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Gene: Cyp8b1 (cytochrome P450 family 8 subfamily B member 1) Ictidomys tridecemlineatus

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Symbol:

Cyp8b1

Name:

cytochrome P450 family 8 subfamily B member 1

RGD ID:

12734546

Description:

ENCODES a protein that exhibits sterol 12-alpha-hydroxylase activity (ortholog); INVOLVED IN positive regulation of intestinal cholesterol absorption (ortholog); response to cholesterol (ortholog); response to nutrient levels (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); extrahepatic cholestasis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; LOC101977223

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mIctTri1.hap1 - mIctTri1.hap1 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	2	19,914,375 - 19,916,713 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024405118	199,911,411 - 199,913,713 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936695	2,263,868 - 2,265,373 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936695	2,263,868 - 2,265,373 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

cholestasis (ISO)

extrahepatic cholestasis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bile acid biosynthetic process (IEA)

lipid metabolic process (IEA)

monocarboxylic acid biosynthetic process (IEA)

positive regulation of intestinal cholesterol absorption (ISO)

response to cholesterol (ISO)

response to nutrient levels (ISO)

Cellular Component

endoplasmic reticulum membrane (IEA)

Molecular Function

heme binding (IEA)

iron ion binding (IEA)

monooxygenase activity (IEA)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (IEA)

sterol 12-alpha-hydroxylase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

bile acid biosynthetic pathway (ISO)

cerebrotendinous xanthomatosis pathway (ISO)

congenital bile acid synthesis defect pathway (ISO)

familial hypercholanemia pathway (ISO)

Zellweger syndrome pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Cyp8b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	2	19,914,375 - 19,916,713 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024405118	199,911,411 - 199,913,713 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936695	2,263,868 - 2,265,373 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936695	2,263,868 - 2,265,373 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CYP8B1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	42,872,192 - 42,875,879 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	42,855,944 - 42,875,920 (-)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	3	42,913,684 - 42,917,371 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	42,888,688 - 42,892,637 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	42,888,687 - 42,892,637	NCBI
Celera	3	42,851,598 - 42,855,548 (-)	NCBI		Celera
Cytogenetic Map	3	p22.1	NCBI
HuRef	3	42,956,837 - 42,960,786 (-)	NCBI		HuRef
CHM1_1	3	42,863,684 - 42,867,633 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	42,887,769 - 42,891,456 (-)	NCBI		T2T-CHM13v2.0

Cyp8b1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	121,743,422 - 121,745,371 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	121,743,422 - 121,745,371 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	121,914,356 - 121,916,305 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	121,914,356 - 121,916,305 (-)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	9	121,823,474 - 121,825,423 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	121,763,054 - 121,764,989 (-)	NCBI		MGSCv36	mm8
Celera	9	122,389,259 - 122,391,208 (-)	NCBI		Celera
Cytogenetic Map	9	F4	NCBI
cM Map	9	72.73	NCBI

Cyp8b1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	130,455,622 - 130,457,592 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	130,442,503 - 130,457,689 (-)	Ensembl				GRCr8
mRatBN7.2	8	121,578,123 - 121,580,093 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	121,557,062 - 121,580,166 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	127,169,678 - 127,171,641 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	125,368,752 - 125,370,715 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	123,198,141 - 123,200,111 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	8	131,311,613 - 131,313,576 (-)	NCBI
Lyon_Normotensive	8	133,413,341 - 133,415,304 (-)	NCBI
Lyon_Hypertensive	8	131,899,990 - 131,901,953 (-)	NCBI
F344_StmMcwi	8	123,306,796 - 123,308,759 (-)	NCBI
Rnor_6.0	8	130,548,418 - 130,550,388 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	130,548,418 - 130,550,388 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	8	129,723,896 - 129,725,866 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	127,018,908 - 127,020,878 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	120,702,850 - 120,704,820 (-)	NCBI		Celera
RGSC_v3.1	8	127,038,644 - 127,040,615 (+)	NCBI
Cytogenetic Map	8	q32	NCBI

LOC102019604
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955420	27,988,067 - 27,990,637 (+)	NCBI	ChiLan1.0	ChiLan1.0

CYP8B1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	42,832,717 - 42,836,407 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	42,837,479 - 42,841,169 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	42,775,679 - 42,779,440 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	43,838,315 - 43,842,260 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	43,824,423 - 43,842,716 (-)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

CYP8B1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	11,965,685 - 11,968,994 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	11,967,341 - 11,968,846 (-)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	11,939,545 - 11,942,820 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	12,255,398 - 12,258,673 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	12,257,054 - 12,258,559 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	12,057,378 - 12,060,653 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	12,199,554 - 12,202,829 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	12,202,997 - 12,206,280 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

CYP8B1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	26,330,233 - 26,331,738 (-)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	13	26,330,233 - 26,331,738 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CYP8B1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	22	96,987,219 - 96,990,895 (+)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666041	162,874,321 - 162,895,194 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	22	4,323,840 - 4,326,459 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	4,324,396 - 4,325,901 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

LOC116907995
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	113,075,343 - 113,077,363 (-)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005337918	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JBPVTT010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000009689 ⟹ ENSSTOP00000023860

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936695	2,263,868 - 2,265,373 (+)	Ensembl

RefSeq Acc Id:

XM_005337918 ⟹ XP_005337975

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
mIctTri1.hap1	2	19,914,375 - 19,916,713 (+)	NCBI
HiC_Itri_2	NW_024405118	199,911,411 - 199,913,713 (+)	NCBI
SpeTri2.0	NW_004936695	2,263,868 - 2,265,373 (+)	NCBI

Sequence:

show sequence

ATGGTACTCTGGGGTCAAGTGCTGGGAGCTTTGCTGGTGATCCTTGTGGGATACCTGTGTCTTC
CAGGGTTACTCCGACGACGCAAGCCCCAGGAACCTCCTCTAGACAAGGGCTCCATGCCCTGGCT
GGGCCATGCCATAGCTTTCCGGAAGAATATGTTTGAATTCTTAAAGGGAATGCGGGCCAAGCAT
GGGGATATTTTCACAGTGCAGCTAGGGGGCCAGTACTTCACCTTTGTAATGGATCCCCTCTCCT
TTGGCCCCATCATCAAGGACACTCAGAGAACACTAGATTTTGTGCAGTATGCACAAGAACTGGT
ACGAAAGGTATTTGGATACCAACCTACAGAGGGGGACCACCAGATGGTACATTCAGCCAGTAGC
AAGCATCTGATGGGAGATGGCTTGGAGGATCTCAATAAGGTCATGCTGAACAGCCTGTCCTTGA
TAATGTTGGGGCCCAAAGGCTGGAGTCTGGATGCCAGTTTCTGGCATGAGGATGGTCTCTTCCA
GTTCTGCTACAATACCTTGTTCAAGGCTGGTTACCTGAGCTTGTTTGGCTATACAAAGAACGTG
GCACAGGACCTGCTACAGGCAGAAGAGCTATTCATGAAGTTTCGCAGGTTTGATCTTCTTTTTC
CAAGGTTTGTCTACTCCCTGCTGAGTCCCCGGGAGTGGCTAGAAGTGGGCCAGCTCCAGCGTCT
CTTTCACAAGACACTCTCTGTGGAACACAACCTGGAGAAGGATGGCGTGAGCGGCTGGTTATGC
TACATGCTTCAGTTTCTGAGGGAGCAGGGAGTGGCCCCAGCTATGCAGGCCAAGTTCAATTTCA
TGATGCTCTGGGCTTCCCAAGGGAACACAGGGCCAACCTCTTTCTGGGCTCTCTTGTTCCTCCT
GAAGCACCCAGAAGCCCTGCAGGCTGTGAGGAAGGAAGCCACTGAGGTCCTAGGTGAAGCCAGG
CTGGAAGCCACCCAGTTCTTCACCTTCAAACTGAGCGCCTTACAACACACCCCAGTGCTGAACA
GCGTAATGGAGGAGACCCTGAGGCTGGCAGCTTCACCCACCCTCCTCAGGGCAATACAGAAGGA
CTATATCTTGAAGATGGCCAATGGACAAGAGTACCTGCTCCGTCAGGGAGATAAAGTGGCTCTC
TTCCCCTACCTCTCAGTGCACATGGACCCTGACATCCACCCCAAGCCCACTACCTTCAAGTATG
ATCGATTCCTGAACCCCAATGGCAGCAGAAAAATGCACTTCTATAAGGAGGGCAAGAAGATCCA
CCACTACAACATGCCTTGGGGCTCAGGCGTCTCCATCTGCCCTGGTAGGTTTTTTGCCCTCAGT
GAAATTAAACTCTTTATTTTGATCATGATCACATATTTTGACCTGGAGCTGATGGACTCTGATA
CACCTGTGCCCCCTATGGACCCACAGCGCTGGGGCTTTGGCACCTTACAGCCCAGGCACGATGT
GCGCTTCCGATACCGCCTAAAGTGTATGGAATAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005337975	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000023860.1
GenBank Protein	KAG3279734	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005337975 ⟸ XM_005337918

- UniProtKB:

I3NHL3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVLWGQVLGALLVILVGYLCLPGLLRRRKPQEPPLDKGSMPWLGHAIAFRKNMFEFLKGMRAKH
GDIFTVQLGGQYFTFVMDPLSFGPIIKDTQRTLDFVQYAQELVRKVFGYQPTEGDHQMVHSASS
KHLMGDGLEDLNKVMLNSLSLIMLGPKGWSLDASFWHEDGLFQFCYNTLFKAGYLSLFGYTKNV
AQDLLQAEELFMKFRRFDLLFPRFVYSLLSPREWLEVGQLQRLFHKTLSVEHNLEKDGVSGWLC
YMLQFLREQGVAPAMQAKFNFMMLWASQGNTGPTSFWALLFLLKHPEALQAVRKEATEVLGEAR
LEATQFFTFKLSALQHTPVLNSVMEETLRLAASPTLLRAIQKDYILKMANGQEYLLRQGDKVAL
FPYLSVHMDPDIHPKPTTFKYDRFLNPNGSRKMHFYKEGKKIHHYNMPWGSGVSICPGRFFALS
EIKLFILIMITYFDLELMDSDTPVPPMDPQRWGFGTLQPRHDVRFRYRLKCME

hide sequence

Ensembl Acc Id:

ENSSTOP00000023860 ⟸ ENSSTOT00000009689

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000009690	Ensembl, UniProtKB/TrEMBL
	ENSSTOG00015022733	ENTREZGENE
Ensembl Transcript	ENSSTOT00000009689.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.630.10	UniProtKB/TrEMBL
InterPro	Cyt_P450	UniProtKB/TrEMBL
	Cyt_P450_CYP7A1-type	UniProtKB/TrEMBL
	Cyt_P450_E_grp-IV	UniProtKB/TrEMBL
	Cyt_P450_sf	UniProtKB/TrEMBL
	Cytochrome_CYP8B1	UniProtKB/TrEMBL
KEGG Report	iti:101977223	UniProtKB/TrEMBL
NCBI Gene	LOC101977223	ENTREZGENE
PANTHER	PTHR24306	UniProtKB/TrEMBL
	PTHR24306:SF0	UniProtKB/TrEMBL
Pfam	p450	UniProtKB/TrEMBL
PIRSF	Cytochrome_CYP8B1	UniProtKB/TrEMBL
	Cytochrome_CYPVIIA1	UniProtKB/TrEMBL
PRINTS	EP450IV	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48264	UniProtKB/TrEMBL
UniProt	I3NHL3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2025-12-16	Cyp8b1	cytochrome P450 family 8 subfamily B member 1	LOC101977223	7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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Imported Disease Annotations - CTD

Imported Annotations - SMPDB