32406909

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Biological Process
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
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Source
Original Reference(s)
PfasRat'de novo' AMP biosynthetic process involved_inISORGD:13126481624291 PMID:27590927RGDPMID:27590927
PfasRat'de novo' AMP biosynthetic process involved_inIEAUniProtKB:O15067|ensembl:ENSP000003134901600115GO_REF:0000107EnsemblGO_REF:0000107
PfasRat'de novo' IMP biosynthetic process involved_inIEAUniPathway:UPA000741600115GO_REF:0000041UniProtGO_REF:0000041
PfasRat'de novo' IMP biosynthetic process involved_inIEAUniProtKB:O15067|ensembl:ENSP000003134901600115GO_REF:0000107EnsemblGO_REF:0000107
PfasRat'de novo' IMP biosynthetic process involved_inIEAInterPro:IPR0100731600115GO_REF:0000002InterProGO_REF:0000002
PfasRat'de novo' IMP biosynthetic process involved_inISORGD:13126481624291 PMID:27590927RGDPMID:27590927
PfasRat'de novo' XMP biosynthetic process involved_inISORGD:13126481624291 PMID:27590927RGDPMID:27590927
PfasRat'de novo' XMP biosynthetic process involved_inIEAUniProtKB:O15067|ensembl:ENSP000003134901600115GO_REF:0000107EnsemblGO_REF:0000107
PfasRatanterior head development acts_upstream_of_or_withinISORGD:16141541624291MGI:3717451|MGI:5476717|MGI:5514227|MGI:5514246|MGI:5514248|MGI:5691529 PMID:26234751RGDPMID:26234751
PfasRatanterior head development acts_upstream_of_or_withinIEAUniProtKB:Q5SUR0|ensembl:ENSMUSP000000212821600115GO_REF:0000107EnsemblGO_REF:0000107
PfasRatglutamine metabolic process  IDA 1599004 RGD 
PfasRatGMP biosynthetic process involved_inISORGD:13126481624291 PMID:27590927RGDPMID:27590927
PfasRatGMP biosynthetic process involved_inIEAUniProtKB:O15067|ensembl:ENSP000003134901600115GO_REF:0000107EnsemblGO_REF:0000107
PfasRatpurine nucleotide biosynthetic process involved_inIEAUniProtKB-KW:KW-06581600115GO_REF:0000043UniProtGO_REF:0000043
PfasRatpurine nucleotide biosynthetic process involved_inIBAPANTHER:PTN008493809|PomBase:SPAC6F12.10c|SGD:S000003293|UniProtKB:O150671600115GO_REF:0000033GO_CentralGO_REF:0000033
PfasRatresponse to xenobiotic stimulus  IEP 5135300acivicinRGD 
1 to 16 of 16 rows

Cellular Component

  
Object Symbol
Species
Term
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Evidence
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Reference
Notes
Source
Original Reference(s)
PfasRatcytoplasm is_active_inIBAPANTHER:PTN008493809|PomBase:SPAC6F12.10c|TAIR:locus:2019637|UniProtKB:P152541600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function
1 to 9 of 9 rows

  
Object Symbol
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Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
PfasRatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
PfasRatligase activity enablesIEAUniProtKB-KW:KW-04361600115GO_REF:0000043UniProtGO_REF:0000043
PfasRatmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
PfasRatnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
PfasRatphosphoribosylformylglycinamidine synthase activity enablesISORGD:13126481624291 PMID:10548741, PMID:27590927RGDPMID:10548741|PMID:27590927
PfasRatphosphoribosylformylglycinamidine synthase activity enablesIEAEC:6.3.5.31600115GO_REF:0000003UniProtGO_REF:0000003
PfasRatphosphoribosylformylglycinamidine synthase activity enablesIEAInterPro:IPR0100731600115GO_REF:0000002InterProGO_REF:0000002
PfasRatphosphoribosylformylglycinamidine synthase activity enablesIBAFB:FBgn0000052|PANTHER:PTN008493809|SGD:S000003293|UniProtKB:O15067|UniProtKB:P152541600115GO_REF:0000033GO_CentralGO_REF:0000033
PfasRatphosphoribosylformylglycinamidine synthase activity enablesIEAUniProtKB:O15067|ensembl:ENSP000003134901600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 9 of 9 rows

Imported Annotations - SMPDB

1 to 15 of 15 rows
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
PfasRatadenine phoshoribosyltransferase deficiency pathway  ISORGD:131264810402751 SMPDBSMP:00535
PfasRatadenosine monophosphate deaminase deficiency pathway  ISORGD:131264810402751 SMPDBSMP:00537
PfasRatadenylosuccinate lyase deficiency pathway  ISORGD:131264810402751 SMPDBSMP:00167
PfasRatAICA-ribosuria pathway  ISORGD:131264810402751 SMPDBSMP:00168
PfasRatazathioprine pharmacodynamics pathway  ISORGD:131264810402751 SMPDBSMP:00427
PfasRatKelley-Seegmiller syndrome pathway  ISORGD:131264810402751 SMPDBSMP:00365
PfasRatLesch-Nyhan syndrome pathway  ISORGD:131264810402751 SMPDBSMP:00364
PfasRatmercaptopurine pharmacodynamics pathway  ISORGD:131264810402751 SMPDBSMP:00428
PfasRatmolybdenum cofactor deficiency pathway  ISORGD:131264810402751 SMPDBSMP:00203
PfasRatpurine metabolic pathway  ISORGD:131264810402751 SMPDBSMP:00050
PfasRatpurine nucleoside phosphorylase deficiency pathway  ISORGD:131264810402751 SMPDBSMP:00210
PfasRattioguanine pharmacodynamics pathway  ISORGD:131264810402751 SMPDBSMP:00430
PfasRatxanthinuria type I pathway  ISORGD:131264810402751 SMPDBSMP:00512
PfasRatxanthinuria pathway  ISORGD:131264810402751 SMPDBSMP:00220
PfasRatxanthinuria type II pathway  ISORGD:131264810402751 SMPDBSMP:00513
1 to 15 of 15 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PfasRatpurine metabolic pathway  IEA 6907045 KEGGrno:00230

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#
Reference Title
Reference Citation
1. Proliferation-linked increase in phosphoribosylformylglycinamidine synthetase activity (EC 6.3.5.3). Elliott WL and Weber G, Cancer Res. 1984 Jun;44(6):2430-4.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Purification and characterization of GMP synthetase from Yoshida sarcoma ascites cells. Hirai K, etal., J Biochem (Tokyo). 1987 Oct;102(4):893-902.
5. Insulin regulatory effects on purine- and pyrimidine metabolism in alloxan diabetic rat liver. Pillwein K, etal., Padiatr Padol. 1988;23(2):135-44.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Control of enzymic programs and nucleotide pattern in cancer cells by acivicin and tiazofurin. Weber G, etal., Adv Enzyme Regul. 1984;22:69-93.
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PMID:10548741   PMID:20458337   PMID:26234751   PMID:29337348  



Pfas
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,189,157 - 54,210,685 (-)NCBIGRCr8
mRatBN7.21053,690,301 - 53,711,811 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1053,691,626 - 53,708,420 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,352,061 - 58,370,245 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01057,840,655 - 57,858,839 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,349,123 - 53,367,092 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01055,571,881 - 55,593,384 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,571,118 - 55,589,978 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,314,680 - 55,336,185 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41055,745,617 - 55,761,944 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11055,759,631 - 55,771,591 (-)NCBI
Celera1052,858,284 - 52,874,638 (-)NCBICelera
Cytogenetic Map10q24NCBI
PFAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38178,247,608 - 8,270,486 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl178,247,618 - 8,270,491 (+)EnsemblGRCh38hg38GRCh38
GRCh37178,152,607 - 8,173,804 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36178,093,362 - 8,114,528 (+)NCBINCBI36Build 36hg18NCBI36
Build 34178,093,361 - 8,114,528NCBI
Celera178,181,466 - 8,202,639 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef178,048,239 - 8,069,519 (+)NCBIHuRef
CHM1_1178,161,523 - 8,182,731 (+)NCBICHM1_1
T2T-CHM13v2.0178,153,834 - 8,176,708 (+)NCBIT2T-CHM13v2.0
Pfas
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391168,876,527 - 68,899,286 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1168,876,523 - 68,899,286 (-)EnsemblGRCm39 Ensembl
GRCm381168,985,701 - 69,008,460 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1168,985,697 - 69,008,460 (-)EnsemblGRCm38mm10GRCm38
MGSCv371168,799,203 - 68,821,962 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361168,803,482 - 68,824,649 (-)NCBIMGSCv36mm8
Celera1175,928,697 - 75,951,460 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.26NCBI
Pfas
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554678,640,044 - 8,660,979 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554678,640,044 - 8,660,950 (-)NCBIChiLan1.0ChiLan1.0
PFAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21965,484,101 - 65,504,296 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11770,293,598 - 70,313,731 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01743,389,389 - 43,409,454 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11748,121,601 - 48,141,728 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1748,121,606 - 48,141,720 (-)Ensemblpanpan1.1panPan2
PFAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1533,055,144 - 33,076,823 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl533,060,929 - 33,076,287 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha533,191,282 - 33,212,476 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0533,158,221 - 33,179,437 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl533,162,526 - 33,179,478 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1533,124,973 - 33,146,201 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0533,080,723 - 33,102,164 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0533,260,701 - 33,281,894 (+)NCBIUU_Cfam_GSD_1.0
Pfas
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560248,009,422 - 48,025,476 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365951,483,689 - 1,501,364 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365951,483,688 - 1,499,716 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11253,458,401 - 53,477,254 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,933,799 - 55,951,227 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PFAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,618,952 - 7,639,700 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,623,817 - 7,638,594 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605913,760,889 - 13,781,648 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pfas
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,836,943 - 10,853,274 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478610,831,287 - 10,854,526 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Pfas
103 total Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
10 55326393 55326394 A G snv DOB/Oda (KyushuU) View more Information

Predicted Target Of
Summary Value
Count of predictions:280
Count of miRNA genes:182
Interacting mature miRNAs:208
Transcripts:ENSRNOT00000007087
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 72 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat

1 to 10 of 72 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000007087   ⟹   ENSRNOP00000007087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1053,691,626 - 53,708,420 (-)Ensembl
Rnor_6.0 Ensembl1055,573,651 - 55,589,978 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080769   ⟹   ENSRNOP00000068779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1055,571,118 - 55,586,034 (-)Ensembl
RefSeq Acc Id: NM_001395097   ⟹   NP_001382026
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,189,157 - 54,207,272 (-)NCBI
mRatBN7.21053,690,301 - 53,708,420 (-)NCBI
RefSeq Acc Id: XM_006246610   ⟹   XP_006246672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,190,220 - 54,210,684 (-)NCBI
mRatBN7.21053,690,301 - 53,711,811 (-)NCBI
Rnor_6.01055,571,881 - 55,593,384 (-)NCBI
Rnor_5.01055,314,680 - 55,336,185 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246611   ⟹   XP_006246673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,190,220 - 54,210,684 (-)NCBI
mRatBN7.21053,692,347 - 53,711,811 (-)NCBI
Rnor_6.01055,573,927 - 55,593,384 (-)NCBI
Rnor_5.01055,314,680 - 55,336,185 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246612   ⟹   XP_006246674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,190,220 - 54,210,648 (-)NCBI
mRatBN7.21053,692,347 - 53,711,778 (-)NCBI
Rnor_6.01055,573,927 - 55,593,380 (-)NCBI
Rnor_5.01055,314,680 - 55,336,185 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063268632   ⟹   XP_063124702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,190,220 - 54,210,592 (-)NCBI
RefSeq Acc Id: XM_063268633   ⟹   XP_063124703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,190,220 - 54,210,514 (-)NCBI
RefSeq Acc Id: XM_063268634   ⟹   XP_063124704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,195,400 - 54,210,685 (-)NCBI
RefSeq Acc Id: XP_006246674   ⟸   XM_006246612
- Peptide Label: isoform X2
- UniProtKB: A6HFM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246673   ⟸   XM_006246611
- Peptide Label: isoform X2
- UniProtKB: A6HFM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246672   ⟸   XM_006246610
- Peptide Label: isoform X1
- UniProtKB: D4AB17 (UniProtKB/TrEMBL),   A6HFM5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068779   ⟸   ENSRNOT00000080769
Ensembl Acc Id: ENSRNOP00000007087   ⟸   ENSRNOT00000007087
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JTN4-F1-model_v2 AlphaFold A0A0G2JTN4 1-1337 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697305
Promoter ID:EPDNEW_R7827
Type:multiple initiation site
Name:Pfas_1
Description:phosphoribosylformylglycinamidine synthase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01055,589,993 - 55,590,053EPDNEW


1 to 36 of 36 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-24608 BioCyc
Ensembl Genes ENSRNOG00000005193 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007087 ENTREZGENE
  ENSRNOT00000007087.8 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1330.10 UniProtKB/TrEMBL
  3.40.50.880 UniProtKB/TrEMBL
  3.90.650.10 UniProtKB/TrEMBL
  Phosphoribosylformylglycinamidine synthase, linker domain UniProtKB/TrEMBL
InterPro AIR_synth_C UniProtKB/TrEMBL
  Class_I_gatase-like UniProtKB/TrEMBL
  FGAR-AT_N UniProtKB/TrEMBL
  FGAR-AT_PurM_N-like UniProtKB/TrEMBL
  PRibForGlyAmidine_synth UniProtKB/TrEMBL
  PurL_linker UniProtKB/TrEMBL
  PurM-like_C_sf UniProtKB/TrEMBL
  PurM-like_N_sf UniProtKB/TrEMBL
  PurS-like_sf UniProtKB/TrEMBL
NCBI Gene 287420 ENTREZGENE
PANTHER PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE UniProtKB/TrEMBL
  PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE UniProtKB/TrEMBL
Pfam AIRS_C UniProtKB/TrEMBL
  FGAR-AT_linker UniProtKB/TrEMBL
  FGAR-AT_N UniProtKB/TrEMBL
  FGAR-AT_PurM_N-like UniProtKB/TrEMBL
  GATase_5 UniProtKB/TrEMBL
PhenoGen Pfas PhenoGen
PROSITE GATASE_TYPE_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005193 RatGTEx
SMART GATase_5 UniProtKB/TrEMBL
Superfamily-SCOP AIR_synth_C UniProtKB/TrEMBL
  FGAM synthase PurL, linker domain UniProtKB/TrEMBL
  SSF52317 UniProtKB/TrEMBL
  SSF55326 UniProtKB/TrEMBL
  SSF82697 UniProtKB/TrEMBL
UniProt A6HFM5 ENTREZGENE, UniProtKB/TrEMBL
  D4AB17 ENTREZGENE, UniProtKB/TrEMBL
1 to 36 of 36 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Pfas  phosphoribosylformylglycinamidine synthase  LOC687570  similar to phosphoribosylformylglycinamidine synthase  Data merged from RGD:1584195 1643240 APPROVED
2009-02-26 Pfas  phosphoribosylformylglycinamidine synthase  Pfas  phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pfas  phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)   Pfas_predicted  phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 Pfas_predicted  phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) (predicted)  LOC687787  similar to Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (Formylglycinamide ribotide amidotransferase) (FGARAT) (Formylglycinamide ribotide synthetase)  Data merged from RGD:1597498 1643240 APPROVED
2006-11-20 LOC687787  similar to Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (Formylglycinamide ribotide amidotransferase) (FGARAT) (Formylglycinamide ribotide synthetase)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687570  similar to phosphoribosylformylglycinamidine synthase      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Pfas_predicted  phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) (predicted)      Symbol and Name status set to approved 70820 APPROVED