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Gene: CYP8B1 (cytochrome P450 family 8 subfamily B member 1) Pan paniscus

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Symbol:

CYP8B1

Name:

cytochrome P450 family 8 subfamily B member 1

RGD ID:

11703542

Description:

ENCODES a protein that exhibits sterol 12-alpha-hydroxylase activity (ortholog); INVOLVED IN positive regulation of intestinal cholesterol absorption (ortholog); response to cholesterol (ortholog); response to nutrient levels (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); extrahepatic cholestasis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; LOC100969929

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	42,832,717 - 42,836,407 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	42,837,479 - 42,841,169 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	42,775,679 - 42,779,440 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	43,838,315 - 43,842,260 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	43,824,423 - 43,842,716 (-)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

cholestasis (ISO)

extrahepatic cholestasis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bile acid biosynthetic process (IEA)

lipid metabolic process (IEA)

monocarboxylic acid biosynthetic process (IEA)

positive regulation of intestinal cholesterol absorption (ISO)

response to cholesterol (ISO)

response to nutrient levels (ISO)

Cellular Component

endoplasmic reticulum membrane (IEA)

Molecular Function

heme binding (IEA)

iron ion binding (IEA)

monooxygenase activity (IEA)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (IEA)

sterol 12-alpha-hydroxylase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

bile acid biosynthetic pathway (ISO)

cerebrotendinous xanthomatosis pathway (ISO)

congenital bile acid synthesis defect pathway (ISO)

familial hypercholanemia pathway (ISO)

Zellweger syndrome pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CYP8B1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	42,832,717 - 42,836,407 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	42,837,479 - 42,841,169 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	42,775,679 - 42,779,440 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	43,838,315 - 43,842,260 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	43,824,423 - 43,842,716 (-)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

CYP8B1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	42,872,192 - 42,875,879 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	42,855,944 - 42,875,920 (-)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	3	42,913,684 - 42,917,371 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	42,888,688 - 42,892,637 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	42,888,687 - 42,892,637	NCBI
Celera	3	42,851,598 - 42,855,548 (-)	NCBI		Celera
Cytogenetic Map	3	p22.1	NCBI
HuRef	3	42,956,837 - 42,960,786 (-)	NCBI		HuRef
CHM1_1	3	42,863,684 - 42,867,633 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	42,887,769 - 42,891,456 (-)	NCBI		T2T-CHM13v2.0

Cyp8b1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	121,743,422 - 121,745,371 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	121,743,422 - 121,745,371 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	121,914,356 - 121,916,305 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	121,914,356 - 121,916,305 (-)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	9	121,823,474 - 121,825,423 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	121,763,054 - 121,764,989 (-)	NCBI		MGSCv36	mm8
Celera	9	122,389,259 - 122,391,208 (-)	NCBI		Celera
Cytogenetic Map	9	F4	NCBI
cM Map	9	72.73	NCBI

Cyp8b1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	130,455,622 - 130,457,592 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	130,442,503 - 130,457,689 (-)	Ensembl				GRCr8
mRatBN7.2	8	121,578,123 - 121,580,093 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	121,557,062 - 121,580,166 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	127,169,678 - 127,171,641 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	125,368,752 - 125,370,715 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	123,198,141 - 123,200,111 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	8	131,311,613 - 131,313,576 (-)	NCBI
Lyon_Normotensive	8	133,413,341 - 133,415,304 (-)	NCBI
Lyon_Hypertensive	8	131,899,990 - 131,901,953 (-)	NCBI
F344_StmMcwi	8	123,306,796 - 123,308,759 (-)	NCBI
Rnor_6.0	8	130,548,418 - 130,550,388 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	130,548,418 - 130,550,388 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	8	129,723,896 - 129,725,866 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	127,018,908 - 127,020,878 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	120,702,850 - 120,704,820 (-)	NCBI		Celera
RGSC_v3.1	8	127,038,644 - 127,040,615 (+)	NCBI
Cytogenetic Map	8	q32	NCBI

LOC102019604
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955420	27,988,067 - 27,990,637 (+)	NCBI	ChiLan1.0	ChiLan1.0

CYP8B1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	11,965,685 - 11,968,994 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	11,967,341 - 11,968,846 (-)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	11,939,545 - 11,942,820 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	12,255,398 - 12,258,673 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	12,257,054 - 12,258,559 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	12,057,378 - 12,060,653 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	12,199,554 - 12,202,829 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	12,202,997 - 12,206,280 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cyp8b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	2	19,914,375 - 19,916,713 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024405118	199,911,411 - 199,913,713 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936695	2,263,868 - 2,265,373 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936695	2,263,868 - 2,265,373 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CYP8B1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	26,330,233 - 26,331,738 (-)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	13	26,330,233 - 26,331,738 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CYP8B1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	22	96,987,219 - 96,990,895 (+)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666041	162,874,321 - 162,895,194 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	22	4,323,840 - 4,326,459 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	4,324,396 - 4,325,901 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

LOC116907995
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	113,075,343 - 113,077,363 (-)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003809295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000051436 ⟹ ENSPPAP00000028587

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	3	43,824,423 - 43,842,055 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000051440 ⟹ ENSPPAP00000028592

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	3	43,835,537 - 43,842,716 (-)	Ensembl

RefSeq Acc Id:

XM_003809295 ⟹ XP_003809343

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	2	42,832,717 - 42,836,407 (-)	NCBI
NHGRI_mPanPan1	3	42,837,479 - 42,841,169 (-)	NCBI
Mhudiblu_PPA_v0	3	42,775,679 - 42,779,440 (-)	NCBI
PanPan1.1	3	43,838,315 - 43,842,260 (-)	NCBI

Sequence:

show sequence

GCAAGAGCTGTCTGAAAAGGTCAGAGCAAAGCATGAAGCTGGTGAGCAGCTGTGACCATAGCTG
GAGGCTTCTCTCTGAGCTTTCTCCTGGTTACCTCCTCCTCCCCTACGTGACCAGTCAGCCAAGT
GTTAAGTCCAGGGGAACATTTTGCTGCTTCCAAGTACTGTCTCACTAGTGTTATTTGCCATAAC
TTGCGGCCACAGGGCAAGGTCCAGGTGCTCAGACCTTTACATCCTGGACTTTCCAAGGCCTCCC
AAAGCTCTCTGGCACCCAGGGAACAGTGTGCGTGTCGAGAGCTTAATCCGCAGGAGCATAGCCA
TGGTTCTCTGGGGTCCAGTGCTGGGAGCTCTGCTGGTGGTCATTGCTGGATACCTGTGCCTGCC
AGGGATGCTCCGACAACGCAGGCCATGGGAGCCCCCTCTGGACAAGGGTACCGTGCCCTGGCTT
GGCCATGCCATGGCTTTCCGGAAGAATATGTTTGAATTTCTGAAGCGCATGAGGACCAAGCATG
GGGATGTGTTCACAGTGCAGCTAGGGGGCCAGTACTTCACCTTCGTCATGGACCCCCTCTCCTT
TGGCCCCATCCTCAAGGACACACAGAGAAAACTAGACTTTGGGCAATATGCAAAAAAACTGGTG
CTGAAGGTATTTGGATACCGTTCAGTGCAAGGGGACCATGAGATGATACACTCAGCCAGCACCA
AGCATCTGAGGGGGGATGGCTTGAAGGATCTTAATGAGACCATGCTGGACAGCCTGTCCTTTGT
AATGCTGACGTCCAAAGGCTCGAGTCTGGATGCCAGTTGCTGGCATGAGGACAGCCTCTTTCGC
TTCTGCTATTACATCTTGTTCACAGCTGGCTACCTGAGCTTGTTCGGCTACACGAAGGACAAGG
AGCAGGACCTGCTACAGGCAGGAGAGTTATTCATGGAGTTCCGCAAGTTTGACCTTCTTTTCCC
CAGGTTTGTCTACTCCCTGCTGTGGCCCCGGGAGTGGCTAGAAGTGGGCCGACTCCAGCGTCTC
TTTCACAAGATGCTCTCCGTGAGCCACAGCCAGGAGAAGGAGGGCATCAGCAACTGGCTGGGCA
ACATGCTTCAGTTTCTGAGGGAGCAGGGGGTACCCTCAGCTATGCAGGACAAGTTCAACTTCAT
GATGCTCTGGGCCTCCCAGGGGAACACGGGGCCTACCTCTTTCTGGGCCCTCTTGTTCCTCCTG
AAGCACCCAGAAGCTATTCGGGCTGTGAGGGAGGAAGCTACCCAGGTCCTGGGTGAGGCCAGGC
TGGAGACCAAGCAGTCCTTTGCCTTCAAACTCGGTGCCCTGCAACACACCCCAGTTCTAGACAG
CGTGGTGGAGGAGACGCTGCGGCTGAGGGCTGCACCCACCCTCCTCAGGTTGGTTCATGAAGAC
TATACCCTGAAGATGTCCAGTGGGCAGGAGTATCTGTTCCGCCATGGAGACATCCTGGCCCTCT
TTCCCTACCTCTCAGTGCACATGGACCCTGACATCCACCCTGAGCCCACCGTCTTCAAGTACGA
TCGCTTCCTCAACCCTAATGGCAGCCGGAAAGTGGACTTCTTCAAGGCAGGCAAGAAGATCCAC
CACTACACCATGCCCTGGGGTTCAGGCGTTTCCATCTGCCCTGGGAGGTTCTTTGCACTCAGTG
AGGTGAAGCTCTTTATCCTGCTTATGGTCACACACTTTGACTTAGAGTTGGTGGACCCTGACAC
ACCACTACCCCATGTTGACCCGCAGCGCTGGGGTTTTGGCACCATGCAGCCCAGCCACGATGTG
CGCTTCCGCTACCGCCTGCATCCTACAGAGTGAGCTTGGCCAAGCCAGCTGCAAACCTGGCCAG
AGGAGTTCTATTGCATCTCTCACCTGTTCTCACCCTTCTGCAGCCCCAAGACCCCACTGGCCAC
CCCTCCCTCTGGTCCTGTGGCACCCCCTACCTCTGTTCTGCCTGTCCTCGCTCTCTCCCCGCCT
AGTCATCTGACAGGCTTATCGTTCTCTTTAAAATACCATCTCTCAGAGTGGGTTCTGCCGAACC
CTCCTCTCACAGGAAGTCCAGAGGAAGGGGGAGTATCTGTGGGCAACTTGGTTTGGGAGATGAT
GCCTGCCTTGAGAAGTCCTGAGTACAGAGACTGGTTCCCCCCAGACATGAGTAACATGGCATCT
TGCAAACATCAGCCTCCACTCTCCCAGCTTGCTTTAGTTTTTTCAGCAACACTTATCCCACATC
CTATGGAATTCAGGTTCTAGAACAGTGTCATCCAACATAAATATGAAGCAAGCTACATGAGTAG
TGGCGTTTTTTGGTTTTGTTTGTTTGTTTTGAGACAGAGTCTTGCTCTGTTGCCGAGGCTGCGG
TGCAGCGGTGCGATCTCTGCTCACTGCAACCTCTGCCTCCTGGGTTTAAGCAATTCTCCTGCCT
CAGCCTCCCCAGTAGCTGGGATTACAGGCACCTACCACCTTGCCCAGCTAATTTAGTTTCCTGG
TAAACACATTTTTAAAAAGTAAAATGAAACAATTCATTTTTATAATATACTTTACTTAATCTAA
TATATCCAAAATATTGGCATTTCAACGGGATCACTATTAAAAATTTTAACGTAATAGTTTTTAC
CTTCTCTTTTTCATCCTGTCTTCAAAGTCTGGTATGTACTGTACTTTTGCAGTTCTTCCCAGTT
CAGACTAGCCACATTCCAAGTGCTTAATTGCCGTGTGTGGCAGGTGGCTGCCCTATTGGATAGC
ACAGGTCTAGAGAAATGATACCTTTTTTTTTTTTTGTTAGACAGAGTCTCACTCTGTTGCCCAG
GCTGCAGTGCAGTGGTGTGATCTTGGCTCACTACAACCTCTGCCTCCCGGGTTCAAGTAATTCT
CCTGCCTCAGGCTTCTGAGTAGCTGGGATTATAGATGCGCACCACCACACCCGGCTAGTTTCTG
TATTTGTAGTAGAGACGGCGTTTCACCATTTTGGCCGGCCTCCTCGGCCTCCCAAAGTTCTGGG
ATTACAGGCATGAGCCACTGTGCCCAGCCAGGATGTCTTTAATGTAGGAATCATTCAAGATCCC
TCCTCAGTGCCCATGTCTCCCCCACCTCAGGGTGCTGTCAACCCTCCCTTGGTTTCCATGATCA
TTGCTGAACTCAGAGCTTTCTTCTATCCCCAGACCCACATGGGAGTCTCCCAGCACCTCTGACT
CAGCTTGGCCAATGCAGAACTTGGCATCTCAGCCCCTGCCTCTTCCCTGAACCACTCCTCCTCC
TGATTTCCCTGCTCTCTCTGCTCAGAACACTACCATTCACCCCATCTCCCAGAGACACTCTCCC
TCCTCCTCTTTCACCTTCATACAAGCAGGCCCCCGTCCTATCAGTACACCCCCCTGTGATGCCT
CTGAAATATGTACCCTCCTCCCCTCTCCTACTGTCATTCTTATACCTGTGATCTCTGCGTTTCT
CTTCTACACTGCTGCCAGAGGCCTTTTTGCCAAAAGCACTGCTGATTGTCACTCTTTTACTTTC
CTGGTTCCCCTTTGACTTCACACACTTGACGTTTACATTTTGTCACAGTTGGTCCCCCTTGCCT
TCACATACCTGATGTTTAAATTTTGTCACGGTTGGTCTCCAAACTTCTCAACTTTGCCAACTTT
CTCCAGTGAAACCATCAGTAGAGGCATTGCTGTTCCTGCCCATCCCAGTGCCAGCTACTCCTTC
CTGGAAGCCTTCCTGGATTTCACGCATCCCATCCTCTGGCCAGAAATGGCCTCCGAACTGTGCA
GCTCCTGCAGCACCATTTGTATCATAGCATATCTGTTATGTGTCGTTGCTTTCCGTGTCTTGGT
TTCTGCCTGCTGCCCACTTCCCTAGACTGGAGCCTACTGGGGCATGGTATTTTATTCATTTCTG
ACCTCCAATTCCCTAAGTGGAGATTAAATGTTAGAAACCTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003809343	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000028587.1
	ENSPPAP00000028592.1

RefSeq Acc Id:

XP_003809343 ⟸ XM_003809295

- UniProtKB:

A0A2R9BJT1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVLWGPVLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKRMRTKH
GDVFTVQLGGQYFTFVMDPLSFGPILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDHEMIHSAST
KHLRGDGLKDLNETMLDSLSFVMLTSKGSSLDASCWHEDSLFRFCYYILFTAGYLSLFGYTKDK
EQDLLQAGELFMEFRKFDLLFPRFVYSLLWPREWLEVGRLQRLFHKMLSVSHSQEKEGISNWLG
NMLQFLREQGVPSAMQDKFNFMMLWASQGNTGPTSFWALLFLLKHPEAIRAVREEATQVLGEAR
LETKQSFAFKLGALQHTPVLDSVVEETLRLRAAPTLLRLVHEDYTLKMSSGQEYLFRHGDILAL
FPYLSVHMDPDIHPEPTVFKYDRFLNPNGSRKVDFFKAGKKIHHYTMPWGSGVSICPGRFFALS
EVKLFILLMVTHFDLELVDPDTPLPHVDPQRWGFGTMQPSHDVRFRYRLHPTE

hide sequence

Ensembl Acc Id:

ENSPPAP00000028587 ⟸ ENSPPAT00000051436

Ensembl Acc Id:

ENSPPAP00000028592 ⟸ ENSPPAT00000051440

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000037336	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000051436.1	UniProtKB/TrEMBL
	ENSPPAT00000051440.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.630.10	UniProtKB/TrEMBL
InterPro	Cyt_P450	UniProtKB/TrEMBL
	Cyt_P450_CYP7A1-type	UniProtKB/TrEMBL
	Cyt_P450_E_grp-IV	UniProtKB/TrEMBL
	Cyt_P450_sf	UniProtKB/TrEMBL
	Cytochrome_CYP8B1	UniProtKB/TrEMBL
NCBI Gene	LOC100969929	ENTREZGENE
PANTHER	PTHR24306	UniProtKB/TrEMBL
	PTHR24306:SF0	UniProtKB/TrEMBL
Pfam	p450	UniProtKB/TrEMBL
PIRSF	Cytochrome_CYP8B1	UniProtKB/TrEMBL
	Cytochrome_CYPVIIA1	UniProtKB/TrEMBL
PRINTS	EP450IV	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48264	UniProtKB/TrEMBL
UniProt	A0A2R9BJS6_PANPA	UniProtKB/TrEMBL
	A0A2R9BJT1	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:83066	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-02-25	CYP8B1	cytochrome P450 family 8 subfamily B member 1	LOC100969929	7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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Imported Disease Annotations - CTD

Imported Annotations - SMPDB