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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:insulin signaling pathway
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Accession:PW:0000143 term browser browse the term
Definition:Insulin, the peptide hormone secreted by pancreatic beta cells, plays essential roles in glucose and energy homeostasis. Insulin signaling activates two main intracellular pathways to regulate carbohydrate and fat metabolism and to prompt glucose absorption in insulin sensitive tissues such as skeletal muscle and adipocytes. Deregulation of the pathway has been associated with a number of conditions, primarily diabetes.
Synonyms:related_synonym: Signaling by Insulin receptor;   insulin receptor signaling pathway
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insulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 ISO PID
SMPDB		 PID:200014 SMP:00391 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756 		JBrowse link
G AKT2 AKT serine/threonine kinase 2 ISO PID PID:200014 NCBI chr19:37,275,799...37,331,971
Ensembl chr19:45,791,800...45,840,271 		JBrowse link
G CAV1 caveolin 1 ISO PID PID:200014 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655 		JBrowse link
G CBL Cbl proto-oncogene ISO PID PID:200014 NCBI chr11:114,044,996...114,149,204
Ensembl chr11:117,973,187...118,074,671 		JBrowse link
G DOK1 docking protein 1 ISO PID PID:200014 NCBI chr2A:74,615,542...74,624,183
Ensembl chr2A:76,126,749...76,130,162 		JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 ISO PID PID:200014 NCBI chr 8:37,336,698...37,362,768
Ensembl chr 8:34,513,359...34,538,936 		JBrowse link
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ISO RGD PMID:17347799 RGD:1625124 NCBI chr 6:129,591,858...129,673,000
Ensembl chr 6:133,698,640...133,783,644 		JBrowse link
G EXOC1 exocyst complex component 1 ISO PID PID:200014 NCBI chr 4:68,024,177...68,075,565
Ensembl chr 4:74,591,574...74,642,955 		JBrowse link
G EXOC2 exocyst complex component 2 ISO PID PID:200014 NCBI chr 6:299,500...504,029
Ensembl chr 6:435,538...583,027 		JBrowse link
G EXOC3 exocyst complex component 3 ISO PID PID:200014 Ensembl chr 5:568,471...596,723 JBrowse link
G EXOC4 exocyst complex component 4 ISO PID PID:200014 NCBI chr 7:125,226,107...126,030,486
Ensembl chr 7:137,734,400...138,536,214 		JBrowse link
G EXOC5 exocyst complex component 5 ISO PID PID:200014 NCBI chr14:37,775,555...37,839,751
Ensembl chr14:56,050,175...56,089,615 		JBrowse link
G EXOC6 exocyst complex component 6 ISO PID PID:200014 NCBI chr10:89,569,961...89,803,658
Ensembl chr10:93,088,914...93,316,030 		JBrowse link
G EXOC7 exocyst complex component 7 ISO PID PID:200014 NCBI chr17:70,031,236...70,053,987
Ensembl chr17:75,584,270...75,606,461 		JBrowse link
G F2RL2 coagulation factor II thrombin receptor like 2 ISO PID PID:200014 NCBI chr 5:38,680,372...38,688,509
Ensembl chr 5:39,297,424...39,305,370 		JBrowse link
G FOXO3 forkhead box O3 ISO PID PID:200014 NCBI chr 6:106,360,519...106,485,676
Ensembl chr 6:110,406,266...110,516,272 		JBrowse link
G GRB10 growth factor receptor bound protein 10 ISO PID
RGD		 PMID:17347799 PID:200014 RGD:1625124 NCBI chr 7:51,230,945...51,434,560
Ensembl chr 7:51,474,166...51,666,638 		JBrowse link
G GRB14 growth factor receptor bound protein 14 ISO PID
RGD		 PMID:9748281 PMID:17347799 PID:200014 RGD:1625124 RGD:61620 NCBI chr2B:51,773,844...51,902,420
Ensembl chr2B:169,135,231...169,263,874 		JBrowse link
G GRB2 growth factor receptor bound protein 2 ISO SMPDB
PID
RGD		 PMID:12891559 PID:200014 RGD:1299201 SMP:00391 NCBI chr17:69,265,307...69,352,835
Ensembl chr17:74,817,471...74,903,796 		JBrowse link
G HRAS HRas proto-oncogene, GTPase ISO SMPDB
PID		 PID:200014 SMP:00391 NCBI chr11:537,488...540,810
Ensembl chr11:568,305...571,078 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D ISO PID PID:200014 NCBI chr2B:120,287,606...120,436,526
Ensembl chr2B:239,201,762...239,350,190 		JBrowse link
G INS insulin ISO PID
RGD
SMPDB		 PMID:17347799 PID:200014 RGD:1625124 SMP:00391 NCBI chr11:2,200,785...2,202,579
Ensembl chr11:2,218,117...2,231,666 		JBrowse link
G INSR insulin receptor ISO RGD
SMPDB
PID		 PMID:12850498 PMID:12891559 PMID:17347799 PMID:29896241 PID:200014 RGD:1299201 RGD:14700925 RGD:1580595 RGD:1625124 SMP:00391 NCBI chr19:6,393,407...6,578,234
Ensembl chr19:7,260,246...7,414,889 		JBrowse link
G IRS1 insulin receptor substrate 1 ISO PID
RGD
SMPDB		 PMID:12850498 PMID:16445997 PMID:23055040 PID:200014 RGD:1580595 RGD:1581310 RGD:7248547 SMP:00391 NCBI chr2B:113,973,191...114,041,127
Ensembl chr2B:232,849,239...232,852,967 		JBrowse link
G IRS2 insulin receptor substrate 2 ISO SMPDB
RGD		 PMID:12850498 PMID:12891559 PMID:23055040 RGD:1299201 RGD:1580595 RGD:7248547 SMP:00391 NCBI chr13:90,886,095...90,917,724 JBrowse link
G IRS4 insulin receptor substrate 4 ISO RGD PMID:23055040 RGD:7248547 NCBI chr  X:97,818,895...97,835,986
Ensembl chr  X:108,202,208...108,205,821 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 ISO SMPDB SMP:00391 NCBI chr15:45,337,117...45,438,826
Ensembl chr15:63,613,961...63,714,161 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 ISO SMPDB SMP:00391 NCBI chr19:3,114,445...3,148,619
Ensembl chr19:4,064,626...4,097,933 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO SMPDB SMP:00391 NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335 		JBrowse link
G NCK1 NCK adaptor protein 1 ISO PID PID:200014 NCBI chr 3:133,902,463...133,990,414
Ensembl chr 3:141,427,870...141,451,444 		JBrowse link
G NCK2 NCK adaptor protein 2 ISO PID PID:200014 NCBI chr2A:95,939,197...96,089,163
Ensembl chr2A:106,898,547...106,976,363 		JBrowse link
G PARD6A par-6 family cell polarity regulator alpha ISO PID PID:200014 NCBI chr16:48,004,822...48,006,656
Ensembl chr16:67,394,252...67,395,991 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO PID
SMPDB		 PID:200014 SMP:00391 NCBI chr16:1,394,447...1,463,735 JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO PID PID:200014 NCBI chr 3:176,182,765...176,272,024
Ensembl chr 3:184,355,785...184,441,977 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO SMPDB SMP:00391 NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISO RGD
PID		 PMID:12891559 PID:200014 RGD:1299201 NCBI chr 5:45,701,219...45,786,652
Ensembl chr 5:47,267,286...47,350,960 		JBrowse link
G PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 ISO SMPDB SMP:00391 NCBI chr17:42,782,422...42,851,692
Ensembl chr17:47,518,629...47,585,160 		JBrowse link
G PRKCA protein kinase C alpha ISO RGD PMID:17347799 RGD:1625124 NCBI chr17:60,246,485...60,747,158
Ensembl chr17:65,454,907...65,947,903 		JBrowse link
G PRKCB protein kinase C beta ISO RGD PMID:17347799 RGD:1625124 NCBI chr16:13,888,936...14,268,759
Ensembl chr16:24,091,289...24,466,203 		JBrowse link
G PRKCG protein kinase C gamma ISO RGD PMID:17347799 RGD:1625124 NCBI chr19:50,823,372...50,849,003
Ensembl chr19:59,672,097...59,695,977 		JBrowse link
G PRKCI protein kinase C iota ISO PID PID:200014 NCBI chr 3:167,237,093...167,320,522
Ensembl chr 3:175,426,774...175,510,072 		JBrowse link
G PRKCQ protein kinase C theta ISO RGD PMID:17347799 RGD:1625124 NCBI chr10:6,458,138...6,610,781
Ensembl chr10:6,440,316...6,593,900 		JBrowse link
G PRKCZ protein kinase C zeta ISO PID PID:200014 NCBI chr 1:763,942...901,531
Ensembl chr 1:1,920,219...2,045,855 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 ISO RGD
PID		 PMID:7711057 PMID:12850498 PMID:17347799 PID:200014 RGD:1580595 RGD:1625124 RGD:2293185 NCBI chr20:46,854,918...46,929,509
Ensembl chr20:47,983,098...48,057,421 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 ISO PID
RGD		 PMID:7711057 PMID:12891559 PID:200014 RGD:1299201 RGD:2293185 NCBI chr12:110,016,364...110,107,462
Ensembl chr12:113,435,669...113,503,762 		JBrowse link
G PTPRA protein tyrosine phosphatase receptor type A ISO PID PID:200014 NCBI chr20:2,962,701...3,125,282
Ensembl chr20:2,801,905...2,888,195 		JBrowse link
G PTPRF protein tyrosine phosphatase receptor type F ISO RGD PMID:7711057 PMID:17347799 RGD:1625124 RGD:2293185 NCBI chr 1:42,878,344...42,923,539
Ensembl chr 1:44,220,991...44,297,647 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase ISO SMPDB SMP:00391 NCBI chr 3:12,510,084...12,590,598
Ensembl chr 3:12,853,415...12,932,871 		JBrowse link
G RAPGEF1 Rap guanine nucleotide exchange factor 1 ISO PID PID:200014 NCBI chr 9:102,698,970...102,861,482
Ensembl chr 9:131,337,001...131,495,664 		JBrowse link
G RASA1 RAS p21 protein activator 1 ISO PID PID:200014 NCBI chr 5:27,980,907...28,104,368
Ensembl chr 5:28,115,159...28,240,321 		JBrowse link
G RHOQ ras homolog family member Q ISO PID PID:200014 NCBI chr2A:46,657,884...46,698,604 JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 ISO PID PID:200014 NCBI chr17:53,958,807...54,014,752
Ensembl chr17:58,799,069...58,853,653 		JBrowse link
G SGK1 serum/glucocorticoid regulated kinase 1 ISO PID PID:200014 NCBI chr 6:131,936,397...132,082,670
Ensembl chr 6:136,033,851...136,180,121 		JBrowse link
G SH2B2 SH2B adaptor protein 2 ISO PID
RGD		 PMID:17347799 PID:200014 RGD:1625124 NCBI chr 7:94,425,297...94,447,644 JBrowse link
G SHC1 SHC adaptor protein 1 ISO SMPDB
RGD
PID		 PMID:17347799 PID:200014 RGD:1625124 SMP:00391 NCBI chr 1:130,310,778...130,323,001
Ensembl chr 1:133,920,532...133,929,008 		JBrowse link
G SLC2A4 solute carrier family 2 member 4 ISO SMPDB SMP:00391 NCBI chr17:7,312,605...7,319,430
Ensembl chr17:7,299,966...7,306,344 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 ISO RGD PMID:17010638 RGD:1625125 NCBI chr16:10,196,432...10,198,205 JBrowse link
G SOCS3 suppressor of cytokine signaling 3 ISO RGD PMID:17010638 RGD:1625125 NCBI chr17:72,433,206...72,436,500
Ensembl chr17:77,983,389...77,984,066 		JBrowse link
G SOCS6 suppressor of cytokine signaling 6 ISO RGD PMID:17010638 RGD:1625125 NCBI chr18:63,666,761...63,710,085
Ensembl chr18:66,994,489...66,996,096 		JBrowse link
G SOCS7 suppressor of cytokine signaling 7 ISO RGD PMID:17010638 RGD:1625125 NCBI chr17:18,867,241...18,921,792
Ensembl chr17:19,193,860...19,236,427 		JBrowse link
G SORBS1 sorbin and SH3 domain containing 1 ISO PID PID:200014 NCBI chr10:91,922,292...92,172,339
Ensembl chr10:95,432,824...95,559,022 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO SMPDB
PID
RGD		 PMID:12891559 PID:200014 RGD:1299201 SMP:00391 NCBI chr2A:39,019,046...39,162,248
Ensembl chr2A:39,773,760...39,911,961 		JBrowse link
G SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 ISO RGD PMID:12891559 RGD:1299201 NCBI chr14:30,707,477...30,822,029
Ensembl chr14:49,014,782...49,101,764 		JBrowse link
G TRIP10 thyroid hormone receptor interactor 10 ISO PID PID:200014 NCBI chr19:5,772,225...5,784,078
Ensembl chr19:6,693,646...6,705,399 		JBrowse link
altered insulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin ISO RGD PMID:9809695 RGD:2313694 NCBI chr11:2,200,785...2,202,579
Ensembl chr11:2,218,117...2,231,666 		JBrowse link
G INSR insulin receptor ISO RGD PMID:9809695 RGD:2313694 NCBI chr19:6,393,407...6,578,234
Ensembl chr19:7,260,246...7,414,889 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4064
    regulatory pathway 2507
      homeostasis pathway 1306
        energy homeostasis pathway 234
          insulin signaling pathway 64
            altered insulin signaling pathway 2
paths to the root