CYP8B1 (cytochrome P450 family 8 subfamily B member 1) - Rat Genome Database

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Gene: CYP8B1 (cytochrome P450 family 8 subfamily B member 1) Sus scrofa
Analyze
Symbol: CYP8B1
Name: cytochrome P450 family 8 subfamily B member 1
RGD ID: 13905714
Description: ENCODES a protein that exhibits sterol 12-alpha-hydroxylase activity; INVOLVED IN bile acid biosynthetic process; bile acid signaling pathway (ortholog); positive regulation of intestinal cholesterol absorption (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; bile acid signaling pathway; cerebrotendinous xanthomatosis pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); extrahepatic cholestasis (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase; CYPVIIIB1; cytochrome P-450 8B1; cytochrome P450 8B1; sterol 12-alpha-hydroxylase; sterol 12alpha-hydroxylase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1326,330,171 - 26,337,379 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11326,330,233 - 26,331,738 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14643796  


Genomics

Comparative Map Data
CYP8B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1326,330,171 - 26,337,379 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11326,330,233 - 26,331,738 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP8B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl342,856,005 - 42,875,898 (-)EnsemblGRCh38hg38GRCh38
GRCh38342,872,192 - 42,875,879 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37342,913,684 - 42,917,371 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36342,888,688 - 42,892,637 (-)NCBINCBI36hg18NCBI36
Build 34342,888,687 - 42,892,637NCBI
Celera342,851,598 - 42,855,548 (-)NCBI
Cytogenetic Map3p22.1NCBI
HuRef342,956,837 - 42,960,786 (-)NCBIHuRef
CHM1_1342,863,684 - 42,867,633 (-)NCBICHM1_1
Cyp8b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399121,743,422 - 121,745,371 (-)NCBIGRCm39mm39
GRCm39 Ensembl9121,743,422 - 121,745,371 (-)Ensembl
GRCm389121,914,356 - 121,916,305 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9121,914,356 - 121,916,305 (-)EnsemblGRCm38mm10GRCm38
MGSCv379121,823,474 - 121,825,423 (-)NCBIGRCm37mm9NCBIm37
MGSCv369121,763,054 - 121,764,989 (-)NCBImm8
Celera9122,389,259 - 122,391,208 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map972.73NCBI
Cyp8b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28121,578,123 - 121,580,093 (-)NCBI
Rnor_6.0 Ensembl8130,548,418 - 130,550,388 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08130,548,418 - 130,550,388 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08129,723,896 - 129,725,866 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48127,018,908 - 127,020,878 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18127,038,644 - 127,040,615 (+)NCBI
Celera8120,702,850 - 120,704,820 (-)NCBICelera
Cytogenetic Map8q32NCBI
LOC102019604
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542027,988,067 - 27,990,637 (+)NCBIChiLan1.0ChiLan1.0
CYP8B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1343,838,315 - 43,842,260 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl343,824,423 - 43,842,716 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0342,775,679 - 42,779,440 (-)NCBIMhudiblu_PPA_v0panPan3
CYP8B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12311,965,685 - 11,968,994 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2311,967,341 - 11,968,846 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2311,939,545 - 11,942,820 (-)NCBI
ROS_Cfam_1.02312,255,398 - 12,258,673 (-)NCBI
UMICH_Zoey_3.12312,057,378 - 12,060,653 (-)NCBI
UNSW_CanFamBas_1.02312,199,554 - 12,202,829 (-)NCBI
UU_Cfam_GSD_1.02312,202,997 - 12,206,280 (-)NCBI
LOC101977223
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118199,911,411 - 199,913,713 (+)NCBI
SpeTri2.0NW_0049366952,263,868 - 2,265,373 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP8B1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1224,323,840 - 4,326,459 (-)NCBI
ChlSab1.1 Ensembl224,324,396 - 4,325,901 (-)Ensembl


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system musculoskeletal system reproductive system respiratory system
High
Medium
Low 3 1 2 1 2
Below cutoff 7 2 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000059518   ⟹   ENSSSCP00000040274
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1326,330,171 - 26,337,379 (-)Ensembl
RefSeq Acc Id: NM_214426   ⟹   NP_999591
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11326,330,233 - 26,331,738 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999591 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAD32936 (Get FASTA)   NCBI Sequence Viewer  
  Q7YRB2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_999591   ⟸   NM_214426
- UniProtKB: Q7YRB2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000040274   ⟸   ENSSSCT00000059518


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000034388 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000040274 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000059518 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CYP7A1-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytochrome_CYP8B1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:403328 UniProtKB/Swiss-Prot
NCBI Gene CYP8B1 ENTREZGENE
PANTHER PTHR24306:SF0 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Cytochrome_CYP8B1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytochrome_CYPVIIA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS EP450IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287A907_PIG UniProtKB/TrEMBL
  CP8B1_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:103365 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-21 CYP8B1  cytochrome P450 family 8 subfamily B member 1  CYP8B1  cytochrome P-450 8B1  Symbol and/or name change 19259463 PROVISIONAL