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ONTOLOGY REPORT - ANNOTATIONS

Term:acyl-CoA dehydrogenase activity
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Accession:GO:0003995 term browser browse the term
Definition:Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].
Synonyms:exact_synonym: acyl-CoA reductase activity
 related_synonym: acyl coenzyme A dehydrogenase activity;   fatty acyl coenzyme A dehydrogenase activity;   fatty-acyl-CoA dehydrogenase activity;   general acyl CoA dehydrogenase activity
 alt_id: GO:0019109
 xref: MetaCyc:ACYLCOADEHYDROG-RXN;   MetaCyc:RXN-13624;   RHEA:44704;   reactome:R-HSA-109341 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA";   reactome:R-HSA-5695980 "ACAD10 dehydrogenates S-2MPDA-CoA";   reactome:R-HSA-5695989 "ACAD11 dehydrogenates BH-CoA";   reactome:R-HSA-70800 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2";   reactome:R-HSA-70859 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2";   reactome:R-HSA-77263 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2";   reactome:R-HSA-77274 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2";   reactome:R-HSA-77299 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2";   reactome:R-HSA-77319 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2";   reactome:R-HSA-77327 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2";   reactome:R-HSA-77338 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2";   reactome:R-HSA-77345 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2"


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acyl-CoA dehydrogenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAD10 acyl-CoA dehydrogenase family member 10 enables IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr14:32,841,863...32,890,983
Ensembl chr14:32,841,911...32,890,981 		JBrowse link
G ACAD11 acyl-CoA dehydrogenase family member 11 enables IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr13:73,733,508...73,831,496
Ensembl chr13:73,730,171...73,831,701 		JBrowse link
G ACAD8 acyl-CoA dehydrogenase family member 8 enables IEA InterPro GO_REF:0000002 NCBI chr 9:60,807,405...60,828,379
Ensembl chr 9:60,807,486...60,828,389 		JBrowse link
G ACAD9 acyl-CoA dehydrogenase family member 9 enables IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr13:71,374,926...71,422,431
Ensembl chr13:71,374,944...71,427,126 		JBrowse link
G ACADM acyl-CoA dehydrogenase medium chain enables ISO
IEA
ISS		 RGD
InterPro
Ensembl
UniProt		 PMID:3968063 PMID:15358373 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 RGD:1358266 RGD:2317678 NCBI chr 6:137,541,481...137,575,544
Ensembl chr 6:137,541,381...137,595,108 		JBrowse link
G ACADS acyl-CoA dehydrogenase short chain enables ISO
IEA
ISS		 RGD
InterPro
UniProt
Ensembl		 PMID:9459013 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 RGD:1598700 NCBI chr14:40,642,810...40,656,922
Ensembl chr14:40,642,881...40,659,081 		JBrowse link
G ACADSB acyl-CoA dehydrogenase short/branched chain enables ISO
IEA
IBA		 RGD
TreeGrafter
GO_Central
InterPro		 PMID:8660691 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 RGD:631739 NCBI chr14:132,563,002...132,607,574
Ensembl chr14:132,563,309...132,626,841 		JBrowse link
G ACADVL acyl-CoA dehydrogenase very long chain enables ISO
IEA		 RGD
InterPro
Ensembl		 PMID:8034667 GO_REF:0000002 GO_REF:0000107 RGD:631729 NCBI chr12:52,573,521...52,581,755
Ensembl chr12:52,576,402...52,581,748 		JBrowse link
G GCDH glutaryl-CoA dehydrogenase enables IEA InterPro GO_REF:0000002 NCBI chr 2:66,131,154...66,138,963
Ensembl chr 2:66,130,625...66,138,868 		JBrowse link
G IVD isovaleryl-CoA dehydrogenase enables IEA InterPro GO_REF:0000002 NCBI chr 1:130,916,956...130,930,172
Ensembl chr 1:130,916,146...130,930,078 		JBrowse link
G IVD isovaleryl-CoA dehydrogenase enables IEA InterPro GO_REF:0000002 NCBI chr 1:130,896,488...130,910,582
Ensembl chr 1:130,893,984...130,910,586 		JBrowse link
G UNC119B unc-119 lipid binding chaperone B enables IEA InterPro GO_REF:0000002 NCBI chr14:40,624,196...40,638,497
Ensembl chr14:40,627,730...40,638,493 		JBrowse link
2-methylbutanoyl-CoA dehydrogenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACADSB acyl-CoA dehydrogenase short/branched chain enables IEA Ensembl GO_REF:0000107 NCBI chr14:132,563,002...132,607,574
Ensembl chr14:132,563,309...132,626,841 		JBrowse link
3-hydroxyisobutyryl-CoA hydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ECHDC2 enoyl-CoA hydratase domain containing 2 enables IEA UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 6:159,326,146...159,347,178
Ensembl chr 6:159,326,150...159,347,173 		JBrowse link
G HIBCH 3-hydroxyisobutyryl-CoA hydrolase enables IEA
IBA		 RHEA
TreeGrafter
GO_Central
Ensembl
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 NCBI chr15:94,795,744...94,941,362
Ensembl chr15:94,792,985...94,941,266 		JBrowse link
butyryl-CoA dehydrogenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACADS acyl-CoA dehydrogenase short chain enables ISO
IBA
IEA
ISS		 RGD
GO_Central
TreeGrafter
RHEA
UniProt		 PMID:3968063 PMID:8952487 GO_REF:0000024 GO_REF:0000033 GO_REF:0000116 GO_REF:0000118 RGD:1598701 RGD:2317678 NCBI chr14:40,642,810...40,656,922
Ensembl chr14:40,642,881...40,659,081 		JBrowse link
G UNC119B unc-119 lipid binding chaperone B enables IEA TreeGrafter GO_REF:0000118 NCBI chr14:40,624,196...40,638,497
Ensembl chr14:40,627,730...40,638,493 		JBrowse link
glutaryl-CoA dehydrogenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCDH glutaryl-CoA dehydrogenase enables ISO
IBA
IEA		 RGD
GO_Central
TreeGrafter
UniProt
Ensembl
RHEA		 PMID:2899130 PMID:6895440 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 RGD:1598697 RGD:1598698 NCBI chr 2:66,131,154...66,138,963
Ensembl chr 2:66,130,625...66,138,868 		JBrowse link
isovaleryl-CoA dehydrogenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAD9 acyl-CoA dehydrogenase family member 9 enables IEA TreeGrafter GO_REF:0000118 NCBI chr13:71,374,926...71,422,431
Ensembl chr13:71,374,944...71,427,126 		JBrowse link
G ACADL acyl-CoA dehydrogenase long chain enables IEA TreeGrafter GO_REF:0000118 NCBI chr15:112,935,631...112,969,381
Ensembl chr15:112,933,506...112,969,577 		JBrowse link
G IVD isovaleryl-CoA dehydrogenase enables ISO
IEA		 RGD
TreeGrafter
UniProt		 PMID:2777793 GO_REF:0000003 GO_REF:0000118 RGD:631718 NCBI chr 1:130,896,488...130,910,582
Ensembl chr 1:130,893,984...130,910,586 		JBrowse link
long-chain fatty acyl-CoA dehydrogenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAD11 acyl-CoA dehydrogenase family member 11 enables IEA Ensembl GO_REF:0000107 NCBI chr13:73,733,508...73,831,496
Ensembl chr13:73,730,171...73,831,701 		JBrowse link
G ACAD9 acyl-CoA dehydrogenase family member 9 enables IEA Ensembl GO_REF:0000107 NCBI chr13:71,374,926...71,422,431
Ensembl chr13:71,374,944...71,427,126 		JBrowse link
G ACADL acyl-CoA dehydrogenase long chain enables ISO
IBA
IEA		 RGD
GO_Central
RHEA
InterPro
UniProt		 PMID:3968063 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 RGD:2317678 NCBI chr15:112,935,631...112,969,381
Ensembl chr15:112,933,506...112,969,577 		JBrowse link
G ACADVL acyl-CoA dehydrogenase very long chain enables ISO
IEA		 RGD
Ensembl		 PMID:8034667 GO_REF:0000107 RGD:631729 NCBI chr12:52,573,521...52,581,755
Ensembl chr12:52,576,402...52,581,748 		JBrowse link
medium-chain fatty acyl-CoA dehydrogenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAD11 acyl-CoA dehydrogenase family member 11 enables IEA Ensembl GO_REF:0000107 NCBI chr13:73,733,508...73,831,496
Ensembl chr13:73,730,171...73,831,701 		JBrowse link
G ACAD9 acyl-CoA dehydrogenase family member 9 enables IEA Ensembl GO_REF:0000107 NCBI chr13:71,374,926...71,422,431
Ensembl chr13:71,374,944...71,427,126 		JBrowse link
G ACADM acyl-CoA dehydrogenase medium chain enables IEA
IBA		 InterPro
Ensembl
RHEA
UniProt
GO_Central		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr 6:137,541,481...137,575,544
Ensembl chr 6:137,541,381...137,595,108 		JBrowse link
short-chain fatty acyl-CoA dehydrogenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACADS acyl-CoA dehydrogenase short chain enables IEA UniProt GO_REF:0000003 NCBI chr14:40,642,810...40,656,922
Ensembl chr14:40,642,881...40,659,081 		JBrowse link
G ACADSB acyl-CoA dehydrogenase short/branched chain enables IEA Ensembl GO_REF:0000107 NCBI chr14:132,563,002...132,607,574
Ensembl chr14:132,563,309...132,626,841 		JBrowse link
G IVD isovaleryl-CoA dehydrogenase enables IEA UniProt GO_REF:0000117 NCBI chr 1:130,896,488...130,910,582
Ensembl chr 1:130,893,984...130,910,586 		JBrowse link
very-long-chain fatty acyl-CoA dehydrogenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAD11 acyl-CoA dehydrogenase family member 11 enables IEA Ensembl GO_REF:0000107 NCBI chr13:73,733,508...73,831,496
Ensembl chr13:73,730,171...73,831,701 		JBrowse link
G ACADVL acyl-CoA dehydrogenase very long chain enables ISO
IEA
IBA		 RGD
Ensembl
GO_Central
TreeGrafter		 PMID:1730632 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 RGD:2317689 NCBI chr12:52,573,521...52,581,755
Ensembl chr12:52,576,402...52,581,748 		JBrowse link
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