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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10355
Species: Mus musculus
RGD Object: Gene
Symbol: Chrna4
Name: cholinergic receptor, nicotinic, alpha polypeptide 4
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna4multiple interactionsISOChrna4 (Rattus norvegicus)2303194RGDnicotine affects binding to Chrna4 protein; nicotine competes with [Epibatidine binds to Chrna4 protein] 
Chrna4multiple interactionsISOChrna4 (Rattus norvegicus)2303195RGDnicotine affects binding to Chrna4 protein; nicotine inhibits the reaction [epibatidine affects binding to Chrna4 protein] in rat retina 
Chrna4affects response to substanceEXP 6480464CTDCHRNA4 gene polymorphism affects the susceptibility to Nicotine; CHRNA4 protein affects the susceptibility to Nicotine; CHRNA4 protein mutant form affects the susceptibility to NicotinePMID:10734154 PMID:10942032 PMID:19404753
Chrna4decreases expressionEXP 6480464CTDNicotine results in decreased expression of CHRNA4 mRNAPMID:17135361
Chrna4increases expressionEXP 6480464CTDNicotine results in increased expression of CHRNA4 mRNA; Nicotine results in increased expression of CHRNA4 proteinPMID:14500745 PMID:19594327 PMID:29293602 PMID:7756618
Chrna4increases response to substanceEXP 6480464CTDCHRNA4 protein mutant form results in increased susceptibility to NicotinePMID:16339034
Chrna4multiple interactionsEXP 6480464CTD[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide co-treated with Nicotine] inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNA4 protein]; cytisine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Nicotine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CHRNA4 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]PMID:15551346 PMID:19481067 PMID:19594327 PMID:7756618
Chrna4affects bindingISOCHRNA4 (Homo sapiens)6480464CTDNicotine binds to [CHRNA4 protein binds to CHRNB2 protein]PMID:9336329
Chrna4affects bindingISOChrna4 (Rattus norvegicus)6480464CTDNicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]PMID:15615518 PMID:19252481
Chrna4decreases expressionISOChrna4 (Rattus norvegicus)6480464CTDNicotine results in decreased expression of CHRNA4 mRNAPMID:20060465
Chrna4increases expressionISOCHRNA4 (Homo sapiens)6480464CTDNicotine results in increased expression of CHRNA4 proteinPMID:19139119 PMID:20106947
Chrna4increases expressionISOChrna4 (Rattus norvegicus)6480464CTDNicotine results in increased expression of CHRNA4 mRNA; Nicotine results in increased expression of CHRNA4 proteinPMID:24368670 PMID:28555334 PMID:29486207 PMID:31846720 PMID:34153408
Chrna4multiple interactionsISOCHRNA4 (Homo sapiens)6480464CTD[CHRNA4 protein binds to CHRNB2 protein] which results in increased susceptibility to Nicotine; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]PMID:14645658 PMID:18448488 PMID:19139119 PMID:20943775 PMID:34628512 PMID:9336329 PMID:9454827
Chrna4multiple interactionsISOChrna4 (Rattus norvegicus)6480464CTD1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of [CHRNA4 protein binds to CHRNB2 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of CHRNA4 mRNA]; imidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; N-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased expression of [CHRNA4 protein binds to CHRNB2 protein]PMID:10336510 PMID:10377228 PMID:10945867 PMID:11124396 PMID:11150171 PMID:16915382 PMID:28555334 PMID:30247698 PMID:34153408
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