ADCY2 (adenylate cyclase 2) - Rat Genome Database

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Gene: ADCY2 (adenylate cyclase 2) Canis lupus familiaris
Analyze
Symbol: ADCY2
Name: adenylate cyclase 2
RGD ID: 12171801
Description: ENCODES a protein that exhibits adenylate cyclase activity (ortholog); adenylate cyclase binding (ortholog); G-protein beta/gamma-subunit complex binding (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cAMP biosynthetic process (ortholog); cAMP-mediated signaling (ortholog); PARTICIPATES IN adenosine signaling pathway; dopamine signaling pathway via D1 family of receptors; endothelin signaling pathway; ASSOCIATED WITH asthma (ortholog); bipolar disorder (ortholog); genetic disease (ortholog); FOUND IN dendrite (ortholog); membrane raft (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adenylate cyclase type 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1346,139,931 - 6,527,677 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl346,140,276 - 6,527,677 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3410,648,056 - 11,035,866 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0346,045,474 - 6,434,089 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl346,045,476 - 6,434,095 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1346,095,233 - 6,483,250 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0346,075,965 - 6,464,063 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0346,288,901 - 6,677,489 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADCY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1346,139,931 - 6,527,677 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl346,140,276 - 6,527,677 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3410,648,056 - 11,035,866 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0346,045,474 - 6,434,089 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl346,045,476 - 6,434,095 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1346,095,233 - 6,483,250 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0346,075,965 - 6,464,063 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0346,288,901 - 6,677,489 (-)NCBIUU_Cfam_GSD_1.0
ADCY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3857,396,138 - 7,830,081 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl57,396,138 - 7,830,081 (+)EnsemblGRCh38hg38GRCh38
GRCh3757,396,251 - 7,830,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3657,449,343 - 7,883,194 (+)NCBINCBI36Build 36hg18NCBI36
Build 3457,449,344 - 7,883,194NCBI
Celera57,439,102 - 7,871,262 (+)NCBICelera
Cytogenetic Map5p15.31NCBI
HuRef57,725,521 - 7,811,956 (+)NCBIHuRef
HuRef57,378,757 - 7,709,814 (+)NCBIHuRef
CHM1_157,396,258 - 7,830,278 (+)NCBICHM1_1
T2T-CHM13v2.057,334,987 - 7,769,222 (+)NCBIT2T-CHM13v2.0
Adcy2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391368,768,162 - 69,147,719 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1368,768,162 - 69,147,660 (-)EnsemblGRCm39 Ensembl
GRCm381368,620,043 - 68,999,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1368,620,043 - 68,999,541 (-)EnsemblGRCm38mm10GRCm38
MGSCv371368,758,920 - 69,138,419 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361369,087,431 - 69,466,658 (-)NCBIMGSCv36mm8
Celera1370,976,336 - 71,362,097 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1335.55NCBI
Adcy2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8136,204,054 - 36,650,645 (+)NCBIGRCr8
mRatBN7.2134,375,639 - 34,822,252 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl134,375,895 - 34,822,236 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx134,237,007 - 34,683,571 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0140,227,844 - 40,674,423 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0134,402,593 - 34,849,151 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0137,043,071 - 37,698,390 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl137,507,276 - 37,698,390 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0139,075,253 - 39,080,014 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0138,434,800 - 39,001,909 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4174,543,466 - 5,040,433 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera132,960,049 - 33,391,637 (+)NCBICelera
Cytogenetic Map1p11NCBI
Adcy2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555045,004,903 - 5,376,328 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555044,990,634 - 5,376,990 (+)NCBIChiLan1.0ChiLan1.0
ADCY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v247,647,272 - 8,082,790 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan155,800,880 - 6,236,399 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v057,718,581 - 8,154,006 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.157,540,762 - 7,975,853 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl57,540,790 - 7,975,853 (+)Ensemblpanpan1.1panPan2
Adcy2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213239,063,958 - 239,560,683 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493664347,837 - 339,007 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493664347,830 - 338,891 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1674,305,736 - 74,524,295 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11674,305,729 - 74,729,999 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21680,359,861 - 80,498,999 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.146,989,077 - 7,415,282 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl46,989,169 - 7,414,617 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606421,200,037 - 21,628,571 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adcy2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247515,004,263 - 5,413,994 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247515,004,186 - 5,409,891 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADCY2
4715 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 12
Low 3 4 6 5 8 5 6
Below cutoff 2 5 12 6 6 1 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000016298   ⟹   ENSCAFP00000015076
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl346,140,276 - 6,527,677 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000067201   ⟹   ENSCAFP00000054522
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl346,140,276 - 6,527,677 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000075401   ⟹   ENSCAFP00000062936
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl346,140,276 - 6,527,677 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000075659   ⟹   ENSCAFP00000043444
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl346,140,276 - 6,527,677 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000078173   ⟹   ENSCAFP00000057049
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl346,140,276 - 6,527,677 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000086585   ⟹   ENSCAFP00000049019
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl346,140,276 - 6,527,677 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000089958   ⟹   ENSCAFP00000048744
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl346,140,276 - 6,527,495 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845040868   ⟹   ENSCAFP00845032001
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl346,045,476 - 6,434,095 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845041061   ⟹   ENSCAFP00845032176
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl346,045,476 - 6,434,095 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845041269   ⟹   ENSCAFP00845032352
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl346,045,476 - 6,434,095 (-)Ensembl
RefSeq Acc Id: XM_038445519   ⟹   XP_038301447
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0346,045,474 - 6,434,051 (-)NCBI
RefSeq Acc Id: XM_038519698   ⟹   XP_038375626
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1346,095,233 - 6,483,212 (-)NCBI
RefSeq Acc Id: XM_038583952   ⟹   XP_038439880
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0346,288,901 - 6,677,489 (-)NCBI
RefSeq Acc Id: XM_038647755   ⟹   XP_038503683
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0346,075,965 - 6,464,025 (-)NCBI
RefSeq Acc Id: XM_535798   ⟹   XP_535798
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1346,139,931 - 6,527,677 (-)NCBI
Dog10K_Boxer_Tasha3410,648,056 - 11,035,828 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005306710
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0346,066,305 - 6,434,089 (-)NCBI
RefSeq Acc Id: XR_005317544
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha3410,668,878 - 11,035,866 (-)NCBI
RefSeq Acc Id: XR_005349696
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1346,116,064 - 6,483,250 (-)NCBI
RefSeq Acc Id: XR_005417333
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0346,096,776 - 6,464,063 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_535798   ⟸   XM_535798
- Peptide Label: isoform X1
- UniProtKB: A0A8P0NCA2 (UniProtKB/TrEMBL),   A0A8C0RHT0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000057049   ⟸   ENSCAFT00000078173
RefSeq Acc Id: ENSCAFP00000049019   ⟸   ENSCAFT00000086585
RefSeq Acc Id: ENSCAFP00000054522   ⟸   ENSCAFT00000067201
RefSeq Acc Id: ENSCAFP00000015076   ⟸   ENSCAFT00000016298
RefSeq Acc Id: ENSCAFP00000062936   ⟸   ENSCAFT00000075401
RefSeq Acc Id: ENSCAFP00000048744   ⟸   ENSCAFT00000089958
RefSeq Acc Id: ENSCAFP00000043444   ⟸   ENSCAFT00000075659
RefSeq Acc Id: XP_038375626   ⟸   XM_038519698
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038503683   ⟸   XM_038647755
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038301447   ⟸   XM_038445519
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PRI5 (UniProtKB/TrEMBL),   A0A8C0RHT0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038439880   ⟸   XM_038583952
- Peptide Label: isoform X2
- UniProtKB: A0A8C0RHT0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845032352   ⟸   ENSCAFT00845041269
RefSeq Acc Id: ENSCAFP00845032001   ⟸   ENSCAFT00845040868
RefSeq Acc Id: ENSCAFP00845032176   ⟸   ENSCAFT00845041061
Protein Domains
Guanylate cyclase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010238 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011231 UniProtKB/TrEMBL
  ENSCAFG00040023765 UniProtKB/TrEMBL
  ENSCAFG00845023075 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000016298.5 UniProtKB/TrEMBL
  ENSCAFT00000067201.2 UniProtKB/TrEMBL
  ENSCAFT00000075401.2 UniProtKB/TrEMBL
  ENSCAFT00000078173.2 UniProtKB/TrEMBL
  ENSCAFT00030021050.1 UniProtKB/TrEMBL
  ENSCAFT00030021199.1 UniProtKB/TrEMBL
  ENSCAFT00040044362.1 UniProtKB/TrEMBL
  ENSCAFT00040044447.1 UniProtKB/TrEMBL
  ENSCAFT00845040868 ENTREZGENE
  ENSCAFT00845040868.1 UniProtKB/TrEMBL
  ENSCAFT00845041061.1 UniProtKB/TrEMBL
  ENSCAFT00845041269.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/TrEMBL
  AC_N UniProtKB/TrEMBL
  Adcy UniProtKB/TrEMBL
  Adcy_conserved_dom UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/TrEMBL
NCBI Gene ADCY2 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 1 UniProtKB/TrEMBL
  ADENYLATE CYCLASE TYPE 2 UniProtKB/TrEMBL
Pfam AC_N UniProtKB/TrEMBL
  DUF1053 UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/TrEMBL
PIRSF Ade_cyc UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/TrEMBL
SMART CYCc UniProtKB/TrEMBL
Superfamily-SCOP SSF55073 UniProtKB/TrEMBL
UniProt A0A8C0NBG4_CANLF UniProtKB/TrEMBL
  A0A8C0RHT0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TQ58_CANLF UniProtKB/TrEMBL
  A0A8I3PES3_CANLF UniProtKB/TrEMBL
  A0A8I3PLK8_CANLF UniProtKB/TrEMBL
  A0A8I3PRI5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NCA2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0P6B7_CANLF UniProtKB/TrEMBL
  A0A8P0PBM8_CANLF UniProtKB/TrEMBL
  A0A8P0T6U1_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:37619 ENTREZGENE