HTR2C (5-hydroxytryptamine receptor 2C)

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Gene: HTR2C (5-hydroxytryptamine receptor 2C) Canis lupus familiaris

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Symbol:

HTR2C

Name:

5-hydroxytryptamine receptor 2C

RGD ID:

12160870

Description:

ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); Gq/11-coupled serotonin receptor activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); behavioral fear response (ortholog); behavioral response to nicotine (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); anxiety disorder (ortholog); autistic disorder (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

5-HT-2C; 5-HT2C; 5-HTR2C; serotonin receptor 2C

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	87,342,800 - 87,641,224 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	87,342,792 - 87,638,579 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	73,595,073 - 73,759,737 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	89,055,367 - 89,357,473 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	89,055,355 - 89,357,011 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	86,633,342 - 86,797,977 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	88,307,583 - 88,472,268 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	88,140,047 - 88,305,373 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol use disorder (ISO)

anxiety disorder (ISO)

autistic disorder (ISO)

autosomal hemophilia A (ISO)

bipolar disorder (ISO)

cocaine abuse (ISO)

cocaine dependence (ISO)

Experimental Liver Neoplasms (ISO)

factor VIII deficiency (ISO)

genetic disease (ISO)

Hyperkinesis (ISO)

major depressive disorder (ISO)

Metabolic Syndrome (ISO)

Neuralgia (ISO)

nicotine dependence (ISO)

obesity (ISO)

Pain (ISO)

Prader-Willi syndrome (ISO)

prostate cancer (ISO)

schizophrenia (ISO)

substance-related disorder (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

type 2 diabetes mellitus (ISO)

Weight Gain (ISO)

withdrawal disorder (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ regeneration (ISO)

behavioral fear response (IEA,ISS)

behavioral response to nicotine (ISO)

cGMP-mediated signaling (IEA)

chemical synaptic transmission (IBA)

feeding behavior (IEA,ISO,ISS)

G protein-coupled receptor signaling pathway (IEA)

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (IBA)

G protein-coupled serotonin receptor signaling pathway (IEA)

intracellular calcium ion homeostasis (IEA)

locomotory behavior (IEA)

negative regulation of dopamine metabolic process (ISO)

phospholipase C-activating G protein-coupled receptor signaling pathway (IEA,ISS)

phospholipase C-activating serotonin receptor signaling pathway (IBA,IEA,ISO,ISS)

phospholipase D-activating G protein-coupled receptor signaling pathway (ISO)

positive regulation of acetylcholine secretion, neurotransmission (ISO)

positive regulation of calcium-mediated signaling (IEA,ISO)

positive regulation of ERK1 and ERK2 cascade (IEA)

positive regulation of fat cell differentiation (IEA,ISO)

positive regulation of gamma-aminobutyric acid secretion (ISO)

positive regulation of phosphatidylinositol biosynthetic process (IEA)

positive regulation of vasoconstriction (ISO)

regulation of appetite (IEA,ISS)

regulation of corticotropin-releasing hormone secretion (IEA,ISS)

regulation of nervous system process (IEA,ISS)

release of sequestered calcium ion into cytosol (IBA,IEA)

response to xenobiotic stimulus (ISO)

sensitization (ISO)

serotonin receptor signaling pathway (IBA)

Cellular Component

cell surface (ISO)

dendrite (IBA)

external side of plasma membrane (ISO)

G protein-coupled serotonin receptor complex (IEA)

membrane (IEA)

plasma membrane (IBA,IEA,ISS)

synapse (IEA)

Molecular Function

1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding (IEA)

G protein-coupled receptor activity (IEA)

G protein-coupled serotonin receptor activity (IBA,IEA,ISO)

Gq/11-coupled serotonin receptor activity (IEA,ISS)

identical protein binding (IEA)

neurotransmitter receptor activity (IBA)

protein binding (ISO)

serotonin binding (IEA)

serotonin receptor activity (IEA)

References

Additional References at PubMed

PMID:15353848	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

HTR2C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	87,342,800 - 87,641,224 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	87,342,792 - 87,638,579 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	73,595,073 - 73,759,737 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	89,055,367 - 89,357,473 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	89,055,355 - 89,357,011 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	86,633,342 - 86,797,977 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	88,307,583 - 88,472,268 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	88,140,047 - 88,305,373 (+)	NCBI		UU_Cfam_GSD_1.0

HTR2C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	114,584,086 - 114,910,061 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	114,584,078 - 114,910,061 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	113,818,559 - 114,144,624 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	113,724,807 - 114,050,880 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	113,641,530 - 113,967,604	NCBI
Celera	X	114,253,715 - 114,579,778 (+)	NCBI		Celera
Cytogenetic Map	X	q23	NCBI
HuRef	X	103,403,272 - 103,731,741 (+)	NCBI		HuRef
CHM1_1	X	113,729,484 - 114,055,500 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	112,992,593 - 113,318,748 (+)	NCBI		T2T-CHM13v2.0

Htr2c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	145,745,509 - 145,980,273 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	145,745,509 - 145,980,273 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	146,962,464 - 147,197,277 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	146,962,513 - 147,197,277 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	143,397,056 - 143,631,820 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	142,208,881 - 142,443,644 (+)	NCBI		MGSCv36	mm8
Celera	X	130,902,904 - 131,136,225 (+)	NCBI		Celera
Cytogenetic Map	X	F2	NCBI
cM Map	X	68.46	NCBI

Htr2c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	115,453,190 - 115,682,325 (+)	NCBI		GRCr8
mRatBN7.2	X	110,640,777 - 110,870,288 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	110,641,153 - 110,870,287 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	112,734,293 - 112,956,059 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	116,233,146 - 116,454,918 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	113,792,877 - 114,014,236 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	118,084,520 - 118,318,040 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	118,084,890 - 118,318,039 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	118,226,113 - 118,460,830 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	31,012,921 - 31,244,127 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	31,069,048 - 31,185,684 (-)	NCBI
Celera	X	109,958,913 - 110,179,824 (+)	NCBI		Celera
Cytogenetic Map	X	q34	NCBI

Htr2c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955490	910,415 - 1,126,373 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955490	912,615 - 1,126,347 (-)	NCBI	ChiLan1.0	ChiLan1.0

HTR2C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	114,026,594 - 114,352,146 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	114,030,203 - 114,355,755 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	103,673,172 - 103,999,133 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	114,169,823 - 114,503,179 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	114,199,485 - 114,503,201 (+)	Ensembl	panpan1.1		panPan2

Htr2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	86,426,392 - 86,655,882 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936499	1,004,732 - 1,109,377 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936499	1,002,083 - 1,109,446 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HTR2C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	94,053,456 - 94,313,355 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	94,053,415 - 94,313,352 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	108,811,549 - 108,871,722 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Sscrofa10.2	X	108,566,657 - 108,733,261 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HTR2C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	102,190,355 - 102,499,928 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	102,325,731 - 102,497,278 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	27,537,759 - 27,837,340 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Htr2c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624940	1,040,911 - 1,157,057 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624940	1,040,744 - 1,299,266 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in HTR2C
2329 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
3	4	2	21	19	13	6	6	6	5	22	12	12	14	7

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001006648	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005640991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038448836	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000146	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB193091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000394	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000175	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000039	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000047976 ⟹ ENSCAFP00000043222

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	X	87,342,792 - 87,638,579 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000069149 ⟹ ENSCAFP00000046494

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	X	87,481,105 - 87,638,579 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845028138 ⟹ ENSCAFP00845022140

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	X	89,055,355 - 89,355,633 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845028162 ⟹ ENSCAFP00845022156

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	X	89,055,355 - 89,354,307 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845028179 ⟹ ENSCAFP00845022171

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	X	89,055,479 - 89,357,011 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845028193 ⟹ ENSCAFP00845022184

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	X	89,193,742 - 89,355,633 (+)	Ensembl

RefSeq Acc Id:

NM_001006648 ⟹ NP_001006649

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	X	87,476,890 - 87,638,579 (+)	NCBI
Dog10K_Boxer_Tasha	X	73,595,073 - 73,759,737 (+)	NCBI
ROS_Cfam_1.0	X	89,189,526 - 89,354,842 (+)	NCBI
UMICH_Zoey_3.1	X	86,633,342 - 86,797,977 (+)	NCBI
UNSW_CanFamBas_1.0	X	88,307,583 - 88,472,268 (+)	NCBI
UU_Cfam_GSD_1.0	X	88,140,047 - 88,305,373 (+)	NCBI

Sequence:

show sequence

ATGGTGAACCTGAGGAAAGCGGTGCATTCGTTCCTTGTGCACCTAATTGGCCTACTGGTTTGGC
AATGCGATATTTCTGTGAGCCCTGTTGCAGCTCTAGTAACTGACATTTTCAATACCTCCGATGG
TGGACGCTTCAAATTCCCAGACGGGGTACAAAACTGGCCAGCACTTTCAATCGTCATCATCATA
ATCTTGACAATAGGTGGCAACATTCTCGTTATCATGGCAGTAAGCTTGGAAAAGAAACTGCACA
ATGCCACCAATTACTTCCTAATGTCCCTAGCCATTGCTGATATGCTAGTGGGACTACTTGTCAT
GCCACTGTCTCTGCTTGCAATTCTTTATGATTATGTCTGGCCACTACCTAGATATTTGTGCCCC
GTCTGGATTTCTTTGGATGTTTTATTTTCTACAGCGTCCATCATGCACCTCTGCGCTATCTCGC
TGGATCGGTATGTAGCAATACGTAATCCTGTTGAGCATAGCCGTTTCAATTCGCGGACTAAGGC
CATCATGAAGATTGCTATTGTTTGGGCAATTTCGATAGGTGTGTCCGTTCCCATCCCAGTGATC
GGACTGAGAGATGAAGAGAAAGTGTTCGTCAACAACACCACATGCGTGCTGAACGACCCAAACT
TCGTTCTCATTGGGTCCTTCGTCGCTTTCTTCATACCGTTGACGATCATGGTGATCACATACTG
CCTGACCATCCACGTTCTTCGCCGTCAAGCCCTGATGTTACTGCACGGCCACGTCGAGGAACCG
CCCAGAATAAACCTGGACTTTCTGAAGTGCTGCAGGAGGAACGGCACGGAGGAAGAGAACTCTG
CCAACCCGAACCAAGATTCGAACCCACGCCGAAGAAAGAAGAAAGAGCGACGTCCCAGGGGCAC
CATGCAAGCCATCAACAACGAACGGAAAGCGTCGAAAGTCCTTGGCATTGTTTTCTTTGTGTTT
CTGGTCATGTGGTGCCCGTTTTTCATTACCAATATTCTGTCGGTTCTGTGCGGGAAGGCCTGTA
ACCAAAAGCTCATGGAAAAGCTTCTGAACGTGTTTGTTTGGATTGGCTATGTCTGTTCGGGAAT
CAATCCTCTGGTGTACACGCTTTTCAACAAAATTTACCGCAGGGCTTTCTCTAACTATTTGCGC
TGCAATTATAAGCCAGAAAAGAAGCCTCCCGTGAGACAGATGCCCAGAGTGGCTGCTACCGCTT
TGTCCGGAAGGGAGCTCAATGTTAACATTTACCGGCACACCAACGAACCGGTGCTTAAGAAAGC
TAATGACAAGGAGCCCGGTATAGAGATGCAGGTGGAGAATTTGGAGCTACCAGTTAATCCCTCC
AGTGTGGTTAGTGAAAGGATCAGCAGCGTGTAA

hide sequence

RefSeq Acc Id:

XM_038448836 ⟹ XP_038304764

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	X	89,055,367 - 89,357,473 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001006649	(Get FASTA)	NCBI Sequence Viewer
	XP_038304764	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAD60921	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000043222.2
	ENSCAFP00000046494.1
	ENSCAFP00000073574.1
	ENSCAFP00000074476.1
	ENSCAFP00040025736.1
	ENSCAFP00040025766.1
	ENSCAFP00845022140
	ENSCAFP00845022140.1
	ENSCAFP00845022156.1
	ENSCAFP00845022171.1
	ENSCAFP00845022184
	ENSCAFP00845022184.1
GenBank Protein	Q60F97	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001006649 ⟸ NM_001006648
- Peptide Label:	precursor
- UniProtKB:	Q60F97 (UniProtKB/Swiss-Prot), A0A8C0JU26 (UniProtKB/TrEMBL), A0A8C0SRJ8 (UniProtKB/TrEMBL), A0A8I3S1Q6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVNLRKAVHSFLVHLIGLLVWQCDISVSPVAALVTDIFNTSDGGRFKFPDGVQNWPALSIVIII ILTIGGNILVIMAVSLEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCP VWISLDVLFSTASIMHLCAISLDRYVAIRNPVEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVI GLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIHVLRRQALMLLHGHVEEP PRINLDFLKCCRRNGTEEENSANPNQDSNPRRRKKKERRPRGTMQAINNERKASKVLGIVFFVF LVMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLR CNYKPEKKPPVRQMPRVAATALSGRELNVNIYRHTNEPVLKKANDKEPGIEMQVENLELPVNPS SVVSERISSV hide sequence

Ensembl Acc Id:

ENSCAFP00000046494 ⟸ ENSCAFT00000069149

Ensembl Acc Id:

ENSCAFP00000043222 ⟸ ENSCAFT00000047976

RefSeq Acc Id:	XP_038304764 ⟸ XM_038448836
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0YZL3 (UniProtKB/TrEMBL), A0A8I3NYQ9 (UniProtKB/TrEMBL), A0A8C0JU26 (UniProtKB/TrEMBL), A0A8C0SRJ8 (UniProtKB/TrEMBL), A0A8I3S1Q6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845022140 ⟸ ENSCAFT00845028138

Ensembl Acc Id:

ENSCAFP00845022184 ⟸ ENSCAFT00845028193

Ensembl Acc Id:

ENSCAFP00845022156 ⟸ ENSCAFT00845028162

Ensembl Acc Id:

ENSCAFP00845022171 ⟸ ENSCAFT00845028179

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000029120	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00040016067	UniProtKB/TrEMBL
	ENSCAFG00845015792	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000047976.3	UniProtKB/TrEMBL
	ENSCAFT00000069149.2	UniProtKB/TrEMBL
	ENSCAFT00000094384.1	UniProtKB/TrEMBL
	ENSCAFT00000101278.1	UniProtKB/TrEMBL
	ENSCAFT00040029627.1	UniProtKB/TrEMBL
	ENSCAFT00040029663.1	UniProtKB/TrEMBL
	ENSCAFT00845028138	ENTREZGENE
	ENSCAFT00845028138.1	UniProtKB/TrEMBL
	ENSCAFT00845028162.1	UniProtKB/TrEMBL
	ENSCAFT00845028179.1	UniProtKB/TrEMBL
	ENSCAFT00845028193	ENTREZGENE
	ENSCAFT00845028193.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	5HT2C_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	5HT_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	cfa:450240	UniProtKB/Swiss-Prot
NCBI Gene	HTR2C	ENTREZGENE
PANTHER	5-HYDROXYTRYPTAMINE RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR24247:SF32	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	5HT2CRECEPTR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	5HTRECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	7TM_GPCR_Srsx	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	5HT2C_CANLF	UniProtKB/Swiss-Prot
	A0A8C0JU26	ENTREZGENE
	A0A8C0SRJ8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0YZL3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3NNR2_CANLF	UniProtKB/TrEMBL
	A0A8I3NXN8_CANLF	UniProtKB/TrEMBL
	A0A8I3NYQ9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3S1Q6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0NTP4_CANLF	UniProtKB/TrEMBL
	A0A8P0TSP2_CANLF	UniProtKB/TrEMBL
	Q60F97	ENTREZGENE
VGNC ID	VGNC:41828	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI