Pfas (phosphoribosylformylglycinamidine synthase) - Rat Genome Database

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Gene: Pfas (phosphoribosylformylglycinamidine synthase) Chinchilla lanigera
Analyze
Symbol: Pfas
Name: phosphoribosylformylglycinamidine synthase
RGD ID: 8995125
Description: ENCODES a protein that exhibits phosphoribosylformylglycinamidine synthase activity (ortholog); INVOLVED IN 'de novo' AMP biosynthetic process (ortholog); 'de novo' IMP biosynthetic process (ortholog); 'de novo' XMP biosynthetic process (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Autosomal Recessive Dyskeratosis Congenita (ortholog); Cerebroretinal Microangiopathy with Calcifications and Cysts 1 (ortholog); colon adenocarcinoma (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554678,640,044 - 8,660,979 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554678,640,044 - 8,660,950 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species

Genomics

Comparative Map Data
Pfas
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554678,640,044 - 8,660,979 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554678,640,044 - 8,660,950 (-)NCBIChiLan1.0ChiLan1.0
PFAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38178,247,608 - 8,270,486 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl178,247,618 - 8,270,491 (+)EnsemblGRCh38hg38GRCh38
GRCh37178,152,607 - 8,173,804 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36178,093,362 - 8,114,528 (+)NCBINCBI36Build 36hg18NCBI36
Build 34178,093,361 - 8,114,528NCBI
Celera178,181,466 - 8,202,639 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef178,048,239 - 8,069,519 (+)NCBIHuRef
CHM1_1178,161,523 - 8,182,731 (+)NCBICHM1_1
T2T-CHM13v2.0178,153,834 - 8,176,708 (+)NCBIT2T-CHM13v2.0
Pfas
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391168,876,527 - 68,899,286 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1168,876,523 - 68,899,286 (-)EnsemblGRCm39 Ensembl
GRCm381168,985,701 - 69,008,460 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1168,985,697 - 69,008,460 (-)EnsemblGRCm38mm10GRCm38
MGSCv371168,799,203 - 68,821,962 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361168,803,482 - 68,824,649 (-)NCBIMGSCv36mm8
Celera1175,928,697 - 75,951,460 (-)NCBICelera
Cytogenetic Map11B3NCBI
Pfas
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21053,690,301 - 53,711,811 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1053,691,626 - 53,708,420 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,352,061 - 58,370,245 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01057,840,655 - 57,858,839 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01053,349,123 - 53,367,092 (-)NCBIRnor_WKY
Rnor_6.01055,571,881 - 55,593,384 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,571,118 - 55,589,978 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,314,680 - 55,336,185 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41055,745,617 - 55,761,944 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11055,759,631 - 55,771,591 (-)NCBI
Celera1052,858,284 - 52,874,638 (-)NCBICelera
Cytogenetic Map10q24NCBI
PFAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11770,293,598 - 70,313,731 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01743,389,389 - 43,409,454 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11748,121,601 - 48,141,728 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1748,121,606 - 48,141,720 (-)Ensemblpanpan1.1panPan2
PFAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1533,055,144 - 33,076,823 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl533,060,929 - 33,076,287 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha533,191,282 - 33,212,476 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0533,158,221 - 33,179,437 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl533,162,526 - 33,179,478 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1533,124,973 - 33,146,201 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0533,080,723 - 33,102,164 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0533,260,701 - 33,281,894 (+)NCBIUU_Cfam_GSD_1.0
Pfas
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560248,009,422 - 48,025,476 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365951,483,689 - 1,501,364 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365951,483,688 - 1,499,716 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11253,458,401 - 53,477,254 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,933,799 - 55,951,227 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PFAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,618,952 - 7,639,700 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,623,817 - 7,638,594 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605913,760,889 - 13,781,648 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pfas
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,836,943 - 10,853,274 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478610,831,287 - 10,854,526 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000022707   ⟹   ENSCLAP00000022500
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554678,640,044 - 8,660,979 (-)Ensembl
RefSeq Acc Id: XM_005399417   ⟹   XP_005399474
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554678,640,044 - 8,660,950 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005399420   ⟹   XP_005399477
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554678,640,044 - 8,660,950 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005399421   ⟹   XP_005399478
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554678,640,044 - 8,660,900 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013522183   ⟹   XP_013377637
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554678,640,044 - 8,660,939 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013522184   ⟹   XP_013377638
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554678,640,044 - 8,660,939 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005399477   ⟸   XM_005399420
- UniProtKB: A0A8C2W5D2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005399474   ⟸   XM_005399417
- UniProtKB: A0A8C2W5D2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005399478   ⟸   XM_005399421
- UniProtKB: A0A8C2W5D2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013377638   ⟸   XM_013522184
- UniProtKB: A0A8C2W5D2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013377637   ⟸   XM_013522183
- UniProtKB: A0A8C2W5D2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000022500   ⟸   ENSCLAT00000022707
Protein Domains
Phosphoribosylformylglycinamidine synthase linker   Phosphoribosylformylglycinamidine synthase N-   PurM-like C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000015433 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000022500 ENTREZGENE
  ENSCLAP00000022500.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000022707 ENTREZGENE
  ENSCLAT00000022707.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1330.10 UniProtKB/TrEMBL
  3.40.50.880 UniProtKB/TrEMBL
  3.90.650.10 UniProtKB/TrEMBL
  Phosphoribosylformylglycinamidine synthase, linker domain UniProtKB/TrEMBL
InterPro Class_I_gatase-like UniProtKB/TrEMBL
  FGAR-AT_N UniProtKB/TrEMBL
  PurL_large UniProtKB/TrEMBL
  PurL_linker UniProtKB/TrEMBL
  PurM-like_C_dom UniProtKB/TrEMBL
  PurM-like_C_sf UniProtKB/TrEMBL
  PurM-like_N_sf UniProtKB/TrEMBL
  PurS-like_sf UniProtKB/TrEMBL
NCBI Gene Pfas ENTREZGENE
PANTHER PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE UniProtKB/TrEMBL
  PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE UniProtKB/TrEMBL
Pfam AIRS_C UniProtKB/TrEMBL
  FGAR-AT_linker UniProtKB/TrEMBL
  FGAR-AT_N UniProtKB/TrEMBL
  GATase_5 UniProtKB/TrEMBL
PROSITE GATASE_TYPE_1 UniProtKB/TrEMBL
SMART GATase_5 UniProtKB/TrEMBL
Superfamily-SCOP FGAM synthase PurL, linker domain UniProtKB/TrEMBL
  SSF52317 UniProtKB/TrEMBL
  SSF55326 UniProtKB/TrEMBL
  SSF56042 UniProtKB/TrEMBL
  SSF82697 UniProtKB/TrEMBL
TIGRFAMs FGAM_synt UniProtKB/TrEMBL
UniProt A0A8C2W5D2 ENTREZGENE, UniProtKB/TrEMBL