RGD Reference Report - Membrane associated Ca2+ buffers in the heart. - Rat Genome Database

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Membrane associated Ca2+ buffers in the heart.

Authors: Lee, D  Michalak, M 
Citation: Lee D and Michalak M, BMB Rep. 2010 Mar;43(3):151-7.
RGD ID: 7204686
Pubmed: PMID:20356453   (View Abstract at PubMed)

Ca2+ is a universal signalling molecule that affects a variety of cellular processes including cardiac development. The majority of intracellular Ca2+ is stored in the endoplasmic and sarcoplasmic reticulum of muscle and non-muscle cells. Calreticulin is a well studied Ca2+-buffering protein in the endoplasmic reticulum, and calreticulin deficiency is embryonic lethal due to impaired cardiac development. Despite calsequestrin being the most abundant Ca2+-buffering protein in the sarcoplasmic reticulum, viability is maintained in embryos without calsequestrin and normal Ca2+ release and contractile function is observed. The Ca2+ homeostasis regulated by the endoplasmic and sarcoplasmic reticulum is critical for the development and proper function of the heart.



Molecular Pathway Annotations    Click to see Annotation Detail View
Objects Annotated

Genes (Rattus norvegicus)
Calr  (calreticulin)
Casq1  (calsequestrin 1)
Casq2  (calsequestrin 2)

Genes (Mus musculus)
Calr  (calreticulin)
Casq1  (calsequestrin 1)
Casq2  (calsequestrin 2)

Genes (Homo sapiens)
CALR  (calreticulin)
CASQ1  (calsequestrin 1)
CASQ2  (calsequestrin 2)


Additional Information