ACADM (acyl-CoA dehydrogenase medium chain) - Rat Genome Database

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Gene: ACADM (acyl-CoA dehydrogenase medium chain) Sus scrofa
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Symbol: ACADM
Name: acyl-CoA dehydrogenase medium chain
RGD ID: 14032407
Description: ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (ortholog); flavin adenine dinucleotide binding (ortholog); isomerase activity (ortholog); INVOLVED IN cardiac muscle cell differentiation (ortholog); carnitine metabolic process (ortholog); fatty acid beta-oxidation (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH Congenital Hydrocephalus 2, with or without Brain or Eye Anomalies (ortholog); genetic disease (ortholog); Liver Failure (ortholog); FOUND IN axon (inferred); mitochondrial matrix (inferred); mitochondrial membrane (inferred); INTERACTS WITH cadmium atom; cadmium dichloride
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acyl-CoA dehydrogenase, C-4 to C-12 straight chain; acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain; MCAD; medium-chain acyl-CoA dehydrogenase; medium-chain specific acyl-CoA dehydrogenase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6137,541,381 - 137,595,108 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16137,541,481 - 137,575,544 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26127,513,877 - 127,547,942 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:8356049   PMID:14681463   PMID:16879370   PMID:17145712   PMID:19470521   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ACADM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6137,541,381 - 137,595,108 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16137,541,481 - 137,575,544 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26127,513,877 - 127,547,942 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACADM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38175,724,709 - 75,763,679 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl175,724,431 - 75,787,575 (+)EnsemblGRCh38hg38GRCh38
GRCh37176,190,394 - 76,229,364 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36175,962,870 - 76,001,771 (+)NCBINCBI36Build 36hg18NCBI36
Build 34175,902,302 - 75,941,204NCBI
Celera174,429,931 - 74,469,272 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef174,319,974 - 74,359,196 (+)NCBIHuRef
CHM1_1176,305,398 - 76,344,690 (+)NCBICHM1_1
T2T-CHM13v2.0175,561,369 - 75,600,339 (+)NCBIT2T-CHM13v2.0
Acadm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393153,627,990 - 153,650,280 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3153,627,994 - 153,650,269 (-)EnsemblGRCm39 Ensembl
GRCm383153,922,353 - 153,944,643 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3153,922,357 - 153,944,632 (-)EnsemblGRCm38mm10GRCm38
MGSCv373153,585,323 - 153,607,396 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363153,859,745 - 153,881,818 (-)NCBIMGSCv36mm8
Celera3160,386,018 - 160,408,092 (-)NCBICelera
Cytogenetic Map3H3NCBI
cM Map378.77NCBI
Acadm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82245,518,693 - 245,542,864 (-)NCBIGRCr8
mRatBN7.22242,858,865 - 242,883,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2242,858,865 - 242,883,147 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2250,681,651 - 250,705,889 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02248,575,474 - 248,599,714 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02243,474,041 - 243,498,277 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02260,124,418 - 260,148,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2260,124,418 - 260,148,589 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02278,788,485 - 278,812,656 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42251,866,645 - 251,890,729 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12251,881,251 - 251,905,336 (-)NCBI
Celera2234,791,302 - 234,815,446 (-)NCBICelera
RH 3.4 Map21631.1RGD
Cytogenetic Map2q45NCBI
Acadm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542317,172,779 - 17,199,090 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542317,173,648 - 17,199,189 (-)NCBIChiLan1.0ChiLan1.0
ACADM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21151,129,587 - 151,168,926 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11150,290,108 - 150,329,365 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0174,939,477 - 74,978,815 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1176,911,763 - 76,950,840 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl176,911,763 - 76,950,840 (+)Ensemblpanpan1.1panPan2
ACADM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1670,852,223 - 70,881,979 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl670,853,061 - 70,878,668 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha673,516,991 - 73,547,426 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0671,444,858 - 71,475,297 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl671,444,855 - 71,475,372 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1670,941,180 - 70,971,613 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0670,886,684 - 70,917,117 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0671,380,006 - 71,410,441 (-)NCBIUU_Cfam_GSD_1.0
Acadm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505887,250,876 - 87,286,693 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365712,761,254 - 2,797,045 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACADM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12057,428,863 - 57,468,422 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2057,428,472 - 57,468,359 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603360,040,155 - 60,081,642 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acadm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474221,188,062 - 21,215,436 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ACADM
738 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000004179   ⟹   ENSSSCP00000004085
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6137,541,381 - 137,571,623 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000061492   ⟹   ENSSSCP00000046096
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6137,541,381 - 137,595,108 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000067399   ⟹   ENSSSCP00000065963
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6137,541,381 - 137,595,108 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000070971   ⟹   ENSSSCP00000074548
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6137,541,380 - 137,575,519 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000072479   ⟹   ENSSSCP00000067530
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6137,541,381 - 137,595,108 (-)Ensembl
RefSeq Acc Id: NM_214039   ⟹   NP_999204
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16137,541,481 - 137,575,544 (-)NCBI
Sequence:
RefSeq Acc Id: NP_999204   ⟸   NM_214039
- Peptide Label: precursor
- UniProtKB: Q58XQ3 (UniProtKB/Swiss-Prot),   P41367 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSSSCP00000074548   ⟸   ENSSSCT00000070971
Ensembl Acc Id: ENSSSCP00000046096   ⟸   ENSSSCT00000061492
Ensembl Acc Id: ENSSSCP00000004085   ⟸   ENSSSCT00000004179
Ensembl Acc Id: ENSSSCP00000067530   ⟸   ENSSSCT00000072479
Ensembl Acc Id: ENSSSCP00000065963   ⟸   ENSSSCT00000067399

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003776 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00005037890 UniProtKB/TrEMBL
  ENSSSCG00025014343 UniProtKB/Swiss-Prot
  ENSSSCG00070017536 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000004179.5 UniProtKB/TrEMBL
  ENSSSCT00000061492 ENTREZGENE
  ENSSSCT00000061492.2 UniProtKB/TrEMBL
  ENSSSCT00000061492.3 UniProtKB/Swiss-Prot
  ENSSSCT00000072479.2 UniProtKB/TrEMBL
  ENSSSCT00005061191.1 UniProtKB/TrEMBL
  ENSSSCT00025019283.1 UniProtKB/Swiss-Prot
  ENSSSCT00070034689.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.540.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Butyryl-CoA Dehydrogenase, subunit A, domain 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Acyl-CoA_dehydrogenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_DH_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_Oxase/DH_cen-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_Oxase/DH_mid-dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCo_DH-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCo_DH/oxidase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCoA_DH/ox_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCoA_DH/ox_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCoA_DH/oxidase_NM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397104 UniProtKB/Swiss-Prot
NCBI Gene ACADM ENTREZGENE
PANTHER MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Acyl-CoA_dh_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_dh_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_dh_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF HsaA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ACYL_COA_DH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACYL_COA_DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47203 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56645 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2C9F350_PIG UniProtKB/TrEMBL
  A0A4X1UK62_PIG UniProtKB/TrEMBL
  A0A5G2R006_PIG UniProtKB/TrEMBL
  ACADM_PIG UniProtKB/Swiss-Prot, ENTREZGENE
  Q58XQ3 ENTREZGENE
UniProt Secondary A0A5S6HU82 UniProtKB/TrEMBL
  Q58XQ3 UniProtKB/Swiss-Prot
VGNC ID VGNC:85000 ENTREZGENE