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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10355
Species: Mus musculus
RGD Object: Gene
Symbol: Chrna4
Name: cholinergic receptor, nicotinic, alpha polypeptide 4
Acc ID: CHEBI:27827
Term: paraoxon
Definition: An aryl dialkyl phosphate where both the alkyl groups are ethyl and the aryl group is 4-nitrophenyl.
Chemical ID: MESH:D010261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna4decreases expressionISOChrna4 (Rattus norvegicus)6480464CTDParaoxon results in decreased expression of CHRNA4 mRNA; Paraoxon results in decreased expression of CHRNA4 proteinPMID:21791372
Chrna4multiple interactionsISOChrna4 (Rattus norvegicus)6480464CTDAtropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]; Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]; Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]PMID:21791372
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