CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit)

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Gene: CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit) Chlorocebus sabaeus

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Symbol:

CHRNA4

Name:

cholinergic receptor nicotinic alpha 4 subunit

RGD ID:

18511705

Description:

ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); B cell activation (ortholog); behavioral response to nicotine (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); attention deficit hyperactivity disorder (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cholinergic synapse (ortholog); dendrite (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC103242748; LOC103242768; neuronal acetylcholine receptor subunit alpha-4; neuronal acetylcholine receptor subunit alpha-4-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	851,790 - 862,685 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666050	48,462,591 - 48,480,754 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

amyotrophic lateral sclerosis (ISO)

attention deficit hyperactivity disorder (ISO)

autistic disorder (ISO)

autosomal dominant nocturnal frontal lobe epilepsy (ISO)

autosomal dominant nocturnal frontal lobe epilepsy 1 (ISO)

autosomal recessive dyskeratosis congenita 5 (ISO)

benign familial infantile seizures 6 (ISO)

congestive heart failure (ISO)

developmental and epileptic encephalopathy (ISO)

developmental and epileptic encephalopathy 33 (ISO)

developmental and epileptic encephalopathy 94 (ISO)

Developmental Disabilities (ISO)

dystonia (ISO)

early infantile epileptic encephalopathy (ISO)

epilepsy (ISO)

frontal lobe epilepsy (ISO)

frontotemporal dementia (ISO)

genetic disease (ISO)

Inflammation (ISO)

intellectual disability (ISO)

Lewy body dementia (ISO)

nervous system disease (ISO)

neuronal ceroid lipofuscinosis (ISO)

nicotine dependence (ISO)

sleep disorder (ISO)

Tobacco Use Disorder (ISO)

visual epilepsy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetylcholine receptor signaling pathway (ISO)

B cell activation (ISO)

behavioral response to nicotine (ISO)

calcium ion transport (ISO)

cognition (ISO)

DNA repair (ISO)

exploration behavior (ISO)

inhibitory postsynaptic potential (ISO)

locomotory behavior (ISO)

membrane depolarization (ISO)

nervous system process (ISO)

neuronal action potential (ISO)

presynaptic modulation of chemical synaptic transmission (ISO)

regulation of acetylcholine-gated cation channel activity (ISO)

regulation of dopamine secretion (ISO)

regulation of membrane potential (ISO)

respiratory gaseous exchange by respiratory system (ISO)

response to acetylcholine (ISO)

response to hypoxia (ISO)

response to nicotine (ISO)

response to oxidative stress (ISO)

sensory perception of pain (ISO)

signal transduction (ISO)

synaptic transmission, cholinergic (ISO)

Cellular Component

acetylcholine-gated channel complex (ISO)

cholinergic synapse (ISO)

dendrite (ISO)

dopaminergic synapse (ISO)

external side of plasma membrane (ISO)

membrane (ISO)

neuronal cell body (ISO)

plasma membrane (ISO)

postsynaptic specialization membrane (ISO)

presynapse (ISO)

presynaptic membrane (ISO)

protein-containing complex (ISO)

Molecular Function

acetylcholine binding (ISO)

acetylcholine receptor activity (ISO)

acetylcholine-gated monoatomic cation-selective channel activity (ISO)

heterocyclic compound binding (ISO)

monoatomic ion channel activity (ISO)

protein binding (ISO)

protein-containing complex binding (ISO)

quaternary ammonium group binding (ISO)

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylcholine signaling pathway via nicotinic acetylcholine receptor (ISO)

alfentanil pharmacodynamics pathway (ISO)

bupivacaine pharmacodynamics pathway (ISO)

buprenorphine pharmacodynamics pathway (ISO)

chloroprocaine pharmacodynamics pathway (ISO)

citalopram pharmacodynamics pathway (ISO)

cocaine pharmacodynamics pathway (ISO)

codeine and morphine pharmacodynamics pathway (ISO)

desipramine pharmacodynamics pathway (ISO)

diphenoxylate pharmacodynamics pathway (ISO)

escitalopram pharmacodynamics pathway (ISO)

ethylmorphine pharmacodynamics pathway (ISO)

fentanyl pharmacodynamics pathway (ISO)

fluoxetine pharmacodynamics pathway (ISO)

heroin pharmacodynamics pathway (ISO)

hydrocodone pharmacodynamics pathway (ISO)

hydromorphone pharmacodynamics pathway (ISO)

imipramine pharmacodynamics pathway (ISO)

levacetylmethadol pharmacodynamics pathway (ISO)

levobupivacaine phgarmacodynamics pathway (ISO)

levorphanol pharmacodynamics pathway (ISO)

lidocaine pharmacodynamics pathway (ISO)

mepivacaine pharmacodynamics pathway (ISO)

methadone pharmacodynamics pathway (ISO)

nalbuphine pharmacodynamics pathway (ISO)

naloxone pharmacodynamics pathway (ISO)

naltrexone pharmacodynamics pathway (ISO)

nicotine pharmacodynamics pathway (ISO)

nicotine pharmacokinetics pathway (ISO)

oxybuprocaine pharmacodynamics pathway (ISO)

oxycodone pharmacodynamics pathway (ISO)

oxymorphone pharmacodynamics pathway (ISO)

pentazocine pharmacodynamics pathway (ISO)

prilocaine pharmacodynamics pathway (ISO)

procaine pharmacodynamics pathway (ISO)

remifentanil pharmacodynamics pathway (ISO)

ropivacaine pharmacodynamics pathway (ISO)

tramadol pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CHRNA4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	851,790 - 862,685 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666050	48,462,591 - 48,480,754 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

CHRNA4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	63,343,223 - 63,361,349 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	63,343,223 - 63,378,401 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	61,974,575 - 61,992,701 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	61,445,109 - 61,463,192 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	61,446,464 - 61,463,192	NCBI
Celera	20	58,652,104 - 58,670,128 (-)	NCBI		Celera
Cytogenetic Map	20	q13.33	NCBI
HuRef	20	58,700,254 - 58,717,202 (-)	NCBI		HuRef
CHM1_1	20	61,875,694 - 61,893,903 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	65,149,372 - 65,167,972 (-)	NCBI		T2T-CHM13v2.0

Chrna4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	180,664,104 - 180,685,339 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	180,660,173 - 180,685,339 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	181,022,311 - 181,043,579 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	181,018,380 - 181,043,546 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	180,757,016 - 180,773,882 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	180,951,719 - 180,968,585 (-)	NCBI		MGSCv36	mm8
Celera	2	185,108,778 - 185,125,645 (-)	NCBI		Celera
Cytogenetic Map	2	H4	NCBI
cM Map	2	103.54	NCBI

Chrna4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	188,506,802 - 188,535,558 (-)	NCBI		GRCr8
mRatBN7.2	3	168,136,246 - 168,157,839 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	168,136,266 - 168,156,957 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	172,520,220 - 172,537,355 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	181,479,311 - 181,496,446 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	178,140,859 - 178,157,919 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	176,533,182 - 176,547,965 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	176,527,516 - 176,548,208 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	180,243,234 - 180,258,017 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	170,171,214 - 170,185,998 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	170,077,249 - 170,092,033 (-)	NCBI
Celera	3	164,428,976 - 164,443,759 (+)	NCBI		Celera
RH 3.4 Map	3	1564.7	RGD
RH 3.4 Map	3	1531.39	RGD
Cytogenetic Map	3	q43	NCBI

Chrna4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955528	825,308 - 841,270 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955528	825,314 - 840,994 (+)	NCBI	ChiLan1.0	ChiLan1.0

CHRNA4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	69,134,670 - 69,153,450 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	69,126,676 - 69,145,454 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	59,730,759 - 59,748,678 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	61,267,958 - 61,284,640 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	61,270,631 - 61,283,005 (-)	Ensembl	panpan1.1		panPan2

CHRNA4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	47,024,948 - 47,036,507 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	47,025,187 - 47,042,266 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	46,208,582 - 46,223,310 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	47,978,552 - 47,993,300 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	47,977,796 - 47,988,696 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	46,993,833 - 47,005,225 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	47,118,082 - 47,132,739 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	47,874,247 - 47,888,996 (-)	NCBI		UU_Cfam_GSD_1.0

Chrna4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	195,227,250 - 195,242,216 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936514	10,680,859 - 10,695,865 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936514	10,680,893 - 10,695,859 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CHRNA4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	62,423,878 - 62,435,728 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	62,424,672 - 62,436,646 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Chrna4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	29,026,908 - 29,044,464 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	29,024,668 - 29,039,684 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008011080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008011090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008011096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008011104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037983014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_008011090 ⟹ XP_008009281

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	2	851,836 - 862,685 (+)	NCBI
Vero_WHO_p1.0	NW_023666050	48,469,579 - 48,480,754 (+)	NCBI

Sequence:

show sequence

CTGGGACCCAGCTGACTATGAGAACGTCACCTCCATCCGCATCCCCTCCGAGCTCATCTGGCGG
CCGGACATCGTCCTCTACAACAAAACTGCACCATGAAATTCGGCTCCTGGACCTACGACAAGGC
CAAGATCGACCTGGTGAATATGCACAGCCGCGTGGACCAGCTGGACTTCTGGGAGAGCGGCGAG
TGGGTCATCGTGGACGCCGTGGGCACCTACAACACCAGGAAGTACGAGTGCTGTGCTGAGATCT
ACCCAGACATCACCTACGCCTTCGTCATCCGGCGGCTGCCGCTCTTCTACACCATCAACCTCAT
CATTCCCTGCCTGCTCATCTCCTGCCTCACTGTGCTGGTCTTCTACCTGCCCTCCGAGTGCGGC
GAGAAGATCACGCTGTGCATCTCCGTGCTGCTGTCGCTCACCGTCTTCCTGCTGCTCATCACCG
AGATCATCCCGTCCACCTCGCTGGTCATCCCGCTCATCGGCGAGTACCTGCTGTTCACCATGAT
CTTCGTCACCCTGTCCATCGTCATCACGGTCTTCGTGCTCAACGTGCACCACCGCTCGCCGCGC
ACGCACACCATGCCCGCCTGGGTACGCAGAGTCTTCCTGGACATCGTGCCGCGCCTGCTCCTCA
TGAAGCGGCCGTCCGTGGTCAAGGACAATTGCCGGCGACTCATTGAGTCCATGCACAAGATGGC
CAGTGCCCCGCGCTTCTGGCCCGAGCCGGAGGGGGAGCCTGCTGCCACAAGCGGCACCCAGAGC
CGGCACCCGCCCTCGCCGTCCTTCTGTGTCCCCCTGGATGTGCCGGCTGAGTCTGGGCCTGCCT
GCAAGTCGCCCTCCGACCAGCTCCCCGCTCTGCAGCCCCCGGAAGCTGAGAAAGCCAGTCCCCA
CCCCTCGCCTGGACCCTACCGCCCACCCCACAGCACCCAGGCACCAGGGCTGGCCAAAGCCAGG
TCCCTCAGCGTCCAGCACATGTCCAGCCCTGGAGAAGCGGTGGAAGGTGGTGTCCGGTGCCGGT
CTCGGAGCATCCAGTACTGCGTTCCCCGAGACAATGCCGCCCCCGAGGCGGACGGCCAGGCTGC
CGGCGCCCTGGCCTCTCGCAAGACCCACTCGGCTGAGCTCCCGCCCCCAGACCAGCCCTCTCCG
CACAAATGCACCTGCGGGAAGGAGCCCCCTTCCGTGTCCCCGAGCGCCACGCTCAAGGCCCGCG
GCACCAAAGCACCGCCCCGGCACCTGCCCCTGTCGCCGGCCCTGACCCGGGCGGTGGAGGGTGT
CCAGTACATCGCGGACCACCTGAAGGCCGAAGACGCAGACTTCTCGGTGAAGGAGGACTGGAAG
TACGTGGCCATGGTCATCGACCGCATCTTCCTCTGGATGTTCATCATCGTTTGCCTGCTGGGGA
CCGTGGGCCTCTTCCTGCCGCCCTGGCTGGCTGGCATGATCTAGGAAGGGACCAGGAGCCTGCG
TGGCCTGCGGCTGCAGCACATGGGGTCAGCGTCCATGCGGCCGGCCTGGGGCCGGGCTGGCTCC
TCCCTGGACTCTGCAGGGCCACACGTTTGCCACATTATCCTTCCTGTTCTGTGTCTGCTGTAAG
ACGGCCTTGGACAGGGACACAGCCTCTGGGGAGACTGAGTGCGGAGCTGCTTCCAGCTGGGCTG
AGGCCCCAGGAGGCAGCGGCTTGGAGCAGCGGCTTCTACCTGCAGGACTCGGGTTAGGTCCAGT
GCAAGAGTCTCCTGAGCTTCCCTGCAGGTGGGACTCCCTCCTCCCGGTCTCTCAGCAGACCCGG
TGATGGTCCCGACCGCCCCAAGGGGCCCTTGAAGGGACTTCATGCTCCTTCTGCCCCAAGTGTC
CCGTCTTCTGGAGGCCTGACCACCTCTCCCACCCACCGCATCCTGCACCTGTGTGGGCCTCAGT
TTCTCCCCGACGGTCCTCGGGCCTCGCTGGCCCCATAAGCGTGAGCCAGCGGCGCTCCAATCTC
CTTCACTAGGAGTGGGTCCAGGCAGGGATTGTGTTCGGCTGTGTTTTGGGTAAGTTAGAACTCA
AGTCTTGTGCCTGAGGACCCTTGGAGAACAGAGCTTTGTGGAGCTGGTCCCGCGTGGGGAGAAT
CGGGTGGCAGGCCCTCCACGGGGGACAGGAGCACCCAGCCCCAGAGAGTCCCGAGACCAGGGCT
CTGCCTTCCCAGTGTGGGGCCAGGGCTCTGTGGCAGGTGGCCAGGGCTCCACGGGGGCCTAGTG
GCTCTGGCCCCGGGATTACTTCTGTGTTGTGATTTCCCAGGGCTGGGAGGGTCCCGAATGGAGC
CCAGACCCGGGCCCTGGTTCCCCCAGGACCCTGAGGGTTTCTACCTTGGTGCACAGCCCGGGAG
ATCCGCCCAGGGCTCTGGGTTTGGGAAGAAGGATTTCCCGTCACAGTAGCCTTGGGGAGTTGGT
GGGGGCATCCCTGAGAACCTCCACCCGGGAGATGCTGGGACCCTCGGGGCAGGAAGCTCCCGAG
AAACCTCATGGGGGTCAAGGAGCCCTGGGGTTTCCACACAGGCCTGTGCCCTCCATCCTGGCAG
GGCAAGCAGAGCTAAGCAGGGCCTCACCCCTGCAGGCGGTACCCAGAGGTGGGGGAGGCCTGAA
GTGTCTCCAGGCATGACCCTGGAGCCTGGCAGTGCACCTCCTGAAGACGGCGCACCTGGCAGGC
CCCCAGGGTCCCCAGGGGCACACTTCCCCCGGGGGGTGGGCACAGGCTGCCCCACCCCTCCATG
ATTCTAAGGGCTCAGAGGGGCGGGGCCAGGACGGCGTGTCCCTTGCCTGCGAGTGACGTTGGTT
CAGGAAGGCAGTCAGGAAACCTCCCACTGAGTGGTCCACATTCTGCCACCCCCAGACCCCATCC
AGCCTGGGGCGGGGCTGGGGTCGGGCCCTGTGTCCCACTGTGTCTCATCCGTCTGTCCCTGAGC
CAAGCTCTCCTGGGCCAGGGTCTCCTCAGAAGGTGTCTGAGAGCAGAATGAATAATTGAAGTTT
GGAACGCAGCACGCTGAGTGCCCAGGAAATGCCACTGTGTCCCCGCGGGCAGTGACATGAGTGG
GGAGGAGACTCAGGCTCACATTGCCCACACCTGCCTCTGAACTGCTGCTGGTCATCCCCACCCC
CGGGTGCCTGTGACTGGGGTCCTGAGGCTGGGGCTCTTGTGCCAGGAGTGAGTGGGACGCAGAG
ACCCTCGTGCCAAATCCTGGGCATCCCCAGCCCCCCGGCCCCTCCACATCCCCTGTGTATTCAG
GACTCCATCTGCTGAACTCTGACCTGTCCCCACTCCGCCATCAGCCCCTGCTGCCCCTCGGCCA
GAGAACCCAGGATCCAGGGAGACCCTGGGCGAGTGAGGTCATCCTGGGGCCATGGAAGCTGGCA
GGAGACACTGGTCTCAGAGGAGGGAGAGAGACGCAGATTTCAGATATAAGAAGCTGGATCCACA
TTGCATAAGCAGATCCAGCTGCCAGATGTGTGGGCAGCTGCAGGGAGCGGCCCGGGGTGCTGGG
CCCAGCTGTGGTTGTTCTTTCCTGGGTCGGGAGCGACTGCGGAGTGGCTGGGACGCTCCTGCTG
GGAGACCCTCCTGCTGGGGGTGACTGCTTGCCTGGGGGAAGACCCCTTTCCCTTTCTTCTTCTT
CTTTATATATATTTTTTTGAGGCTCAAAAAAAAAAATCCAAATAAAGCACCATATTCCCACCAC
GCCAAATTAACCTGGACAACAATGTTGGCGTA

hide sequence

RefSeq Acc Id:

XM_008011104 ⟹ XP_008009295

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	2	851,790 - 862,685 (+)	NCBI
Vero_WHO_p1.0	NW_023666050	48,470,082 - 48,480,754 (+)	NCBI

Sequence:

show sequence

TCCCCCCACCCCACCCCGTCCAGGAGTGGCATGACTACAAGCTGCGCTGGGACCCAGCTGACTA
TGAGAACGTCACCTCCATCCGCATCCCCTCCGAGCTCATCTGGCGGCCGGACATCGTCCTCTAC
AACAACTGCAGGAGAGCCCTTTTGGGCTGGAGTGCTTTTCACGATCAGACCCCATCCTGGGATT
TCTGGAAGAATAGTGTGGACCGCAGGGTGCCGTGGAGAAGGTGCTGATGGGGACTTCGCAGTCA
CCCACCTGACCAAGGCCCACCTGTTCCATGACGGGCGGGTGCAGTGGACGCCCCCGGCCATCTA
CAAGAGCTCCTGCAGCATCGATGTCACCTTCTTCCCCTTCGACCAGCAGAACTGCACCATGAAA
TTCGGCTCCTGGACCTACGACAAGGCCAAGATCGACCTGGTGAATATGCACAGCCGCGTGGACC
AGCTGGACTTCTGGGAGAGCGGCGAGTGGGTCATCGTGGACGCCGTGGGCACCTACAACACCAG
GAAGTACGAGTGCTGTGCTGAGATCTACCCAGACATCACCTACGCCTTCGTCATCCGGCGGCTG
CCGCTCTTCTACACCATCAACCTCATCATTCCCTGCCTGCTCATCTCCTGCCTCACTGTGCTGG
TCTTCTACCTGCCCTCCGAGTGCGGCGAGAAGATCACGCTGTGCATCTCCGTGCTGCTGTCGCT
CACCGTCTTCCTGCTGCTCATCACCGAGATCATCCCGTCCACCTCGCTGGTCATCCCGCTCATC
GGCGAGTACCTGCTGTTCACCATGATCTTCGTCACCCTGTCCATCGTCATCACGGTCTTCGTGC
TCAACGTGCACCACCGCTCGCCGCGCACGCACACCATGCCCGCCTGGGTACGCAGAGTCTTCCT
GGACATCGTGCCGCGCCTGCTCCTCATGAAGCGGCCGTCCGTGGTCAAGGACAATTGCCGGCGA
CTCATTGAGTCCATGCACAAGATGGCCAGTGCCCCGCGCTTCTGGCCCGAGCCGGAGGGGGAGC
CTGCTGCCACAAGCGGCACCCAGAGCCGGCACCCGCCCTCGCCGTCCTTCTGTGTCCCCCTGGA
TGTGCCGGCTGAGTCTGGGCCTGCCTGCAAGTCGCCCTCCGACCAGCTCCCCGCTCTGCAGCCC
CCGGAAGCTGAGAAAGCCAGTCCCCACCCCTCGCCTGGACCCTACCGCCCACCCCACAGCACCC
AGGCACCAGGGCTGGCCAAAGCCAGGTCCCTCAGCGTCCAGCACATGTCCAGCCCTGGAGAAGC
GGTGGAAGGTGGTGTCCGGTGCCGGTCTCGGAGCATCCAGTACTGCGTTCCCCGAGACAATGCC
GCCCCCGAGGCGGACGGCCAGGCTGCCGGCGCCCTGGCCTCTCGCAAGACCCACTCGGCTGAGC
TCCCGCCCCCAGACCAGCCCTCTCCGCACAAATGCACCTGCGGGAAGGAGCCCCCTTCCGTGTC
CCCGAGCGCCACGCTCAAGGCCCGCGGCACCAAAGCACCGCCCCGGCACCTGCCCCTGTCGCCG
GCCCTGACCCGGGCGGTGGAGGGTGTCCAGTACATCGCGGACCACCTGAAGGCCGAAGACGCAG
ACTTCTCGGTGAAGGAGGACTGGAAGTACGTGGCCATGGTCATCGACCGCATCTTCCTCTGGAT
GTTCATCATCGTTTGCCTGCTGGGGACCGTGGGCCTCTTCCTGCCGCCCTGGCTGGCTGGCATG
ATCTAGGAAGGGACCAGGAGCCTGCGTGGCCTGCGGCTGCAGCACATGGGGTCAGCGTCCATGC
GGCCGGCCTGGGGCCGGGCTGGCTCCTCCCTGGACTCTGCAGGGCCACACGTTTGCCACATTAT
CCTTCCTGTTCTGTGTCTGCTGTAAGACGGCCTTGGACAGGGACACAGCCTCTGGGGAGACTGA
GTGCGGAGCTGCTTCCAGCTGGGCTGAGGCCCCAGGAGGCAGCGGCTTGGAGCAGCGGCTTCTA
CCTGCAGGACTCGGGTTAGGTCCAGTGCAAGAGTCTCCTGAGCTTCCCTGCAGGTGGGACTCCC
TCCTCCCGGTCTCTCAGCAGACCCGGTGATGGTCCCGACCGCCCCAAGGGGCCCTTGAAGGGAC
TTCATGCTCCTTCTGCCCCAAGTGTCCCGTCTTCTGGAGGCCTGACCACCTCTCCCACCCACCG
CATCCTGCACCTGTGTGGGCCTCAGTTTCTCCCCGACGGTCCTCGGGCCTCGCTGGCCCCATAA
GCGTGAGCCAGCGGCGCTCCAATCTCCTTCACTAGGAGTGGGTCCAGGCAGGGATTGTGTTCGG
CTGTGTTTTGGGTAAGTTAGAACTCAAGTCTTGTGCCTGAGGACCCTTGGAGAACAGAGCTTTG
TGGAGCTGGTCCCGCGTGGGGAGAATCGGGTGGCAGGCCCTCCACGGGGGACAGGAGCACCCAG
CCCCAGAGAGTCCCGAGACCAGGGCTCTGCCTTCCCAGTGTGGGGCCAGGGCTCTGTGGCAGGT
GGCCAGGGCTCCACGGGGGCCTAGTGGCTCTGGCCCCGGGATTACTTCTGTGTTGTGATTTCCC
AGGGCTGGGAGGGTCCCGAATGGAGCCCAGACCCGGGCCCTGGTTCCCCCAGGACCCTGAGGGT
TTCTACCTTGGTGCACAGCCCGGGAGATCCGCCCAGGGCTCTGGGTTTGGGAAGAAGGATTTCC
CGTCACAGTAGCCTTGGGGAGTTGGTGGGGGCATCCCTGAGAACCTCCACCCGGGAGATGCTGG
GACCCTCGGGGCAGGAAGCTCCCGAGAAACCTCATGGGGGTCAAGGAGCCCTGGGGTTTCCACA
CAGGCCTGTGCCCTCCATCCTGGCAGGGCAAGCAGAGCTAAGCAGGGCCTCACCCCTGCAGGCG
GTACCCAGAGGTGGGGGAGGCCTGAAGTGTCTCCAGGCATGACCCTGGAGCCTGGCAGTGCACC
TCCTGAAGACGGCGCACCTGGCAGGCCCCCAGGGTCCCCAGGGGCACACTTCCCCCGGGGGGTG
GGCACAGGCTGCCCCACCCCTCCATGATTCTAAGGGCTCAGAGGGGCGGGGCCAGGACGGCGTG
TCCCTTGCCTGCGAGTGACGTTGGTTCAGGAAGGCAGTCAGGAAACCTCCCACTGAGTGGTCCA
CATTCTGCCACCCCCAGACCCCATCCAGCCTGGGGCGGGGCTGGGGTCGGGCCCTGTGTCCCAC
TGTGTCTCATCCGTCTGTCCCTGAGCCAAGCTCTCCTGGGCCAGGGTCTCCTCAGAAGGTGTCT
GAGAGCAGAATGAATAATTGAAGTTTGGAACGCAGCACGCTGAGTGCCCAGGAAATGCCACTGT
GTCCCCGCGGGCAGTGACATGAGTGGGGAGGAGACTCAGGCTCACATTGCCCACACCTGCCTCT
GAACTGCTGCTGGTCATCCCCACCCCCGGGTGCCTGTGACTGGGGTCCTGAGGCTGGGGCTCTT
GTGCCAGGAGTGAGTGGGACGCAGAGACCCTCGTGCCAAATCCTGGGCATCCCCAGCCCCCCGG
CCCCTCCACATCCCCTGTGTATTCAGGACTCCATCTGCTGAACTCTGACCTGTCCCCACTCCGC
CATCAGCCCCTGCTGCCCCTCGGCCAGAGAACCCAGGATCCAGGGAGACCCTGGGCGAGTGAGG
TCATCCTGGGGCCATGGAAGCTGGCAGGAGACACTGGTCTCAGAGGAGGGAGAGAGACGCAGAT
TTCAGATATAAGAAGCTGGATCCACATTGCATAAGCAGATCCAGCTGCCAGATGTGTGGGCAGC
TGCAGGGAGCGGCCCGGGGTGCTGGGCCCAGCTGTGGTTGTTCTTTCCTGGGTCGGGAGCGACT
GCGGAGTGGCTGGGACGCTCCTGCTGGGAGACCCTCCTGCTGGGGGTGACTGCTTGCCTGGGGG
AAGACCCCTTTCCCTTTCTTCTTCTTCTTTATATATATTTTTTTGAGGCTCAAAAAAAAAAATC
CAAATAAAGCACCATATTCCCACCACGCCAAATTAACCTGGACAACAATGTTGGCGTA

hide sequence

RefSeq Acc Id:

XM_037983014 ⟹ XP_037838942

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666050	48,462,591 - 48,480,754 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_008009281	(Get FASTA)	NCBI Sequence Viewer
	XP_008009295	(Get FASTA)	NCBI Sequence Viewer
	XP_037838942	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_008009295 ⟸ XM_008011104
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_008009281 ⟸ XM_008011090
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_037838942 ⟸ XM_037983014
- Peptide Label:	isoform X1

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	LOC103242748	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-12-08	CHRNA4	cholinergic receptor nicotinic alpha 4 subunit	LOC103242748	neuronal acetylcholine receptor subunit alpha-4	Symbol and/or name change	5135510	APPROVED
2020-12-03	LOC103242748	neuronal acetylcholine receptor subunit alpha-4	LOC103242768	neuronal acetylcholine receptor subunit alpha-4-like	Data merged from RGD:18576687	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB