CALR (calreticulin) - Rat Genome Database

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Gene: CALR (calreticulin) Canis lupus familiaris
Analyze
Symbol: CALR
Name: calreticulin
RGD ID: 12328768
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); hormone binding (ortholog); iron ion binding (ortholog); INVOLVED IN cardiac muscle cell differentiation (ortholog); cellular response to electrical stimulus (ortholog); cellular response to lithium ion (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); Aicardi-Goutieres Syndrome 4 (ortholog); alpha-mannosidosis (ortholog); FOUND IN acrosomal vesicle (ortholog); cell surface (ortholog); collagen-containing extracellular matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Calregulin; CRP55; Endoplasmic reticulum resident protein 60; ERp60; HACBP
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,251,390 - 49,255,291 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,251,777 - 49,255,245 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,123,639 - 49,127,542 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,768,253 - 49,772,156 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,768,253 - 49,772,135 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,979,448 - 48,983,351 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02049,405,934 - 49,409,839 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,648,459 - 49,652,362 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle cell differentiation  (ISO)
cellular response to electrical stimulus  (ISO)
cellular response to lithium ion  (ISO)
cellular response to virus  (ISO)
cellular senescence  (IEA)
cortical actin cytoskeleton organization  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of intracellular steroid hormone receptor signaling pathway  (IEA)
negative regulation of neuron differentiation  (IEA)
negative regulation of retinoic acid receptor signaling pathway  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of translation  (IEA)
negative regulation of trophoblast cell migration  (IEA)
peptide antigen assembly with MHC class I protein complex  (IEA)
positive regulation of cell cycle  (IEA,ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of dendritic cell chemotaxis  (IEA)
positive regulation of endothelial cell migration  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of phagocytosis  (IEA)
positive regulation of substrate adhesion-dependent cell spreading  (IEA)
protein export from nucleus  (IEA)
protein folding  (IEA)
protein localization to nucleus  (IEA)
protein stabilization  (IEA,ISS)
regulation of meiotic nuclear division  (IEA,ISO)
response to biphenyl  (ISO)
response to estradiol  (ISO)
response to glycoside  (ISO)
response to peptide  (ISO)
response to testosterone  (ISO)
response to xenobiotic stimulus  (ISO)
spermatogenesis  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:8537405   PMID:21126744   PMID:21557298   PMID:22301074   PMID:28327184   PMID:30032202  


Genomics

Comparative Map Data
CALR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,251,390 - 49,255,291 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,251,777 - 49,255,245 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,123,639 - 49,127,542 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,768,253 - 49,772,156 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,768,253 - 49,772,135 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,979,448 - 48,983,351 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02049,405,934 - 49,409,839 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,648,459 - 49,652,362 (-)NCBIUU_Cfam_GSD_1.0
CALR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,938,609 - 12,944,489 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1912,938,578 - 12,944,489 (+)EnsemblGRCh38hg38GRCh38
GRCh371913,049,423 - 13,055,303 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,910,423 - 12,916,303 (+)NCBINCBI36Build 36hg18NCBI36
Build 341912,910,422 - 12,916,303NCBI
Celera1912,939,147 - 12,945,035 (+)NCBICelera
Cytogenetic Map19p13.13NCBI
HuRef1912,621,315 - 12,627,203 (+)NCBIHuRef
CHM1_11913,049,914 - 13,055,824 (+)NCBICHM1_1
T2T-CHM13v2.01913,063,097 - 13,068,974 (+)NCBIT2T-CHM13v2.0
Calr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,568,717 - 85,573,560 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl885,568,479 - 85,573,563 (-)EnsemblGRCm39 Ensembl
GRCm38884,842,088 - 84,846,931 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,841,850 - 84,846,934 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,365,987 - 87,370,830 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36887,731,955 - 87,736,972 (-)NCBIMGSCv36mm8
Celera889,141,243 - 89,146,089 (-)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.21NCBI
Calr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,213,367 - 40,218,262 (+)NCBIGRCr8
mRatBN7.21923,308,525 - 23,313,420 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,308,351 - 23,313,414 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,131,431 - 30,136,323 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01930,785,793 - 30,790,685 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,008,476 - 33,013,368 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,956,771 - 25,961,666 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,956,771 - 25,961,666 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,932,394 - 36,937,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,964,775 - 24,969,670 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11924,969,631 - 24,974,494 (+)NCBI
Celera1922,865,445 - 22,870,340 (+)NCBICelera
Cytogenetic Map19q11NCBI
Calr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,985,147 - 31,989,372 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,985,147 - 31,989,372 (+)NCBIChiLan1.0ChiLan1.0
CALR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22017,867,887 - 17,873,926 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11916,868,542 - 16,874,580 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01912,501,013 - 12,506,909 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11913,242,900 - 13,249,416 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,242,900 - 13,249,416 (+)Ensemblpanpan1.1panPan2
Calr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,355,637 - 208,360,018 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,994,648 - 1,999,430 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,994,695 - 1,999,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,098,229 - 66,102,132 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,098,263 - 66,102,074 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,283,767 - 66,287,604 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CALR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,618,691 - 11,624,299 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl611,618,396 - 11,623,792 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660748,162,943 - 8,168,575 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Calr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624901511,052 - 516,757 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624901511,295 - 515,208 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CALR
138 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000027074   ⟹   ENSCAFP00000025174
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2049,251,777 - 49,255,245 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845027177   ⟹   ENSCAFP00845021381
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2049,768,253 - 49,772,135 (-)Ensembl
RefSeq Acc Id: XM_038428450   ⟹   XP_038284378
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02049,768,253 - 49,772,156 (-)NCBI
RefSeq Acc Id: XM_038504094   ⟹   XP_038360022
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12048,979,448 - 48,983,351 (-)NCBI
RefSeq Acc Id: XM_038567123   ⟹   XP_038423051
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02049,648,459 - 49,652,362 (-)NCBI
RefSeq Acc Id: XM_038631266   ⟹   XP_038487194
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02049,405,934 - 49,409,839 (-)NCBI
RefSeq Acc Id: XM_862217   ⟹   XP_867310
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12049,251,390 - 49,255,291 (-)NCBI
Dog10K_Boxer_Tasha2049,123,639 - 49,127,542 (-)NCBI
Sequence:
RefSeq Acc Id: XP_867310   ⟸   XM_862217
- UniProtKB: A0A8C0P5H0 (UniProtKB/TrEMBL),   A0A8C0QVL8 (UniProtKB/TrEMBL),   A0A8I3NM03 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000025174   ⟸   ENSCAFT00000027074
RefSeq Acc Id: XP_038360022   ⟸   XM_038504094
RefSeq Acc Id: XP_038487194   ⟸   XM_038631266
RefSeq Acc Id: XP_038284378   ⟸   XM_038428450
- UniProtKB: A0A8C0P5H0 (UniProtKB/TrEMBL),   A0A8C0QVL8 (UniProtKB/TrEMBL),   A0A8I3NM03 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038423051   ⟸   XM_038567123
- UniProtKB: A0A8C0P5H0 (UniProtKB/TrEMBL),   A0A8C0QVL8 (UniProtKB/TrEMBL),   A0A8I3NM03 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845021381   ⟸   ENSCAFT00845027177

Promoters
RGD ID:13687002
Promoter ID:EPDNEW_C5070
Type:multiple initiation site
Name:CALR_1
Description:calreticulin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12049,255,282 - 49,255,342EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017093 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030018673 UniProtKB/TrEMBL
  ENSCAFG00040023589 UniProtKB/TrEMBL
  ENSCAFG00845015220 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000027074.5 UniProtKB/TrEMBL
  ENSCAFT00030034380.1 UniProtKB/TrEMBL
  ENSCAFT00040043906.1 UniProtKB/TrEMBL
  ENSCAFT00845027177 ENTREZGENE
  ENSCAFT00845027177.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.250.10 UniProtKB/TrEMBL
  2.60.120.200 UniProtKB/TrEMBL
  Helix hairpin bin UniProtKB/TrEMBL
InterPro Calret/calnex UniProtKB/TrEMBL
  Calret/calnex_CS UniProtKB/TrEMBL
  Calreticulin UniProtKB/TrEMBL
  Calreticulin/calnexin_P_dom_sf UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/TrEMBL
NCBI Gene CALR ENTREZGENE
PANTHER CALRETICULIN UniProtKB/TrEMBL
  PTHR11073 UniProtKB/TrEMBL
Pfam Calreticulin UniProtKB/TrEMBL
PIRSF Calreticulin UniProtKB/TrEMBL
PRINTS CALRETICULIN UniProtKB/TrEMBL
PROSITE CALRETICULIN_1 UniProtKB/TrEMBL
  CALRETICULIN_2 UniProtKB/TrEMBL
  CALRETICULIN_REPEAT UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/TrEMBL
  SSF63887 UniProtKB/TrEMBL
UniProt A0A8C0P5H0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QVL8 ENTREZGENE
  A0A8I3NM03 ENTREZGENE, UniProtKB/TrEMBL
  CALR_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:54585 ENTREZGENE