Chrna4 (cholinergic receptor, nicotinic, alpha polypeptide 4) - Rat Genome Database

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Gene: Chrna4 (cholinergic receptor, nicotinic, alpha polypeptide 4) Mus musculus
Analyze
Symbol: Chrna4
Name: cholinergic receptor, nicotinic, alpha polypeptide 4
RGD ID: 10355
MGI Page MGI
Description: Enables acetylcholine-gated monoatomic cation-selective channel activity. Contributes to acetylcholine receptor activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including behavioral response to nicotine; neuronal action potential; and synaptic signaling. Located in external side of plasma membrane. Part of acetylcholine-gated channel complex. Is active in dopaminergic synapse and presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 1 and nicotine dependence. Orthologous to human CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a4 nicotinic receptor; Ac; acetylcholine receptor alpha 4 neural; acetylcholine receptor, neuronal, nicotinic, alpha-4 subunit; Acr; Acra-4; Acra4; alpha4 nAChR; alpha4-nAChR; EBN1; ENFL1; neuronal acetylcholine receptor subunit alpha-4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,664,104 - 180,685,339 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,660,173 - 180,685,339 (-)EnsemblGRCm39 Ensembl
GRCm382181,022,311 - 181,043,579 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,018,380 - 181,043,546 (-)EnsemblGRCm38mm10GRCm38
MGSCv372180,757,016 - 180,773,882 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362180,951,719 - 180,968,585 (-)NCBIMGSCv36mm8
Celera2185,108,778 - 185,125,645 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-lobeline  (ISO)
(S)-anabasine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (EXP)
1,1-dimethyl-4-phenylpiperazinium iodide  (ISO)
1,2-dichloroethane  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
13-desmethylspirolide C  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamiprid  (EXP)
acetylcholine  (EXP,ISO)
acrylamide  (ISO)
alcuronium  (ISO)
aldicarb  (ISO)
aldrin  (EXP)
all-trans-retinoic acid  (EXP)
aluminium hydroxide  (ISO)
Amaranth  (ISO)
ammonium chloride  (ISO)
Antimony trioxide  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
atracurium  (ISO)
atropine  (ISO)
azoxystrobin  (ISO)
barium(0)  (ISO)
bendiocarb  (ISO)
bentonite  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Brilliant Blue  (ISO)
butan-1-ol  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
carbachol  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon nanotube  (EXP)
chloroethene  (EXP)
chlorpyrifos  (EXP)
choline  (EXP,ISO)
cisatracurium  (ISO)
Citreoviridin  (EXP)
clothianidin  (ISO)
cocaine  (ISO)
Cuprizon  (ISO)
cytisine  (EXP,ISO)
decabromodiphenyl ether  (ISO)
decamethonium  (ISO)
deguelin  (ISO)
Desformylflustrabromine  (ISO)
diazinon  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (EXP)
dichlorvos  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dihydro-beta-erythroidine  (EXP,ISO)
dioxygen  (EXP)
dopamine  (ISO)
elemental selenium  (ISO)
epibatidine  (EXP,ISO)
epoxiconazole  (EXP)
EPTC  (ISO)
ethanol  (EXP)
ethylparaben  (ISO)
fenoxycarb  (ISO)
fulvestrant  (ISO)
galanthamine  (ISO)
galanthamine Trifluoroacetic acid  (ISO)
genistein  (EXP,ISO)
hexachlorophene  (EXP)
Hexamethonium  (EXP,ISO)
imidacloprid  (ISO)
indigo carmine  (ISO)
magnesium dihydroxide  (ISO)
Mecamylamine  (EXP,ISO)
mercury dichloride  (ISO)
methoxychlor  (ISO)
methyllycaconitine  (ISO)
Mivacurium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nicotine  (EXP,ISO)
nitrofen  (ISO)
NS-398  (EXP)
ozone  (ISO)
pancuronium  (ISO)
paracetamol  (EXP)
paraoxon  (ISO)
phenobarbital  (EXP)
physostigmine  (ISO)
picoxystrobin  (ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
propoxur  (ISO)
pyrazines  (ISO)
pyridines  (ISO)
pyrimidifen  (ISO)
resveratrol  (ISO)
rivastigmine  (ISO)
rocuronium  (ISO)
rotenone  (ISO)
scopolamine  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
streptozocin  (EXP)
succinylcholine  (ISO)
Sunset Yellow FCF  (ISO)
T-2 toxin  (EXP)
tacrine  (EXP,ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetraphene  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thifluzamide  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tubocurarine  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
varenicline  (EXP,ISO)
vecuronium bromide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylcholine signaling pathway via nicotinic acetylcholine receptor  (ISO)
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nicotine pharmacokinetics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mammalian nicotinic acetylcholine receptors: from structure to function. Albuquerque EX, etal., Physiol Rev. 2009 Jan;89(1):73-120. doi: 10.1152/physrev.00015.2008.
2. Regulation of neuronal type genes in congestive heart failure rats. Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27.
3. Varenicline is a potent partial agonist at alpha6beta2* nicotinic acetylcholine receptors in rat and monkey striatum. Bordia T, etal., J Pharmacol Exp Ther. 2012 Aug;342(2):327-34. doi: 10.1124/jpet.112.194852. Epub 2012 May 1.
4. Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes. Marritt AM, etal., Mol Pharmacol. 2005 Dec;68(6):1656-68. Epub 2005 Aug 29.
5. Mutation (Ser284Leu) of neuronal nicotinic acetylcholine receptor alpha 4 subunit associated with frontal lobe epilepsy causes faster desensitization of the rat receptor expressed in oocytes. Matsushima N, etal., Epilepsy Res 2002 Feb;48(3):181-6.
6. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Nicotinic acetylcholine receptor immunohistochemistry in Alzheimer's disease and dementia with Lewy bodies: differential neuronal and astroglial pathology. Teaktong T, etal., J Neurol Sci 2004 Oct 15;225(1-2):39-49.
16. The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells. Xiao Y and Kellar KJ, J Pharmacol Exp Ther. 2004 Jul;310(1):98-107. Epub 2004 Mar 11.
Additional References at PubMed
PMID:1450513   PMID:1492743   PMID:1505988   PMID:2338144   PMID:7781998   PMID:8020960   PMID:8069308   PMID:8563774   PMID:8787861   PMID:8795617   PMID:8838678   PMID:8884288  
PMID:8889548   PMID:9539760   PMID:9749753   PMID:10095079   PMID:10235262   PMID:10349636   PMID:10964949   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11222635   PMID:11226318  
PMID:11226321   PMID:11344259   PMID:11352901   PMID:11434511   PMID:11904435   PMID:11906696   PMID:12059039   PMID:12130686   PMID:12213259   PMID:12225896   PMID:12438103   PMID:12477932  
PMID:12623222   PMID:12684443   PMID:12700166   PMID:12713636   PMID:12766617   PMID:12871652   PMID:12944511   PMID:14610273   PMID:14681479   PMID:14681929   PMID:15199190   PMID:15489334  
PMID:15528443   PMID:15569257   PMID:15705531   PMID:15741168   PMID:15963492   PMID:16104380   PMID:16141072   PMID:16141073   PMID:16313899   PMID:16339034   PMID:16602821   PMID:16675851  
PMID:17072836   PMID:17146052   PMID:17434683   PMID:17670967   PMID:17712039   PMID:17881519   PMID:17953485   PMID:17981562   PMID:18095155   PMID:18184794   PMID:18248619   PMID:18287559  
PMID:18321647   PMID:18446824   PMID:18528848   PMID:18582447   PMID:18789953   PMID:18848921   PMID:19111588   PMID:19139153   PMID:19228980   PMID:19246390   PMID:19404753   PMID:19474315  
PMID:19481067   PMID:19567877   PMID:19573576   PMID:19720621   PMID:20061993   PMID:20660270   PMID:20668200   PMID:20974182   PMID:21239887   PMID:21406211   PMID:21485013   PMID:21502501  
PMID:21606356   PMID:21795541   PMID:21873635   PMID:22030359   PMID:22064677   PMID:22279206   PMID:22396410   PMID:22483693   PMID:22647603   PMID:22836257   PMID:23056257   PMID:23213462  
PMID:23352115   PMID:23401504   PMID:23421903   PMID:23688922   PMID:23831952   PMID:23869214   PMID:24107512   PMID:24144909   PMID:24422997   PMID:24607281   PMID:24837029   PMID:24952961  
PMID:24953818   PMID:25031416   PMID:25038610   PMID:25086772   PMID:25131634   PMID:25193667   PMID:25451094   PMID:25596543   PMID:25816313   PMID:25948261   PMID:25972004   PMID:26103136  
PMID:26139609   PMID:26269589   PMID:26276394   PMID:26500498   PMID:26684647   PMID:26688111   PMID:26740650   PMID:26961950   PMID:27012889   PMID:27559543   PMID:27793780   PMID:28401925  
PMID:28648825   PMID:28759616   PMID:28766701   PMID:29074617   PMID:29114204   PMID:29293602   PMID:29791835   PMID:30176987   PMID:30326594   PMID:30414940   PMID:31078140   PMID:31078264  
PMID:31369741   PMID:31881170   PMID:32747456   PMID:32988984   PMID:33844281   PMID:34321999   PMID:34999827   PMID:35723023   PMID:36690450   PMID:36897571   PMID:37113156   PMID:39572675  


Genomics

Comparative Map Data
Chrna4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,664,104 - 180,685,339 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,660,173 - 180,685,339 (-)EnsemblGRCm39 Ensembl
GRCm382181,022,311 - 181,043,579 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,018,380 - 181,043,546 (-)EnsemblGRCm38mm10GRCm38
MGSCv372180,757,016 - 180,773,882 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362180,951,719 - 180,968,585 (-)NCBIMGSCv36mm8
Celera2185,108,778 - 185,125,645 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.54NCBI
CHRNA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,343,223 - 63,361,349 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2063,343,223 - 63,378,401 (-)EnsemblGRCh38hg38GRCh38
GRCh372061,974,575 - 61,992,701 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,445,109 - 61,463,192 (-)NCBINCBI36Build 36hg18NCBI36
Build 342061,446,464 - 61,463,192NCBI
Celera2058,652,104 - 58,670,128 (-)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2058,700,254 - 58,717,202 (-)NCBIHuRef
CHM1_12061,875,694 - 61,893,903 (-)NCBICHM1_1
T2T-CHM13v2.02065,149,372 - 65,167,972 (-)NCBIT2T-CHM13v2.0
Chrna4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,506,802 - 188,535,558 (-)NCBIGRCr8
mRatBN7.23168,136,246 - 168,157,839 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,136,266 - 168,156,957 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,520,220 - 172,537,355 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,479,311 - 181,496,446 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,140,859 - 178,157,919 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,533,182 - 176,547,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,527,516 - 176,548,208 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,243,234 - 180,258,017 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,171,214 - 170,185,998 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,077,249 - 170,092,033 (-)NCBI
Celera3164,428,976 - 164,443,759 (+)NCBICelera
RH 3.4 Map31564.7RGD
RH 3.4 Map31531.39RGD
Cytogenetic Map3q43NCBI
Chrna4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528825,308 - 841,270 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955528825,314 - 840,994 (+)NCBIChiLan1.0ChiLan1.0
CHRNA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22169,134,670 - 69,153,450 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12069,126,676 - 69,145,454 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02059,730,759 - 59,748,678 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12061,267,958 - 61,284,640 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2061,270,631 - 61,283,005 (-)Ensemblpanpan1.1panPan2
CHRNA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12447,024,948 - 47,036,507 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2447,025,187 - 47,042,266 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2446,208,582 - 46,223,310 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02447,978,552 - 47,993,300 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2447,977,796 - 47,988,696 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12446,993,833 - 47,005,225 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02447,118,082 - 47,132,739 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02447,874,247 - 47,888,996 (-)NCBIUU_Cfam_GSD_1.0
Chrna4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,227,250 - 195,242,216 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651410,680,859 - 10,695,865 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651410,680,893 - 10,695,859 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,423,878 - 62,435,728 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11762,424,672 - 62,436,646 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CHRNA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12851,790 - 862,685 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605048,462,591 - 48,480,754 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrna4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474129,026,908 - 29,044,464 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474129,024,668 - 29,039,684 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chrna4
1016 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1290
Count of miRNA genes:685
Interacting mature miRNAs:819
Transcripts:ENSMUST00000067120, ENSMUST00000108851, ENSMUST00000124400, ENSMUST00000135766
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302003Sluc17_msusceptibility to lung cancer 17 (mouse)Not determined2162433493181755017Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
1558748Vacq1_mvoluntary alcohol consumption QTL 1 (mouse)Not determined2178442338181515280Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156196464181755017Mouse
1301348Alcp5_malcohol preference locus 5 (mouse)Not determined2163486407181755017Mouse
1300676Prdt2_mprion disease incubation time 2 (mouse)Not determined2164515154181755017Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155823920181755017Mouse
1301677Alcp6_malcohol preference locus 6 (mouse)Not determined2163486407181755017Mouse

Markers in Region
Chrna4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382181,028,338 - 181,029,236UniSTSGRCm38
MGSCv372180,763,043 - 180,763,941UniSTSGRCm37
Celera2185,114,806 - 185,115,704UniSTS
Cytogenetic Map2H4UniSTS
cM Map2108.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001416868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_015730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB010002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF225912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF325347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL450341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY574263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM572024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM572025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM572026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM572027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM572028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM572029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM572030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM572031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM572032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM572033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM572034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM572035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM572036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM572037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000067120   ⟹   ENSMUSP00000066338
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2180,664,104 - 180,681,098 (-)Ensembl
GRCm38.p6 Ensembl2181,022,311 - 181,039,305 (-)Ensembl
Ensembl Acc Id: ENSMUST00000108851   ⟹   ENSMUSP00000104479
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2180,660,173 - 180,680,868 (-)Ensembl
GRCm38.p6 Ensembl2181,018,380 - 181,039,075 (-)Ensembl
Ensembl Acc Id: ENSMUST00000124400   ⟹   ENSMUSP00000123043
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2180,675,817 - 180,685,339 (-)Ensembl
GRCm38.p6 Ensembl2181,034,024 - 181,043,546 (-)Ensembl
Ensembl Acc Id: ENSMUST00000135766
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2180,671,218 - 180,681,018 (-)Ensembl
GRCm38.p6 Ensembl2181,029,425 - 181,039,225 (-)Ensembl
Ensembl Acc Id: ENSMUST00000198922   ⟹   ENSMUSP00000143253
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2180,660,174 - 180,670,121 (-)Ensembl
GRCm38.p6 Ensembl2181,018,381 - 181,028,328 (-)Ensembl
RefSeq Acc Id: NM_001416868   ⟹   NP_001403797
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392180,664,104 - 180,685,339 (-)NCBI
RefSeq Acc Id: NM_015730   ⟹   NP_056545
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392180,664,104 - 180,681,108 (-)NCBI
GRCm382181,022,311 - 181,039,177 (-)NCBI
MGSCv372180,757,016 - 180,773,882 (-)RGD
Celera2185,108,778 - 185,125,645 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030246772   ⟹   XP_030102632
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392180,664,104 - 180,681,825 (-)NCBI
GRCm382181,022,311 - 181,033,997 (-)NCBI
Sequence:
RefSeq Acc Id: NP_056545   ⟸   NM_015730
- Peptide Label: isoform 1 precursor
- UniProtKB: O70174 (UniProtKB/Swiss-Prot),   Q8VI10 (UniProtKB/Swiss-Prot),   Q8BHE9 (UniProtKB/Swiss-Prot),   Q9ET51 (UniProtKB/Swiss-Prot),   B7ZBU7 (UniProtKB/TrEMBL),   Q53YK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030102632   ⟸   XM_030246772
- Peptide Label: isoform X2
Ensembl Acc Id: ENSMUSP00000143253   ⟸   ENSMUST00000198922
Ensembl Acc Id: ENSMUSP00000123043   ⟸   ENSMUST00000124400
Ensembl Acc Id: ENSMUSP00000066338   ⟸   ENSMUST00000067120
Ensembl Acc Id: ENSMUSP00000104479   ⟸   ENSMUST00000108851
RefSeq Acc Id: NP_001403797   ⟸   NM_001416868
- Peptide Label: isoform 2
- UniProtKB: B7ZBU7 (UniProtKB/TrEMBL)
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70174-F1-model_v2 AlphaFold O70174 1-629 view protein structure

Promoters
RGD ID:6831036
Promoter ID:MM_KWN:33589
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000039490
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362180,778,096 - 180,778,596 (-)MPROMDB
RGD ID:6880110
Promoter ID:EPDNEW_M3503
Type:initiation region
Name:Chrna4_1
Description:Mus musculus cholinergic receptor, nicotinic, alpha polypeptide4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382181,039,240 - 181,039,300EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87888 AgrOrtholog
Ensembl Genes ENSMUSG00000027577 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000067120 ENTREZGENE
  ENSMUST00000067120.14 UniProtKB/Swiss-Prot
  ENSMUST00000108851.8 UniProtKB/TrEMBL
  ENSMUST00000124400.2 UniProtKB/TrEMBL
  ENSMUST00000198922.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11438 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:87888 ENTREZGENE
NCBI Gene 11438 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CHRNA4 RGD
PhenoGen Chrna4 PhenoGen
PRINTS NICOTINICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JFP3_MOUSE UniProtKB/TrEMBL
  ACHA4_MOUSE UniProtKB/Swiss-Prot
  B7ZBU7 ENTREZGENE, UniProtKB/TrEMBL
  B7ZBV1_MOUSE UniProtKB/TrEMBL
  O70174 ENTREZGENE
  Q53YK0 ENTREZGENE, UniProtKB/TrEMBL
  Q8BHE9 ENTREZGENE
  Q8VI10 ENTREZGENE
  Q9ET51 ENTREZGENE
UniProt Secondary Q8BHE9 UniProtKB/Swiss-Prot
  Q8VI10 UniProtKB/Swiss-Prot
  Q9ET51 UniProtKB/Swiss-Prot