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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:vasopressin signaling pathway via receptor type 2
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Accession:PW:0000713 term browser browse the term
Definition:Vasopressin signaling via receptor type 2 plays a central role in water homeostasis by regulating the translocation of Aqp2 channel. The receptor couples to Gs alpha subunit leading to activation of adenylyl cyclase, production of cyclic AMP and triggering of protein kinase A (PKA) signaling pathway. PKA regulates both the translocation and the expression of the channel.
Synonyms:related_synonym: KEGG:04962;   SMP:00322
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vasopressin signaling pathway via receptor type 2 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY2 adenylate cyclase 2 ISO SMPDB SMP:00322 NCBI chr34:6,139,931...6,527,677
Ensembl chr34:6,140,276...6,527,677 		JBrowse link
G ADCY6 adenylate cyclase 6 ISO RGD PMID:15579502 PMID:18431594 PMID:18971210 RGD:2312654 RGD:2312656 RGD:2313211 NCBI chr27:5,739,514...5,752,888
Ensembl chr27:5,733,586...5,752,888 		JBrowse link
G AKAP7 A-kinase anchoring protein 7 ISO RGD PMID:15037626 PMID:18431594 RGD:1303982 RGD:2312656 NCBI chr 1:69,360,664...69,483,102
Ensembl chr 1:69,360,781...69,483,113 		JBrowse link
G AQP2 aquaporin 2 ISO RGD PMID:15037626 PMID:15579502 PMID:18431594 PMID:18971210 RGD:1303982 RGD:2312654 RGD:2312656 RGD:2313211 NCBI chr27:4,743,127...4,750,907
Ensembl chr27:4,743,127...4,750,907 		JBrowse link
G AVP arginine vasopressin ISO RGD PMID:14624682 PMID:18431594 RGD:1579891 RGD:2312656 NCBI chr24:18,183,057...18,184,827
Ensembl chr24:18,183,057...18,184,883 		JBrowse link
G AVPR2 arginine vasopressin receptor 2 ISO SMPDB
RGD		 PMID:14624682 PMID:18431594 PMID:18971210 RGD:1579891 RGD:2312654 RGD:2312656 SMP:00322 NCBI chr  X:121,751,606...121,754,771
Ensembl chr  X:121,752,027...121,754,771 		JBrowse link
G FSHR follicle stimulating hormone receptor ISO SMPDB SMP:00322 NCBI chr10:50,765,591...50,938,643
Ensembl chr10:50,770,995...50,938,474 		JBrowse link
G GNAS GNAS complex locus ISO SMPDB
RGD		 PMID:14624682 PMID:15579502 PMID:18431594 PMID:18971210 RGD:1579891 RGD:2312654 RGD:2312656 RGD:2313211 SMP:00322 NCBI chr24:43,643,409...43,658,641
Ensembl chr24:43,643,405...43,658,657 		JBrowse link
G GNB1 G protein subunit beta 1 ISO SMPDB SMP:00322 NCBI chr 5:56,777,854...56,879,619
Ensembl chr 5:56,779,354...56,817,295 		JBrowse link
G GNG12 G protein subunit gamma 12 ISO SMPDB SMP:00322 NCBI chr 6:77,316,649...77,378,356
Ensembl chr 6:77,338,685...77,374,937 		JBrowse link
G MYO5B myosin VB ISO RGD PMID:18431594 RGD:2312656 NCBI chr 7:78,671,636...79,006,010
Ensembl chr 7:78,671,616...79,006,006 		JBrowse link
G PDE4D phosphodiesterase 4D ISO RGD PMID:18431594 RGD:2312656 NCBI chr 2:45,843,767...47,245,263
Ensembl chr 2:45,846,294...46,949,912 		JBrowse link
G PRKACB protein kinase cAMP-activated catalytic subunit beta ISO SMPDB SMP:00322 NCBI chr 6:63,615,445...63,729,386
Ensembl chr 6:63,618,323...63,730,146 		JBrowse link
G RAB11A RAB11A, member RAS oncogene family ISO RGD PMID:18431594 RGD:2312656 NCBI chr30:30,200,831...30,218,412
Ensembl chr30:30,200,831...30,218,411 		JBrowse link
G RAB11FIP2 RAB11 family interacting protein 2 ISO RGD PMID:18431594 RGD:2312656 NCBI chr28:28,415,139...28,457,215
Ensembl chr28:28,415,639...28,457,286 		JBrowse link
G SIPA1 signal-induced proliferation-associated 1 ISO RGD PMID:18431594 RGD:2312656 NCBI chr18:51,560,551...51,571,291
Ensembl chr18:51,560,551...51,568,885 		JBrowse link
G SNAP23 synaptosome associated protein 23 ISO RGD PMID:18431594 RGD:2312656 NCBI chr30:9,453,931...9,493,506
Ensembl chr30:9,456,084...9,492,329 		JBrowse link
G VAMP2 vesicle associated membrane protein 2 ISO RGD PMID:18431594 RGD:2312656 NCBI chr 5:32,975,372...32,977,967 JBrowse link
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  pathway 4045
    regulatory pathway 2499
      homeostasis pathway 1305
        cardiovascular system homeostasis pathway 264
          vasopressin signaling pathway 22
            vasopressin signaling pathway via receptor type 2 18
              altered vasopressin signaling pathway via receptor type 2 0
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