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Gene: Chrna4 (cholinergic receptor, nicotinic, alpha polypeptide 4) Mus musculus
Symbol: Chrna4
Name: cholinergic receptor, nicotinic, alpha polypeptide 4
Description: Exhibits acetylcholine-gated cation-selective channel activity. Contributes to acetylcholine receptor activity. Involved in several processes, including behavioral response to nicotine; chemical synaptic transmission; and regulation of secretion by cell. Localizes to the dopaminergic synapse; external side of plasma membrane; and integral component of plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 1 and nicotine dependence. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 1,1-dichloroethene; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: a4 nicotinic receptor; acetylcholine receptor alpha 4 neural; acetylcholine receptor, neuronal, nicotinic, alpha-4 subunit; Acra-4; Acra4; alpha4 nAChR; alpha4-nAChR; EBN1; ENFL1; neuronal acetylcholine receptor subunit alpha-4
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382181,022,311 - 181,043,579 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372180,757,016 - 180,773,882 (-)NCBIGRCm37mm9NCBIm37
MGSCv362180,951,719 - 180,968,585 (-)NCBImm8
Celera2185,108,778 - 185,125,645 (-)NCBICelera
Cytogenetic Map2 H4NCBI
cM Map2103.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Chrna4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10355
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.