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ONTOLOGY REPORT - ANNOTATIONS

Term:class I DNA-(apurinic or apyrimidinic site) endonuclease activity
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Accession:GO:0140078 term browser browse the term
Definition:Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.
Comment:Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV.
Synonyms:exact_synonym: AP site-DNA 5'-phosphomonoester-lyase activity;   DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity;   DNA-(apurinic or apyrimidinic site) lyase activity;   class I DNA-(apurinic or apyrimidinic site) lyase activity
 related_synonym: AP endonuclease class I activity;   AP lyase activity
 xref: EC:4.2.99.18;   MetaCyc:4.2.99.18-RXN;   RHEA:66592;   Wikipedia:AP_endonuclease


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class I DNA-(apurinic or apyrimidinic site) endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh1 alkB homolog 1, histone H2A dioxygenase enables ISO (PMID:19959401) RGD PMID:19959401 NCBI chr 6:107,068,301...107,088,784
Ensembl chr 6:107,068,475...107,088,759 		JBrowse link
G Neil2 nei-like DNA glycosylase 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:37,444,676...37,454,863
Ensembl chr15:37,445,381...37,454,863 		JBrowse link
G Neil3 nei-like DNA glycosylase 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr16:38,359,305...38,418,528
Ensembl chr16:38,359,371...38,418,527 		JBrowse link
G Nthl1 nth-like DNA glycosylase 1 enables ISO (PMID:8990169) RGD PMID:8990169 NCBI chr10:13,655,791...13,661,958
Ensembl chr10:13,655,785...13,661,957 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Polb DNA polymerase beta enables ISO (PMID:9614142) RGD PMID:9614142 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812 		JBrowse link
G Rps3 ribosomal protein S3 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680 		JBrowse link
G Rps3l1 ribosomal protein S3 like 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 3:51,559,683...51,560,522
Ensembl chr 3:51,559,683...51,560,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20626
    catalytic activity 6028
      lyase activity 213
        carbon-oxygen lyase activity 89
          class I DNA-(apurinic or apyrimidinic site) endonuclease activity 8
Path 2
Term Annotations click to browse term
  molecular_function 20626
    catalytic activity 6028
      catalytic activity, acting on a nucleic acid 649
        catalytic activity, acting on DNA 283
          DNA-(apurinic or apyrimidinic site) endonuclease activity 15
            class I DNA-(apurinic or apyrimidinic site) endonuclease activity 8
paths to the root