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ONTOLOGY REPORT - ANNOTATIONS

Term:tRNA methyltransferase activity
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Accession:GO:0008175 term browser browse the term
Definition:Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule.
Synonyms:xref: reactome:R-HSA-6782879 "TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe)";   reactome:R-HSA-6782881 "LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe)";   reactome:R-HSA-6782890 "LCMT2 methoxycarbonylates yW-58 yielding yW (wybutosine) at nucleotide 37 of tRNA(Phe)";   reactome:R-HSA-6783473 "LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe)";   reactome:R-HSA-6786500 "ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34";   reactome:R-HSA-6786567 "KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine"


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tRNA methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALKBH8 alkB homolog 8, tRNA methyltransferase enables IEA UniProt GO_REF:0000117 NCBI chr11:102,390,687...102,456,357
Ensembl chr11:105,872,588...105,937,472 		JBrowse link
G BCDIN3D BCDIN3 domain containing RNA methyltransferase enables IEA Ensembl GO_REF:0000107 NCBI chr12:38,907,254...38,913,958
Ensembl chr12:39,802,601...39,807,948 		JBrowse link
G FTSJ1 FtsJ RNA 2'-O-methyltransferase 1 enables IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chr  X:40,774,056...40,784,290
Ensembl chr  X:48,638,454...48,648,779 		JBrowse link
G LCMT2 leucine carboxyl methyltransferase 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr15:22,288,992...22,291,814
Ensembl chr15:40,444,633...40,446,693 		JBrowse link
G TRDMT1 tRNA aspartic acid methyltransferase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr10:17,460,091...17,518,855
Ensembl chr10:17,738,374...17,791,345 		JBrowse link
G TRMT13 tRNA methyltransferase 13 homolog enables IEA TreeGrafter GO_REF:0000118 NCBI chr 1:102,790,960...102,808,365
Ensembl chr 1:101,506,349...101,523,722 		JBrowse link
G TRMT5 tRNA methyltransferase 5 enables IEA TreeGrafter GO_REF:0000118 NCBI chr14:41,578,241...41,588,494
Ensembl chr14:59,836,906...59,845,936 		JBrowse link
G TRMT9B tRNA methyltransferase 9B (putative) enables IEA UniProt GO_REF:0000117 NCBI chr 8:12,150,772...12,228,454
Ensembl chr 8:8,904,500...8,983,939 		JBrowse link
tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALKBH8 alkB homolog 8, tRNA methyltransferase enables IEA UniProt
TreeGrafter		 GO_REF:0000003 GO_REF:0000118 NCBI chr11:102,390,687...102,456,357
Ensembl chr11:105,872,588...105,937,472 		JBrowse link
G TRMT9B tRNA methyltransferase 9B (putative) enables IEA TreeGrafter GO_REF:0000118 NCBI chr 8:12,150,772...12,228,454
Ensembl chr 8:8,904,500...8,983,939 		JBrowse link
tRNA (adenine(58)-N1)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRMT61A tRNA methyltransferase 61A enables IEA UniProt
RHEA
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 NCBI chr14:84,151,067...84,167,111
Ensembl chr14:103,966,755...103,974,697 		JBrowse link
G TRMT61B tRNA methyltransferase 61B enables IEA UniProt
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 NCBI chr2A:28,856,360...28,876,817
Ensembl chr2A:28,935,376...28,955,575 		JBrowse link
tRNA (adenine(9)-N1)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRMT10C tRNA methyltransferase 10C, mitochondrial RNase P subunit enables ISO (PMID:23042678) GO_Central PMID:23042678 NCBI chr 3:98,671,176...98,675,743 JBrowse link
tRNA (cytidine(32)-2'-O)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FTSJ1 FtsJ RNA 2'-O-methyltransferase 1 enables IEA UniProt
RHEA
Ensembl		 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chr  X:40,774,056...40,784,290
Ensembl chr  X:48,638,454...48,648,779 		JBrowse link
tRNA (cytidine) methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FTSJ1 FtsJ RNA 2'-O-methyltransferase 1 enables IEA UniProt GO_REF:0000117 NCBI chr  X:40,774,056...40,784,290
Ensembl chr  X:48,638,454...48,648,779 		JBrowse link
G METTL2B methyltransferase 2B, tRNA N3-cytidine enables ISO (PMID:21518805) UniProt PMID:21518805 NCBI chr 7:120,467,773...120,493,024 JBrowse link
tRNA (cytidine-3-)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G METTL2A methyltransferase 2A, tRNA N3-cytidine enables ISO (PMID:28655767)
(PMID:34268557)		 UniProt
MGI		 PMID:28655767 PMID:34268557 NCBI chr17:56,488,631...56,515,661 JBrowse link
G METTL2B methyltransferase 2B, tRNA N3-cytidine enables ISO (PMID:28655767) UniProt PMID:28655767 NCBI chr 7:120,467,773...120,493,024 JBrowse link
G METTL6 methyltransferase 6, tRNA N3-cytidine enables IEA Ensembl GO_REF:0000107 NCBI chr 3:15,306,890...15,353,505
Ensembl chr 3:15,643,545...15,690,238 		JBrowse link
G METTL8 methyltransferase 8, tRNA N3-cytidine enables IEA TreeGrafter GO_REF:0000118 NCBI chr2B:58,605,042...58,725,999
Ensembl chr2B:176,070,609...176,183,862 		JBrowse link
tRNA (cytidine-5-)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOP2 NOP2 nucleolar protein enables IEA TreeGrafter GO_REF:0000118 NCBI chr12:6,687,763...6,699,234
Ensembl chr12:6,606,036...6,617,260 		JBrowse link
G NSUN2 NOP2/Sun RNA methyltransferase 2 enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:6,921,073...6,953,622
Ensembl chr 5:6,596,414...6,629,121 		JBrowse link
G NSUN3 NOP2/Sun RNA methyltransferase 3 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:91,128,431...91,203,337
Ensembl chr 3:97,807,732...97,878,472 		JBrowse link
G NSUN6 NOP2/Sun RNA methyltransferase 6 enables IEA Ensembl GO_REF:0000107 NCBI chr10:18,864,484...18,978,297
Ensembl chr10:19,199,642...19,304,089 		JBrowse link
G TRDMT1 tRNA aspartic acid methyltransferase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr10:17,460,091...17,518,855
Ensembl chr10:17,738,374...17,791,345 		JBrowse link
tRNA (guanine(10)-N2)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRMT11 tRNA methyltransferase 11 homolog enables IEA InterPro GO_REF:0000002 NCBI chr 6:123,770,783...123,825,179
Ensembl chr 6:127,888,697...127,941,505 		JBrowse link
G TRMT1L tRNA methyltransferase 1 like enables IEA InterPro GO_REF:0000002 NCBI chr 1:160,642,659...160,681,709
Ensembl chr 1:164,795,113...164,833,940 		JBrowse link
tRNA (guanine(26)-N2)-dimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRMT1 tRNA methyltransferase 1 enables ISO (PMID:10982862) Reactome PMID:10982862 NCBI chr19:12,666,426...12,679,454 JBrowse link
tRNA (guanine(34)-2'-O)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FTSJ1 FtsJ RNA 2'-O-methyltransferase 1 enables IEA Ensembl
UniProt
RHEA		 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chr  X:40,774,056...40,784,290
Ensembl chr  X:48,638,454...48,648,779 		JBrowse link
tRNA (guanine(37)-N1)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRMT5 tRNA methyltransferase 5 enables IEA UniProt
InterPro
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000116 NCBI chr14:41,578,241...41,588,494
Ensembl chr14:59,836,906...59,845,936 		JBrowse link
tRNA (guanine(46)-N7)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G METTL1 methyltransferase 1, tRNA methylguanosine enables IEA Ensembl
TreeGrafter
InterPro
UniProt
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 NCBI chr12:31,154,374...31,158,175
Ensembl chr12:31,414,941...31,418,588 		JBrowse link
tRNA (guanine(6)-N2)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G THUMPD3 THUMP domain containing 3 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:9,315,275...9,338,096
Ensembl chr 3:9,557,894...9,581,157 		JBrowse link
tRNA (guanine(7)-N2)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G THUMPD3 THUMP domain containing 3 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:9,315,275...9,338,096
Ensembl chr 3:9,557,894...9,581,157 		JBrowse link
tRNA (guanine) methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FTSJ1 FtsJ RNA 2'-O-methyltransferase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr  X:40,774,056...40,784,290
Ensembl chr  X:48,638,454...48,648,779 		JBrowse link
G TARBP1 TAR (HIV-1) RNA binding protein 1 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:209,957,637...210,018,398
Ensembl chr 1:214,951,792...215,039,121 		JBrowse link
G THUMPD2 THUMP domain containing 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr2A:39,768,913...39,816,471
Ensembl chr2A:40,526,774...40,571,909 		JBrowse link
G THUMPD3 THUMP domain containing 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 3:9,315,275...9,338,096
Ensembl chr 3:9,557,894...9,581,157 		JBrowse link
tRNA (guanosine(9)-N1)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRMT10A tRNA methyltransferase 10A enables IEA UniProt
Ensembl		 GO_REF:0000003 GO_REF:0000107 NCBI chr 4:91,970,440...91,987,722
Ensembl chr 4:102,631,501...102,648,454 		JBrowse link
G TRMT10B tRNA methyltransferase 10B enables IEA UniProt
Ensembl		 GO_REF:0000003 GO_REF:0000107 NCBI chr 9:37,602,757...37,628,693
Ensembl chr 9:38,526,496...38,551,902 		JBrowse link
G TRMT10C tRNA methyltransferase 10C, mitochondrial RNase P subunit enables ISO (PMID:23042678) GO_Central PMID:23042678 NCBI chr 3:98,671,176...98,675,743 JBrowse link
tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRMO tRNA methyltransferase O enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:68,994,715...69,013,456
Ensembl chr 9:97,115,398...97,133,361 		JBrowse link
tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRMT2A tRNA methyltransferase 2 homolog A enables IEA Ensembl GO_REF:0000107 NCBI chr22:2,872,328...2,877,732
Ensembl chr22:18,544,736...18,550,174 		JBrowse link
G TRMT2B tRNA methyltransferase 2 homolog B enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr  X:90,210,740...90,253,863
Ensembl chr  X:100,347,795...100,389,981 		JBrowse link
tRNA (uridine) methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALKBH8 alkB homolog 8, tRNA methyltransferase enables IEA Ensembl GO_REF:0000107 NCBI chr11:102,390,687...102,456,357
Ensembl chr11:105,872,588...105,937,472 		JBrowse link
G TRMT44 tRNA methyltransferase 44 homolog enables IEA TreeGrafter GO_REF:0000118 Ensembl chr 4:8,506,313...8,542,353 JBrowse link
tRNA 2'-O-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FTSJ1 FtsJ RNA 2'-O-methyltransferase 1 enables ISO (PMID:25404562), (PMID:26310293) Reactome PMID:25404562 PMID:26310293 NCBI chr  X:40,774,056...40,784,290
Ensembl chr  X:48,638,454...48,648,779 		JBrowse link
G TRMT13 tRNA methyltransferase 13 homolog enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chr 1:102,790,960...102,808,365
Ensembl chr 1:101,506,349...101,523,722 		JBrowse link
tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRMT44 tRNA methyltransferase 44 homolog enables IEA UniProt GO_REF:0000003 Ensembl chr 4:8,506,313...8,542,353 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17493
    catalytic activity 5389
      catalytic activity, acting on a nucleic acid 593
        catalytic activity, acting on RNA 366
          RNA methyltransferase activity 62
            tRNA methyltransferase activity 32
              tRNA (adenine) methyltransferase activity + 4
              tRNA (cytidine) methyltransferase activity + 10
              tRNA (guanine) methyltransferase activity + 12
              tRNA (uridine) methyltransferase activity + 5
              tRNA 2'-O-methyltransferase activity + 2
Path 2
Term Annotations click to browse term
  molecular_function 17493
    catalytic activity 5389
      transferase activity 2182
        transferase activity, transferring one-carbon groups 213
          methyltransferase activity 201
            RNA methyltransferase activity 62
              tRNA methyltransferase activity 32
                tRNA (adenine) methyltransferase activity + 4
                tRNA (cytidine) methyltransferase activity + 10
                tRNA (guanine) methyltransferase activity + 12
                tRNA (uridine) methyltransferase activity + 5
                tRNA 2'-O-methyltransferase activity + 2
paths to the root