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ONTOLOGY REPORT - ANNOTATIONS

Term:calcidiol 1-monooxygenase activity
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Accession:GO:0004498 term browser browse the term
Definition:Catalysis of the reaction: calcidiol + H+ + NADPH + O2 = calcitriol + H2O + NADP+.
Synonyms:exact_synonym: 25-hydroxy vitamin D3 1-alpha-hydroxylase activity;   calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
 narrow_synonym: cytochrome P450 CYP27B
 related_synonym: 1-hydroxylase-25-hydroxyvitamin D3 activity;   25-OHD-1 alpha-hydroxylase activity;   25-hydroxy D3-1alpha-hydroxylase activity;   25-hydroxycholecalciferol 1-monooxygenase activity;   25-hydroxycholecalciferol 1alpha-hydroxylase activity;   25-hydroxycholecalciferol-1-hydroxylase activity;   25-hydroxyvitamin D-1 alpha hydroxylase activity;   25-hydroxyvitamin D3 1alpha-hydroxylase activity
 xref: EC:1.14.15.18;   KEGG_REACTION:R03610;   MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN;   RHEA:20573;   Reactome:R-HSA-5602186 "Defective CYP27B1 does not hydroxylate CDL";   reactome:R-HSA-209868 "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D"

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calcidiol 1-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G CYP27B1 cytochrome P450 family 27 subfamily B member 1 enables ISO
IEA		 RGD
Ensembl		 PMID:9371776 GO_REF:0000107 RGD:69372 NCBI chr11:53,675,704...53,681,372
Ensembl chr11:53,675,226...53,680,443 		JBrowse link
G P CYP27B1 cytochrome P450 family 27 subfamily B member 1 enables ISO
IEA		 RGD
Ensembl		 PMID:9371776 GO_REF:0000107 RGD:69372 NCBI chr 5:23,053,129...23,058,865
Ensembl chr 5:23,053,892...23,058,470 		JBrowse link
G D CYP27B1 cytochrome P450 family 27 subfamily B member 1 enables ISO
IEA		 RGD
Ensembl		 PMID:9371776 GO_REF:0000107 RGD:69372 NCBI chr10:1,825,224...1,830,845
Ensembl chr10:1,826,046...1,829,911 		JBrowse link
G B CYP27B1 cytochrome P450 family 27 subfamily B member 1 enables ISO
IEA		 RGD
Ensembl		 PMID:9371776 GO_REF:0000107 RGD:69372 NCBI chr12:31,158,814...31,164,462
Ensembl chr12:31,419,773...31,424,822 		JBrowse link
G R Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 enables TAS
IEA
ISO
IDA		 GO_REF:0000107
(MGI:1097206|PMID:9295274), (MGI:3590419|PMID:15972816)
PMID:9333115
(PMID:15795327), (PMID:16549446), (PMID:17023519), (PMID:22862690), (PMID:9415400)		 Ensembl
RGD		 PMID:9295274 PMID:9415400 PMID:15795327 PMID:15972816 PMID:16549446 More... GO_REF:0000107 MGI:1097206 MGI:3590419, RGD:68680, RGD:69373, RGD:69372 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G M Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 enables IDA
IBA
ISO		 (MGI:1097206|PMID:9295274), (MGI:3590419|PMID:15972816) UniProt
GO_Central
MGI
RGD		 PMID:9295274 PMID:9371776 PMID:15972816 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:1097206 MGI:3590419 MGI:4417868 MGI:4834177 RGD:69372 NCBI chr10:126,884,115...126,891,897
Ensembl chr10:126,884,119...126,888,875 		JBrowse link
G H CYP27B1 cytochrome P450 family 27 subfamily B member 1 enables ISO
IDA
TAS
IEA		 (PMID:15795327), (PMID:16549446), (PMID:17023519), (PMID:22862690), (PMID:9415400) RGD
UniProt
Reactome
Ensembl
RHEA		 PMID:9371776 PMID:9415400 PMID:15795327 PMID:16549446 PMID:17023519 More... GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 RGD:69372 Reactome:R-HSA-209868 Reactome:R-HSA-5602186 NCBI chr12:57,762,334...57,767,078
Ensembl chr12:57,762,334...57,768,986 		JBrowse link
G N LOC101700851 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial enables ISO
IEA		 RGD
Ensembl		 PMID:9371776 GO_REF:0000107 RGD:69372 NCBI chrNW_004624802:10,176,865...10,181,725
Ensembl chrNW_004624802:10,176,919...10,181,657 		JBrowse link
G S LOC101978323 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial enables ISO
IEA		 RGD
Ensembl		 PMID:9371776 GO_REF:0000107 RGD:69372 NCBI chrNW_004936646:1,899,686...1,904,104
Ensembl chrNW_004936646:1,900,259...1,904,104 		JBrowse link
G C LOC102011841 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial enables ISO (MGI:1097206|PMID:9295274), (MGI:3590419|PMID:15972816)
PMID:9333115
(PMID:15795327), (PMID:16549446), (PMID:17023519), (PMID:22862690), (PMID:9415400)		 RGD
UniProt
BHF-UCL		 PMID:9295274 PMID:9333115 PMID:9371776 PMID:9415400 PMID:15795327 More... MGI:1097206 MGI:3590419 RGD:69372 RGD:69373 NCBI chrNW_004955458:5,472,404...5,477,001
Ensembl chrNW_004955458:5,472,404...5,477,001 		JBrowse link
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