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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of mRNA splicing, via spliceosome
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Accession:GO:0048025 term browser browse the term
Definition:Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
Synonyms:exact_synonym: down regulation of nuclear mRNA splicing, via spliceosome;   downregulation of nuclear mRNA splicing, via spliceosome;   negative regulation of nuclear mRNA splicing, via spliceosome
 narrow_synonym: down regulation of nuclear mRNA splicing via U2-type spliceosome;   downregulation of nuclear mRNA splicing via U2-type spliceosome;   inhibition of nuclear mRNA splicing via U2-type spliceosome;   inhibition of nuclear mRNA splicing, via spliceosome;   negative regulation of nuclear mRNA splicing via U2-type spliceosome
 broad_synonym: negative regulation of pre-mRNA splicing
 alt_id: GO:0035056

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negative regulation of mRNA splicing, via spliceosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acin1 apoptotic chromatin condensation inducer 1 involved_in ISO (PMID:12665594) UniProt PMID:12665594 NCBI chrNW_004936722:1,252,083...1,264,018
Ensembl chrNW_004936722:1,227,198...1,264,855 		JBrowse link
G C1qbp complement C1q binding protein involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936677:2,371,400...2,376,608
Ensembl chrNW_004936677:2,371,418...2,376,608 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21470964) Ensembl
MGI		 PMID:21470964 GO_REF:0000107 NCBI chrNW_004936500:5,317,109...5,423,593
Ensembl chrNW_004936500:5,316,164...5,404,353 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18480465) Ensembl
MGI		 PMID:18480465 GO_REF:0000107 NCBI chrNW_004936478:2,970,261...2,980,277
Ensembl chrNW_004936478:2,970,468...2,980,381 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23636947) Ensembl
MGI		 PMID:23636947 GO_REF:0000107 NCBI chrNW_004936828:827,660...839,088
Ensembl chrNW_004936828:828,837...838,720 		JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L ISO RGD PMID:22570490 RGD:9999428 NCBI chrNW_004936661:1,793,791...1,806,564
Ensembl chrNW_004936661:1,793,801...1,806,579 		JBrowse link
G LOC106144891 CUGBP Elav-like family member 4 acts_upstream_of_or_within ISO (PMID:23636947) MGI PMID:23636947 NCBI chrNW_004936517:8,010,133...8,010,721 JBrowse link
G Npm1 nucleophosmin 1 acts_upstream_of_or_within ISO (PMID:16376875) MGI PMID:16376875 NCBI chrNW_004936609:3,712,628...3,725,635 JBrowse link
G Pcbp4 poly(rC) binding protein 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23636947) TreeGrafter
MGI		 PMID:23636947 GO_REF:0000118 NCBI chrNW_004936529:3,304,171...3,308,422
Ensembl chrNW_004936529:3,300,712...3,308,288 		JBrowse link
G Ptbp1 polypyrimidine tract binding protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23636947) Ensembl
MGI		 PMID:23636947 GO_REF:0000107 NCBI chrNW_004936588:316,348...326,895
Ensembl chrNW_004936588:316,167...327,044 		JBrowse link
G Ptbp3 polypyrimidine tract binding protein 3 acts_upstream_of_or_within ISO (PMID:23636947) MGI PMID:23636947 NCBI chrNW_004936559:1,091,575...1,186,452
Ensembl chrNW_004936559:1,091,494...1,186,440 		JBrowse link
G Rbm10 RNA binding motif protein 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23636947) Ensembl
MGI		 PMID:23636947 GO_REF:0000107 NCBI chrNW_004936502:12,923,890...12,952,179
Ensembl chrNW_004936502:12,925,910...12,955,470 		JBrowse link
G Rbm20 RNA binding motif protein 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936486:1,472,170...1,652,314
Ensembl chrNW_004936486:1,472,227...1,653,209 		JBrowse link
G Rbm42 RNA binding motif protein 42 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23636947) Ensembl
MGI		 PMID:23636947 GO_REF:0000107 NCBI chrNW_004936570:676,775...685,415
Ensembl chrNW_004936570:676,537...685,419 		JBrowse link
G Rnps1 RNA binding protein with serine rich domain 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936694:1,784,396...1,794,269
Ensembl chrNW_004936694:1,784,480...1,793,481 		JBrowse link
G Sap18 Sin3A associated protein 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936720:610,478...616,529
Ensembl chrNW_004936720:610,478...616,546 		JBrowse link
G Sfswap splicing factor SWAP involved_in ISO PMID:15009664 UniProt PMID:15009664 RGD:8554197 NCBI chrNW_004936660:2,055,180...2,121,008
Ensembl chrNW_004936660:2,054,978...2,121,279 		JBrowse link
G Srsf10 serine and arginine rich splicing factor 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:9,068,012...9,079,717
Ensembl chrNW_004936474:9,066,103...9,079,780 		JBrowse link
G Srsf4 serine and arginine rich splicing factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:13,113,191...13,140,956
Ensembl chrNW_004936474:13,113,867...13,140,599 		JBrowse link
G Srsf6 serine and arginine rich splicing factor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936530:3,086,944...3,092,780
Ensembl chrNW_004936530:3,086,680...3,092,828 		JBrowse link
G Srsf7 serine and arginine rich splicing factor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936508:12,475,906...12,481,501
Ensembl chrNW_004936508:12,475,661...12,481,501 		JBrowse link
G Srsf9 serine and arginine rich splicing factor 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936668:484,922...491,576
Ensembl chrNW_004936668:484,917...495,699 		JBrowse link
G U2af2 U2 small nuclear RNA auxiliary factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936981:176,552...193,798
Ensembl chrNW_004936981:176,647...193,152 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15971
    metabolic process 9633
      negative regulation of metabolic process 2628
        negative regulation of macromolecule metabolic process 2406
          negative regulation of RNA metabolic process 1328
            negative regulation of RNA splicing 28
              negative regulation of mRNA splicing, via spliceosome 23
                negative regulation of mRNA cis splicing, via spliceosome 0
Path 2
Term Annotations click to browse term
  biological_process 15971
    metabolic process 9633
      organic substance metabolic process 9208
        organic cyclic compound metabolic process 5208
          nucleobase-containing compound metabolic process 4758
            nucleic acid metabolic process 4278
              RNA metabolic process 3755
                RNA processing 839
                  RNA splicing 367
                    RNA splicing, via transesterification reactions 290
                      RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 290
                        mRNA splicing, via spliceosome 290
                          regulation of mRNA splicing, via spliceosome 110
                            negative regulation of mRNA splicing, via spliceosome 23
                              negative regulation of mRNA cis splicing, via spliceosome 0
paths to the root