RGD Reference Report - Allelic association analysis of the 5-HT2C receptor gene in bipolar affective disorder. - Rat Genome Database

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Allelic association analysis of the 5-HT2C receptor gene in bipolar affective disorder.

Authors: Gutierrez, B  Fananas, L  Arranz, MJ  Valles, V  Guillamat, R  Van Os, J  Collier, D 
Citation: Gutierrez B, etal., Neurosci Lett 1996 Jul 5;212(1):65-7.
RGD ID: 1358737
Pubmed: PMID:8823764   (View Abstract at PubMed)

We have examined a structural variant of the 5-HT2C receptor (Cys23Ser) for allelic association with bipolar affective disorder in 88 cases and 113 controls. Overall, there was no significant difference in allele frequencies between the two groups, indicating that the 5-HT2C gene is not a major risk factor for bipolar affective disorder. However, when the subjects were analysed according to sex, there was a small excess of the serine ser23 allele in female cases (P = 0.04) and this effect was also seen if the ser23 allele was considered recessive (P = 0.03). A small increase in significance was found if only female cases with a known family history were included (P = 0.01). These results suggest that the ser23 allele may increase susceptibility to bipolar affective disorder in women.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HTR2CHumanbipolar disorder  IAGP DNA:missense mutation:cds:p.C23S (human)RGD 
Htr2cRatbipolar disorder  ISOHTR2C (Homo sapiens)DNA:missense mutation:cds:p.C23S (human)RGD 
Htr2cMousebipolar disorder  ISOHTR2C (Homo sapiens)DNA:missense mutation:cds:p.C23S (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Htr2c  (5-hydroxytryptamine receptor 2C)

Genes (Mus musculus)
Htr2c  (5-hydroxytryptamine (serotonin) receptor 2C)

Genes (Homo sapiens)
HTR2C  (5-hydroxytryptamine receptor 2C)


Additional Information