INHA (inhibin subunit alpha) - Rat Genome Database

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Gene: INHA (inhibin subunit alpha) Pan paniscus
Analyze
Symbol: INHA
Name: inhibin subunit alpha
RGD ID: 11866882
Description: ENCODES a protein that exhibits inhibin binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN male gonad development (ortholog); negative regulation of follicle-stimulating hormone secretion (ortholog); ovarian follicle development (ortholog); ASSOCIATED WITH dysgerminoma (ortholog); embryonal carcinoma (ortholog); Endometrial Neoplasms (ortholog); FOUND IN extracellular space (ortholog); inhibin A complex (ortholog); inhibin B complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inhibin alpha chain; inhibin alpha subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213122,201,726 - 122,205,889 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B122,216,786 - 122,220,855 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,828,948 - 106,832,993 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B225,419,747 - 225,423,386 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B225,419,176 - 225,423,386 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
INHABonobodysgerminoma  ISOINHA (Homo sapiens)9068941protein:increased expression:tumorRGDPMID:11720904 and REF_RGD_ID:2290380
INHABonoboembryonal carcinoma  ISOINHA (Homo sapiens)9068941protein:increased expression:tumorRGDPMID:11720904 and REF_RGD_ID:2290380
INHABonoboEndometrial Neoplasms  ISOINHA (Homo sapiens)9068941mRNA:decreased expression:endometriumRGDPMID:15745937 and REF_RGD_ID:1579943
INHABonoboEndometrioid Carcinomas  ISOINHA (Homo sapiens)9068941protein:decreased expression:tumor:significantly higher in normal compared to malignant tissueRGDPMID:17143484 and REF_RGD_ID:2290368
INHABonoboExperimental Autoimmune Orchitis  ISOInha (Rattus norvegicus)9068941protein:decreased expression:serum:RGDPMID:11431143 and REF_RGD_ID:8694089
INHABonoboGerm Cell and Embryonal Neoplasms  ISOINHA (Homo sapiens)9068941DNA:SNPRGDPMID:18413775 and REF_RGD_ID:2301687
INHABonoboinvasive ductal carcinoma  ISOINHA (Homo sapiens)9068941protein:decreased expression:tumor:significantly lower in invasive and infiltrating and metastatic tumors than in ductal carcinoma in situ tumorsRGDPMID:15583806 and REF_RGD_ID:2290390
INHABonoboLeydig cell tumor  ISOInha (Rattus norvegicus)9068941protein:increased expression:plasma and testis:observed in aged male Tig:Wistar ratsRGDPMID:11545298 and REF_RGD_ID:2290379
INHABonoboOvarian Neoplasms  ISOINHA (Homo sapiens)9068941protein:increased expression:tumorsRGDPMID:10435065 and REF_RGD_ID:2290383
INHABonoboprostate cancer  ISOINHA (Homo sapiens)9068941mRNA and protein:decreased expression:malignant tumorsRGDPMID:9506758 and REF_RGD_ID:2290384
INHABonoboprostate carcinoma  ISOINHA (Homo sapiens)9068941DNA:hypermethylation more ...RGDPMID:11818495 and REF_RGD_ID:2290381
INHABonoboseminoma  ISOINHA (Homo sapiens)9068941protein:increased expression:tumorRGDPMID:11720904 and REF_RGD_ID:2290380
INHABonoboSertoli cell tumor  ISOInha (Mus musculus)9068941reexpression in tumor derived cells eliminates the transformed phenotypeRGDPMID:10602485 and REF_RGD_ID:2290369
INHABonoboSertoli-Leydig cell tumor  ISOINHA (Homo sapiens)9068941protein:increased expression:tumor:focal expression in Sertoli cells and stronger diffuse expression in Leydig cellsRGDPMID:17414107 and REF_RGD_ID:2290367
INHABonobosex cord-gonadal stromal tumor susceptibilityISOInha (Mus musculus)9068941 RGDPMID:8090730 and REF_RGD_ID:2301690
1 to 15 of 15 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
INHABonoboNeurodevelopmental Disorders  ISOINHA (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
INHABonobopolydactyly  ISOINHA (Homo sapiens)8554872ClinVar Annotator: match by term: PolydactylyClinVar 
INHABonoboPrimary Ovarian Failure  ISOINHA (Homo sapiens)8554872ClinVar Annotator: match by term: Primary ovarian failureClinVarPMID:24033266 and PMID:25741868
INHABonoboprimary ovarian insufficiency  ISOINHA (Homo sapiens)8554872ClinVar Annotator: match by term: Premature ovarian failureClinVarPMID:24033266 and PMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
INHABonobofamilial male-limited precocious puberty  ISOINHA (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:16684832
INHABonoboSpontaneous Abortions  ISOINHA (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18539642


Biological Process

  

Cellular Component
1 to 12 of 12 rows

  
1 to 12 of 12 rows

Molecular Function
1 to 13 of 13 rows

  
1 to 13 of 13 rows

PMID:22301074   PMID:30032202  



INHA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213122,201,726 - 122,205,889 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B122,216,786 - 122,220,855 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,828,948 - 106,832,993 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B225,419,747 - 225,423,386 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B225,419,176 - 225,423,386 (+)Ensemblpanpan1.1panPan2
INHA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,572,310 - 219,575,711 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,569,162 - 219,575,711 (+)EnsemblGRCh38hg38GRCh38
GRCh372220,437,032 - 220,440,433 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,145,198 - 220,148,671 (+)NCBINCBI36Build 36hg18NCBI36
Build 342220,262,458 - 220,265,932NCBI
Celera2214,206,917 - 214,210,389 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2212,289,982 - 212,293,463 (+)NCBIHuRef
CHM1_12220,442,773 - 220,446,254 (+)NCBICHM1_1
T2T-CHM13v2.02220,057,015 - 220,060,416 (+)NCBIT2T-CHM13v2.0
Inha
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39175,483,872 - 75,487,010 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl175,483,721 - 75,487,010 (+)EnsemblGRCm39 Ensembl
GRCm38175,507,077 - 75,510,366 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl175,507,077 - 75,510,366 (+)EnsemblGRCm38mm10GRCm38
MGSCv37175,503,652 - 75,506,929 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36175,390,225 - 75,393,502 (+)NCBIMGSCv36mm8
Celera175,996,369 - 75,999,645 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map139.16NCBI
Inha
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,443,109 - 84,446,010 (+)NCBIGRCr8
mRatBN7.2976,994,465 - 76,997,366 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,993,589 - 76,997,248 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx985,438,700 - 85,441,597 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,567,579 - 90,570,476 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,953,758 - 88,956,655 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,700,482 - 82,703,383 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,700,468 - 82,703,400 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0982,469,743 - 82,472,644 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,781,223 - 74,784,124 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,928,355 - 74,931,217 (+)NCBI
Celera974,564,342 - 74,567,243 (+)NCBICelera
Cytogenetic Map9q33NCBI
Inha
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545313,902,277 - 13,905,008 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545313,902,443 - 13,905,008 (-)NCBIChiLan1.0ChiLan1.0
INHA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13726,080,465 - 26,083,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3726,080,510 - 26,083,391 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,905,885 - 26,908,990 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03726,095,548 - 26,098,652 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3726,095,593 - 26,098,473 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,999,522 - 26,002,625 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,935,517 - 25,938,622 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,956,124 - 25,959,282 (+)NCBIUU_Cfam_GSD_1.0
Inha
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,606,985 - 175,611,402 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,950,297 - 1,954,165 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,949,747 - 1,954,179 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INHA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15121,580,803 - 121,586,006 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115121,581,847 - 121,586,020 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215134,507,304 - 134,511,349 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap15q2.5NCBI
INHA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110105,467,575 - 105,471,388 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10105,467,963 - 105,471,688 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604093,930,128 - 93,933,947 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inha
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248235,487,278 - 5,491,635 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248235,487,930 - 5,491,447 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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RefSeq Transcripts XM_003818666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000063771   ⟹   ENSPPAP00000040850
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B225,419,176 - 225,423,386 (+)Ensembl
RefSeq Acc Id: XM_003818666   ⟹   XP_003818714
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v213122,201,726 - 122,205,889 (+)NCBI
NHGRI_mPanPan12B122,216,786 - 122,220,855 (+)NCBI
Mhudiblu_PPA_v02B106,828,948 - 106,832,993 (+)NCBI
PanPan1.12B225,419,747 - 225,423,386 (+)NCBI
Sequence:
Protein RefSeqs XP_003818714 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000040850.1
RefSeq Acc Id: XP_003818714   ⟸   XM_003818666
- UniProtKB: A0A2R9CFY0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000040850   ⟸   ENSPPAT00000063771
TGF-beta family profile



1 to 20 of 20 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSPPAG00000043060 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000063771.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  Inhibin_asu UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
KEGG Report pps:100972844 UniProtKB/TrEMBL
NCBI Gene INHA ENTREZGENE
PANTHER PTHR11848 UniProtKB/TrEMBL
  PTHR11848:SF117 UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
PIRSF Inhibin_alpha_subunit UniProtKB/TrEMBL
PRINTS INHIBINA UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A2R9CFY0 ENTREZGENE, UniProtKB/TrEMBL
1 to 20 of 20 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 INHA  inhibin subunit alpha    inhibin alpha subunit  Symbol and/or name change 5135510 APPROVED